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1. 发明授权

US11978269B2 Reconfigurable integrated circuits for adjusting cell sorting classification 有权
公开(公告)号：US11978269B2
公开(公告)日：2024-05-07
申请号：US18210911
申请日：2023-06-16
申请人： Becton, Dickinson and Company
发明人： Paul Barclay Purcell
IPC分类号： G06V20/69 , G01N21/01 , G01N21/17 , G01N21/84 , G06N3/08
CPC分类号： G06V20/698 , G01N21/01 , G01N21/17 , G01N21/84 , G06N3/08 , G01N2021/0112 , G01N2021/0181 , G01N2021/0193 , G01N2021/1765 , G01N2021/845 , G01N2201/125
摘要： Aspects of the present disclosure include reconfigurable integrated circuits for characterizing particles of a sample in a flow stream. Reconfigurable integrated circuits according to certain embodiments are programmed to calculate parameters of a particle in a flow stream from detected light; compare the calculated parameters of the particle with parameters of one or more particle classifications; classify the particle based on the comparison between the parameters of the particle classifications and the calculated parameters of the particle; and adjust one or more parameters of the particle classifications based on the calculated parameters of the particle. Methods for characterizing particles in a flow stream with the subject integrated circuits are also described. Systems and integrated circuit devices programmed for practicing the subject methods, such as on a flow cytometer, are also provided.

2. 发明申请

US20160223436A1 REMOTE SAMPLING BYPASS FOR A GAS ANALYSER 有权
标题翻译：用于气体分析仪的远程采样旁路
公开(公告)号：US20160223436A1
公开(公告)日：2016-08-04
申请号：US15022914
申请日：2013-10-11
申请人： DRAEGER SAFETY, INC.
发明人： Michael V. CARUSO , Eric J. ROBEY
IPC分类号： G01N1/22
CPC分类号： G01N1/2273 , G01N1/24 , G01N33/0016 , G01N2021/0193
摘要： Described herein is a gas detection system (5) including a housing (10) having an inlet (20) in fluid communication with an atmosphere; an analyzer (25) within the housing (20) and configured to detect and measure a gas species in the atmosphere using a gas sensor (37); and a pneumatic system (60) contained within the housing (10) and in fluid communication with the inlet (20) to draw an air sample from the atmosphere. The pneumatic system (60) includes a pump (15); a low flow branch (65) in fluid communication with the pump (15) and having an airflow sensor (90) and a first orifice (85); and a high flow branch (70) in fluid communication with the pump (15) and having a second orifice (95). Such a system is particularly suitable for remote sampling because it prevents the high flow needed for remote sampling to be directed towards the gas sensor withstanding only low flow. Related apparatus, systems, methods and/or articles are described.
摘要翻译：这里描述了一种气体检测系统（5），包括具有与大气流体连通的入口（20）的壳体（10）壳体（20）内的分析器（25），并且被配置为使用气体传感器（37）来检测和测量大气中的气体种类; 以及包含在所述壳体（10）内并与所述入口（20）流体连通以从大气抽出空气样本的气动系统（60）。气动系统（60）包括泵（15）; 与所述泵（15）流体连通并具有气流传感器（90）和第一孔口（85）的低流量分支（65）; 以及与所述泵（15）流体连通并具有第二孔口（95）的高流量分支（70）。这样的系统特别适用于远程采样，因为它防止远程采样所需的高流量仅通过低流量被引向气体传感器。描述了相关装置，系统，方法和/或制品。

3. 发明授权

US08506778B2 Diagnostic devices incorporating fluidics and methods of manufacture 有权
标题翻译：包含流体学和制造方法的诊断装置
公开(公告)号：US08506778B2
公开(公告)日：2013-08-13
申请号：US12870463
申请日：2010-08-27
申请人： Imants Lauks , Andrzej Maczuszenko
发明人： Imants Lauks , Andrzej Maczuszenko
IPC分类号： G01N27/416
CPC分类号： G01N27/26 , B01L3/502707 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2200/025 , B01L2200/0689 , B01L2200/148 , B01L2200/16 , B01L2300/0645 , B01L2300/0816 , B01L2300/0887 , B01L2300/1805 , B01L2300/1827 , B01L2400/0481 , B01L2400/0487 , B01L2400/0683 , B32B37/06 , B32B37/10 , B32B38/04 , B32B2038/047 , B32B2425/00 , G01N27/3272 , G01N27/403 , G01N2021/0193 , G01N2035/00148
摘要： The present invention relates to diagnostic devices incorporating electrode modules and fluidics for performing chemical analyses. The invented devices consist of a sensor array formed on an electrode module, the sensor array being contained within a fluidic housing. The electrode module is a laminate of a perforated epoxy foil and a photo-formed metal foil with sensor membranes deposited into the perforations. The fluidic housing is an element consisting of a plastic card-like body with fluidic conduits and a sealed fluid reservoir contained in a foil-lined cavity.
摘要翻译：本发明涉及包含用于进行化学分析的电极模块和流体学的诊断装置。本发明的装置由形成在电极模块上的传感器阵列组成，传感器阵列包含在流体壳体内。电极模块是穿孔环氧箔和光致成形金属箔的叠层，传感膜沉积在穿孔中。流体外壳是由具有流体导管的塑料卡状体和包含在箔衬里腔中的密封流体储存器组成的元件。

4. 发明授权

US08264683B2 Dynamic characterization of particles with flow cytometry 有权
标题翻译：流式细胞术对颗粒的动态表征
公开(公告)号：US08264683B2
公开(公告)日：2012-09-11
申请号：US12497281
申请日：2009-07-02
申请人： Thomas J. Matula , Jarred Swalwell
发明人： Thomas J. Matula , Jarred Swalwell
IPC分类号： G01N21/00
CPC分类号： G01N21/49 , A61B5/0059 , A61B8/481 , G01N15/1459 , G01N21/01 , G01N21/70 , G01N33/15 , G01N2015/1493 , G01N2021/0193
摘要： Flow cytometry concepts are modified to enable dynamic characterizations of particles to be obtained using optical scattering data. Particles in flow will be introduced into a sample volume. Light scattered by a particle in the sample volume is collected and analyzed. What differentiates the concepts disclosed herein from conventional flow cytometry is the use of an acoustic source that is disposed to direct acoustic energy into the sample volume. As the particle passes through the sample volume, it responds to the acoustic energy, causing changes in the light scattered by the particle. Those changes, which are not measured during conventional flow cytometry, can be analyzed to determine additional physical properties of the particle.
摘要翻译：流式细胞术概念被修改以使得能够使用光学散射数据获得的粒子的动态表征。流入的颗粒将被引入样品体积。收集并分析由样品体积中的颗粒散射的光。将本文公开的概念与常规流式细胞术区分开来的是使用声源，其被设置为将声能引导到样本体积中。当颗粒通过样品体积时，其响应于声能，引起颗粒散射的光的变化。可以分析在常规流式细胞术中不测量的那些变化，以确定颗粒的附加物理性质。

5. 发明申请

US20120003124A1 CHEMICAL ANALYSER 有权
标题翻译：化学分析仪
公开(公告)号：US20120003124A1
公开(公告)日：2012-01-05
申请号：US13211943
申请日：2011-08-17
申请人： Stephen Charles Davis , John David Petty , John Thomas Huberts
发明人： Stephen Charles Davis , John David Petty , John Thomas Huberts
IPC分类号： G01N33/48
CPC分类号： G01N31/16 , G01N21/01 , G01N21/75 , G01N21/79 , G01N35/1002 , G01N2021/0193 , G01N2021/8411 , G01N2035/1058 , Y10T436/193333
摘要： A chemical analyser analyses a sample for a target chemical. The sample and reagent are added to a measurement cell until a detectable change is observed. A reference compound, which does not take part in the reaction between the target chemical and reagent, is added to the reagent. By measuring the concentration of the reference compound, the amount of reagent used may be determined. In one embodiment, a mechanism introduces the sample, adds reagent, mixes, cleans, and flushes the measurement cell, which incorporates a longitudinal chamber having inlets for the sample and reagent and an outlet for measured sample/reagent mixtures. A detector located in or adjacent to the chamber between the inlets and outlet and a piston movable in the chamber carries seals such that movement of a piston sequentially opens the inlets and expels the fluid. The analyzer also includes a device that delivers reagent to a measurement cell.
摘要翻译：化学分析仪分析目标化学品的样品。将样品和试剂加入到测量池中，直至观察到可检测的变化。将不参与目标化学品和试剂之间的反应的参考化合物加入到试剂中。通过测量参考化合物的浓度，可以测定所用试剂的量。在一个实施例中，机构引入样品，添加试剂，混合，清洗和冲洗测量池，其包含具有用于样品和试剂的入口的纵向室和用于测量的样品/试剂混合物的出口。位于入口和出口之间或邻近腔室的检测器可在腔室中移动的活塞承载密封件，使得活塞的移动顺序地打开入口并排出流体。分析仪还包括将试剂输送到测量单元的装置。

6. 发明授权

US06954702B2 Gas monitoring system and sidestream gas measurement system adapted to communicate with a mainstream gas measurement system 失效
标题翻译：气体监测系统和侧流气体测量系统适用于与主流气体测量系统进行通信
公开(公告)号：US06954702B2
公开(公告)日：2005-10-11
申请号：US10781382
申请日：2004-02-18
申请人： Anthony T. Pierry , David R. Rich
发明人： Anthony T. Pierry , David R. Rich
IPC分类号： A61B5/083 , G01N21/01 , G01N21/05 , G01N21/35 , G01N33/497 , G01N33/00
CPC分类号： A61B5/087 , A61B5/0205 , A61B5/083 , A61B2562/226 , G01N21/05 , G01N21/3504 , G01N33/497 , G01N2021/0118 , G01N2021/0193 , G01N2201/1215
摘要： A method and apparatus for interfacing a plurality of gas measurement systems, including a mainstream and a sidestream gas measurement system, to a host system via an interface unit. The present invention also pertains to a sidestream gas measurement system that output signals emulating the signals output by a mainstream gas measurement system or portion thereof, so that the sidestream gas measurement system can seamlessly communicate with a host system configured to communicate only a mainstream gas measurement system or a portion thereof.
摘要翻译：一种用于经由接口单元将多个气体测量系统（包括主流和侧流气体测量系统）连接到主机系统的方法和装置。本发明还涉及一种侧流气体测量系统，其输出仿真由主流气体测量系统或其一部分输出的信号的信号，使得侧流气体测量系统可与主系统无缝地通信，该主机系统仅配置为仅传送主流气体测量系统或其一部分。

7. 发明授权

US5116759A Reservoir chemical sensors 失效
标题翻译：水库化学传感器
公开(公告)号：US5116759A
公开(公告)日：1992-05-26
申请号：US544681
申请日：1990-06-27
申请人： Stanley M. Klainer , Johnny R. Thomas , Marcus S. Butler
发明人： Stanley M. Klainer , Johnny R. Thomas , Marcus S. Butler
IPC分类号： G01N21/01 , G01N21/03 , G01N21/25 , G01N21/75 , G01N21/77 , G01N21/80
CPC分类号： G01N21/253 , G01N21/75 , G01N2021/0193 , G01N2021/0325 , G01N2021/0385 , G01N2021/1738 , G01N21/77 , G01N21/80 , G01N2201/024 , G01N2201/0415 , Y10S436/811 , Y10T436/17 , Y10T436/172307 , Y10T436/18 , Y10T436/19 , Y10T436/206664 , Y10T436/212
摘要： Single or multi-cell reservoir sensors with single illumination sources and one or more detectors per cell unit have an arrangement whereby a gaseous, vapor or liquid sample enters the cell body and interacts with a sensing solution to detect and quantify a given species. Entrance of the sample into the sensor is through an opening in the cell body which may be covered with a membrane to contain the sensing reagent and to presort the species entering the cell. Reservoir cells can be used with organic, inorganic or biochemical sensing materials. A variety of sensors as alcohol, drugs of abuse, organic halides, cyanide and inorganic ions are provided.
摘要翻译：具有单个照明源和每个单元单元的一个或多个检测器的单池或多池容器传感器具有这样的布置，其中气体，蒸气或液体样品进入细胞体并与感测溶液相互作用以检测和定量给定物种。样品进入传感器的入口通过细胞体中的开口，其可以用膜覆盖以容纳感测试剂并且预先分解进入细胞的物质。储层细胞可用于有机，无机或生化传感材料。提供各种传感器作为酒精，滥用药物，有机卤化物，氰化物和无机离子。

8. 发明公开

US20230417655A1 FLOW CELL FOR COLOUR MEASUREMENT SYSTEM 审中-公开
公开(公告)号：US20230417655A1
公开(公告)日：2023-12-28
申请号：US18214036
申请日：2023-06-26
申请人： TINTOMETER GmbH
发明人： Peter CLARKE , Amy PENN , Nicholas BARNES , Thomas GARWOOD
IPC分类号： G01N21/25 , G01N21/47 , G01N21/85
CPC分类号： G01N21/251 , G01N21/474 , G01N21/85 , G01N2021/0193
摘要： A flow cell for a colour measurement system is described that includes a body with a fluid inlet and a fluid outlet linked by a fluid pathway. An entrance window for allowing light transmission into the flow cell is provided, along with a coupler configured to couple a light source to the flow cell. The entrance window is fixedly coupled to the body of the flow cell, and the coupler is carried by a coupler mount that attaches to the body of the flow cell independently of the entrance window.

9. 发明授权

US10627319B2 Sampling apparatus for use in explosive environments, a dryer comprising such a sampling apparatus, and method of estimating the flowability of a sample 有权
公开(公告)号：US10627319B2
公开(公告)日：2020-04-21
申请号：US15580329
申请日：2016-06-09
申请人： GEA Process Engineering A/S
发明人： Thomas Kniep Jørgensen , Anders Sehested , Esben Krauthammer
IPC分类号： G01N1/20 , G01N21/01 , G01N21/85 , G01N33/04 , G01N1/10
CPC分类号： G01N1/20 , G01N1/2035 , G01N21/01 , G01N21/85 , G01N33/04 , G01N2001/1018 , G01N2021/0193
摘要： The invention relates to a sampling apparatus for use in explosive environments comprising particles of a mean size of up to 500 μm, the sampling apparatus comprising a displaceable arm having a sample container, which displaceable arm has a first position where the sample container is inserted into a first zone for collecting a sample of particles into the sample container, and a second zone where the displaceable arm is outside the product stream, the second zone being contained in a housing with an opening for the displaceable arm. The sampling apparatus has an interface between the first and the second zone, which interface is selected from the list consisting of a closable member, a gate valve or an air knife. The invention also relates to a dryer comprising a drying chamber and a sampling apparatus of the invention. In a further aspect the invention relates to a method of estimating the flowability of a sample of organic particles.

10. 发明申请

US20180306703A1 CELL SURVIVAL RATE DETERMINING DEVICE AND CELL SURVIVAL RATE DETERMINING METHOD 审中-公开
公开(公告)号：US20180306703A1
公开(公告)日：2018-10-25
申请号：US15955982
申请日：2018-04-18
申请人： AZBIL CORPORATION
发明人： Norio Hasegawa
IPC分类号： G01N21/17 , G01N15/14 , G06T7/00
CPC分类号： G01N21/17 , G01N15/1434 , G01N2015/1481 , G01N2021/0112 , G01N2021/0181 , G01N2021/0193 , G01N2021/1744 , G06T7/0016
摘要： A cell survival rate determining device includes a distribution acquisition unit acquiring a particle size distribution in a solution containing particles including cultured cells; a classification unit classifying the particles into a small particle group and a large particle group using a predetermined threshold in the distribution; a ratio calculation unit calculating the value of a ratio between the number of particles belonging to the small particle group and the number of particles belonging to the large particle group; and a survival rate determination unit determining the survival rate of the cultured cells from the value of the ratio using a pre-acquired relationship between the ratio and cell survival rate.

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