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1. 发明申请

US20090188098A1 Multimen brachytherapy balloon catheter 审中-公开
标题翻译：多股近距离放射治疗气球导管
公开(公告)号：US20090188098A1
公开(公告)日：2009-07-30
申请号：US12321244
申请日：2009-01-20
申请人： George M. Acosta , Paul Lubock
发明人： George M. Acosta , Paul Lubock
IPC分类号： B23P11/00
CPC分类号： A61N5/1015 , A61F7/123 , A61M25/10 , A61M25/1034 , A61M25/1036 , A61M2025/0036 , A61M2025/004 , A61N1/403 , A61N2005/1018
摘要： The disclosure describes a device for asymmetrical irradiation of a body cavity or site, such as after removal of tissue, e.g. biopsy or lumpectomy. The device includes an elongated tubular shaft having an inner lumen and a tubular wall with a plurality of lumens extending within the wall which are configured for receiving a radiation source. The distal portion of the tubular shaft is cut into a plurality of longitudinally separated wall segments with a lumen extending within at least one of the wall segments. A support member is positioned within the separated wall segments to support and position the wall segments in a desired configuration for brachytherapy. An expandable member such as an inflatable balloon is mounted on the distal shaft portion about the separated wall segments wall which when inflated secures the distal shaft portion within a desired intracorporeal site for brachytherapy treatment.
摘要翻译：本公开描述了用于体腔或部位的不对称照射的装置，例如在去除组织之后，例如，活检或肿瘤切除术。该装置包括细长的管状轴，其具有内腔和具有在壁内延伸的多个内腔的管状壁，其构造成用于接收辐射源。管状轴的远端部分被切割成多个纵向分离的壁段，其中内腔在至少一个壁段内延伸。支撑构件被定位在分离的壁段内以支撑和定位所需的构造的壁段用于近距离放射治疗。诸如可膨胀气囊的可膨胀构件围绕分离的壁段壁安装在远侧轴部分上，当被充气时将远端轴部分固定在期望的体内位置以进行近距离放射治疗。

2. 发明授权

US5242437A Medical device applying localized high intensity light and heat, particularly for destruction of the endometrium 失效
标题翻译：医疗器械应用局部高强度光和热，特别是用于子宫内膜的破坏
公开(公告)号：US5242437A
公开(公告)日：1993-09-07
申请号：US460843
申请日：1990-01-11
申请人： Royice B. Everett , George M. Acosta , Hany M. G. Hussein
发明人： Royice B. Everett , George M. Acosta , Hany M. G. Hussein
IPC分类号： A61B17/00 , A61B17/42 , A61B18/22 , A61B18/24 , A61B18/28
CPC分类号： A61B18/24 , A61B18/28 , A61B17/42 , A61B2017/0007 , A61B2017/00084 , A61B2017/4216 , A61B2018/2272
摘要： A medical device applies localized heat to a site in a patient's body by irradiation with light and by conduction. The device includes a radiant energy transmitting conduit, typically an optic fiber, that carries radiant energy, typically high intensity light such as laser, into a body cavity, typically the uterus, from an energy source, typically a laser source, that is located exterior to the body. At the operative head of the device within the body cavity a portion of the transmitted radiant energy is absorbed and converted to heat. This heat is radiated or conducted from the device head substantially omnidirectionally in order to aid in destruction of tissue. Meanwhile, another portion of the transmitted radiant energy is emitted through an aperture in the device head as light energy suitable for more localized and intense heating and destruction of tissue or other organic matter. This light emission is preferably directionally transverse to an elongate body of the device head. The device is suitable for selective destruction of tissue or other matter by highly localized heating.
摘要翻译： PCT No.PCT / US89 / 02492 Sec。 371 1990年1月11日第 102（e）1990年1月11日PCT PCT。1989年6月7日PCT公布。出版物WO89 / 日期：1989年12月14日。医疗器械通过照射和传导将局部热量施加到患者体内的部位。该装置包括通常是光纤的辐射能量传输导管，其通常将辐射能（通常为高强度光如激光）通过位于外部的能量源（通常为激光源）进入体腔（通常为子宫）到身体在体腔内的装置的操作头部，透射的辐射能量的一部分被吸收并转换成热量。这种热量大体上是从设备头部全面辐射或传导的，以帮助破坏组织。同时，透射辐射能的另一部分通过设备头部中的孔发射，作为适合于更局部和强烈加热和破坏组织或其它有机物质的光能。该发光优选地在与器件头部的细长主体的方向上横向。该装置适用于通过高度局部加热来选择性地破坏组织或其它物质。

3. 发明授权

US08246676B2 Implantable venous valve 有权
标题翻译：植入式静脉瓣
公开(公告)号：US08246676B2
公开(公告)日：2012-08-21
申请号：US11217648
申请日：2005-09-01
申请人： George M. Acosta , George F. Kick
发明人： George M. Acosta , George F. Kick
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/2412 , A61F2/2418
摘要： A venous valve prosthesis includes a hollow conduit (40) defining a central passageway through which blood may flow. Opposing, pliable leaflet members (30) are located within the conduit and move back and forth between a first, open position, whereby blood may flow through the central passageway in a first direction, and a second, closed position, whereby blood is prevented from backflowing through the central passageway in a second direction which is opposite the first direction. A hollow and generally cylindrical support member (10, 20) retains the leaflet members and is coaxially disposed within the conduit. The support member includes opposing cutaway regions (18) defining two axially extending struts (16) supporting the leaflet members. The cutaway regions, in cooperation with the struts, allow the leaflet members to collapse inwardly to the closed position.
摘要翻译：静脉瓣膜假体包括限定中心通道的中空导管（40），血液可以通过该中心通道流动。相对的，柔韧的小叶构件（30）位于导管内并且在第一打开位置之间来回移动，由此血液可以沿着第一方向流过中央通道，并且第二闭合位置被阻止在与第一方向相反的第二方向上回流通过中央通道。中空的和大致圆柱形的支撑构件（10,20）保持叶片构件并同轴地设置在导管内。支撑构件包括限定支撑叶片构件的两个轴向延伸的支柱（16）的相对的切口区域（18）。与支柱协作的切口区域允许小叶构件向内折叠到关闭位置。

4. 发明授权

US07505801B2 Apparatus and method for easing use of a spectrophotometric based noninvasive analyzer 有权
标题翻译：用于分光光度计的无创分析仪的装置和方法
公开(公告)号：US07505801B2
公开(公告)日：2009-03-17
申请号：US11848139
申请日：2007-08-30
申请人： Stephen L. Monfre , George M. Acosta , Thomas B. Blank , Kevin H. Hazen
发明人： Stephen L. Monfre , George M. Acosta , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/1455
CPC分类号： A61B5/6841 , A61B5/14532 , A61B5/1455 , G01N21/359 , G01N21/474
摘要： A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.
摘要翻译：公开了一种具有改进的水合诱导塞的放置引导装置，其用于将非侵入性分析器耦合到取样部位以确定人体中的分析物。水合诱导塞包括至少一种可用作偶联剂的含氟聚合物。引导装置还可以包括自动化或半自动化耦合流体输送系统。使用这些耦合剂中的任一种可减轻与相关技术相关的问题，并增强非侵入性分析物测量，例如基于近红外漫反射的非侵入性葡萄糖浓度分析仪。

5. 发明授权

US06587702B1 Classification and characterization of tissue through features related to adipose tissue 有权
标题翻译：通过与脂肪组织相关的特征对组织进行分类和表征
公开(公告)号：US06587702B1
公开(公告)日：2003-07-01
申请号：US09489617
申请日：2000-01-21
申请人： Timothy L. Ruchti , Kevin H. Hazen , Marcy R. Makarewicz , George M. Acosta
发明人： Timothy L. Ruchti , Kevin H. Hazen , Marcy R. Makarewicz , George M. Acosta
IPC分类号： A61B500
CPC分类号： A61B5/4872 , A61B5/0059 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/7264 , G01N21/359 , G01N2201/1293
摘要： A non-invasive system for characterizing and classifying the state and structure of a tissue sample operates on a near infrared absorbance spectrum of in vivo tissue. A method that uses near-infrared spectral measurements to characterize and classify the state and structure of tissue sampled based on absorbance features related to fat in adipose tissue is provided. Also provided is a method of estimating skin fold thickness. The approach provides information about sources of tissue variability and is therefore useful for establishing the general category of the tissue structure. Categorization of subjects on the basis of the determination is suitable for further spectral analysis and the measurement of biological and chemical compounds, such as blood analytes. The invention further provides a method of estimating percent body fat based on a skin fold thickness estimate. The invention also provides an apparatus for measuring the absorbance spectra coupled with a digital processor for performing the required analyses.
摘要翻译：用于表征和分类组织样品的状态和结构的非侵入性系统在体内组织的近红外吸收光谱上操作。提供了一种使用近红外光谱测量来表征和分类基于与脂肪组织中的脂肪相关的吸光度特征所采集的组织的状态和结构的方法。还提供了估计皮肤褶皱厚度的方法。该方法提供了关于组织变异性来源的信息，因此可用于建立组织结构的一般类别。在确定的基础上对受试者进行分类适用于进一步的光谱分析和生物化学化合物如血液分析物的测量。本发明还提供了一种基于皮肤折叠厚度估计估计身体脂肪百分比的方法。本发明还提供了一种用于测量与数字处理器耦合的吸光度谱进行所需分析的装置。

6. 发明授权

US06267758B1 Apparatus for in situ saphenous vein bypass and less-invasive varicose vein treatment 失效
标题翻译：用于原位隐静脉旁路和少入静脉曲张静脉治疗的装置
公开(公告)号：US06267758B1
公开(公告)日：2001-07-31
申请号：US08789266
申请日：1997-01-28
申请人： Derek J. Daw , George M. Acosta , John R. Brustad
发明人： Derek J. Daw , George M. Acosta , John R. Brustad
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B17/32 , A61B18/1206 , A61B2017/00026 , A61B2017/00084 , A61B2017/22097 , A61B2017/4233 , A61B2018/00107 , A61B2018/00119 , A61B2018/00684 , A61B2018/00702 , A61B2018/00761 , A61B2018/00779 , A61B2018/00803 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00982 , A61B2018/044 , A61B2090/064
摘要： An apparatus for in situ saphenous vein bypass includes an operating catheter which includes an optical fiber and an electrode, and a control catheter which includes a valvulotome. The operating catheter and control catheter are locked together and advanced through an incision in the leg. The catheters are closely spaced from each other, on opposite sides of a valve to be disrupted. Then, the valvulotome is manipulated to disrupt the valve, the electrode is manipulated to stanch blood flow from the valve and to close off side branches, and both procedures are viewed by means of the optical fiber. The valves of the saphenous vein are thusly disrupted in sequence, and the side branches to the saphenous vein closed off, to thereby modify the saphenous vein in situ for arterial use. In alternate embodiments, the electrode is used with delivery catheters to stop blood flow through a side branch or varicose vein. The electrode includes an embedded temperature sensor for sensing electrode temperature.
摘要翻译：用于原位隐静脉旁路的装置包括包括光纤和电极的操作导管，以及包括瓣膜切开机的控制导管。操作导管和控制导管锁定在一起并通过腿部的切口前进。导管在阀的相对侧彼此紧密分开以被破坏。然后，操作瓣膜切断器以破坏瓣膜，操作电极以阻断来自瓣膜的血流并关闭侧分支，并且通过光纤观察两个步骤。因此，隐静脉的瓣膜顺序地被破坏，并且分离到隐静脉的侧面封闭，从而将隐静脉原位修改以供动脉使用。在替代实施例中，电极与输送导管一起使用以阻止血流通过侧分支或静脉曲张静脉。电极包括用于感测电极温度的嵌入式温度传感器。

7. 发明授权

US5772627A Ultrasonic tissue resector for neurosurgery 失效
标题翻译：超声组织切除术用于神经外科
公开(公告)号：US5772627A
公开(公告)日：1998-06-30
申请号：US684425
申请日：1996-07-19
申请人： George M. Acosta , Derek J. Daw
发明人： George M. Acosta , Derek J. Daw
IPC分类号： A61B17/32 , A61B19/00 , A61M1/00 , A61B17/20
CPC分类号： A61B17/320068 , A61B2017/320084 , A61B2217/005 , A61B90/10
摘要： An ultrasonic tissue resector is slidably engaged with a working channel of a flexible neuroendoscope for resecting brain tumors, cysts, hematomas, and herniated spinal discs. The resector includes a piezoelectric transducer for generating ultrasonic energy. The ultrasonic energy is coupled to an ultrasonic probe having a rigid proximal segment for transmitting the energy therealong and a flexible distal segment which can bend to conform to the flexible neuroendoscope. An aspiration channel is provided, and the resector can be endoscopically positioned in the brain through the neuroendoscope and energized to ultrasonically break up tissue such as tumors, cysts, and hematomas and remove the tissue through the aspiration channel.
摘要翻译：超声波组织切除器与柔性神经内窥镜的工作通道可滑动地接合，用于切除脑肿瘤，囊肿，血肿和突出的脊椎盘。该检测器包括用于产生超声波能量的压电换能器。超声能量耦合到具有用于传输能量的刚性近端段的超声波探头和可弯曲以符合柔性神经内窥镜的柔性远端段。提供抽吸通道，并且可以通过神经内窥镜内窥镜放置在脑中，并通电以超声破坏诸如肿瘤，囊肿和血肿的组织，并通过抽吸通道去除组织。

8. 发明授权

US5649924A Medical device for irradiation of tissue 失效
标题翻译：用于照射组织的医疗装置
公开(公告)号：US5649924A
公开(公告)日：1997-07-22
申请号：US370673
申请日：1995-01-10
申请人： Royice B. Everett , George M. Acosta , Hany M. G. Hussein
发明人： Royice B. Everett , George M. Acosta , Hany M. G. Hussein
IPC分类号： A61B17/00 , A61B17/42 , A61B18/22 , A61B18/24 , A61B18/28 , A61B17/32
CPC分类号： A61B18/24 , A61B18/28 , A61B17/42 , A61B2017/0007 , A61B2017/00084 , A61B2017/4216 , A61B2018/2272
摘要： A medical device applies localized heat to a site in a patient's body by irradiation with light and by conduction. The device includes a radiant energy transmitting conduit, typically an optic fiber, that carries radiant energy, typically high intensity light such as laser, into a body cavity, typically the uterus, from an energy source, typically a laser source, that is located exterior to the body. At the operative head of the device within the body cavity a portion of the transmitted radiant energy is absorbed and converted to heat. This heat is radiated or conducted from the device head substantially omnidirectionally in order to aid in destruction of tissue, Meanwhile, another portion of the transmitted radiant energy is emitted through an aperture in the device head as light energy suitable for more localized and intense heating and destruction of tissue or other organic matter. This light emission is preferably directionally transverse to an elongate body of the device head. The device is suitable for selective destruction of tissue or other matter by highly localized heating.
摘要翻译：医疗器械通过照射和传导将局部热量施加到患者体内的部位。该装置包括通常是光纤的辐射能量传输导管，其通常将辐射能（通常为高强度光如激光）通过位于外部的能量源（通常为激光源）进入体腔（通常为子宫）到身体在体腔内的装置的操作头部，透射的辐射能量的一部分被吸收并转换成热量。这种热量大体上是从设备头部全面辐射或传导的，以便有助于组织的破坏。同时，透射辐射能的另一部分通过设备头部的孔口发射，作为适合于更局部和强烈加热的光能，以及破坏组织或其他有机物质。该发光优选地在与器件头部的细长主体的方向上横向。该装置适用于通过高度局部加热来选择性地破坏组织或其它物质。

9. 发明授权

US4816029A Stent for aortic heart valve 失效
标题翻译：支架用于主动脉瓣膜
公开(公告)号：US4816029A
公开(公告)日：1989-03-28
申请号：US261393
申请日：1981-05-07
申请人： William H. Penny, III , Jonathan J. Rosen , George M. Acosta
发明人： William H. Penny, III , Jonathan J. Rosen , George M. Acosta
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , Y10S623/90
摘要： A plastic stent for a prosthetic trileaflet heart valve consisting of a cylindrical body portion terminating at one end in three apical, spaced commissure posts, and at the other end, in a skirt comprising three arcuate extensions, each extension being provided with an interrupted channel adjacent the outer edge thereof. An optional metal ring may be mounted over the skirt adjacent the body portion. A cloth cover is secured to the stent by stitching directly through the skirt in the area of reduced thickness resulting from the interrupted channel.
摘要翻译：一种用于假体三叉瓣心脏瓣膜的塑料支架，其由在一个端部处终止于三个顶部和间隔的合缝柱的圆柱体部分组成，而另一端在包括三个弧形延伸部的裙部中，每个延伸部设置有相邻的中断通道其外边缘。可选的金属环可以安装在靠近主体部分的裙部上。通过从中断的通道导致的厚度减小的区域中直接穿过裙部，将布盖固定到支架上。

10. 发明授权

US07787924B2 Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权
标题翻译：用于通过近红外光谱法无损测量葡萄糖的紧凑装置
公开(公告)号：US07787924B2
公开(公告)日：2010-08-31
申请号：US11324876
申请日：2006-01-03
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyte is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译：本发明涉及通过紧凑型分析仪监测生物参数。优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。优选的目标分析物是葡萄糖。优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。

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