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1. 发明授权

US09668915B2 Drug eluting ocular implant 有权
公开(公告)号：US09668915B2
公开(公告)日：2017-06-06
申请号：US13989037
申请日：2011-11-22
申请人： David Haffner , Ken Curry , Harold Heitzmann , David Applegate
发明人： David Haffner , Ken Curry , Harold Heitzmann , David Applegate
IPC分类号： A61F9/00 , A61F9/007 , A61K9/00 , A61K9/20
CPC分类号： A61F9/0017 , A61F9/00781 , A61F2210/0061 , A61K9/0051 , A61K9/0092 , A61K9/2072
摘要： Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

2. 发明授权

US09636255B2 Uveoscleral drug delivery implant and methods for implanting the same 有权
公开(公告)号：US09636255B2
公开(公告)日：2017-05-02
申请号：US13201423
申请日：2010-02-12
申请人： David Haffner , Kenneth Curry
发明人： David Haffner , Kenneth Curry
IPC分类号： A61F2/14 , A61F9/007 , A61F9/00 , A61K31/00 , A61L27/18 , A61L27/54 , A61M27/00 , A61M37/00 , A61M25/00 , A61M25/01 , A61M25/02
CPC分类号： A61F9/00781 , A61F9/0017 , A61K31/00 , A61L27/18 , A61L27/54 , A61L2300/604 , A61L2430/16 , A61M25/00 , A61M25/0105 , A61M27/00 , A61M37/00 , A61M2025/0286 , A61M2210/0612 , C08L67/04
摘要： Devices and methods for treating intraocular pressure are disclosed. The devices include drug delivery implants for treating ocular tissue. Optionally, the devices also include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The drug delivery implants can be implanted in ab interno or ab externo procedures.

3. 发明申请

US20120253258A1 OCULAR SYSTEM WITH ANCHORING IMPLANT AND THERAPEUTIC AGENT 有权
标题翻译：具有锚固植入物和治疗剂的OCULAR系统
公开(公告)号：US20120253258A1
公开(公告)日：2012-10-04
申请号：US13399760
申请日：2012-02-17
申请人： Hosheng Tu , Jason Artof , David Haffner
发明人： Hosheng Tu , Jason Artof , David Haffner
IPC分类号： A61F9/00 , A61M1/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2220/0008 , A61F2230/0069 , A61F2250/0067 , A61K31/215
摘要： Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.
摘要翻译：公开了眼部植入物，递送装置和治疗眼部疾病的方法。一种方法是将植入物插入眼睛的一侧。植入物具有位于锚固件近侧的远端部分上的锚固件和出口开口。植入物通过眼睛前进到眼睛的另一侧。将锚固体插入眼睛另一侧的眼睛组织中。使用植入物洗脱治疗剂。

4. 发明申请

US20120165933A1 UVEOSCLERAL DRUG DELIVERY IMPLANT AND METHODS FOR IMPLANTING THE SAME 有权
标题翻译： UVEOSCLERAL DRUG DELIVERY IMPLANT AND METHODS FOR IMPARTING THE SAME
公开(公告)号：US20120165933A1
公开(公告)日：2012-06-28
申请号：US13201423
申请日：2010-02-12
申请人： David Haffner , Kenneth Curry
发明人： David Haffner , Kenneth Curry
IPC分类号： A61F2/14
CPC分类号： A61F9/00781 , A61F9/0017 , A61K31/00 , A61L27/18 , A61L27/54 , A61L2300/604 , A61L2430/16 , A61M25/00 , A61M25/0105 , A61M27/00 , A61M37/00 , A61M2025/0286 , A61M2210/0612 , C08L67/04
摘要： Devices and methods for treating intraocular pressure are disclosed. The devices include drug delivery implants for treating ocular tissue. Optionally, the devices also include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The drug delivery implants can be implanted in ab interno or ab externo procedures.
摘要翻译：公开了用于治疗眼内压的装置和方法。这些装置包括用于治疗眼组织的药物递送植入物。可选地，所述装置还包括用于将房水从前房排出至囊肿流出路径的分流器，包括上附近的空间和脉管外空间。药物输送植入物可以以内部或外部程序植入。

5. 发明申请

US20120071809A1 OCULAR IMPLANT SYSTEMS 有权
标题翻译： OCULAR植物系统
公开(公告)号：US20120071809A1
公开(公告)日：2012-03-22
申请号：US13301648
申请日：2011-11-21
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61F9/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

6. 发明授权

US07879001B2 Devices and methods for treatment of ocular disorders 有权
标题翻译：用于治疗眼部疾病的装置和方法
公开(公告)号：US07879001B2
公开(公告)日：2011-02-01
申请号：US11836106
申请日：2007-08-08
申请人： David Haffner , Gregory T Smedley , Hosheng Tu
发明人： David Haffner , Gregory T Smedley , Hosheng Tu
IPC分类号： A61M5/00 , A61M1/00 , A61F11/00 , A61M31/00
CPC分类号： A61F9/00781
摘要： Intraocular implants and delivery instruments are disclosed for treating ophthalmic conditions and ocular disorders, such as glaucoma. The implants are configured to extend between the anterior chamber of the eye and a fluid outflow path or physiologic outflow pathway, such as Schlemm's canal, of the eye for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The implants can have features for anchoring the implant into the physiologic outflow pathway as well as preventing the walls of the physiologic outflow pathway from closing the outlet of the implants. The delivery instruments can be steerable so as to make implantation easier. Additionally, the delivery instruments can be configured to hold a plurality of implants so that multiple implants can be implanted through one incision without removing the delivery instrument from the incision between serial implantations.
摘要翻译：公开了用于治疗眼部疾病和眼部疾病如青光眼的眼内植入物和递送仪器。植入物构造成在眼睛的前房和眼睛的流体流出路径或生理流出路径（例如施莱姆氏管）之间延伸，以增强从前房的水流出，从而降低眼内压。植入物可以具有用于将植入物锚定到生理流出路径中的特征，以及防止生理流出路径的壁关闭植入物的出口。输送仪器可以引导，使植入更容易。另外，输送器械可被配置为保持多个植入物，使得可以通过一个切口植入多个植入物，而不需要从串联植入物之间的切口移除输送器械。

7. 发明授权

US07857782B2 Ocular implant delivery system and method thereof 有权
标题翻译：眼植入物递送系统及其方法
公开(公告)号：US07857782B2
公开(公告)日：2010-12-28
申请号：US12366585
申请日：2009-02-05
申请人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
发明人： Hosheng Tu , Gregory T Smedley , David Haffner , Barbara A Niksch
IPC分类号： A61M5/00 , A61F11/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.
摘要翻译：公开了用于治疗眼部疾病的系统和方法。一个系统具有带非线性轴线的输送器具，其配置成插入眼睛的前房并移动到靠近眼睛生理流出路径的位置。递送仪器携带植入物，其具有大小适于插入组织的远端，使得房水从前房排出至生理流出路径。一种方法包括将输送装置的非线性部分插入前房以将植入物定位在眼睛内。另一种方法包括使用具有弯曲远端部分的递送装置，以在与生理流出路径连通的位置处植入植入物。输送可以通过角膜切口并且植入物可以包含药物。

8. 发明申请

US20090036819A1 DRUG ELUTING OCULAR IMPLANT WITH ANCHOR AND METHODS THEREOF 有权
标题翻译：用固定剂药物治疗眼科植入物及其方法
公开(公告)号：US20090036819A1
公开(公告)日：2009-02-05
申请号：US12246448
申请日：2008-10-06
申请人： Hosheng Tu , Jason Artof , David Haffner
发明人： Hosheng Tu , Jason Artof , David Haffner
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2220/0008 , A61F2230/0069 , A61F2250/0067 , A61K31/215
摘要： Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.
摘要翻译：公开了眼部植入物，递送装置和治疗眼部疾病的方法。一种方法是将植入物插入眼睛的一侧。植入物具有位于锚固件近侧的远端部分上的锚固件和出口开口。植入物通过眼睛前进到眼睛的另一侧。将锚固体插入眼睛另一侧的眼睛组织中。使用植入物洗脱治疗剂。

9. 发明授权

US07431710B2 Ocular implants with anchors and methods thereof 有权
标题翻译：具有锚的眼植入物及其方法
公开(公告)号：US07431710B2
公开(公告)日：2008-10-07
申请号：US11083713
申请日：2005-03-18
申请人： Hosheng Tu , Jason Artof , David Haffner
发明人： Hosheng Tu , Jason Artof , David Haffner
IPC分类号： A61M5/00
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2220/0008 , A61F2230/0069 , A61F2250/0067 , A61K31/215
摘要： Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.
摘要翻译：公开了用于治疗青光眼的眼内支架和敷贴器。支架构造成在眼前房和施乐姆氏管之间延伸，以增强从前房的水流出，以便降低眼内压。支架可以具有用于将支架锚定到施乐姆运河中的特征，以及阻止施莱姆运河的墙壁关闭支架的出口。施加器可以是可操纵的，以便使植入更容易。此外，施用器可以被配置成保持多个支架，使得可以通过一个切口植入多个支架，而不会从串联注入之间的切口移除施加器。

10. 发明授权

US08579846B2 Ocular implant systems 有权
标题翻译：眼植入系统
公开(公告)号：US08579846B2
公开(公告)日：2013-11-12
申请号：US13301648
申请日：2011-11-21
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61B19/00 , A61F11/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

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