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1. 发明授权

US07229469B1 Methods for treating and repairing mitral valve annulus 失效
标题翻译：二尖瓣环治疗和修复方法
公开(公告)号：US07229469B1
公开(公告)日：2007-06-12
申请号：US10423999
申请日：2003-04-26
申请人： Thomas Witzel , Wallace N Hauck , John A. Osth , Hosheng Tu
发明人： Thomas Witzel , Wallace N Hauck , John A. Osth , Hosheng Tu
IPC分类号： A61N1/05 , A61B18/12
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00369 , A61B2018/00898 , A61B2018/1435
摘要： A catheter system and methods for repairing a valvular annulus or an annular organ structure of a patient comprising intimately contacting the annular organ structure by a tissue-contactor member having energy-delivering elements, and delivering tissue-shrinkable energy at the annular organ structure through the elements, wherein the tissue-shrinkable energy is applied at a distance wirelessly from the elements sufficient to shrink and tighten the organ structure.
摘要翻译：一种用于修复患者的瓣膜环或环形器官结构的导管系统和方法，包括通过具有能量输送元件的组织接触器构件使环形器官结构紧密接触，并且通过所述环形器官结构递送组织可收缩能量元件，其中组织可收缩能量以足以收缩和收紧器官结构的元件无线地施加。

2. 发明授权

US08328798B2 Method for treating and repairing mitral valve annulus 失效
标题翻译：二尖瓣环治疗和修复方法
公开(公告)号：US08328798B2
公开(公告)日：2012-12-11
申请号：US11749005
申请日：2007-05-15
申请人： Thomas Witzel , Wallace N Hauck , John A. Osth , Hosheng Tu
发明人： Thomas Witzel , Wallace N Hauck , John A. Osth , Hosheng Tu
IPC分类号： A61B18/12
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00369 , A61B2018/00898 , A61B2018/1435
摘要： A catheter system for repairing an annular organ structure of a patient, comprising: intimately contacting the annular organ structure by a tissue-contactor member having energy-delivering elements; and delivering tissue-shrinkable energy at the annular organ structure through the elements, wherein the tissue-shrinkable energy is applied at a distance wirelessly from the elements sufficient to shrink and tighten the organ structure. Tissue-shrinkable energy is infrared energy, ultrasound energy, focused ultrasound energy, ultrasound energy, radiofrequency energy, microwave energy, electromagnetic energy, laser energy, or a combination thereof.
摘要翻译：一种用于修复患者的环形器官结构的导管系统，包括：通过具有能量输送元件的组织接触器构件使所述环形器官结构紧密接触; 以及通过所述元件在所述环形器官结构处输送组织可收缩能量，其中所述组织可收缩能量以足以收缩和收紧所述器官结构的所述元件无线地施加。组织收缩能量是红外能量，超声能量，聚焦超声能量，超声能量，射频能量，微波能量，电磁能量，激光能量或其组合。

3. 发明授权

US06485489B2 Catheter system for repairing a mitral valve annulus 失效
标题翻译：用于修复二尖瓣环的导管系统
公开(公告)号：US06485489B2
公开(公告)日：2002-11-26
申请号：US10101230
申请日：2002-03-19
申请人： Paul Teirstein , John A. Osth , Thomas H. Witzel , Cary Hata , Wallace N Hauck , Hosheng Tu
发明人： Paul Teirstein , John A. Osth , Thomas H. Witzel , Cary Hata , Wallace N Hauck , Hosheng Tu
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B18/1477 , A61B2018/00214 , A61B2018/00291 , A61B2018/00351 , A61B2018/00369 , A61B2018/00898 , A61B2018/1425 , A61B2018/1435
摘要： A catheter system and methods for repairing a valvular annulus or an annular organ structure of a patient comprising sandwiching and compressing the annulus and applying heat sufficient to shrink or tighten tissue surrounding the annulus defect.
摘要翻译：一种用于修复患者的瓣膜环或环形器官结构的导管系统和方法，包括夹持和压缩环空并施加足以收缩或收紧环带缺损周围的组织的热量。

4. 发明授权

US06575971B2 Cardiac valve leaflet stapler device and methods thereof 有权
公开(公告)号：US06575971B2
公开(公告)日：2003-06-10
申请号：US10000992
申请日：2001-11-15
申请人： Wallace N. Hauck , Samuel Victor Lichtenstein , Hosheng Tu
发明人： Wallace N. Hauck , Samuel Victor Lichtenstein , Hosheng Tu
IPC分类号： A61B1818
CPC分类号： A61B18/1442 , A61B18/1492 , A61B2017/00243 , A61B2017/00566 , A61B2017/306 , A61B2018/00357 , A61B2018/00619
摘要： A medical device system comprising a guide catheter and a leaflet fastening applicator, the guide catheter having suitable dimensions for deployment and insertion percutaneously into a human heart in a vicinity of a heart valve, the leaflet fastening applicator having a size allowing insertion through the guide catheter and being capable of holding portions of opposing heart valve leaflets, wherein the fastening applicator comprises a pair of grasping-electrodes adapted for holding and engaging the portions of opposing heart valve leaflets together and for applying energy to fasten the portions, in which heart valve leaflets can be captured and securely fastened, thereby improving coaptation of the leaflets and improving competence of the valve.

5. 发明申请

US20080091191A1 METHOD FOR TREATING AND REPAIRING MITRAL VALVE ANNULUS 失效
标题翻译：用于治疗和修复麻醉阀的方法
公开(公告)号：US20080091191A1
公开(公告)日：2008-04-17
申请号：US11749005
申请日：2007-05-15
申请人： Thomas Witzel , Wallace Hauck , John Osth , Hosheng Tu
发明人： Thomas Witzel , Wallace Hauck , John Osth , Hosheng Tu
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00369 , A61B2018/00898 , A61B2018/1435
摘要： A catheter system for repairing an annular organ structure of a patient, comprising: intimately contacting the annular organ structure by a tissue-contactor member having energy-delivering elements; and delivering tissue-shrinkable energy at the annular organ structure through the elements, wherein the tissue-shrinkable energy is applied at a distance wirelessly from the elements sufficient to shrink and tighten the organ structure. Tissue-shrinkable energy is infrared energy, ultrasound energy, focused ultrasound energy, ultrasound energy, radiofrequency energy, microwave energy, electromagnetic energy, laser energy, or a combination thereof.
摘要翻译：一种用于修复患者的环形器官结构的导管系统，包括：通过具有能量输送元件的组织接触器构件使所述环形器官结构紧密接触; 以及通过所述元件在所述环形器官结构处输送组织可收缩能量，其中所述组织可收缩能量以足以收缩和收紧所述器官结构的所述元件无线地施加。组织收缩能量是红外能量，超声能量，聚焦超声能量，超声能量，射频能量，微波能量，电磁能量，激光能量或其组合。

6. 发明申请

US20050240249A1 Methods for treating mitral valve annulus with biodegradable compression element 审中-公开
标题翻译：用可生物降解压缩元件治疗二尖瓣环的方法
公开(公告)号：US20050240249A1
公开(公告)日：2005-10-27
申请号：US10978288
申请日：2004-10-28
申请人： Hosheng Tu , Thomas Witzel , Wallace Hauck
发明人： Hosheng Tu , Thomas Witzel , Wallace Hauck
IPC分类号： A61B17/00 , A61B18/14 , A61F7/00 , A61F7/12
CPC分类号： A61B18/1492 , A61B2017/00004 , A61B2018/00214 , A61B2018/0022 , A61B2018/00261 , A61B2018/00267 , A61B2018/00291 , A61B2018/00369
摘要： A catheter system and methods for repairing a valvular annulus or an annular organ structure of a patient comprising intimately contacting the annular organ structure by a tissue-contactor member having energy-delivering elements, and delivering tissue-shrinkable energy at the annular organ structure through the elements, wherein the tissue-shrinkable energy is applied at a distance wirelessly from the elements sufficient to shrink and tighten the organ structure.
摘要翻译：一种用于修复患者的瓣膜环或环形器官结构的导管系统和方法，包括通过具有能量输送元件的组织接触器构件使环形器官结构紧密接触，并且通过所述环形器官结构递送组织可收缩能量元件，其中组织可收缩能量以足以收缩和收紧器官结构的元件无线地施加。

7. 发明授权

US08579846B2 Ocular implant systems 有权
标题翻译：眼植入系统
公开(公告)号：US08579846B2
公开(公告)日：2013-11-12
申请号：US13301648
申请日：2011-11-21
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61B19/00 , A61F11/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

8. 发明授权

US08318198B1 Pharmaceutical composition of nanoparticles 失效
公开(公告)号：US08318198B1
公开(公告)日：2012-11-27
申请号：US13527886
申请日：2012-06-20
申请人： Hsing-Wen Sung , Zi-Xian Liao , Min-Fan Chung , Ko-Jie Chen , Hosheng Tu
发明人： Hsing-Wen Sung , Zi-Xian Liao , Min-Fan Chung , Ko-Jie Chen , Hosheng Tu
IPC分类号： A61L15/00
CPC分类号： A61K9/0004 , A61K9/1272 , A61K9/1278 , A61K9/5146 , A61K9/5153 , A61K9/5161 , A61K31/337 , A61K31/4745 , A61K31/704
摘要： The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy.

9. 发明授权

US08287594B2 Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis 有权
标题翻译：膝关节假体和用于治疗骨关节炎的透明质酸盐组合物
公开(公告)号：US08287594B2
公开(公告)日：2012-10-16
申请号：US12949204
申请日：2010-11-18
申请人： Andrew H. Cragg , Richard J. Greff , George Wallace , Robert J. Socci, Jr. , Jonathan Kagan , Rodolfo C. Quijano , Hosheng Tu
发明人： Andrew H. Cragg , Richard J. Greff , George Wallace , Robert J. Socci, Jr. , Jonathan Kagan , Rodolfo C. Quijano , Hosheng Tu
IPC分类号： A61F2/08
CPC分类号： A61F2/30756 , A61F2/3872 , A61F2/461 , A61F2002/4635 , A61L27/20 , A61L27/50 , A61L27/52 , C08L5/08
摘要： A medical device and methods to relieve joint pain and adapted for knee joint repair, replacement and augmentation. The invention discloses joint lubricant, particularly hyaluronate compositions and methods for treatment of osteoarthritis.
摘要翻译：一种减轻关节疼痛并适应膝关节修复，置换和增大的医疗装置和方法。本发明公开了关节润滑剂，特别是透明质酸盐组合物和治疗骨关节炎的方法。

10. 发明授权

US08236281B1 Pharmaceutical composition of nanoparticles 有权
标题翻译：纳米粒子的药物组成
公开(公告)号：US08236281B1
公开(公告)日：2012-08-07
申请号：US13449157
申请日：2012-04-17
申请人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
发明人： Hsing-Wen Sung , Kiran Sonaje , Hosheng Tu
IPC分类号： A61K51/00
CPC分类号： A61K31/13 , A61K9/0043 , A61K9/5146 , A61K9/5161 , A61K31/445 , A61K31/55
摘要： The invention relates to a pharmaceutical composition of nanoparticles, wherein the nanoparticles comprise positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating diabetes of an animal subject.
摘要翻译：本发明涉及纳米颗粒的药物组合物，其中纳米颗粒包含带正电荷的壳聚糖，带负电荷的底物，任选的零电荷化合物和用于治疗动物受试者的糖尿病的至少一种生物活性剂。

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