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1. 发明授权

US06587702B1 Classification and characterization of tissue through features related to adipose tissue 有权
标题翻译：通过与脂肪组织相关的特征对组织进行分类和表征
公开(公告)号：US06587702B1
公开(公告)日：2003-07-01
申请号：US09489617
申请日：2000-01-21
申请人： Timothy L. Ruchti , Kevin H. Hazen , Marcy R. Makarewicz , George M. Acosta
发明人： Timothy L. Ruchti , Kevin H. Hazen , Marcy R. Makarewicz , George M. Acosta
IPC分类号： A61B500
CPC分类号： A61B5/4872 , A61B5/0059 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/7264 , G01N21/359 , G01N2201/1293
摘要： A non-invasive system for characterizing and classifying the state and structure of a tissue sample operates on a near infrared absorbance spectrum of in vivo tissue. A method that uses near-infrared spectral measurements to characterize and classify the state and structure of tissue sampled based on absorbance features related to fat in adipose tissue is provided. Also provided is a method of estimating skin fold thickness. The approach provides information about sources of tissue variability and is therefore useful for establishing the general category of the tissue structure. Categorization of subjects on the basis of the determination is suitable for further spectral analysis and the measurement of biological and chemical compounds, such as blood analytes. The invention further provides a method of estimating percent body fat based on a skin fold thickness estimate. The invention also provides an apparatus for measuring the absorbance spectra coupled with a digital processor for performing the required analyses.
摘要翻译：用于表征和分类组织样品的状态和结构的非侵入性系统在体内组织的近红外吸收光谱上操作。提供了一种使用近红外光谱测量来表征和分类基于与脂肪组织中的脂肪相关的吸光度特征所采集的组织的状态和结构的方法。还提供了估计皮肤褶皱厚度的方法。该方法提供了关于组织变异性来源的信息，因此可用于建立组织结构的一般类别。在确定的基础上对受试者进行分类适用于进一步的光谱分析和生物化学化合物如血液分析物的测量。本发明还提供了一种基于皮肤折叠厚度估计估计身体脂肪百分比的方法。本发明还提供了一种用于测量与数字处理器耦合的吸光度谱进行所需分析的装置。

2. 发明授权

US07787924B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07787924B2
公开(公告)日：2010-08-31
申请号：US11324876
申请日：2006-01-03
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析物是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

3. 发明授权

US07519406B2 Noninvasive analyzer sample probe interface method and apparatus 有权
标题翻译：无创分析仪样品探针接口方法和装置
公开(公告)号：US07519406B2
公开(公告)日：2009-04-14
申请号：US11117104
申请日：2005-04-27
申请人： Thomas B. Blank , George M. Acosta , Timothy L. Ruchti , Mutua Mattu , Alexander D. Lorenz , Kevin H. Hazen , James R. Henderson
发明人： Thomas B. Blank , George M. Acosta , Timothy L. Ruchti , Mutua Mattu , Alexander D. Lorenz , Kevin H. Hazen , James R. Henderson
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/1495 , A61B5/4869 , A61B2560/0223 , A61B2560/0233 , A61B2562/0242 , G01N21/359
摘要： A method and apparatus are provided for noninvasive sampling. More particularly, the method and apparatus relate to control of motion of an optical sample probe interface relative to a tissue sample site. A dynamic probe interface, is used to collect spectra of a targeted sample, control positioning of the sample probe relative to the tissue sample in terms of at least one of x-, y-, and z-axes, and/or control of sample tissue displacement to minimize spectral variations resulting from the sampling process and increase analyte property estimation precision and accuracy.
摘要翻译：提供了一种用于无创采样的方法和装置。更具体地，该方法和装置涉及光学样本探针界面相对于组织样本位点的运动的控制。使用动态探针接口来收集目标样品的光谱，根据x-，y-和z-轴中的至少一个来控制样品探针相对于组织样品的定位和/或样品的控制组织位移以最小化由采样过程导致的频谱变化，并增加分析物质的估计精度和精度。

4. 发明授权

US07133710B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07133710B2
公开(公告)日：2006-11-07
申请号：US10472856
申请日：2003-03-07
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyze is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

5. 发明授权

US07505801B2 Apparatus and method for easing use of a spectrophotometric based noninvasive analyzer 有权
标题翻译：用于分光光度计的无创分析仪的装置和方法
公开(公告)号：US07505801B2
公开(公告)日：2009-03-17
申请号：US11848139
申请日：2007-08-30
申请人： Stephen L. Monfre , George M. Acosta , Thomas B. Blank , Kevin H. Hazen
发明人： Stephen L. Monfre , George M. Acosta , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/1455
CPC分类号： A61B5/6841 , A61B5/14532 , A61B5/1455 , G01N21/359 , G01N21/474
摘要： A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.
摘要翻译：公开了一种具有改进的水合诱导塞的放置引导装置，其用于将非侵入性分析器耦合到取样部位以确定人体中的分析物。水合诱导塞包括至少一种可用作偶联剂的含氟聚合物。引导装置还可以包括自动化或半自动化耦合流体输送系统。使用这些耦合剂中的任一种可减轻与相关技术相关的问题，并增强非侵入性分析物测量，例如基于近红外漫反射的非侵入性葡萄糖浓度分析仪。

6. 发明授权

US07015782B2 Magneto-mechanical apparatus 失效
标题翻译：磁力机械装置
公开(公告)号：US07015782B2
公开(公告)日：2006-03-21
申请号：US10752369
申请日：2004-01-05
申请人： Stephen Kincaid , George M. Acosta , Roxanne Abul-Haj , Kevin H. Hazen
发明人： Stephen Kincaid , George M. Acosta , Roxanne Abul-Haj , Kevin H. Hazen
IPC分类号： H01F7/20 , H01H9/00
CPC分类号： F04B9/02 , A61B5/14532 , F04B17/00 , G01N21/49 , H01H3/34 , H01H36/0073
摘要： A magnetic field based mechanical apparatus is disclosed. The apparatus is based on coupled attracting or opposing magnets in conjunction with the insertion or removal of a magnetic field modifier. In the preferred embodiment, two repelling magnets are drawn together with the insertion of a magnetic field modifier. The field modifier may be another magnet having an opposing pole. Removal of the field modifier returns the forces to their original states. This oscillating motion may be driven with a low energy and/or small power supply. The resulting motion of the opposing magnets can drive mechanical system such as a linear, gear, ratchet, or reciprocating drive.
摘要翻译：公开了一种基于磁场的机械装置。该装置基于耦合的吸引或相对的磁体与磁场修改器的插入或移除相结合。在优选实施例中，两个排斥磁体一起插入磁场调节器。场修正器可以是具有相对极的另一个磁体。删除字段修饰符将力转移到其原始状态。这种振荡运动可以用低能量和/或小的电源来驱动。所产生的对置磁体的运动可以驱动诸如线性，齿轮，棘轮或往复驱动的机械系统。

7. 发明授权

US06956649B2 Spectroscopic system and method using a ceramic optical reference 有权
标题翻译：光谱系统和方法使用陶瓷光学参考
公开(公告)号：US06956649B2
公开(公告)日：2005-10-18
申请号：US10723353
申请日：2003-11-25
申请人： George M. Acosta , Kevin H. Hazen , N. Alan Abul-Haj , Stephen L. Monfre , Thomas B. Blank
发明人： George M. Acosta , Kevin H. Hazen , N. Alan Abul-Haj , Stephen L. Monfre , Thomas B. Blank
IPC分类号： G01N21/27 , G01N21/47 , G01N21/49 , G01J3/28
CPC分类号： G01N21/278 , G01N21/4738 , G01N21/4785 , G01N21/49 , G01N2021/4735
摘要： A ceramic reference in conjunction with a spectrometer, a metallized ceramic material, and a method of utilizing a ceramic material as a reference in the ultraviolet, visible, near-infrared, or infrared spectral regions are presented. The preferred embodiments utilize a ceramic reference material to diffusely reflect incident source light toward a detector element for quantification in a reproducible fashion. Alternative embodiments metallize either the incident surface or back surface of to form a surface diffuse reflectance standard. Optional wavelength reference layers or protective layers may be added to the ceramic or to the metallized layer. The reference ceramic is used to provide a measure of optical signal of an analyzer as a function of the analyzers spatial, temporal, and environmental state.
摘要翻译：介绍了陶瓷参考文献，结合光谱仪，金属化陶瓷材料以及在紫外线，可见光，近红外或红外光谱区域中利用陶瓷材料作为参考的方法。优选实施例利用陶瓷参考材料将入射光源漫反射到检测器元件，以便以可再现的方式进行定量。替代实施例将入射表面或后表面金属化以形成表面漫反射标准。可选的波长参考层或保护层可以添加到陶瓷或金属化层。参考陶瓷用于根据分析仪的空间，时间和环境状态提供分析仪的光信号测量。

8. 发明申请

US20090188098A1 Multimen brachytherapy balloon catheter 审中-公开
标题翻译：多股近距离放射治疗气球导管
公开(公告)号：US20090188098A1
公开(公告)日：2009-07-30
申请号：US12321244
申请日：2009-01-20
申请人： George M. Acosta , Paul Lubock
发明人： George M. Acosta , Paul Lubock
IPC分类号： B23P11/00
CPC分类号： A61N5/1015 , A61F7/123 , A61M25/10 , A61M25/1034 , A61M25/1036 , A61M2025/0036 , A61M2025/004 , A61N1/403 , A61N2005/1018
摘要： The disclosure describes a device for asymmetrical irradiation of a body cavity or site, such as after removal of tissue, e.g. biopsy or lumpectomy. The device includes an elongated tubular shaft having an inner lumen and a tubular wall with a plurality of lumens extending within the wall which are configured for receiving a radiation source. The distal portion of the tubular shaft is cut into a plurality of longitudinally separated wall segments with a lumen extending within at least one of the wall segments. A support member is positioned within the separated wall segments to support and position the wall segments in a desired configuration for brachytherapy. An expandable member such as an inflatable balloon is mounted on the distal shaft portion about the separated wall segments wall which when inflated secures the distal shaft portion within a desired intracorporeal site for brachytherapy treatment.
摘要翻译：本公开描述了用于体腔或部位的不对称照射的装置，例如在去除组织之后，例如，活检或肿瘤切除术。该装置包括细长的管状轴，其具有内腔和具有在壁内延伸的多个内腔的管状壁，其构造成用于接收辐射源。管状轴的远端部分被切割成多个纵向分离的壁段，其中内腔在至少一个壁段内延伸。支撑构件被定位在分离的壁段内以支撑和定位所需的构造的壁段用于近距离放射治疗。诸如可膨胀气囊的可膨胀构件围绕分离的壁段壁安装在远侧轴部分上，当被充气时将远端轴部分固定在期望的体内位置以进行近距离放射治疗。

9. 发明授权

US5242437A Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium 失效
标题翻译：医疗器械应用局部高强度光和热，特别是用于子宫内膜的破坏
公开(公告)号：US5242437A
公开(公告)日：1993-09-07
申请号：US460843
申请日：1990-01-11
申请人： Royice B. Everett , George M. Acosta , Hany M. G. Hussein
发明人： Royice B. Everett , George M. Acosta , Hany M. G. Hussein
IPC分类号： A61B17/00 , A61B17/42 , A61B18/22 , A61B18/24 , A61B18/28
CPC分类号： A61B18/24 , A61B18/28 , A61B17/42 , A61B2017/0007 , A61B2017/00084 , A61B2017/4216 , A61B2018/2272
摘要： A medical device applies localized heat to a site in a patient's body by irradiation with light and by conduction. The device includes a radiant energy transmitting conduit, typically an optic fiber, that carries radiant energy, typically high intensity light such as laser, into a body cavity, typically the uterus, from an energy source, typically a laser source, that is located exterior to the body. At the operative head of the device within the body cavity a portion of the transmitted radiant energy is absorbed and converted to heat. This heat is radiated or conducted from the device head substantially omnidirectionally in order to aid in destruction of tissue. Meanwhile, another portion of the transmitted radiant energy is emitted through an aperture in the device head as light energy suitable for more localized and intense heating and destruction of tissue or other organic matter. This light emission is preferably directionally transverse to an elongate body of the device head. The device is suitable for selective destruction of tissue or other matter by highly localized heating.
摘要翻译： PCT No.PCT / US89 / 02492 Sec。 371 1990年1月11日第 102（e）1990年1月11日PCT PCT。1989年6月7日PCT公布。出版物WO89 / 日期：1989年12月14日。医疗器械通过照射和传导将局部热量施加到患者体内的部位。该装置包括通常是光纤的辐射能量传输导管，其通常将辐射能（通常为高强度光如激光）通过位于外部的能量源（通常为激光源）进入体腔（通常为子宫）到身体在体腔内的装置的操作头部，透射的辐射能量的一部分被吸收并转换成热量。这种热量大体上是从设备头部全面辐射或传导的，以帮助破坏组织。同时，透射辐射能的另一部分通过设备头部中的孔发射，作为适合于更局部和强烈加热和破坏组织或其它有机物质的光能。该发光优选地在与器件头部的细长主体的方向上横向。该装置适用于通过高度局部加热来选择性地破坏组织或其它物质。

10. 发明授权

US5437664A Apparatus and method for venous ligation 失效
标题翻译：静脉结扎装置及方法
公开(公告)号：US5437664A
公开(公告)日：1995-08-01
申请号：US183994
申请日：1994-01-18
申请人： Donald Cohen , Derek J. Daw , George F. Kick , George M. Acosta
发明人： Donald Cohen , Derek J. Daw , George F. Kick , George M. Acosta
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61B17/42 , A61B18/00 , A61B18/04 , A61B18/12 , A61B18/14 , A61B17/36
CPC分类号： A61B18/1206 , A61B18/1492 , A61B17/32 , A61B2017/00026 , A61B2017/00084 , A61B2017/22097 , A61B2017/4233 , A61B2018/00107 , A61B2018/00119 , A61B2018/00684 , A61B2018/00702 , A61B2018/00761 , A61B2018/00779 , A61B2018/00803 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00982 , A61B2018/044 , A61B2090/064
摘要： A minimally-invasive surgery apparatus for causing the lumen of a vein to collapse to prevent blood flow through the vein, e.g., a varicose vein or a side branch of the saphenous vein, includes an electrode which is electrically connected to a power source, and the electrode is percutaneously advanced into the vein. Then, the power source is activated to energize the electrode and thus the blood vein until the blood vein sufficiently collapses to block the lumen of the vein. A feedback loop is also provided for sensing electrical impedance of the tissue within the vein being energized and for deenergizing the electrode when the impedance reaches a predetermined value.
摘要翻译：一种用于使静脉内腔塌陷以防止血液流过静脉（例如静脉曲张静脉或隐静脉的侧分支）的微创手术设备，包括电连接到电源的电极，以及电极经皮进入静脉。然后，电源被激活以激励电极，从而激活血液静脉，直到血液静脉充分塌陷以阻塞静脉的内腔。还提供了一个反馈回路，用于感测被激活的静脉内的组织的电阻抗，并且当阻抗达到预定值时，使电极断电。

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