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1. 发明申请

US20070038265A1 Responsive electrical stimulation for movement disorders 有权
标题翻译：反应性电刺激运动障碍
公开(公告)号：US20070038265A1
公开(公告)日：2007-02-15
申请号：US11517783
申请日：2006-09-08
申请人： Thomas Tcheng , Robert Fischell , Benjamin Pless
发明人： Thomas Tcheng , Robert Fischell , Benjamin Pless
IPC分类号： A61N1/32
CPC分类号： A61N1/36067 , A61N1/36135
摘要： An implantable neurostimulator system for treating movement disorders includes a sensor, a detection subsystem capable of identifying episodes of a movement disorder by analyzing a signal received from the sensor, and a therapy subsystem capable of applying therapeutic electrical stimulation to treat the movement disorder. The system treats movement disorders by detecting physiological conditions characteristic of an episode of symptoms of the movement disorder and selectively initiating therapy when such conditions are detected.
摘要翻译：用于治疗运动障碍的可植入神经刺激器系统包括传感器，能够通过分析从传感器接收的信号来识别运动障碍的发作的检测子系统，以及能够施加治疗性电刺激以治疗运动障碍的治疗子系统。该系统通过检测运动障碍症状发作特征的生理条件来治疗运动障碍，并且当检测到这种病症时选择性地开始治疗。

2. 发明申请

US20060224216A1 System and method for controlling neurological disorders with spatially separated detection and therapy locations 审中-公开
标题翻译：用空间分离的检测和治疗位置控制神经系统疾病的系统和方法
公开(公告)号：US20060224216A1
公开(公告)日：2006-10-05
申请号：US11436189
申请日：2006-05-16
申请人： Benjamin Pless , Robert Fischell , David Fischell
发明人： Benjamin Pless , Robert Fischell , David Fischell
IPC分类号： A61N1/00
CPC分类号： A61N1/0529 , A61B5/0002 , A61B5/0476 , A61B5/4094 , A61B5/7217 , A61M5/14276 , A61N1/0534 , A61N1/36064 , A61N1/36082
摘要： A system and method for controlling epilepsy and other neurological disorders by providing electrical stimulation to a patient's brain in response to detected neurological conditions. An implantable device includes a stimulation subsystem coupled to a stimulation electrode to provide responsive electrical brain stimulation in response to an event detected via an on-board processor's analysis of data received from a detection subsystem coupled to a detection electrode located in a different portion of the patient's brain.
摘要翻译：一种通过响应于检测到的神经病症向患者的大脑提供电刺激来控制癫痫和其他神经障碍的系统和方法。可植入装置包括耦合到刺激电极的刺激子系统，以响应于经由车载处理器对从耦合到位于所述第二部分的不同部分的检测电极的检测子系统接收的数据的分析而检测的事件来响应电脑刺激病人的大脑

3. 发明申请

US20070142886A1 Magnetic pulsing system for inducing electric currents in a human body 有权
标题翻译：用于在人体内诱导电流的磁脉冲系统
公开(公告)号：US20070142886A1
公开(公告)日：2007-06-21
申请号：US11305276
申请日：2005-12-19
申请人： Robert Fischell , Scott Fischell , David Fischell , Emily Ma , Kuen Chang , Dave Vondle , Benjamin Pless
发明人： Robert Fischell , Scott Fischell , David Fischell , Emily Ma , Kuen Chang , Dave Vondle , Benjamin Pless
IPC分类号： A61F2/00
CPC分类号： A61N2/02 , A61N2/008
摘要： Disclosed is a means and method for the treatment of migraine headaches and other disorders of the human body by the application of one or more intense magnetic pulses. By placing an intense magnetic field pulse(s) onto a certain region of the brain, an electrical current can be generated in the cerebral cortex that can stop a migraine headache in some patients or at least decrease its severity. The device to perform this function can be called a “magnetic pulser system.” This system can be made in one piece and powered by plugging into a household or automobile receptacle or from a battery. The pulser system uses capacitors that are first charged to a high voltage and then discharged into a coil that creates the intense magnetic pulse. Both visual and auditory signals can be provided by the pulser system to assist the patient in using the device.
摘要翻译：公开了通过施加一个或多个强磁脉冲来治疗偏头痛和人体其它疾病的方法和方法。通过在大脑的某个区域放置强烈的磁场脉冲，可以在大脑皮质中产生电流，可以阻止一些患者的偏头痛，或至少降低其严重程度。执行此功能的设备可称为“磁脉冲发生器系统”。该系统可以制成一体并通过插入家用或汽车插座或从电池供电。脉冲发生器系统使用首先充电到高电压然后放电到产生强磁脉冲的线圈中的电容器。视觉和听觉信号都可以由脉冲发生器系统提供，以帮助患者使用该装置。

4. 发明申请

US20050281860A1 Surgically implanted devices having reduced scar tissue formation 审中-公开
标题翻译：具有减少瘢痕组织形成的手术植入装置
公开(公告)号：US20050281860A1
公开(公告)日：2005-12-22
申请号：US11084948
申请日：2005-03-21
申请人： Robert Fischell , David Fischell , Tim Fischell , Scott Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell , Scott Fischell
IPC分类号： A61B17/04 , A61B17/00 , A61B17/06 , A61B17/064 , A61F2/00 , A61F2/02 , A61F9/007 , A61F13/00 , A61L15/44 , A61L17/00 , A61L26/00 , A61L27/00 , A61L27/54 , A61L31/16 , A61K31/4745
CPC分类号： A61L27/54 , A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2/0063 , A61F2013/00451 , A61L15/44 , A61L31/16 , A61L2300/416 , A61L2300/424 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/626
摘要： An anti-proliferative drug, such as rapamycin or taxol, is placed onto or within a sheet of material or mesh. The strands onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. Surgical sutures or staples may also be coated and used for connecting human tissues (i.e., for example, an anastomosis).
摘要翻译：将抗增生药物，例如雷帕霉素或紫杉醇放置在一片材料或网状物上或内。药物放置在其上或其中的线可以是永久性植入物，也可以是可生物降解的。手术缝线或缝钉也可以被涂覆并用于连接人体组织（例如，吻合）。

5. 发明申请

US20050246011A1 Stent having a multiplicity of undulating longitudinals 审中-公开
标题翻译：支架有多个起伏的纵骨
公开(公告)号：US20050246011A1
公开(公告)日：2005-11-03
申请号：US11179424
申请日：2005-07-12
申请人： Robert Fischell , David Fischell , Tim Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell
IPC分类号： A61F2/00 , A61F2/82 , A61F2/90 , A61F2/06
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： A method for implanting a balloon expandable stent at a site within a passageway of a curved coronary article. The stent includes at least two longitudinally spaced apart circumferential rings. At least one longitudinally extending connector extends between adjacent rings. The connector has at least one turn back portion that can expand or contract in length while being passed through a curved passageway. The stent is disposed on a stent delivery catheter having an inflatable balloon. The stent delivery catheter and the stent is delivered through the passageway to the site of implementation with the connector member expanding or contracting in length to facilitate delivery and placement of the stent. The stent is expanded at the site of implantation by inflating the balloon to force the stent radially outward against the wall of the coronary artery.
摘要翻译：一种用于将球囊可扩张支架植入弯曲冠状动脉制品通道内的部位的方法。支架包括至少两个纵向间隔开的周向环。至少一个纵向延伸的连接器在相邻的环之间延伸。连接器具有至少一个回转部分，其能够在穿过弯曲通道的同时膨胀或收缩。支架设置在具有可膨胀气囊的支架输送导管上。支架输送导管和支架通过通道被输送到实现位置，连接器构件的长度膨胀或收缩以便于支架的输送和放置。通过使气囊膨胀来使支架在植入部位扩张，以使支架径向向外抵靠冠状动脉壁。

6. 发明申请

US20080064973A1 SYSTEM FOR THE DETECTION OF CARDIAC EVENTS 审中-公开
标题翻译：检测心脏事件的系统
公开(公告)号：US20080064973A1
公开(公告)日：2008-03-13
申请号：US11930027
申请日：2007-10-30
申请人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
发明人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
IPC分类号： A61B5/0402
CPC分类号： A61B5/02455 , A61B5/0031 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/746 , A61B5/7465 , A61B2560/0209
摘要： Disclosed is a system for the detection of cardiac events (a guardian system) that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using one or more detection algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the guardian system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means). If the guardian system is put into a pacemaker, the algorithm can utilize a different analysis of the electrogram depending on whether or not the pacemaker is actually pacing the heart.
摘要翻译：公开了一种用于检测心脏事件（监护系统）的系统，其包括称为心脏切除器的植入装置，医师编程器和外部警报系统。该系统旨在提供心脏事件的早期检测，例如由心率增加或运动引起的急性心肌梗死或运动诱发的心肌缺血。如果检测到心律失常，该系统还可以警告患者不太紧急的警报。使用一个或多个检测算法，心脏扫描器可以检测患者的电描记图中的变化，其指示在发生后五分钟内的心脏事件，然后自动向患者发出事件发生。为了提供此警告，监护系统包括在心脏保护器内和/或外部报警系统（外部报警装置）内的内部报警子系统（内部报警装置）。如果将监护人系统放入心脏起搏器，该算法可以根据起搏器是否实际起搏心脏，对电图进行不同的分析。

7. 发明申请

US20070249947A1 Means and method for the detection of cardiac events 有权
公开(公告)号：US20070249947A1
公开(公告)日：2007-10-25
申请号：US11812827
申请日：2007-06-22
申请人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
发明人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

8. 发明申请

US20070163601A1 Apparatus and method for reversible male and female contraceptive implants 审中-公开
标题翻译：可逆男性和女性避孕植入物的装置和方法
公开(公告)号：US20070163601A1
公开(公告)日：2007-07-19
申请号：US11333695
申请日：2006-01-17
申请人： Neil Pollock , David Fishcell , Robert Fischell , John Burton
发明人： Neil Pollock , David Fishcell , Robert Fischell , John Burton
IPC分类号： A61F6/02
CPC分类号： A61F6/22
摘要： The device includes tethered plugs that may be reversibly inserted into the VAS to provide contraception. The method includes a procedure for inserting and removing the device.
摘要翻译：该装置包括可以可逆地插入到VAS中以提供避孕的系留塞。该方法包括插入和移除设备的过程。

9. 发明申请

US20070083253A1 Stent delivery system using a steerable guide wire 有权
标题翻译：支架输送系统采用可转向导丝
公开(公告)号：US20070083253A1
公开(公告)日：2007-04-12
申请号：US11244777
申请日：2005-10-06
申请人： David Fischell , Robert Fischell , Tim Fischell , Scott Fischell
发明人： David Fischell , Robert Fischell , Tim Fischell , Scott Fischell
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/95 , A61M25/104 , A61M2025/1056 , A61M2025/1063
摘要： A thin-walled guide wire tube is fixedly and sealably attached to both a proximal section and a distal section of a balloon angioplasty catheter. A stent is co-axially mounted onto the inflatable balloon of the balloon angioplasty catheter. Because the guide wire tube forms an inner liner for the balloon angioplasty catheter, the fluid inflation lumen of the catheter is sealed so the inflation liquid that pressurizes the balloon will not leak as it would be if there were no “inner liner” and the balloon angioplasty catheter were attached to the guide wire itself. By not having a traditional inner shaft through which a conventional guide wire slides, the deflated balloon on which the stent is mounted can have a reduced diameter.
摘要翻译：薄壁导丝管固定并密封地附接到球囊血管成形术导管的近端部分和远端部分。支架同轴地安装在球囊血管成形术导管的可充气球囊上。由于导丝管形成球囊血管成形术导管的内衬，导管的流体膨胀腔被密封，使得气囊加压的充气液体将不会像没有“内衬”那样泄漏，气球血管成形术导管附着于导丝本身。通过不具有传统导丝通过其传播的传统内轴，其上安装有支架的放气气球可以具有减小的直径。

10. 发明申请

US20050137483A1 Electrogram signal filtering in systems for detecting ischemia 审中-公开
标题翻译：用于检测缺血的系统中的电图信号滤波
公开(公告)号：US20050137483A1
公开(公告)日：2005-06-23
申请号：US10741141
申请日：2003-12-22
申请人： Robert Fischell , David Fischell , Tim Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell
IPC分类号： A61B5/04 , A61B5/0402 , A61B5/0452 , A61N1/04 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0452 , A61B5/04012 , A61N1/3702
摘要： The present invention is a system that utilizes optimized high pass or band pass filtering to provide accurate detection of changes in the ST segment of an electrogram as detected by an implanted cardiosaver system, which ST segment changes are indicative of coronary ischemia. To accurately detect changes in the ST segment of the electrogram, the cardiosaver system uses either analog or digital high pass filtering having an electrogram voltage reduction of 6 dB at some frequency between 0.05 Hz and 1.0 Hz with less than 6 dB of attenuation at frequencies above 1.0 Hz. and more than 6 dB of attenuation for frequencies below 0.05 Hz. The optimized filter would include attenuation of electric power generation frequencies of either 50 Hz or 60 Hz to reduce electromagnetic interference. The system also includes both implanted and external portions that provide a patient alarm if coronary ischemia is sensed.
摘要翻译：本发明是一种利用优化的高通或带通滤波来提供由植入式心血管系统检测到的电描记图ST段变化的精确检测的系统，其中ST段改变指示冠状动脉缺血。为了准确地检测电描记图ST段的变化，心脏扫描器系统使用模拟或数字高通滤波，其频率在0.05Hz至1.0Hz之间的某一频率处具有6dB的电压降，而在上述频率处具有小于6dB的衰减 1.0 Hz。对于0.05Hz以下的频率，衰减超过6dB。优化的滤波器将包括50Hz或60Hz的发电频率的衰减以减少电磁干扰。该系统还包括植入和外部部分，如果感测到冠状动脉缺血则提供患者报警。

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