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1. 发明申请

US20090302493A1 PROCESS FOR PRODUCING A SOLID DISPERSION OF AN ACTIVE INGREDIENT 审中-公开
标题翻译：生产活性成分固体分散体的方法
公开(公告)号：US20090302493A1
公开(公告)日：2009-12-10
申请号：US12279385
申请日：2007-03-12
申请人： Thomas Kessler , Jörg Breitenbach , Christoph Schmidt , Matthias Degenhardt , Jörg Rosenberg , Harald Krull , Gunther Berndl
发明人： Thomas Kessler , Jörg Breitenbach , Christoph Schmidt , Matthias Degenhardt , Jörg Rosenberg , Harald Krull , Gunther Berndl
IPC分类号： B29C47/60
CPC分类号： A61J3/00 , A61K9/2027 , A61K9/2095 , A61K9/2893 , A61K47/32 , B01F7/0045 , B29C35/02 , B29C48/022 , B29C48/03 , B29C48/04 , B29C48/08 , B29C48/2564 , B29C48/268 , B29C48/2886 , B29C48/29 , B29C48/395 , B29C48/40 , B29C48/402 , B29C48/404 , B29C48/505 , B29C48/52 , B29C48/54 , B29C48/55 , B29C48/56 , B29C48/57 , B29C48/625 , B29C48/65 , B29C48/67 , B29C48/76 , B29C48/83 , B29C48/865 , B29C48/875 , B29C48/906 , B29C48/914 , B29K2105/0005 , B29K2105/0035 , B29K2105/0038 , B29K2105/0064 , B29K2105/16
摘要： A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.
摘要翻译：一种制备活性成分的固体分散体的方法，包括将活性成分和基质形成剂加入到挤出机中并形成均匀的挤出物，其中挤出机包括至少两个旋转轴（2），每个轴 2）承载沿轴向布置的多个处理元件，处理元件限定（i）进料和输送段（R; A），（ii）至少一个反向飞行段（D）和（iii））排出部分（E），其中限定反向飞行部分（R; D）的处理元件包括至少一个反向飞行元件（14），该反向飞行元件基于螺旋型元件，其具有与挤出机的一般输送方向。

2. 发明申请

US20090311414A1 PROCESS FOR PRODUCING A SOLID DISPERSION OF AN ACTIVE INGREDIENT 审中-公开
标题翻译：生产活性成分固体分散体的方法
公开(公告)号：US20090311414A1
公开(公告)日：2009-12-17
申请号：US12279415
申请日：2007-03-12
申请人： Thomas Kessler , Jörg Breitenbach , Christoph Schmidt , Matthias Degenhardt , Jörg Rosenberg , Harald Krull
发明人： Thomas Kessler , Jörg Breitenbach , Christoph Schmidt , Matthias Degenhardt , Jörg Rosenberg , Harald Krull
IPC分类号： B05D3/12 , B29C47/60
CPC分类号： A61J3/00 , A61K9/2027 , A61K9/2095 , A61K9/2893 , A61K47/32 , B01F7/0045 , B29C35/02 , B29C48/022 , B29C48/03 , B29C48/04 , B29C48/08 , B29C48/2564 , B29C48/268 , B29C48/2886 , B29C48/29 , B29C48/395 , B29C48/40 , B29C48/402 , B29C48/404 , B29C48/505 , B29C48/52 , B29C48/54 , B29C48/55 , B29C48/56 , B29C48/57 , B29C48/625 , B29C48/65 , B29C48/67 , B29C48/76 , B29C48/83 , B29C48/865 , B29C48/875 , B29C48/906 , B29C48/914 , B29K2105/0005 , B29K2105/0035 , B29K2105/0038 , B29K2105/0064 , B29K2105/16
摘要： A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element (FIG. 2).
摘要翻译：一种制备活性成分的固体分散体的方法，包括将活性成分和基质形成剂加入到挤出机中并形成均匀的挤出物，其中挤出机包括至少两个旋转轴（2），每个轴 2）承载多个沿轴向布置的处理元件，处理元件限定（i）进料和输送段（A），（ii）至少一个混合段（B），和（iii）排出段（E），其中限定混合部分（B）的处理元件包括从螺杆型元件（图2）导出的混合元件（11,12,13）。

3. 发明申请

US20100247635A1 PHARMACEUTICALLY ACCEPTABLE SOLUBILIZING COMPOSITION AND PHARMACEUTICAL DOSAGE FORM CONTAINING SAME 有权
标题翻译：药物可接受的溶解组合物和含有其的药物剂型
公开(公告)号：US20100247635A1
公开(公告)日：2010-09-30
申请号：US12305870
申请日：2007-07-17
申请人： Jörg Rosenberg , Jörg Breitenbach , Kennan Marsh , Bernd Liepold , Christoph Schmidt , Ute Lander
发明人： Jörg Rosenberg , Jörg Breitenbach , Kennan Marsh , Bernd Liepold , Christoph Schmidt , Ute Lander
IPC分类号： A61K9/48 , A61K47/34 , A61K31/513 , A61P31/18
CPC分类号： A61K47/22 , A61K9/145 , A61K9/146 , A61K9/2013 , A61K9/2027 , A61K9/2095 , A61K9/4833 , A61K9/7007 , A61K31/427 , A61K31/513 , A61K47/14 , A61K47/32 , A61K38/55 , A61K2300/00
摘要： A pharmaceutically acceptable solubilizing composition comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono- and diester is disclosed. The solubilizing composition is useful in the manufacture of a pharmaceutical dosage form which comprises a melt-processed mixture of at least one active ingredient, at least one pharmaceutically acceptable polymer. The active ingredient(s) may be inhibitors of HIV protease. The solubilizing composition enhances the bioavailability of the active ingredient after oral intake.
摘要翻译：公开了一种药学可接受的增溶组合物，其包含（i）至少一种具有聚亚烷基二醇部分的生育酚化合物和（ii）至少一种亚烷基二醇脂肪酸单酯或亚烷基二醇脂肪酸单酯和二酯的混合物。增溶组合物可用于制备药物剂型，其包含至少一种活性成分，至少一种药学上可接受的聚合物的经熔融加工的混合物。活性成分可以是HIV蛋白酶的抑制剂。增溶组合物增加了口服摄入后活性成分的生物利用度。

4. 发明授权

US09078921B2 Pharmaceutically acceptable solubilizing composition and pharmaceutical dosage form containing same 有权
标题翻译：药学可接受的增溶组合物和含有它的药物剂型
公开(公告)号：US09078921B2
公开(公告)日：2015-07-14
申请号：US12305870
申请日：2007-07-17
申请人： Jörg Rosenberg , Jörg Breitenbach , Kennan Marsh , Bernd Liepold , Christoph Schmidt , Ute Lander
发明人： Jörg Rosenberg , Jörg Breitenbach , Kennan Marsh , Bernd Liepold , Christoph Schmidt , Ute Lander
IPC分类号： A61P31/18 , A61K47/34 , A61K9/48 , A61K31/513 , A61K47/22 , A61K9/14 , A61K9/20 , A61K31/427 , A61K47/14
CPC分类号： A61K47/22 , A61K9/145 , A61K9/146 , A61K9/2013 , A61K9/2027 , A61K9/2095 , A61K9/4833 , A61K9/7007 , A61K31/427 , A61K31/513 , A61K47/14 , A61K47/32 , A61K38/55 , A61K2300/00
摘要： A pharmaceutically acceptable solubilizing composition comprising (i) at least one tocopheryl compound having a polyalkylene glycol moiety and (ii) at least one alkylene glycol fatty acid monoester or mixture of alkylene glycol fatty acid mono- and diester is disclosed. The solubilizing composition is useful in the manufacture of a pharmaceutical dosage form which comprises a melt-processed mixture of at least one active ingredient, at least one pharmaceutically acceptable polymer. The active ingredient(s) may be inhibitors of HIV protease. The solubilizing composition enhances the bioavailability of the active ingredient after oral intake.
摘要翻译：公开了一种药学可接受的增溶组合物，其包含（i）至少一种具有聚亚烷基二醇部分的生育酚化合物和（ii）至少一种亚烷基二醇脂肪酸单酯或亚烷基二醇脂肪酸单酯和二酯的混合物。增溶组合物可用于制备药物剂型，其包含至少一种活性成分，至少一种药学上可接受的聚合物的熔融加工混合物。活性成分可以是HIV蛋白酶的抑制剂。增溶组合物增加了口服摄入后活性成分的生物利用度。

5. 发明授权

US09250179B2 Goniophotometric measurement method for the characterization of pigments and fillers 有权
标题翻译：用于表征颜料和填料的光度法测量方法
公开(公告)号：US09250179B2
公开(公告)日：2016-02-02
申请号：US13820548
申请日：2011-08-16
申请人： Christoph Schmidt , Christoph Hoffmann , Sabine Schoen
发明人： Christoph Schmidt , Christoph Hoffmann , Sabine Schoen
IPC分类号： G01N21/00 , G01N21/47 , G01N21/57
CPC分类号： G01N21/47 , G01N21/57 , G01N2021/575
摘要： The present invention relates to a method for the characterization of pigments and fillers in which the luminance of a pigmented transparent medium is determined against a dark background. This measurement method is particularly suitable for determining the optical properties of cosmetic fillers.
摘要翻译：本发明涉及用于表征颜料和填料的方法，其中着色的透明介质的亮度是针对深色背景确定的。该测定方法特别适用于测定化妆品填充剂的光学性质。

6. 发明申请

US20130225795A1 RECOMBINANT CODON OPTIMISED FACTOR H 有权
标题翻译：重组代码优化因子H
公开(公告)号：US20130225795A1
公开(公告)日：2013-08-29
申请号：US13518614
申请日：2010-12-23
申请人： Christoph Schmidt , Paul N. Barlow , Anna Richards
发明人： Christoph Schmidt , Paul N. Barlow , Anna Richards
IPC分类号： C07K14/47
CPC分类号： C12N9/88 , C07K14/4702 , C07K14/472 , C12Y402/01002
摘要： The present invention relates to recombinant factor H and variants and conjugates thereof and methods of their production, as well as uses and methods of treatment involving the materials.
摘要翻译：本发明涉及重组因子H及其变体和缀合物及其生产方法，以及涉及该材料的用途和治疗方法。

7. 发明申请

US20120153553A1 Workpiece Retention and Handling Systems 有权
标题翻译：工件保持和处理系统
公开(公告)号：US20120153553A1
公开(公告)日：2012-06-21
申请号：US13329726
申请日：2011-12-19
申请人： Christoph Schmidt
发明人： Christoph Schmidt
IPC分类号： B23Q3/06 , B23Q3/08
CPC分类号： B23Q3/06 , B21D28/265 , B23Q7/043 , B25B5/061 , B25B5/087 , B25B5/16
摘要： In some aspects of the disclosure, a workpiece retention device for securing plate-like workpieces to a workpiece movement unit of a machine tool includes first and second workpiece clamping elements and a clamping drive by which the workpiece clamping elements can be moved towards one another starting from an initial relative position in order to clamp a workpiece that is arranged between the workpiece clamping elements. The workpiece retention device also includes an adjustment device that can adjust the initial relative position of the workpiece clamping elements.
摘要翻译：在本公开的一些方面中，用于将板状工件固定到机床的工件移动单元的工件保持装置包括第一和第二工件夹紧元件和夹紧驱动器，通过该夹紧驱动工件夹紧元件可以朝向彼此移动开始从初始相对位置，以夹紧布置在工件夹紧元件之间的工件。工件保持装置还包括可以调节工件夹紧元件的初始相对位置的调节装置。

8. 发明申请

US20100129411A1 FIVE-LAYERED PIGMENTS 审中-公开
标题翻译：五层颜料
公开(公告)号：US20100129411A1
公开(公告)日：2010-05-27
申请号：US12507331
申请日：2009-07-22
申请人： Christoph Schmidt , Andrea Heyland , Sabine Schoen , Veronika Hochstein , Uta Hensen
发明人： Christoph Schmidt , Andrea Heyland , Sabine Schoen , Veronika Hochstein , Uta Hensen
IPC分类号： A61K8/29 , C09C1/00 , B05D7/00 , C09D11/02 , A61K8/02
CPC分类号： C09C1/0024 , A61K8/0266 , A61K8/11 , A61K8/19 , A61K8/25 , A61K8/26 , A61K8/29 , A61K2800/412 , A61K2800/43 , A61K2800/434 , A61Q1/02 , A61Q1/04 , A61Q1/10 , A61Q1/12 , A61Q3/02 , A61Q5/02 , A61Q19/00 , A61Q19/10 , C01P2004/24 , C01P2004/86 , C01P2004/88 , C01P2006/60 , C08K9/02 , C09C1/3661 , C09C2200/1004 , C09C2200/102 , C09C2200/1062 , C09C2200/1087 , C09C2200/301 , C09C2200/302 , C09C2200/303 , C09C2200/304 , C09C2200/306 , C09C2220/106 , C09D5/36 , C09D11/037 , C09D11/50
摘要： The present invention relates to five-layered pigments based on multicoated platelet-shaped substrates which comprise a layer sequence comprising (A) a layer of SnO2 having a layer thickness of 0.1-50 nm, (B) a high-refractive-index coating consisting of TiO2 in the rutile modification having a layer thickness of 10-800 nm, (C) a colorless coating having a refractive index n≦1.8 having a layer thickness of 20-800 nm, (D) a high-refractive-index coating consisting of SnO2 having a layer thickness of 0.1-50 nm, (E) a layer of TiO2 in the rutile modification having a layer thickness of 10-800 nm, and optionally (F) an outer protective layer, and to the use thereof in paints, coatings, powder coatings, printing inks, security printing inks, plastics, ceramic materials, glasses, as dopants for the laser marking of papers and plastics, in cosmetic formulations and for the preparation of pigment preparations and dry preparations.
摘要翻译：本发明涉及基于多层血小板形基底的五层颜料，其包含层序列，其包含（A）层厚度为0.1-50nm的SnO 2层，（B）高折射率涂层的TiO 2在层厚度为10-800nm的金红石修饰中，（C）具有折射率n

9. 发明申请

US20090077904A1 Modular Testing Plant 审中-公开
标题翻译：模块化测试厂
公开(公告)号：US20090077904A1
公开(公告)日：2009-03-26
申请号：US12087648
申请日：2006-12-21
申请人： Peter Ziegler , Christoph Schmidt
发明人： Peter Ziegler , Christoph Schmidt
IPC分类号： E04H5/02 , E04B1/00
CPC分类号： E04B1/3483 , E04B2001/34892
摘要： A modular testing plant comprising at least two building modules which are designed as transportable containers and which each have two side walls and two transverse walls connecting the side walls, wherein at least one building module having a length L2 and a width B2 and designed as a first testing module for receiving a test item is provided, and at least one building module having a length L4 and a width B4 and designed as a first supply module for receiving supply technology is provided, wherein the first supply module is arranged above the first testing module and the length L4 is less than the length L2. To complete the testing plant, at least a third building module designed as a first testing technology module for receiving testing technology is provided, wherein the first testing technology module has two side walls, two transverse walls connecting the side walls, a length L3 and a width B3, wherein the first testing technology module can be placed, in respect of the side wall, laterally next to the first testing module against the side wall, and the width B4 is at least 20% less than the width B2 or B3, which means that the ratio of B4/B2 or the ratio of B4/B3 is at most 2/2.5.
摘要翻译：模块化测试设备包括至少两个建筑模块，其被设计为可运输的容器，并且每个具有两个侧壁和连接侧壁的两个横向壁，其中至少一个具有长度L2和宽度B2的建筑模块被设计为提供了用于接收测试项目的第一测试模块，并且提供了具有长度L4和宽度B4并被设计为用于接收供应技术的第一供应模块的至少一个构建模块，其中，第一供应模块被布置在第一测试模块，长度L4小于长度L2。为了完成测试工厂，提供了至少第三建筑模块，被设计成用于接收测试技术的第一测试技术模块，其中第一测试技术模块具有两个侧壁，连接侧壁的两个横向壁，长度L3和宽度B3，其中所述第一测试技术模块可相对于所述侧壁相对于所述侧壁横向放置在所述第一测试模块的旁边，并且所述宽度B4比所述宽度B2或B3小至少20％意味着B4 / B2的比例或B4 / B3的比率至多为2 / 2.5。

10. 发明申请

US20080239734A1 SINGLE PATH ROAD GEOMETRY PREDICTIVE ADAPTIVE FRONT LIGHTING ALGORITHM USING VEHCILE POSITIONING AND MAP DATA 有权
标题翻译：单路径几何预测自适应正面照明算法使用车辆定位和地图数据
公开(公告)号：US20080239734A1
公开(公告)日：2008-10-02
申请号：US11691966
申请日：2007-03-27
申请人： Faroog Abdel-Kareem Ibrahim , Markus Klein , Christoph Schmidt
发明人： Faroog Abdel-Kareem Ibrahim , Markus Klein , Christoph Schmidt
IPC分类号： G01B5/00
CPC分类号： B60W40/076 , B60Q1/12 , B60Q2300/112 , B60Q2300/134 , B60Q2300/322 , B60W40/072
摘要： A system for predictive front lighting of a vehicle. The system includes a first and second headlamps, a first and second swivel mechanisms and a controller. The first and second headlamps project a beam pattern for illumination of the vehicle path. The controller receives vehicle position data, for example from a GPS system, and accesses a map database to identify a map location of the vehicle. The controller further analyzes the map to determine a most likely path of the vehicle based on the map location and other vehicle heading parameters. The controller then calculates the desired swivel angle of the first and second headlamps based on the most likely path of the vehicle, and the first and second swivel mechanisms manipulate the first and second headlamps to accordingly change the swivel angle of the headlamps.
摘要翻译：一种用于车辆预测性前照灯的系统。该系统包括第一和第二前照灯，第一和第二旋转机构和控制器。第一和第二头灯投射用于照亮车辆路径的光束图案。控制器例如从GPS系统接收车辆位置数据，并且访问地图数据库以识别车辆的地图位置。控制器进一步分析地图以基于地图位置和其他车辆航向参数确定车辆的最可能路径。然后，控制器基于车辆的最可能的路径计算第一和第二前照灯的期望的旋转角度，并且第一和第二旋转机构操纵第一和第二前照灯，从而相应地改变头灯的旋转角度。

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