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1. 发明授权

US5968040A Systems and methods using asymmetric multiple electrode arrays 失效
标题翻译：使用不对称多电极阵列的系统和方法
公开(公告)号：US5968040A
公开(公告)日：1999-10-19
申请号：US728698
申请日：1996-10-28
申请人： David K. Swanson , Sidney D. Fleischman , Dorin Panescu , James G. Whayne , Thomas F. Kordis
发明人： David K. Swanson , Sidney D. Fleischman , Dorin Panescu , James G. Whayne , Thomas F. Kordis
IPC分类号： A61N1/00 , A61B17/39
CPC分类号： A61N1/00
摘要： Systems and methods support arrays of multiple electrodes in asymmetric pattern, either radially, or axially, or both. Radial asymmetry makes it possible provide localized density of electrodes. Axial asymmetry makes it possible to locate electrodes in a pattern that closely conforms to the irregular contours of an interior body cavity, like the heart. In a preferred embodiment, the systems and methods operate the multiple electrode arrays to form continuous lesion patterns.
摘要翻译：系统和方法以径向或轴向或两者不对称的方式支持多个电极的阵列。径向不对称使得可能提供电极的局部密度。轴向不对称使得可以将电极定位成与内部体腔的不规则轮廓紧密一致的图案，如心脏。在优选实施例中，系统和方法操作多个电极阵列以形成连续的病变图案。

2. 发明授权

US6014590A Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions 失效
标题翻译：使用具有不对称机械性能的结构以支持与内部身体区域中的组织接触的诊断或治疗元件的系统和方法
公开(公告)号：US6014590A
公开(公告)日：2000-01-11
申请号：US742564
申请日：1996-10-28
申请人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
发明人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
IPC分类号： A61B17/39
摘要： Structures having asymmetric mechanical properties provide enhanced ability to support therapeutic or diagnostic elements in contact with tissue in an interior body region. The support structure includes a first region, which exhibits a first mechanical property affecting tissue contact, and a second region spaced from the first region about the axis, which exhibits a second mechanical property, different than the first mechanical property, affecting tissue contact. In a preferred embodiment, the first and second mechanical properties correlate with stiffness of the respective first and second regions, with the first region being more flexible (i.e., less stiff) than the second region. The first region, due to its greater flexibility, is more conformal to tissue than the second region. The less flexible (i.e., more stiff) second region imparts greater force against the tissue to urge the more flexible first region toward intimate tissue contact. In a preferred embodiment, the more flexible first region carries at least one therapeutic or diagnostic element.
摘要翻译：具有不对称机械特性的结构提供增强的能力，以支持与内部身体区域中的组织接触的治疗或诊断元件。支撑结构包括表现出影响组织接触的第一机械特性的第一区域以及围绕轴线与第一区域隔开的第二区域，该第二区域具有影响组织接触的第二机械特性，该第二机械特性不同于第一机械特性。在优选实施例中，第一和第二机械特性与相应的第一和第二区域的刚度相关，其中第一区域比第二区域更加柔性（即，较不硬）。第一个区域由于其更大的灵活性，比第二个区域更适合组织。较不柔性（即更硬）的第二区域赋予组织更大的力以促使更柔性的第一区域朝向紧密的组织接触。在优选实施方案中，更灵活的第一区域携带至少一种治疗或诊断元件。

3. 发明授权

US5911739A Structures for supporting diagnostic or therapeutic elements in internal body regions 失效
标题翻译：用于支持内部身体区域的诊断或治疗元件的结构
公开(公告)号：US5911739A
公开(公告)日：1999-06-15
申请号：US738856
申请日：1996-10-28
申请人： Thomas F. Kordis , James G. Whayne , Dorin Panescu , David K. Swanson , Sidney D. Fleischman
发明人： Thomas F. Kordis , James G. Whayne , Dorin Panescu , David K. Swanson , Sidney D. Fleischman
IPC分类号： A61N1/00 , A61B17/36
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6852 , A61B5/6858 , A61N1/056 , A61B18/14 , A61B18/18 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00839 , A61B2018/1407 , A61B2018/1435 , A61B2018/1465 , A61B2562/0209 , A61B2562/043
摘要： Elongated spline members are threaded through a hub to form depending spline legs. In one embodiment, the spline members are threaded through a puncturable material on the hub. In another embodiment, the spline members are threaded through a slotted hub, which is then encapsulated by a sealing, elastomeric material. In another embodiment, multiple spline members are looped and woven together beyond a distal end of the hub, and the distal end of the hub serves to exert a force that maintains the woven relationship of the spline members. The spline legs, which radiate from the hub, preferable carry one or more diagnostic or therapeutic elements, such as electrodes. Preferably, a base constrains the terminal ends of the spline legs in a normally expanded geometry between the hub and base.
摘要翻译：细长的花键构件穿过轮毂以形成悬垂的花键腿。在一个实施例中，花键构件穿过轮毂上的可刺破材料。在另一个实施例中，花键构件穿过开槽的毂，然后由密封的弹性体材料包封。在另一个实施例中，多个花键构件环绕并且一起超越轮毂的远端编织，轮毂的远端用于施加维持花键构件的编织关系的力。从轮毂辐射的花键腿优选携带一个或多个诊断或治疗元件，例如电极。优选地，基座以轮毂和底座之间的正常展开的几何形状约束花键腿的末端。

4. 发明授权

US5853411A Enhanced electrical connections for electrode structures 失效
标题翻译：电极结构的增强电连接
公开(公告)号：US5853411A
公开(公告)日：1998-12-29
申请号：US629363
申请日：1996-04-08
申请人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
发明人： James G. Whayne , Thomas F. Kordis , Sidney D. Fleischman , Dorin Panescu , David K. Swanson , Patrick M. Owens , Jerome Jackson , Russell B. Thompson , David McGee
IPC分类号： A61B17/00 , A61B17/22 , A61B18/14 , A61N1/05 , A61B17/39 , A61B5/042
CPC分类号： A61N1/056 , A61B18/1492 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022
摘要： Enhanced electrical connections for electrodes are provided. In one implementation, an electrode body comprises a first electrically nonconductive layer and a second electrically nonconductive layer overlying at least a portion of the first layer. An intermediate region is formed between the first and second layers. An electrically conductive pathway extends within the intermediate region. An formed opening extends to the intermediate region, exposing a part of the electrically conductive pathway. An electrically conductive material is deposited on the second layer so that a part of the electrically conductive material passes through the opening to establish electrical contact between the electrically conductive material and the electrically conductive pathway.
摘要翻译：提供了电极的增强电连接。在一个实施方案中，电极体包括覆盖在第一层的至少一部分上的第一非导电层和第二非导电层。在第一和第二层之间形成中间区域。导电通路在中间区域内延伸。形成的开口延伸到中间区域，暴露导电路径的一部分。导电材料沉积在第二层上，使得导电材料的一部分通过开口以在导电材料和导电通路之间建立电接触。

5. 发明授权

US06471699B1 Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements 失效
标题翻译：使用直线或曲线电极元件在身体组织中形成细长病变图案的系统和方法
公开(公告)号：US06471699B1
公开(公告)日：2002-10-29
申请号：US09579730
申请日：2000-05-26
申请人： Sidney D. Fleischman , Thomas Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
发明人： Sidney D. Fleischman , Thomas Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
IPC分类号： A61B1818
CPC分类号： A61B5/0422 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61B18/1402 , A61B18/1492 , A61B18/1815 , A61B2017/00084 , A61B2017/00088 , A61B2017/00092 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00577 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61M25/0041 , A61M2025/09141 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , C08L1/02
摘要： Systems and associated methods position arrays of multiple emitters of ablating energy in straight or curvilinear positions in contact with tissue to form elongated lesion patterns. The elongated lesion patterns can continuous or interrupted, depending upon the orientation of the energy emitters.
摘要翻译：系统和相关方法将多个发射器的阵列放置在与组织接触的直线或曲线位置中，以形成细长的病变图案。取决于能量发射器的取向，细长的损伤图案可以连续或中断。

6. 发明授权

US6113591A Systems and methods for sensing sub-surface temperatures in body tissue 失效
标题翻译：用于感测身体组织中亚表面温度的系统和方法
公开(公告)号：US6113591A
公开(公告)日：2000-09-05
申请号：US942251
申请日：1997-10-01
申请人： James G. Whayne , David K. Swanson , Sidney D. Fleischman , Thomas M. Bourne , Dorin Panescu
发明人： James G. Whayne , David K. Swanson , Sidney D. Fleischman , Thomas M. Bourne , Dorin Panescu
IPC分类号： A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61N1/05 , A61N1/40 , A61B17/36
CPC分类号： A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61N1/056 , A61N1/403 , A61B2017/00017 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/00095 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00791 , A61B2018/00815 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/1861 , A61M2230/50
摘要： Systems and methods supply ablation energy to an electrode in contact with tissue to form a tissue-electrode interface. The system and methods sense, simultaneously with ablation, at least two tissue temperature conditions using at least two tissue temperature sensing elements which are held within a carrier that is substantially isolated from thermal conductive contact with the electrode. The carrier holds the tissue temperature sensing elements in a spaced apart relationship in thermal conductive contact with tissue at different depths beneath the tissue-electrode interface. The systems and methods control the supply of ablation energy to the electrode based, at least in part, upon temperatures sensed by the tissue temperature sensing elements.
摘要翻译：系统和方法向与组织接触的电极提供消融能量以形成组织 - 电极界面。系统和方法同时消融，使用至少两个组织温度感测元件感测至少两个组织温度条件，所述组织温度感测元件保持在与电极的导热接触基本隔离的载体内。载体将组织温度感测元件以间隔开的关系保持在与组织 - 电极界面下方不同深度处的组织的导热接触中。系统和方法至少部分地基于由组织温度感测元件感测到的温度来控制向电极提供消融能量。

7. 发明授权

US06197021B1 Systems and methods for controlling tissue ablation using multiple temperature sensing elements 失效
标题翻译：使用多个温度感测元件控制组织消融的系统和方法
公开(公告)号：US06197021B1
公开(公告)日：2001-03-06
申请号：US09154941
申请日：1998-09-17
申请人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
发明人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
IPC分类号： A61B1818
CPC分类号： A61B5/0422 , A61B5/6858 , A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61B18/20 , A61B2017/00088 , A61B2017/00092 , A61B2017/00154 , A61B2017/003 , A61B2018/00083 , A61B2018/00101 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00636 , A61B2018/0066 , A61B2018/0069 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00821 , A61B2018/124 , A61B2018/126 , A61B2018/128 , A61B2018/1435 , A61B2018/1467 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14
摘要： Systems and associated methods place a temperature sensing element in an “edge region” between an energy transmitting electrode and a non-electrically conducting support body, where higher temperatures are likely to exist. Reliable temperature sensing, which is sensitive to variations in temperatures along the electrode, results.
摘要翻译：系统和相关方法将温度感测元件置于能量传输电极和可能存在较高温度的非导电支撑体之间的“边缘区域”中。可靠的温度感测对电极温度的变化敏感。

8. 发明授权

US6106522A Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements 失效
公开(公告)号：US6106522A
公开(公告)日：2000-08-22
申请号：US763169
申请日：1996-12-10
申请人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
发明人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
IPC分类号： A61B18/04 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , A61M25/00 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B17/39
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , A61B18/1402 , A61B18/1815 , A61B2017/00084 , A61B2017/00088 , A61B2017/00092 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00577 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61M2025/09141 , A61M25/0041
摘要： Systems and associated methods position arrays of multiple emitters of ablating energy in straight or curvilinear positions in contact with tissue to form elongated lesion patterns. The elongated lesion patterns can continuous or interrupted, depending upon the orientation of the energy emitters.

9. 发明授权

US5810802A Systems and methods for controlling tissue ablation using multiple temperature sensing elements 失效
公开(公告)号：US5810802A
公开(公告)日：1998-09-22
申请号：US788782
申请日：1997-01-24
申请人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
发明人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/20 , A61L29/14 , A61L31/10 , A61L31/14 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B17/36
CPC分类号： A61B5/0422 , A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61B5/6858 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , A61B18/20 , A61B2017/00088 , A61B2017/00092 , A61B2017/00154 , A61B2017/003 , A61B2018/00083 , A61B2018/00101 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00636 , A61B2018/0066 , A61B2018/0069 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00821 , A61B2018/124 , A61B2018/126 , A61B2018/128 , A61B2018/1435 , A61B2018/1467
摘要： Systems and associated methods place a temperature sensing element in an "edge region" between an energy transmitting electrode and a non-electrically conducting support body, where higher temperatures are likely to exist. Reliable temperature sensing, which is sensitive to variations in temperatures along the electrode, results.

10. 发明授权

US5582609A Systems and methods for forming large lesions in body tissue using curvilinear electrode elements 失效
公开(公告)号：US5582609A
公开(公告)日：1996-12-10
申请号：US287310
申请日：1994-08-08
申请人： David K. Swanson , Thomas Bourne , Sidney D. Fleischman , Dorin Panescu , James G. Whayne
发明人： David K. Swanson , Thomas Bourne , Sidney D. Fleischman , Dorin Panescu , James G. Whayne
IPC分类号： A61B18/12 , A61B5/042 , A61B17/00 , A61B18/14 , A61L29/14 , A61L31/10 , A61L31/14 , A61M25/00 , A61N1/05 , A61N1/06 , A61N1/40 , A61N1/04
CPC分类号： A61B5/6855 , A61B18/1492 , A61B5/0422 , A61B5/6857 , A61B5/6858 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , A61B18/1402 , A61B18/1815 , A61B2017/00084 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00577 , A61B2018/00755 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61M2025/09141 , A61M25/0041
摘要： Systems and associated methods form larger and deeper lesion patterns by shaping a support body with multiple electrodes in ways that increase the density of the electrodes per given tissue area. The support body can carry either elongated, continuous electrodes or arrays of non-contiguous, segmented electrodes.

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