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1. 发明授权

US5501694A Expandable intravascular occlusion material removal devices and methods of use 失效
标题翻译：可扩张的血管内阻塞材料去除装置及使用方法
公开(公告)号：US5501694A
公开(公告)日：1996-03-26
申请号：US206053
申请日：1994-03-03
申请人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett
发明人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett
IPC分类号： A61B17/22 , A61B17/32 , A61B19/00 , A61B17/00 , A61M25/00
CPC分类号： A61B17/320725 , A61B2017/22042 , A61B2017/22075 , A61B2017/320012 , A61B90/39
摘要： An improved expandable removal element for an atherectomy device wherein the expandable removal element is movable between an expanded position and a contracted position. In one embodiment of the present invention, a drive shaft is operatively connected to the distal end of the expandable removal element for rotating the removal element. A catheter surrounds a portion of the drive shaft. The catheter is shiftable with respect to the drive shaft for moving the material removal element between the expanded position and the contracted position. In another embodiment of the present invention, dual coaxial drive shafts are employed. The inner drive shaft and the outer drive are shiftable with respect to one another for moving the removal element between the expanded position and the contracted position. The present invention also describes several embodiments of a removal element for increasing the durability and effectiveness of the removal element. One embodiment of the removal element of the present invention comprised a plurality of braided wires having an abrasive disposed thereon. Another embodiment of a removal element is to provide a plurality of individual wires within each "braid" to increase the abrasive surface area of the removal element. In this " multi-ended" configuration, a plurality of wires are bundled together to form a single multi-ended strand. These single multi-ended strands are then braided together and an abrasive is disposed thereon to form the removal element. Finally, a number of novel methods for removing vascular occlusion material are provided.
摘要翻译：一种用于粥样斑块切除装置的改进的可扩张去除元件，其中所述可扩张移除元件可在扩张位置和收缩位置之间移动。在本发明的一个实施例中，驱动轴可操作地连接到可扩张去除元件的远端，用于旋转移除元件。导管围绕驱动轴的一部分。导管可相对于驱动轴移动，以便在扩张位置和收缩位置之间移动材料移除元件。在本发明的另一实施例中，采用双同轴驱动轴。内部驱动轴和外部驱动器可相对于彼此移动，用于使移除元件在扩张位置和收缩位置之间移动。本发明还描述了用于提高去除元件的耐久性和有效性的去除元件的几个实施例。本发明的去除元件的一个实施例包括多个编织线，其上布置有磨料。去除元件的另一个实施例是在每个“编织物”内提供多条单独的线，以增加去除元件的研磨表面积。在这种“多端”配置中，多条电线捆绑在一起以形成单个多端线。然后将这些单个多端股线编织在一起，并在其上设置磨料以形成去除元件。最后，提供了许多用于去除血管闭塞材料的新方法。

2. 发明授权

US5836868A Expandable intravascular occlusion material removal devices and methods of use 失效
公开(公告)号：US5836868A
公开(公告)日：1998-11-17
申请号：US621350
申请日：1996-03-25
申请人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett , Chad J. Kugler , Hans A. Mische
发明人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett , Chad J. Kugler , Hans A. Mische
IPC分类号： A61B17/22 , A61B17/32
CPC分类号： A61B17/22 , A61B17/32 , A61B17/320758 , A61B2017/320004
摘要： An improved expandable removal element (16) for an atherectomy device wherein the expandable removal element (16) is movable between an expanded position and a contracted position. In one embodiment of the present invention, a single drive shaft (92) is operatively connected to the distal end of the expandable material removal element (16) for rotating the removal element (16). A catheter (178) may surround a portion of the drive shaft (92). The catheter (178) is shiftable with respect to the drive shaft (92) for moving the material removal element between the expanded position and the contracted position. In another embodiment of the present invention, dual coaxial drive shafts are employed. The inner drive shaft (312) and the outer drive (314) are shiftable with respect to one another for moving the removal element (252) between the expanded position and the contracted position. The present invention also describes several embodiments for an improved removal element (252). One embodiment of the removal element of the present invention comprised a plurality of braided wires having an abrasive disposed thereon. Another embodiment of a removal element is to provide a plurality of individual wires within each "braid" to increase the abrasive surface area of the removal element. In this "multi-ended" configuration, a plurality of wires are bundled together to form a single multi-ended strand (330). These single multi-ended strands are then braided together and an abrasive is disposed thereon to form the removal element (252). In another embodiment or the present invention is to provide a braid pattern wherein each single primary braid wire within the braid pattern is individually radially wrapped with a second "wrapping" wire (342). The "wrapping" wire (342), which may be coated with an abrasive (344), primarily performs the removal function. Finally, a number of novel methods for removing vascular occlusion material are provided.

3. 发明授权

US5490859A Expandable intravascular occlusion material removal devices and methods of use 失效
标题翻译：可扩张的血管内阻塞材料去除装置及使用方法
公开(公告)号：US5490859A
公开(公告)日：1996-02-13
申请号：US55995
申请日：1993-04-29
申请人： Hans A. Mische , Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett
发明人： Hans A. Mische , Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61B19/00
CPC分类号： A61B17/320725 , A61B2017/22042 , A61B2017/22075 , A61B2017/320012 , A61B90/39
摘要： An intravascular occlusion material removal device for removing vascular occlusion material in a vascular lumen comprises an expandable material removal element movable between an expanded position and a contracted position. The material removal element has a distal end and a proximal end. A drive shaft is operatively connected to the distal end of the expandable material removal element for rotating the removal element. A catheter surrounds a portion of the drive shaft. The catheter has a distal end for operatively variably contacting the proximal end of the material removal element such that the removal element is rotatable with respect to the catheter. The catheter is shiftable with respect to the drive shaft for moving the material removal element between the expanded position and the contracted position. A number of novel methods for removing vascular occlusion material are also provided. One such method comprises the steps of: providing a vascular occlusion material removal device having an expandable occlusion material removal element, wherein the removal element comprises a plurality of braided wires, further comprising an abrasive disposed on the wires; providing a drive shaft disposed in and shiftable with respect to the removal element; intravascularly positioning the removal element distally of the occlusion material; shifting the drive shaft with respect to the removal element to expand the element intravascularly; and moving the removal element proximally within the vascular lumen to remove occlusion material. The removal element can also be moved distally within the vascular lumen to engage the occlusion material. Also, removed occlusion material can be collected by a collection portion on the removal element.
摘要翻译：用于去除血管腔中的血管闭塞材料的血管内闭塞材料去除装置包括可在膨胀位置和收缩位置之间移动的可膨胀材料去除元件。材料去除元件具有远端和近端。驱动轴可操作地连接到可膨胀材料去除元件的远端，用于旋转移除元件。导管围绕驱动轴的一部分。导管具有用于可操作地可变地接触材料去除元件的近端的远端，使得移除元件可相对于导管旋转。导管可相对于驱动轴移动，以便在扩张位置和收缩位置之间移动材料移除元件。还提供了许多用于去除血管闭塞材料的新方法。一种这样的方法包括以下步骤：提供具有可扩张闭塞材料去除元件的血管闭塞材料去除装置，其中所述去除元件包括多根编织线，还包括布置在所述线上的磨料; 提供设置在所述移除元件中并相对于所述移除元件移位的驱动轴; 血管内将去除元件远离咬合物定位; 将驱动轴相对于移除元件移动以使血管内的元件膨胀; 并且将移除元件向近端移动到血管腔内以去除闭塞材料。移除元件也可以在血管腔内向远端移动以接合闭塞材料。此外，可以通过去除元件上的收集部分来收集去除的封闭材料。

4. 发明授权

US5540707A Expandable intravascular occlusion material removal devices and methods of use 失效
标题翻译：可扩张的血管内阻塞材料去除装置及使用方法
公开(公告)号：US5540707A
公开(公告)日：1996-07-30
申请号：US261813
申请日：1994-06-17
申请人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett , Chad J. Kugler
发明人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett , Chad J. Kugler
IPC分类号： A61B17/22 , A61B17/32 , A61B19/00
CPC分类号： A61B17/320725 , A61B2017/22042 , A61B2017/22075 , A61B2017/320012 , A61B90/39
摘要： An improved expandable removal element for an atherectomy device wherein the expandable removal element is movable between an expanded position and a contracted position. In one embodiment of the present invention, a single drive shaft is operatively connected to the distal end of the expandable material removal element for rotating the removal element. A catheter surrounds a portion of the drive shaft. The catheter is shiftable with respect to the drive shaft for moving the material removal element between the expanded position and the contracted position. In another embodiment of the present invention, dual coaxial drive shafts are employed. The inner drive shaft and the outer drive are shiftable with respect to one another for moving the removal element between the expanded position and the contracted position. The present invention also describes several embodiments for an improved removal element. One embodiment or the present invention is to provide a braid pattern wherein each single primary braid wire within the braid pattern is individually radially wrapped with a second "wrapping" wire. The "wrapping" wire, which is coated with an abrasive, primarily performs the removal function. Finally, a number of novel methods for removing vascular occlusion material are provided.
摘要翻译：一种用于粥样斑块切除装置的改进的可扩张去除元件，其中所述可扩张移除元件可在扩张位置和收缩位置之间移动。在本发明的一个实施例中，单个驱动轴可操作地连接到可膨胀材料去除元件的远端，用于旋转移除元件。导管围绕驱动轴的一部分。导管可相对于驱动轴移动，以便在扩张位置和收缩位置之间移动材料移除元件。在本发明的另一实施例中，采用双同轴驱动轴。内部驱动轴和外部驱动器可相对于彼此移动，用于使移除元件在扩张位置和收缩位置之间移动。本发明还描述了改进的去除元件的几个实施例。一个实施例或本发明是提供一种编织图案，其中编织图案内的每个单个主编织线用第二“缠绕”线单独径向包裹。涂有研磨剂的“包裹”线主要执行去除功能。最后，提供了许多用于去除血管闭塞材料的新方法。

5. 发明授权

US5897567A Expandable intravascular occlusion material removal devices and methods of use 失效
标题翻译：可扩张的血管内阻塞材料去除装置及使用方法
公开(公告)号：US5897567A
公开(公告)日：1999-04-27
申请号：US924850
申请日：1997-09-09
申请人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett , Chad J. Kugler , Hans A. Mische
发明人： Thomas V. Ressemann , Anthony C. Vrba , Steven S. Hackett , Chad J. Kugler , Hans A. Mische
IPC分类号： A61B17/32
CPC分类号： A61B17/32
摘要： An improved expandable removal element (16) for an atherectomy device wherein the expandable removal element (16) is movable between an expanded position and a contracted position. In one embodiment of the present invention, a single drive shaft (92) is operatively connected to the distal end of the expandable material removal element (16) for rotating the removal element (16). A catheter (178) may surround a portion of the drive shaft (92). The catheter (178) is shiftable with respect to the drive shaft (92) for moving the material removal element between the expanded position and the contracted position. In another embodiment of the present invention, dual coaxial drive shafts are employed. The inner drive shaft (312) and the outer drive (314) are shiftable with respect to one another for moving the removal element (252) between the expanded position and the contracted position. The present invention also describes several embodiments for an improved removal element (252).
摘要翻译：一种用于粥样斑块切除装置的改进的可扩张去除元件（16），其中所述可扩张移除元件（16）可在展开位置和收缩位置之间移动。在本发明的一个实施例中，单个驱动轴（92）可操作地连接到可膨胀材料移除元件（16）的远端，用于旋转移除元件（16）。导管（178）可围绕驱动轴（92）的一部分。导管（178）可相对于驱动轴（92）移动，用于在扩张位置和收缩位置之间移动材料移除元件。在本发明的另一实施例中，采用双同轴驱动轴。内部驱动轴（312）和外部驱动器（314）可以相对于彼此移动，以在移动元件（252）之间在扩张位置和收缩位置之间移动。本发明还描述了改进的去除元件（252）的几个实施例。

6. 发明申请

US20090264907A1 MEDICAL DEVICE FOR CROSSING AN OCCLUDED BLOOD VESSEL 审中-公开
标题翻译：用于穿过血管血管的医疗装置
公开(公告)号：US20090264907A1
公开(公告)日：2009-10-22
申请号：US12106032
申请日：2008-04-18
申请人： Anthony C. Vrba , Todd P. Messal
发明人： Anthony C. Vrba , Todd P. Messal
IPC分类号： A61B17/22
CPC分类号： A61M25/09 , A61M25/00 , A61M2025/09175
摘要： Medical devices and methods for making and using the same. An example medical device includes a tubular shaft and a crossing member disposed within the tubular shaft. The crossing member may include a loop portion. The methods for using the medical device may include advancing the medical device through the vasculature to a position where at least a portion of the device contacts an intravascular lesion and expanding the loop portion of the crossing device to displace the occlusion.
摘要翻译：医疗器械及其制造和使用方法。一种示例性医疗装置包括管状轴和设置在管状轴内的交叉构件。交叉构件可以包括环部分。使用医疗装置的方法可以包括将医疗装置通过脉管系统推进至至少一部分装置与血管内病变接触的位置，并扩大交叉装置的环部分以移位闭塞。

7. 发明授权

US06676666B2 Medical device delivery system with two sheaths 有权
标题翻译：医疗器械输送系统有两个护套
公开(公告)号：US06676666B2
公开(公告)日：2004-01-13
申请号：US09885493
申请日：2001-06-20
申请人： Anthony C. Vrba , David J. Sogard
发明人： Anthony C. Vrba , David J. Sogard
IPC分类号： A61F200
CPC分类号： A61F2/01 , A61F2/07 , A61F2/95 , A61F2/958 , A61F2/966 , A61F2002/011 , A61F2002/9522 , A61F2230/0006 , A61F2230/005
摘要： A medical device delivery system is disclosed which has a distal inner sheath and a distal outer sheath covering a medical device mounting region and any medical device mounted thereon. The outer sheath is designed to retain the medical device for lengthy periods of time while the inner sheath is designed to retain the sheath for shorter periods of time.
摘要翻译：公开了一种医疗装置输送系统，其具有覆盖医疗装置安装区域的远端内护套和远端外护套以及安装在其上的任何医疗装置。外套被设计成在长时间内保持医疗装置，同时内护套被设计成在较短的时间段内保持护套。

8. 发明授权

US06254609B1 Self-expanding stent delivery system with two sheaths 有权
标题翻译：自扩张支架输送系统有两个护套
公开(公告)号：US06254609B1
公开(公告)日：2001-07-03
申请号：US09228097
申请日：1999-01-11
申请人： Anthony C. Vrba , David J. Sogard
发明人： Anthony C. Vrba , David J. Sogard
IPC分类号： A61F200
CPC分类号： A61F2/01 , A61F2/07 , A61F2/95 , A61F2/958 , A61F2/966 , A61F2002/011 , A61F2002/9522 , A61F2230/0006 , A61F2230/005
摘要： A medical device delivery system is disclosed which has a distal inner sheath and a distal outer sheath covering a medical device mounting region and any medical device mounted thereon. The outer sheath is designed to retain the medical device for lengthy periods of time while the inner sheath is designed to retain the sheath for shorter periods of time.
摘要翻译：公开了一种医疗装置输送系统，其具有覆盖医疗装置安装区域的远端内护套和远端外护套以及安装在其上的任何医疗装置。外套被设计成在长时间内保持医疗装置，同时内护套被设计成在较短的时间段内保持护套。

9. 发明授权

US06206888B1 Stent delivery system using shape memory retraction 失效
公开(公告)号：US06206888B1
公开(公告)日：2001-03-27
申请号：US09283444
申请日：1999-04-01
申请人： Andrew D. Bicek , Lance A. Monroe , Anthony C. Vrba , Steven E. Walak
发明人： Andrew D. Bicek , Lance A. Monroe , Anthony C. Vrba , Steven E. Walak
IPC分类号： A61F1100
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9583 , A61F2210/0023
摘要： The inventive stent delivery system includes a catheter having a retractable outer sheath near its distal end. A shape memory contraction member having a memorized contracted shape is connected to the retractable outer sheath. A heat generating device connected to the shape memory contraction member causes the shape memory contraction member to heat up to its transition temperature and assume its contracted position, retracting the retractable outer sheath. Another embodiment utilizes 2 springs, a “normal” spring and a shape memory alloy (SMA) spring, the two springs selected and designed so that the “normal” has an expansion force which is less than SMA spring when the SMA spring is austenitic, but greater than the SMA spring when the SMA spring is martensitic. Yet another embodiment utilizes a shape memory latch which in its martensitic state abuts a stop to prevent a spring from moving the sheath proximally, but in its austenitic state releases the stop, allowing the spring to retract the sheath to release the stent for deployment.

10. 发明授权

US08152832B2 Apparatus for anchoring an intravascular device along a guidewire 失效
标题翻译：用于沿导丝锚定血管内装置的装置
公开(公告)号：US08152832B2
公开(公告)日：2012-04-10
申请号：US11621921
申请日：2007-01-10
申请人： Mel R. Beulke , Thomas E. Broome , Robert L. Cassell , John M. K. Daniel , Alan D. Eskuri , James G. Hansen , Gary R. Kostur , Douglas B. Molland , Scott R. Smith , Jeffrey H. Vogel , Anthony C. Vrba
发明人： Mel R. Beulke , Thomas E. Broome , Robert L. Cassell , John M. K. Daniel , Alan D. Eskuri , James G. Hansen , Gary R. Kostur , Douglas B. Molland , Scott R. Smith , Jeffrey H. Vogel , Anthony C. Vrba
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61B2017/22049 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/005 , A61F2230/0067
摘要： Anchoring mechanisms for releasably securing an intravascular device along an elongated member such as a guidewire or catheter. The anchoring mechanism may include an object that can be actuated between an unlocked position and a locked position. In the unlocked position, the anchoring mechanism is slidably and rotationally disposed about the elongated member. In the locked position, the anchoring mechanism is releasably secured to the elongated member, preventing movement thereon. A placement mechanism such as a tubular member can be utilized to actuate the anchoring mechanism between the unlocked and locked positions.
摘要翻译：锚定机构，用于沿着诸如导丝或导管的细长构件可释放地固定血管内装置。锚固机构可以包括能够在解锁位置和锁定位置之间被致动的物体。在解锁位置，锚定机构围绕细长构件可滑动地和旋转地设置。在锁定位置，锚定机构可释放地固定到细长构件上，防止其上移动。可以使用诸如管状构件的放置机构来致动解锁位置和锁定位置之间的锚固机构。

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