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1. 发明授权

US08722357B2 Automated microdissection instrument 有权
标题翻译：自动显微切割仪
公开(公告)号：US08722357B2
公开(公告)日：2014-05-13
申请号：US11236045
申请日：2005-09-26
申请人： Thomas M. Baer , Michael G. Youngquist , Brian W. Donovan , Alan E. Wessel , Norbert H. Leclerc , Michael A. Smith , George M. Dawson , Craig S. Barker
发明人： Thomas M. Baer , Michael G. Youngquist , Brian W. Donovan , Alan E. Wessel , Norbert H. Leclerc , Michael A. Smith , George M. Dawson , Craig S. Barker
IPC分类号： G01N1/28
CPC分类号： G01N1/2813 , G01B11/002 , G01N2001/282 , G01N2001/284 , Y10T156/10 , Y10T156/1054
摘要： Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.
摘要翻译：公开了用于自动激光显微切割的系统和方法，包括自动滑动检测，切割和捕获激光器的位置检测，用于切割和捕获激光器的聚焦优化，用于切割和捕获激光器的能量和持续时间优化，检查和第二相捕获和/或消融质量控制站和用于将衬底载体或输出显微切割区域与输入样品或载片连接的跟踪信息。

2. 发明授权

US06866461B2 Device and methods for automating transfer of multiple samples to an analytical instrument 失效
标题翻译：自动将多个样品转移到分析仪器的装置和方法
公开(公告)号：US06866461B2
公开(公告)日：2005-03-15
申请号：US10375507
申请日：2003-02-25
申请人： Scott M. DeWinter , John B. Rusconi , Steven M. Clark , Michael P. Lucas , Michael G. Youngquist
发明人： Scott M. DeWinter , John B. Rusconi , Steven M. Clark , Michael P. Lucas , Michael G. Youngquist
IPC分类号： G01N1/00 , B01L3/00 , B01L9/00 , B01L99/00 , G01N1/04 , G01N1/28 , G01N35/02 , G01N37/00 , H01J49/04 , B65G65/00
CPC分类号： H01J49/04 , B01L3/0293 , B01L3/50853 , B01L9/52 , B01L2200/025 , B01L2300/0822 , B01L2300/0829 , G01N1/28 , G01N1/2813 , G01N35/028 , G01N2001/045
摘要： The present invention comprises a loading device for automating transfer of a plurality of probes between a cassette within which the plurality of probes are initially constrained and an analytical instrument, e.g., mass spectrometer. The loading device may be configured to accept a single or a plurality of cassettes each removably constraining a plurality of probes to be analyzed. The loading device may permit each of the plurality of cassettes to be independently interchanged with a separate cassette removably constraining a separate plurality of probes during mass spectrometric analysis, or for additional cassettes to be loaded into the device during analysis. In a useful embodiment, the loading device comprises a cassette transport assembly and a probe insertion assembly. The cassette transport assembly linearly translates one or more cassettes to align the cassette(s) with respect to the mass spectrometer so that a probe may be translated therebetween by the probe insertion assembly. The probe insertion assembly also provides means to rotatably engage said probe.
摘要翻译：本发明包括一个加载装置，用于在多个探针最初被约束的盒和分析仪器例如质谱仪之间自动传送多个探针。加载装置可以被配置为接受单个或多个盒，每个盒可移除地限制待分析的多个探针。加载装置可以允许多个盒中的每一个在质谱分析期间独立地与单独的盒互换，可拆卸地限制分离的多个探针，或者在分析期间将另外的盒装载到装置中。在有用的实施例中，装载装置包括盒传送组件和探针插入组件。盒式传送组件线性平移一个或多个盒，以使盒相对于质谱仪对准，使得探针可以通过探针插入组件在其间平移。探针插入组件还提供可旋转地接合所述探针的装置。

3. 发明授权

US07129483B2 Laser desorption and ionization mass spectrometer with quantitative reproducibility 有权
标题翻译：激光解吸和电离质谱仪具有定量重现性
公开(公告)号：US07129483B2
公开(公告)日：2006-10-31
申请号：US11155302
申请日：2005-06-17
申请人： Michael G. Youngquist , Craig A. Keller
发明人： Michael G. Youngquist , Craig A. Keller
IPC分类号： B01D59/44 , H01J49/40 , H01J49/00
CPC分类号： H01J49/164
摘要： Laser desorption/ionization time-of-flight mass spectrometer (“LDI-TOF-MS”) devices, and methods, that accurately measure the mass of analytes contained in a sample and which also measure the quantities of analytes present in a sample in a consistent manner from instrument-to-instrument and over time on a single instrument. In particular, the invention provides LDI-TOF-MS devices and methods in which: 1) the energy of the laser pulse and the area of the sample illuminated (fluence) is consistent and controlled so as to produce consistent conditions for analyte desorption and ionization; 2) the mass analyzer behaves in a reproducible manner; and 3) the detection system produces a signal that consistently represents the arrival of ions of different masses.
摘要翻译：激光解吸/离子化飞行时间质谱仪（“LDI-TOF-MS”）装置和方法，可精确测量样品中所含分析物的质量，并测量样品中存在的分析物的量从仪器到仪器的一致方式，以及随着时间的推移在单个仪器上。特别地，本发明提供了LDI-TOF-MS装置和方法，其中：1）激光脉冲的能量和照射的样品的面积（注量）一致和控制，以便产生用于分析物解吸和电离的一致条件 ; 2）质量分析仪的行为方式是可重现的; 和3）检测系统产生一致地表示不同质量的离子的到达的信号。

4. 发明授权

US07256393B2 Non-linear signal amplifiers and uses thereof in a mass spectrometer device 失效
标题翻译：非线性信号放大器及其在质谱仪装置中的应用
公开(公告)号：US07256393B2
公开(公告)日：2007-08-14
申请号：US11173236
申请日：2005-06-30
申请人： Craig A. Keller , Steve Waltman , Steve Miller , Michael G. Youngquist
发明人： Craig A. Keller , Steve Waltman , Steve Miller , Michael G. Youngquist
IPC分类号： G01T1/17 , H01J49/40
CPC分类号： H01J49/025 , H03F3/08 , H03F3/45475 , H03F2200/261 , H03F2203/45138
摘要： Signal amplifiers having a non-linear transfer function. A high speed (high bandwidth) circuit with a non-linear transfer function over a limited range of input signal is provided. By appropriate choice of components, the non-linear transfer function can be used to accurately approximate any monotonic function such as a square root transfer function. In another aspect, a piecewise non-linear circuit arrangement using a set of non-linear sub-circuits is provided to accurately generate a desired non-linear transfer function over an extended dynamic range of input signal. In one implementation of such a circuit, each of the sub-circuits approximates the desired non-linear function over a portion of the input range.
摘要翻译：具有非线性传递函数的信号放大器。提供了在有限输入信号范围内具有非线性传递函数的高速（高带宽）电路。通过适当选择组件，可以使用非线性传递函数来精确地近似任何单调函数，如平方根传递函数。在另一方面，提供使用一组非线性子电路的分段非线性电路装置，以在输入信号的扩展动态范围上精确地产生期望的非线性传递函数。在这种电路的一个实现中，每个子电路在输入范围的一部分上接近期望的非线性函数。

5. 发明授权

US06765199B2 Time-dependent digital signal scaling process 失效
标题翻译：时间依赖的数字信号缩放过程
公开(公告)号：US06765199B2
公开(公告)日：2004-07-20
申请号：US10193349
申请日：2002-07-10
申请人： Michael G. Youngquist , Edward Gavin , William E. Rich
发明人： Michael G. Youngquist , Edward Gavin , William E. Rich
IPC分类号： H01J4940
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/40
摘要： A method for processing time-dependent signal data is disclosed. The time-dependent signal data are received in a memory, wherein the time-dependent signal data represent a time-dependent signal, and wherein the time-dependent signal data include representations of time-of-flight values of ions, or values derived from time-of-flight values of ions. The time-dependent signal data are scaled with a time-dependent scaling function.
摘要翻译：公开了一种用于处理时间相关信号数据的方法。时间相关信号数据被接收在存储器中，其中时间相关信号数据表示时间相关信号，并且其中时间相关信号数据包括离子飞行时间值的表示，或从离子的飞行时间值。时间依赖的信号数据用时间依赖的缩放函数进行缩放。

6. 发明授权

US06580071B2 Method for calibrating a mass spectrometer 失效
标题翻译：校准质谱仪的方法
公开(公告)号：US06580071B2
公开(公告)日：2003-06-17
申请号：US10194452
申请日：2002-07-11
申请人： Scot R. Weinberger , Edward J. Gavin , Michael G. Youngquist
发明人： Scot R. Weinberger , Edward J. Gavin , Michael G. Youngquist
IPC分类号： A01J4940
CPC分类号： H01J49/40 , H01J49/0009
摘要： A method for calibrating a time-of-flight mass spectrometer is disclosed. The method includes determining the time-of-flight values, or values derived from the time-of-flight values for a calibration substance at each of a plurality of different addressable locations on a sample substrate. Then, one of the addressable locations on the substrate is identified as a reference addressable location. A plurality correction factors are then calculated for the respective addressable locations on the substrate using the time-of-flight value, or a value derived from the time-of-flight value.
摘要翻译：公开了一种用于校准飞行时间质谱仪的方法。该方法包括确定飞行时间值或从样品基板上的多个不同可寻址位置中的每一个处的校准物质的飞行时间值得到的值。然后，衬底上的可寻址位置之一被识别为参考可寻址位置。然后使用飞行时间值或从飞行时间值导出的值，为基板上的各个可寻址位置计算多个校正因子。

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