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1. 发明申请

US20070293778A1 Means and method for the detection of cardiac events 有权
公开(公告)号：US20070293778A1
公开(公告)日：2007-12-20
申请号：US11812826
申请日：2007-06-22
申请人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
发明人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
IPC分类号： A61B5/0432
CPC分类号： A61B5/0464 , A61B5/0006 , A61B5/0031 , A61B5/02455 , A61B5/04012 , A61B5/042 , A61B5/0432 , A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0472 , A61B5/686 , A61B5/746 , A61B5/7465 , A61N1/3702 , A61N1/37258 , A61N1/3756 , G16H40/67
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

2. 发明申请

US20070110796A1 Devices and methods for reducing scar tissue formation 审中-公开
标题翻译：用于减少瘢痕组织形成的装置和方法
公开(公告)号：US20070110796A1
公开(公告)日：2007-05-17
申请号：US11585697
申请日：2006-10-24
申请人： Robert Fischell , David Fischell , Tim Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell
IPC分类号： A61K31/4745 , A61L15/00
CPC分类号： A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2/0063 , A61F2013/00451 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/416 , A61L2300/424 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/626
摘要： Disclosed is a cytostatic drug attached to a sterile sheet that is designed to be placed between internal body tissues to prevent the formation of post-operative adhesions, which adhesions are really scar tissue formation. This sheet onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. By impregnating an existing product such as the Johnson & Johnson SURGICEL™ absorbable hemostat gauze-like sheet with an anti-proliferative drug such as sirolimus, the biodegradable, drug impregnated mesh would act as a barrier to cell proliferation and hence be a deterrent to the formation of adhesions or scar tissue. Another embodiment of this invention is a cytostatic drug attached to a sheet that is placed at the site of an anastamosis to decrease scar tissue formation from within the vessel at the site of the anastomosis.
摘要翻译：公开了附着在无菌片上的细胞生长抑制药物，其被设计为放置在体内组织之间以防止术后粘连的形成，这些粘连真的是瘢痕组织形成。药物放置在药物上或其中的片材可以是永久植入物，也可以是可生物降解的。通过用诸如西罗莫司之类的抗增殖药物浸渍诸如Johnson＆Johnson SURGICEL TM可吸收止血纱布片之类的现有产品，可生物降解的药物浸渍网将作为细胞增殖的障碍，因此成为威慑形成粘连或瘢痕组织。本发明的另一个实施方案是连接到片材上的细胞生长抑制药物，其被放置在吻合部位以减少在吻合部位的血管内的瘢痕组织形成。

3. 发明申请

US20080064973A1 SYSTEM FOR THE DETECTION OF CARDIAC EVENTS 审中-公开
标题翻译：检测心脏事件的系统
公开(公告)号：US20080064973A1
公开(公告)日：2008-03-13
申请号：US11930027
申请日：2007-10-30
申请人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
发明人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
IPC分类号： A61B5/0402
CPC分类号： A61B5/02455 , A61B5/0031 , A61B5/04012 , A61B5/0422 , A61B5/0452 , A61B5/0456 , A61B5/0468 , A61B5/0472 , A61B5/746 , A61B5/7465 , A61B2560/0209
摘要： Disclosed is a system for the detection of cardiac events (a guardian system) that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using one or more detection algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the guardian system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means). If the guardian system is put into a pacemaker, the algorithm can utilize a different analysis of the electrogram depending on whether or not the pacemaker is actually pacing the heart.
摘要翻译：公开了一种用于检测心脏事件（监护系统）的系统，其包括称为心脏切除器的植入装置，医师编程器和外部警报系统。该系统旨在提供心脏事件的早期检测，例如由心率增加或运动引起的急性心肌梗死或运动诱发的心肌缺血。如果检测到心律失常，该系统还可以警告患者不太紧急的警报。使用一个或多个检测算法，心脏扫描器可以检测患者的电描记图中的变化，其指示在发生后五分钟内的心脏事件，然后自动向患者发出事件发生。为了提供此警告，监护系统包括在心脏保护器内和/或外部报警系统（外部报警装置）内的内部报警子系统（内部报警装置）。如果将监护人系统放入心脏起搏器，该算法可以根据起搏器是否实际起搏心脏，对电图进行不同的分析。

4. 发明申请

US20070249947A1 Means and method for the detection of cardiac events 有权
公开(公告)号：US20070249947A1
公开(公告)日：2007-10-25
申请号：US11812827
申请日：2007-06-22
申请人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
发明人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
IPC分类号： A61B5/0402
CPC分类号： A61B5/0452 , A61B5/0006 , A61B5/0031 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7465 , A61B2560/0209 , A61N1/3627 , A61N1/3702
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

5. 发明申请

US20070083253A1 Stent delivery system using a steerable guide wire 有权
标题翻译：支架输送系统采用可转向导丝
公开(公告)号：US20070083253A1
公开(公告)日：2007-04-12
申请号：US11244777
申请日：2005-10-06
申请人： David Fischell , Robert Fischell , Tim Fischell , Scott Fischell
发明人： David Fischell , Robert Fischell , Tim Fischell , Scott Fischell
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/95 , A61M25/104 , A61M2025/1056 , A61M2025/1063
摘要： A thin-walled guide wire tube is fixedly and sealably attached to both a proximal section and a distal section of a balloon angioplasty catheter. A stent is co-axially mounted onto the inflatable balloon of the balloon angioplasty catheter. Because the guide wire tube forms an inner liner for the balloon angioplasty catheter, the fluid inflation lumen of the catheter is sealed so the inflation liquid that pressurizes the balloon will not leak as it would be if there were no “inner liner” and the balloon angioplasty catheter were attached to the guide wire itself. By not having a traditional inner shaft through which a conventional guide wire slides, the deflated balloon on which the stent is mounted can have a reduced diameter.
摘要翻译：薄壁导丝管固定并密封地附接到球囊血管成形术导管的近端部分和远端部分。支架同轴地安装在球囊血管成形术导管的可充气球囊上。由于导丝管形成球囊血管成形术导管的内衬，导管的流体膨胀腔被密封，使得气囊加压的充气液体将不会像没有“内衬”那样泄漏，气球血管成形术导管附着于导丝本身。通过不具有传统导丝通过其传播的传统内轴，其上安装有支架的放气气球可以具有减小的直径。

6. 发明申请

US20050137483A1 Electrogram signal filtering in systems for detecting ischemia 审中-公开
标题翻译：用于检测缺血的系统中的电图信号滤波
公开(公告)号：US20050137483A1
公开(公告)日：2005-06-23
申请号：US10741141
申请日：2003-12-22
申请人： Robert Fischell , David Fischell , Tim Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell
IPC分类号： A61B5/04 , A61B5/0402 , A61B5/0452 , A61N1/04 , A61N1/365 , A61N1/37
CPC分类号： A61B5/0452 , A61B5/04012 , A61N1/3702
摘要： The present invention is a system that utilizes optimized high pass or band pass filtering to provide accurate detection of changes in the ST segment of an electrogram as detected by an implanted cardiosaver system, which ST segment changes are indicative of coronary ischemia. To accurately detect changes in the ST segment of the electrogram, the cardiosaver system uses either analog or digital high pass filtering having an electrogram voltage reduction of 6 dB at some frequency between 0.05 Hz and 1.0 Hz with less than 6 dB of attenuation at frequencies above 1.0 Hz. and more than 6 dB of attenuation for frequencies below 0.05 Hz. The optimized filter would include attenuation of electric power generation frequencies of either 50 Hz or 60 Hz to reduce electromagnetic interference. The system also includes both implanted and external portions that provide a patient alarm if coronary ischemia is sensed.
摘要翻译：本发明是一种利用优化的高通或带通滤波来提供由植入式心血管系统检测到的电描记图ST段变化的精确检测的系统，其中ST段改变指示冠状动脉缺血。为了准确地检测电描记图ST段的变化，心脏扫描器系统使用模拟或数字高通滤波，其频率在0.05Hz至1.0Hz之间的某一频率处具有6dB的电压降，而在上述频率处具有小于6dB的衰减 1.0 Hz。对于0.05Hz以下的频率，衰减超过6dB。优化的滤波器将包括50Hz或60Hz的发电频率的衰减以减少电磁干扰。该系统还包括植入和外部部分，如果感测到冠状动脉缺血则提供患者报警。

7. 发明申请

US20050281860A1 Surgically implanted devices having reduced scar tissue formation 审中-公开
标题翻译：具有减少瘢痕组织形成的手术植入装置
公开(公告)号：US20050281860A1
公开(公告)日：2005-12-22
申请号：US11084948
申请日：2005-03-21
申请人： Robert Fischell , David Fischell , Tim Fischell , Scott Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell , Scott Fischell
IPC分类号： A61B17/04 , A61B17/00 , A61B17/06 , A61B17/064 , A61F2/00 , A61F2/02 , A61F9/007 , A61F13/00 , A61L15/44 , A61L17/00 , A61L26/00 , A61L27/00 , A61L27/54 , A61L31/16 , A61K31/4745
CPC分类号： A61L27/54 , A61B17/06166 , A61B17/064 , A61B2017/00831 , A61F2/0063 , A61F2013/00451 , A61L15/44 , A61L31/16 , A61L2300/416 , A61L2300/424 , A61L2300/602 , A61L2300/604 , A61L2300/622 , A61L2300/626
摘要： An anti-proliferative drug, such as rapamycin or taxol, is placed onto or within a sheet of material or mesh. The strands onto or into which the drug is placed may be either a permanent implant or it may be biodegradable. Surgical sutures or staples may also be coated and used for connecting human tissues (i.e., for example, an anastomosis).
摘要翻译：将抗增生药物，例如雷帕霉素或紫杉醇放置在一片材料或网状物上或内。药物放置在其上或其中的线可以是永久性植入物，也可以是可生物降解的。手术缝线或缝钉也可以被涂覆并用于连接人体组织（例如，吻合）。

8. 发明申请

US20050246011A1 Stent having a multiplicity of undulating longitudinals 审中-公开
标题翻译：支架有多个起伏的纵骨
公开(公告)号：US20050246011A1
公开(公告)日：2005-11-03
申请号：US11179424
申请日：2005-07-12
申请人： Robert Fischell , David Fischell , Tim Fischell
发明人： Robert Fischell , David Fischell , Tim Fischell
IPC分类号： A61F2/00 , A61F2/82 , A61F2/90 , A61F2/06
CPC分类号： A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91533 , A61F2002/9155 , A61F2210/0019
摘要： A method for implanting a balloon expandable stent at a site within a passageway of a curved coronary article. The stent includes at least two longitudinally spaced apart circumferential rings. At least one longitudinally extending connector extends between adjacent rings. The connector has at least one turn back portion that can expand or contract in length while being passed through a curved passageway. The stent is disposed on a stent delivery catheter having an inflatable balloon. The stent delivery catheter and the stent is delivered through the passageway to the site of implementation with the connector member expanding or contracting in length to facilitate delivery and placement of the stent. The stent is expanded at the site of implantation by inflating the balloon to force the stent radially outward against the wall of the coronary artery.
摘要翻译：一种用于将球囊可扩张支架植入弯曲冠状动脉制品通道内的部位的方法。支架包括至少两个纵向间隔开的周向环。至少一个纵向延伸的连接器在相邻的环之间延伸。连接器具有至少一个回转部分，其能够在穿过弯曲通道的同时膨胀或收缩。支架设置在具有可膨胀气囊的支架输送导管上。支架输送导管和支架通过通道被输送到实现位置，连接器构件的长度膨胀或收缩以便于支架的输送和放置。通过使气囊膨胀来使支架在植入部位扩张，以使支架径向向外抵靠冠状动脉壁。

9. 发明申请

US20080082155A1 Means and method for the accurate placement of a stent at the ostium of an artery 有权
标题翻译：支架在动脉口的准确放置的方法和方法
公开(公告)号：US20080082155A1
公开(公告)日：2008-04-03
申请号：US11975196
申请日：2007-10-18
申请人： Robert Fischell , Tim Fischell , David Fischell , Mark Zyzelewski
发明人： Robert Fischell , Tim Fischell , David Fischell , Mark Zyzelewski
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61F2002/821 , A61F2250/0098
摘要： Disclosed is an ostial stent positioner that has the form of a wire for most of its length and having a short cylinder with a longitudinal slit and expandable legs situated at the positioner's distal end. The slit cylinder with its attached wire acts as an introducer sheath to introduce a stent delivery system with a stent into the artery that is to be stented. A second aspect of the present invention is a method for accurately placing a stent at the ostium of an artery that would have an ostial stenosis. Examples of such arteries that have ostial stenoses are the right and left main coronary arteries, a saphenous vein graft as used in coronary bypass surgery and the renal arteries. Also disclosed are designs for the slit cylinder that provides a variable diameter so as to fit snugly within guiding catheters having different inside diameters.
摘要翻译：公开了一种口腔支架定位器，其具有大部分长度的线的形式，并且具有短圆柱体，其具有位于定位器的远端处的纵向狭缝和可扩展腿。具有连接线的狭缝圆柱体用作导引鞘，以将具有支架的支架输送系统引入到要被固定的动脉中。本发明的第二方面是一种将支架精确地放置在具有口腔狭窄的动脉的口处的方法。具有口腔狭窄的这种动脉的实例是右冠状动脉和左主动脉冠状动脉，用于冠状动脉旁路手术的隐静脉移植物和肾动脉。还公开了用于狭缝筒的设计，其提供可变直径，以便紧密地配合在具有不同内径的引导导管内。

10. 发明申请

US20070293775A1 Means and method for the detection of cardiac events 审中-公开
公开(公告)号：US20070293775A1
公开(公告)日：2007-12-20
申请号：US11812819
申请日：2007-06-22
申请人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
发明人： David Fischell , Tim Fischell , Jonathan Harwood , Robert Fischell , Steven Johnson
IPC分类号： A61B5/0402
CPC分类号： A61B5/0464 , A61B5/0006 , A61B5/0031 , A61B5/02455 , A61B5/04012 , A61B5/042 , A61B5/0432 , A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0472 , A61B5/686 , A61B5/746 , A61B5/7465 , A61N1/3702 , A61N1/37258 , A61N1/3756 , G16H40/67
摘要： Disclosed is a system for the detection of cardiac events that includes an implanted device called a cardiosaver, a physician's programmer and an external alarm system. The system is designed to provide early detection of cardiac events such as acute myocardial infarction or exercise induced myocardial ischemia caused by an increased heart rate or exertion. The system can also alert the patient with a less urgent alarm if a heart arrhythmia is detected. Using different algorithms, the cardiosaver can detect a change in the patient's electrogram that is indicative of a cardiac event within five minutes after it occurs and then automatically warn the patient that the event is occurring. To provide this warning, the system includes an internal alarm sub-system (internal alarm means) within the cardiosaver and/or an external alarm system (external alarm means) which are activated after the ST segment of the electrogram exceeds a preset threshold.

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