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1. 发明授权

US07046357B2 Apparatus for microfluidic processing and reading of biochip arrays 失效
标题翻译：用于微流体处理和读取生物芯片阵列的装置
公开(公告)号：US07046357B2
公开(公告)日：2006-05-16
申请号：US10769293
申请日：2004-01-29
申请人： Scot R. Weinberger , Louis Hlousek
发明人： Scot R. Weinberger , Louis Hlousek
IPC分类号： G01N21/00 , G01N33/00
CPC分类号： G01N33/54366 , B01L3/502715 , B01L9/527 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , B01L2400/0605 , G01N21/553 , G01N27/44782 , G01N30/6095 , G01N33/54386 , Y10T436/24
摘要： A method and a device for detecting an analyte, including a substrate having a chemically selective surface; and a fluidic system disposed on the substrate, the manifold having at least one fluid path in communication with at least a discrete region of the surface, wherein the one fluid path and the discrete region together define a contained sample region on the surface. The fluidic system has a removable portion, wherein the removal of the removable portion of the fluidic system renders the discrete region directly interrogatable by a surface-based analytical tool.
摘要翻译：一种用于检测分析物的方法和装置，包括具有化学选择性表面的基底; 以及设置在所述基底上的流体系统，所述歧管具有与所述表面的至少一个离散区域连通的至少一个流体路径，其中所述一个流体路径和所述离散区域一起限定所述表面上包含的样品区域。流体系统具有可移除部分，其中流体系统的可移除部分的移除使离散的区域通过基于表面的分析工具可直接询问。

2. 发明授权

US06946653B2 Methods and apparatus for improved laser desorption ionization tandem mass spectrometry 有权
标题翻译：改进激光解吸电离串联质谱法的方法和装置
公开(公告)号：US06946653B2
公开(公告)日：2005-09-20
申请号：US10184450
申请日：2002-06-26
申请人： Scot R. Weinberger , Pete Tornatore
发明人： Scot R. Weinberger , Pete Tornatore
IPC分类号： G01N27/62 , G01N27/64 , H01J49/10 , H01J49/16 , H01J49/40 , H01J49/42
CPC分类号： H01J49/004 , H01J49/0481 , H01J49/164
摘要： Laser desorption/ionization tandem mass spectrometer instruments that include immediate post source collisional cooling are presented, as are analytical methods that employ such instruments to achieve increased sensitivity and ion yield. Also presented are laser desorption/ionization mass spectrometry methods that improve sensitivity and relative ion yield by combining affinity capture probes with matrices having low melting point energy absorbing molecules combined with alkali metal scavengers.
摘要翻译：提出了包括立即源源碰撞冷却的激光解吸/电离串联质谱仪器，以及采用这些仪器来实现增加的灵敏度和离子产率的分析方法。还提出了通过将亲和捕获探针与具有与碱金属清除剂结合的低熔点能量吸收分子的基质结合来提高灵敏度和相对离子产率的激光解吸/电离质谱法。

3. 发明授权

US5066382A Thermal control for capillary electrophoresis apparatus 失效
标题翻译：毛细管电泳仪的热控制
公开(公告)号：US5066382A
公开(公告)日：1991-11-19
申请号：US470280
申请日：1990-01-25
申请人： Scot R. Weinberger , James L. Mills
发明人： Scot R. Weinberger , James L. Mills
IPC分类号： G01N27/447
CPC分类号： G01N27/44721 , G01N27/44704 , G01N27/44708
摘要： An electrophoresis instrument includes a capillary tube mounted in an air cooled cartridge. The cartridge also supports a spherical lens which is part of the optical detection apparatus. The cartridge rests in a manifold which includes the sample and buffer reservoirs. The temperature of the capillary tube is controlled by measuring the electrical resistance of the capillary tube during the electrophoresis process and then cooling or heating the cartridge by circulating temperature controlled air over the tube. The optical path associated with the instrument is a fiber optic bundle bifurcated close to dual detectors into a reference arm and a sample arm so as to provide similar reference and sample optical paths. The instrument may be used for temperature control for gradient electrophoresis and also, a neutral marker for determining electro-osmotic flow may be detected.
摘要翻译：电泳仪包括安装在空气冷却筒中的毛细管。墨盒还支持作为光学检测装置的一部分的球面透镜。墨盒位于包含样品和缓冲液储存器的歧管中。通过在电泳过程中测量毛细管的电阻，然后通过将温度受控的空气循环通过管冷却或加热来控制毛细管的温度。与仪器相关联的光路是将近双重检测器分叉到参考臂和样品臂中的光纤束，以便提供相似的参考和样品光路。该仪器可用于梯度电泳的温度控制，并且还可以检测用于确定电渗流的中性标记。

4. 发明授权

US5037523A Air cooled cartridge for capillary electrophoresis 失效
标题翻译：用于毛细管电泳的空气冷却筒
公开(公告)号：US5037523A
公开(公告)日：1991-08-06
申请号：US470209
申请日：1990-01-25
申请人： Scot R. Weinberger , Thomas W. Hoppe , Elia R. Tarantino
发明人： Scot R. Weinberger , Thomas W. Hoppe , Elia R. Tarantino
IPC分类号： G01N27/447
CPC分类号： G01N27/44708 , G01N27/44721
摘要： An electrophoresis instrument includes a capillary tube mounted in an air cooled cartridge. The cartridge also supports a spherical lens which is part of the optical detection apparatus. The cartridge rests in a manifold which includes the sample and buffer reservoirs. The temperature of the capillary tube is controlled by measuring the electrical resistance of the capillary tube during the electrophoresis process and then cooling or heating the cartridge by circulating temperature controlled air over the tube. The optical path associated with the instrument is a fiber optic bundle bifurcated close to dual detectors into a reference arm and a sample arm so as to provide similar reference and sample optical paths. The instrument may be used for temperature control for gradient electrophoresis and also, a neutral marker for determining electro-osmotic flow may be detected.
摘要翻译：电泳仪包括安装在空气冷却筒中的毛细管。墨盒还支持作为光学检测装置的一部分的球面透镜。墨盒位于包含样品和缓冲液储存器的歧管中。通过在电泳过程中测量毛细管的电阻，然后通过将温度受控的空气循环通过管冷却或加热来控制毛细管的温度。与仪器相关联的光路是将近双重检测器分叉到参考臂和样品臂中的光纤束，以便提供相似的参考和样品光路。该仪器可用于梯度电泳的温度控制，并且还可以检测用于确定电渗流的中性标记。

5. 发明授权

US06294790B1 Secondary ion generator detector for time-of-flight mass spectrometry 有权
标题翻译：二次离子发生器检测器，用于飞行时间质谱
公开(公告)号：US06294790B1
公开(公告)日：2001-09-25
申请号：US09158747
申请日：1998-09-22
申请人： Scot R. Weinberger
发明人： Scot R. Weinberger
IPC分类号： G01K108
CPC分类号： H01J49/025
摘要： An ion detector includes a secondary charged particle generator that generates secondary charged particles in response to primary ions that engage the secondary charged particle generator. The secondary charged particle generator has an electrostatic potential that repels the secondary charged particles toward an electro-emissive detector that generates electrons in response to primary ions and secondary charged particles that engage the electro-emissive detector The electro-emissive detector has a field that attracts the secondary charged particles. An anode is provided for detecting electrons generated by the electro-emissive detector and for generating a signal.
摘要翻译：离子检测器包括次级带电粒子发生器，其响应于与次级带电粒子发生器接合的初级离子产生次级带电粒子。二次带电粒子发生器具有将次级带电粒子排斥到电发射检测器的静电电位，电子发射检测器响应于接合电子发射检测器的初级离子和二次带电粒子而产生电子。电子发射检测器具有吸引二次带电粒子。提供阳极用于检测由电子发射检测器产生的电子并产生信号。

6. 发明授权

US5021646A Remote optical path for capillary electrophoresis instrument 失效
标题翻译：用于毛细管电泳仪的远程光路
公开(公告)号：US5021646A
公开(公告)日：1991-06-04
申请号：US470287
申请日：1990-01-25
申请人： Scot R. Weinberger , Thomas W. Hoppe
发明人： Scot R. Weinberger , Thomas W. Hoppe
IPC分类号： G01N27/447
CPC分类号： G01N27/44721 , G01N27/44708
摘要： An electrophoresis instrument includes a capillary tube mounted in an air cooled cartridge. The cartridge also supports a spherical lens which is part of the optical detection apparatus. The cartridge rests in a manifold which includes the sample and buffer reservoirs. The temperature of the capillary tube is controlled by measuring the electrical resistance of the capillary tube during the electrophoresis process and then cooling or heating the cartridge by circulating temperature controlled air over the tube. The optical path associated with the instrument is a fiber optic bundle bifurcated close to dual detectors into a reference arm and a sample arm so as to provide similar reference and sample optical paths. The instrument may be used for controlling temperature in gradient electrophoresis and detecting neutral markers in determining electro-osmotic flow.
摘要翻译：电泳仪包括安装在空气冷却筒中的毛细管。墨盒还支持作为光学检测装置的一部分的球面透镜。墨盒位于包含样品和缓冲液储存器的歧管中。通过在电泳过程中测量毛细管的电阻，然后通过将温度受控的空气循环通过管冷却或加热来控制毛细管的温度。与仪器相关联的光路是将近双重检测器分叉到参考臂和样品臂中的光纤束，以便提供相似的参考和样品光路。该仪器可用于控制梯度电泳中的温度和检测中性标记物以确定电渗流。

7. 发明授权

US06977370B1 Off-resonance mid-IR laser desorption ionization 失效
标题翻译：非共振中红外激光解吸电离
公开(公告)号：US06977370B1
公开(公告)日：2005-12-20
申请号：US10804723
申请日：2004-03-19
申请人： Scot R. Weinberger
发明人： Scot R. Weinberger
IPC分类号： G01N33/48 , G01N33/50 , G01N33/68
CPC分类号： G01N33/6851 , Y10T436/11 , Y10T436/143333 , Y10T436/24 , Y10T436/25
摘要： Methods for producing a preponderance of gas phase ions having higher order charge states during laser desorption ionization of an analyte are presented, the methods comprising irradiating the analyte in the presence of energy absorbing molecules at a mid-IR wavelength that is offset from an IR absorption maximum of the energy absorbing molecules.
摘要翻译：提出了在分析物的激光解吸电离期间产生具有较高阶电荷状态的气相离子优势的方法，所述方法包括在能量吸收分子的存在下以与IR吸收偏离的中红外波长的方式照射分析物最大能量吸收分子。

8. 发明授权

US06707031B1 Laser optical bench for laser desorption ion sources and method of use thereof 失效
标题翻译：用于激光解吸离子源的激光光学台及其使用方法
公开(公告)号：US06707031B1
公开(公告)日：2004-03-16
申请号：US09568745
申请日：2000-05-11
申请人： Scot R. Weinberger , Raymond G. Bryan
发明人： Scot R. Weinberger , Raymond G. Bryan
IPC分类号： H01J4900
CPC分类号： H01J49/164
摘要： A laser optical bench for use with a laser desorption/ionization mass spectrometer. The laser optical bench includes a laser for producing light, a focusing structure that receives light from the laser and focuses predominantly in a single plane, an attenuator that receives light from the focusing structure, beam steering structure for directing light from the attenuator from the target; and a final focusing element for focusing light from the beam steering structure on the target. Further focusing elements may be included for further focusing and dispersing the light beam in different planes. Additionally, photodetectors or photodiodes may be included for energy measurement and sensing a lasing event.
摘要翻译：用于激光解吸/电离质谱仪的激光光台。激光光学平台包括用于产生光的激光器，聚焦结构，其接收来自激光器的光并主要聚焦在单个平面中;衰减器，其接收来自聚焦结构的光;光束转向结构，用于引导来自目标的衰减器的光 ; 以及用于将来自光束转向结构的光聚焦在目标上的最终聚焦元件。可以包括另外的聚焦元件用于进一步聚焦和将光束分散在不同的平面中。此外，可以包括光电检测器或光电二极管用于能量测量和感测激光事件。

9. 发明授权

US5594243A Laser desorption ionization mass monitor (LDIM) 失效
标题翻译：激光解吸电离质量监测仪（LDIM）
公开(公告)号：US5594243A
公开(公告)日：1997-01-14
申请号：US27317
申请日：1993-03-04
申请人： Scot R. Weinberger , Robert W. Egan , Thomas W. Hoppe, deceased , Ernst Gassmann , Martin M. Schar , Klaus O. Bornsen , E. Rocco Tarantino
发明人： Scot R. Weinberger , Robert W. Egan , Thomas W. Hoppe, deceased , Ernst Gassmann , Martin M. Schar , Klaus O. Bornsen , E. Rocco Tarantino
IPC分类号： G01N27/62 , H01J27/24 , H01J37/08 , H01J49/04 , H01J49/10 , H01J49/16 , H01J49/40 , B01D59/44
CPC分类号： H01J49/025 , H01J49/164 , H01J49/40
摘要： A laser desorption ionization instrument for measuring the molecular weight of large organic molecules includes a time of flight (TOF) mass spectrometer. The time of flight mass spectrometer includes a sample lock for holding, under vacuum, a plurality of samples to be analyzed. A sample may be inserted into and removed from the sample lock and into the mass spectrometer without breaking vacuum in the spectrometer. Signal processing electronics of the LDIM instrument include means for identifying quasi-molecular species of a molecule being measured. The instrument includes improvements in ion optics, microchannel plate detectors, laser irradiation of samples, and preparation of samples for measurement.
摘要翻译：用于测量大型有机分子分子量的激光解吸电离仪包括飞行时间（TOF）质谱仪。飞行时间质谱仪包括用于在真空下保持待分析的多个样品的样品锁。可以将样品插入和取出样品锁并进入质谱仪，而不会在光谱仪中破坏真空。 LDIM仪器的信号处理电子装置包括用于识别正在测量的分子的准分子物种的方法。该仪器包括离子光学，微通道板检测器，样品的激光照射以及用于测量的样品的制备的改进。

10. 发明授权

US5053115A Automated neutral marker for capillary electrophoresis 失效
标题翻译：用于毛细管电泳的自动中性标记
公开(公告)号：US5053115A
公开(公告)日：1991-10-01
申请号：US470202
申请日：1990-01-25
申请人： Scot R. Weinberger , Louis Hlousek
发明人： Scot R. Weinberger , Louis Hlousek
IPC分类号： G01N27/447
CPC分类号： G01N27/44721 , G01N27/44704 , G01N27/44708
摘要： An electrophoresis instrument includes a capillary tube mounted in an air cooled cartridge. The cartridge also supports a spherical lens which is part of the optical detection apparatus. The cartridge rests in a manifold which includes the sample and buffer reservoirs. The temperature of the capillary tube is controlled by measuring the electrical resistance of the capillary tube during the electrophoresis process and then cooling or heating the cartridge by circulating temperature controlled air over the tube. The optical path associated with the instrument is a fiber optic bundle bifurcated close to dual detectors into a reference arm and a sample arm so as to provide similar reference and sample optical paths. The instrument may be used for temperature control for gradient electrophoresis and also, a neutral marker for determining electro-osmotic flow may be automatically detected.
摘要翻译：电泳仪包括安装在空气冷却筒中的毛细管。墨盒还支持作为光学检测装置的一部分的球面透镜。墨盒位于包含样品和缓冲液储存器的歧管中。通过在电泳过程中测量毛细管的电阻，然后通过将温度受控的空气循环通过管冷却或加热来控制毛细管的温度。与仪器相关联的光路是将近双重检测器分叉到参考臂和样品臂中的光纤束，以便提供相似的参考和样品光路。该仪器可用于梯度电泳的温度控制，并且可以自动检测用于确定电渗流的中性标记。

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