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1. 发明授权

US07267654B2 Focused shock-wave devices with direct wave cavitation suppressor 有权
标题翻译：具有直射波气蚀抑制器的聚焦冲击波装置
公开(公告)号：US07267654B2
公开(公告)日：2007-09-11
申请号：US10387975
申请日：2003-03-13
申请人： Thomas J. Matula , Paul Hilmo , Michael Bailey
发明人： Thomas J. Matula , Paul Hilmo , Michael Bailey
IPC分类号： A61B17/22
CPC分类号： A61B17/225 , A61B17/22004 , A61B2017/22027
摘要： A reflector (14) reflects energy emitting from an energy source (16) and focuses and directs it to a target. An aperture stop or suppressor disk (18) is positioned between the energy source (16) and target. The outer periphery of the aperture stop or suppressor disk (18) is an irregular curve (FIGS. 12 and 13). This shape of the periphery prevents diffraction enhancement to the direct wave. In another emobidment, the suppressor disk (18) is replaced by a suppressor member (18′) that is directly mounted on a frame portion of the energy source (16). This energy source (16) includes a spark-gap, or the like, and an open frame (36) that surrounds the spark-gap (52) or the like. This frame (32) includes a pair of laterally spaced apart frame members (42, 44) on the side of the frame (36) that faces the target (F2). The suppressor member (18′) is connected to these frame members (32, 44). It may have longitudinal grooves (48, 50) in its side edges into which the frame members (42, 44) snap-fit.
摘要翻译：反射器（14）反射从能量源（16）发射的能量，并将其聚焦并引导到目标。孔径光阑或抑制盘（18）位于能量源（16）和目标物之间。孔径光阑或抑制盘（18）的外周是不规则的曲线（图12和13）。这种外围形状防止对直射波的衍射增强。在另一个方案中，抑制盘（18）被直接安装在能量源（16）的框架部分上的抑制器件（18'）代替。该能源（16）包括火花隙等，以及围绕火花隙（52）等的开放框架（36）。该框架（32）包括在框架（36）侧面对目标（F 2）的一对侧向间隔开的框架构件（42,44）。抑制器构件（18'）连接到这些框架构件（32,44）。它可以在其侧边缘中具有纵向槽（48,50），框架构件（42,44）卡扣配合到纵向槽中。

2. 发明授权

US07033328B2 Direct wave cavitation suppressor for focused shock-wave devices 失效
标题翻译：用于聚焦冲击波装置的直波空穴抑制器
公开(公告)号：US07033328B2
公开(公告)日：2006-04-25
申请号：US10266874
申请日：2002-10-08
申请人： Thomas J. Matula , Paul Hilmo , Michael Bailey
发明人： Thomas J. Matula , Paul Hilmo , Michael Bailey
IPC分类号： A61B17/22
CPC分类号： A61B17/225 , A61B2017/22027
摘要： A reflector (14) reflects energy emitting from an energy source (16) and focuses and directs it to a target. An aperture stop or suppressor disk (18) is positioned between the energy source (16) and target. The outer periphery of the aperture stop or suppressor disk (18) is an irregular curve (FIGS. 12 and 13). This shape of the periphery prevents diffraction enhancement to the direct wave.
摘要翻译：反射器（14）反射从能量源（16）发射的能量，并将其聚焦并引导到目标。孔径光阑或抑制盘（18）位于能量源（16）和目标物之间。孔径光阑或抑制盘（18）的外周是不规则的曲线（图12和13）。这种外围形状防止对直射波的衍射增强。

3. 发明授权

US08264683B2 Dynamic characterization of particles with flow cytometry 有权
标题翻译：流式细胞术对颗粒的动态表征
公开(公告)号：US08264683B2
公开(公告)日：2012-09-11
申请号：US12497281
申请日：2009-07-02
申请人： Thomas J. Matula , Jarred Swalwell
发明人： Thomas J. Matula , Jarred Swalwell
IPC分类号： G01N21/00
CPC分类号： G01N21/49 , A61B5/0059 , A61B8/481 , G01N15/1459 , G01N21/01 , G01N21/70 , G01N33/15 , G01N2015/1493 , G01N2021/0193
摘要： Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which are not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle.
摘要翻译：流式细胞术概念被修改以使得能够使用光学散射数据获得的粒子的动态表征。流入的颗粒将被引入样品体积。收集并分析由样品体积中的颗粒散射的光。将本文公开的概念与常规流式细胞术区分开来的是使用声源，其被设置为将声能引导到样本体积中。当颗粒通过样品体积时，其响应于声能，引起颗粒散射的光的变化。可以分析在常规流式细胞术中不测量的那些变化，以确定颗粒的附加物理性质。

4. 发明申请

US20130003049A1 DYNAMIC CHARACTERIZATION OF PARTICLES WITH FLOW CYTOMETRY 有权
标题翻译：用流式细胞仪测定颗粒的动态特性
公开(公告)号：US20130003049A1
公开(公告)日：2013-01-03
申请号：US13528016
申请日：2012-06-20
申请人： Thomas J. Matula , Jarred Swalwell
发明人： Thomas J. Matula , Jarred Swalwell
IPC分类号： G01N29/04 , G01N21/53
CPC分类号： G01N21/49 , A61B5/0059 , A61B8/481 , G01N15/1459 , G01N21/01 , G01N21/70 , G01N33/15 , G01N2015/1493 , G01N2021/0193
摘要： Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which arc not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle.
摘要翻译：流式细胞术概念被修改以使得能够使用光学散射数据获得的粒子的动态表征。流入的颗粒将被引入样品体积。收集并分析由样品体积中的颗粒散射的光。将本文公开的概念与常规流式细胞术区分开来的是使用声源，其被设置为将声能引导到样本体积中。当颗粒通过样品体积时，其响应于声能，引起颗粒散射的光的变化。可以分析在常规流式细胞术中不测量的那些变化，以确定颗粒的附加物理性质。

5. 发明申请

US20120091632A1 METHOD OF SELECTIVE FOAMING FOR POROUS POLYMERIC MATERIAL 有权
标题翻译：多孔聚合材料的选择性发泡方法
公开(公告)号：US20120091632A1
公开(公告)日：2012-04-19
申请号：US13082133
申请日：2011-04-07
申请人： Wei Li , Hai Wang , Vipin Kumar , Thomas J. Matula
发明人： Wei Li , Hai Wang , Vipin Kumar , Thomas J. Matula
IPC分类号： B29C44/20
CPC分类号： C08J9/00 , B29C35/0261 , B29C44/3469
摘要： A selective high intensity ultrasonic foaming technique is described to fabricate porous polymers for biomedical applications. Process variables, including ultrasound power, scanning speed, and gas concentration have an affect on pore size. Pore size can be controlled with the scanning speed of the ultrasound insonation and interconnected porous structures could be obtained using a partially saturated polymers. A gas concentration range of 3-5% by weight creates interconnected open-celled porous structures. The selective high intensity ultrasonic foaming method can be used on biocompatible polymers so as not to introduce any organic solvents. The method has use in cell related biomedical applications such as studying cell growth behaviors by providing a porous environment with varying topological features.
摘要翻译：描述了选择性高强度超声波发泡技术来制造用于生物医学应用的多孔聚合物。过程变量，包括超声波功率，扫描速度和气体浓度都会影响孔径。可以用超声波的扫描速度控制孔径，并且可以使用部分饱和的聚合物获得互连的多孔结构。 3-5重量％的气体浓度范围产生互连的开孔多孔结构。选择性高强度超声波发泡法可用于生物相容性聚合物，以便不引入任何有机溶剂。该方法可用于细胞相关的生物医学应用，例如通过提供具有不同拓扑特征的多孔环境来研究细胞生长行为。

6. 发明申请

US20090316151A1 DYNAMIC CHARACTERIZATION OF PARTICLES WITH FLOW CYTOMETRY 有权
标题翻译：用流式细胞仪测定颗粒的动态特性
公开(公告)号：US20090316151A1
公开(公告)日：2009-12-24
申请号：US12497281
申请日：2009-07-02
申请人： Thomas J. Matula , Jarred Swalwell
发明人： Thomas J. Matula , Jarred Swalwell
IPC分类号： G01N21/53 , G01N15/06
CPC分类号： G01N21/49 , A61B5/0059 , A61B8/481 , G01N15/1459 , G01N21/01 , G01N21/70 , G01N33/15 , G01N2015/1493 , G01N2021/0193
摘要： Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which are not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle.
摘要翻译：流式细胞术概念被修改以使得能够使用光学散射数据获得的粒子的动态表征。流入的颗粒将被引入样品体积。收集并分析由样品体积中的颗粒散射的光。将本文公开的概念与常规流式细胞术区分开来的是使用声源，其被设置为将声能引导到样本体积中。当颗粒通过样品体积时，其响应于声能，引起颗粒散射的光的变化。可以分析在常规流式细胞术中不测量的那些变化，以确定颗粒的附加物理性质。

7. 发明授权

US08441624B2 Dynamic characterization of particles with flow cytometry 有权
标题翻译：流式细胞术对颗粒的动态表征
公开(公告)号：US08441624B2
公开(公告)日：2013-05-14
申请号：US13528016
申请日：2012-06-20
申请人： Thomas J. Matula , Jarred Swalwell
发明人： Thomas J. Matula , Jarred Swalwell
IPC分类号： G01N21/00
CPC分类号： G01N21/49 , A61B5/0059 , A61B8/481 , G01N15/1459 , G01N21/01 , G01N21/70 , G01N33/15 , G01N2015/1493 , G01N2021/0193
摘要： Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which are not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle.
摘要翻译：流式细胞术概念被修改以使得能够使用光学散射数据获得的粒子的动态表征。流入的颗粒将被引入样品体积。收集并分析由样品体积中的颗粒散射的光。将本文公开的概念与常规流式细胞术区分开来的是使用声源，其被设置为将声能引导到样本体积中。当颗粒通过样品体积时，其响应于声能，引起颗粒散射的光的变化。可以分析在常规流式细胞术中不测量的那些变化，以确定颗粒的附加物理性质。

8. 发明授权

US08247464B2 Method of selective foaming for porous polymeric material 有权
标题翻译：多孔聚合材料选择性发泡方法
公开(公告)号：US08247464B2
公开(公告)日：2012-08-21
申请号：US13082133
申请日：2011-04-07
申请人： Wei Li , Hai Wang , Vipin Kumar , Thomas J. Matula
发明人： Wei Li , Hai Wang , Vipin Kumar , Thomas J. Matula
IPC分类号： C08J9/00 , C08J9/12
CPC分类号： C08J9/00 , B29C35/0261 , B29C44/3469
摘要： A selective high intensity ultrasonic foaming technique is described to fabricate porous polymers for biomedical applications. Process variables, including ultrasound power, scanning speed, and gas concentration have an affect on pore size. Pore size can be controlled with the scanning speed of the ultrasound insonation and interconnected porous structures could be obtained using a partially saturated polymers. A gas concentration range of 3-5% by weight creates interconnected open-celled porous structures. The selective high intensity ultrasonic foaming method can be used on biocompatible polymers so as not to introduce any organic solvents. The method has use in cell related biomedical applications such as studying cell growth behaviors by providing a porous environment with varying topological features.
摘要翻译：描述了选择性高强度超声波发泡技术来制造用于生物医学应用的多孔聚合物。过程变量，包括超声波功率，扫描速度和气体浓度都会影响孔径。可以用超声波的扫描速度控制孔径，并且可以使用部分饱和的聚合物获得互连的多孔结构。 3-5重量％的气体浓度范围产生互连的开孔多孔结构。选择性高强度超声波发泡方法可用于生物相容性聚合物，以便不引入任何有机溶剂。该方法可用于细胞相关的生物医学应用，例如通过提供具有不同拓扑特征的多孔环境来研究细胞生长行为。

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