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1. 发明授权

US6113591A Systems and methods for sensing sub-surface temperatures in body tissue 失效
标题翻译：用于感测身体组织中亚表面温度的系统和方法
公开(公告)号：US6113591A
公开(公告)日：2000-09-05
申请号：US942251
申请日：1997-10-01
申请人： James G. Whayne , David K. Swanson , Sidney D. Fleischman , Thomas M. Bourne , Dorin Panescu
发明人： James G. Whayne , David K. Swanson , Sidney D. Fleischman , Thomas M. Bourne , Dorin Panescu
IPC分类号： A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61N1/05 , A61N1/40 , A61B17/36
CPC分类号： A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61N1/056 , A61N1/403 , A61B2017/00017 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/00095 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00791 , A61B2018/00815 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/1861 , A61M2230/50
摘要： Systems and methods supply ablation energy to an electrode in contact with tissue to form a tissue-electrode interface. The system and methods sense, simultaneously with ablation, at least two tissue temperature conditions using at least two tissue temperature sensing elements which are held within a carrier that is substantially isolated from thermal conductive contact with the electrode. The carrier holds the tissue temperature sensing elements in a spaced apart relationship in thermal conductive contact with tissue at different depths beneath the tissue-electrode interface. The systems and methods control the supply of ablation energy to the electrode based, at least in part, upon temperatures sensed by the tissue temperature sensing elements.
摘要翻译：系统和方法向与组织接触的电极提供消融能量以形成组织 - 电极界面。系统和方法同时消融，使用至少两个组织温度感测元件感测至少两个组织温度条件，所述组织温度感测元件保持在与电极的导热接触基本隔离的载体内。载体将组织温度感测元件以间隔开的关系保持在与组织 - 电极界面下方不同深度处的组织的导热接触中。系统和方法至少部分地基于由组织温度感测元件感测到的温度来控制向电极提供消融能量。

2. 发明授权

US6129724A Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements 失效
公开(公告)号：US6129724A
公开(公告)日：2000-10-10
申请号：US874922
申请日：1997-06-13
申请人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
发明人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , A61M25/00 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B37/39
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , A61B18/1402 , A61B18/1815 , A61B2017/00084 , A61B2017/00088 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61M2025/09141 , A61M25/0041
摘要： Systems and associated methods position arrays of multiple emitters of ablating energy in straight or curvilinear positions in contact with tissue to form elongated lesion patterns. The elongated lesion patterns can continuous or interrupted, depending upon the orientation of the energy emitters.

3. 发明授权

US6106522A Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements 失效
公开(公告)号：US6106522A
公开(公告)日：2000-08-22
申请号：US763169
申请日：1996-12-10
申请人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
发明人： Sidney D. Fleischman , Thomas M Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
IPC分类号： A61B18/04 , A61B5/042 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61L29/08 , A61L29/14 , A61L31/10 , A61L31/14 , A61M25/00 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B17/39
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , A61B18/1402 , A61B18/1815 , A61B2017/00084 , A61B2017/00088 , A61B2017/00092 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00577 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61M2025/09141 , A61M25/0041
摘要： Systems and associated methods position arrays of multiple emitters of ablating energy in straight or curvilinear positions in contact with tissue to form elongated lesion patterns. The elongated lesion patterns can continuous or interrupted, depending upon the orientation of the energy emitters.

4. 发明授权

US06471699B1 Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements 失效
标题翻译：使用直线或曲线电极元件在身体组织中形成细长病变图案的系统和方法
公开(公告)号：US06471699B1
公开(公告)日：2002-10-29
申请号：US09579730
申请日：2000-05-26
申请人： Sidney D. Fleischman , Thomas Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
发明人： Sidney D. Fleischman , Thomas Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
IPC分类号： A61B1818
CPC分类号： A61B5/0422 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61B18/1402 , A61B18/1492 , A61B18/1815 , A61B2017/00084 , A61B2017/00088 , A61B2017/00092 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00577 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61M25/0041 , A61M2025/09141 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , C08L1/02
摘要： Systems and associated methods position arrays of multiple emitters of ablating energy in straight or curvilinear positions in contact with tissue to form elongated lesion patterns. The elongated lesion patterns can continuous or interrupted, depending upon the orientation of the energy emitters.
摘要翻译：系统和相关方法将多个发射器的阵列放置在与组织接触的直线或曲线位置中，以形成细长的病变图案。取决于能量发射器的取向，细长的损伤图案可以连续或中断。

5. 发明授权

US6014590A Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions 失效
标题翻译：使用具有不对称机械性能的结构以支持与内部身体区域中的组织接触的诊断或治疗元件的系统和方法
公开(公告)号：US6014590A
公开(公告)日：2000-01-11
申请号：US742564
申请日：1996-10-28
申请人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
发明人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
IPC分类号： A61B17/39
摘要： Structures having asymmetric mechanical properties provide enhanced ability to support therapeutic or diagnostic elements in contact with tissue in an interior body region. The support structure includes a first region, which exhibits a first mechanical property affecting tissue contact, and a second region spaced from the first region about the axis, which exhibits a second mechanical property, different than the first mechanical property, affecting tissue contact. In a preferred embodiment, the first and second mechanical properties correlate with stiffness of the respective first and second regions, with the first region being more flexible (i.e., less stiff) than the second region. The first region, due to its greater flexibility, is more conformal to tissue than the second region. The less flexible (i.e., more stiff) second region imparts greater force against the tissue to urge the more flexible first region toward intimate tissue contact. In a preferred embodiment, the more flexible first region carries at least one therapeutic or diagnostic element.
摘要翻译：具有不对称机械特性的结构提供增强的能力，以支持与内部身体区域中的组织接触的治疗或诊断元件。支撑结构包括表现出影响组织接触的第一机械特性的第一区域以及围绕轴线与第一区域隔开的第二区域，该第二区域具有影响组织接触的第二机械特性，该第二机械特性不同于第一机械特性。在优选实施例中，第一和第二机械特性与相应的第一和第二区域的刚度相关，其中第一区域比第二区域更加柔性（即，较不硬）。第一个区域由于其更大的灵活性，比第二个区域更适合组织。较不柔性（即更硬）的第二区域赋予组织更大的力以促使更柔性的第一区域朝向紧密的组织接触。在优选实施方案中，更灵活的第一区域携带至少一种治疗或诊断元件。

6. 发明授权

US5911739A Structures for supporting diagnostic or therapeutic elements in internal body regions 失效
标题翻译：用于支持内部身体区域的诊断或治疗元件的结构
公开(公告)号：US5911739A
公开(公告)日：1999-06-15
申请号：US738856
申请日：1996-10-28
申请人： Thomas F. Kordis , James G. Whayne , Dorin Panescu , David K. Swanson , Sidney D. Fleischman
发明人： Thomas F. Kordis , James G. Whayne , Dorin Panescu , David K. Swanson , Sidney D. Fleischman
IPC分类号： A61N1/00 , A61B17/36
CPC分类号： A61B5/0422 , A61B18/1492 , A61B5/6852 , A61B5/6858 , A61N1/056 , A61B18/14 , A61B18/18 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00839 , A61B2018/1407 , A61B2018/1435 , A61B2018/1465 , A61B2562/0209 , A61B2562/043
摘要： Elongated spline members are threaded through a hub to form depending spline legs. In one embodiment, the spline members are threaded through a puncturable material on the hub. In another embodiment, the spline members are threaded through a slotted hub, which is then encapsulated by a sealing, elastomeric material. In another embodiment, multiple spline members are looped and woven together beyond a distal end of the hub, and the distal end of the hub serves to exert a force that maintains the woven relationship of the spline members. The spline legs, which radiate from the hub, preferable carry one or more diagnostic or therapeutic elements, such as electrodes. Preferably, a base constrains the terminal ends of the spline legs in a normally expanded geometry between the hub and base.
摘要翻译：细长的花键构件穿过轮毂以形成悬垂的花键腿。在一个实施例中，花键构件穿过轮毂上的可刺破材料。在另一个实施例中，花键构件穿过开槽的毂，然后由密封的弹性体材料包封。在另一个实施例中，多个花键构件环绕并且一起超越轮毂的远端编织，轮毂的远端用于施加维持花键构件的编织关系的力。从轮毂辐射的花键腿优选携带一个或多个诊断或治疗元件，例如电极。优选地，基座以轮毂和底座之间的正常展开的几何形状约束花键腿的末端。

7. 发明授权

US06668198B2 Structures for supporting porous electrode elements 失效
公开(公告)号：US06668198B2
公开(公告)日：2003-12-23
申请号：US09996235
申请日：2001-11-27
申请人： David K Swanson , Russell B Thompson , Sidney D Fleischman , Dorin Panescu , James G Whayne
发明人： David K Swanson , Russell B Thompson , Sidney D Fleischman , Dorin Panescu , James G Whayne
IPC分类号： A61N100
CPC分类号： A61N1/06 , A61B18/1492 , A61B2018/00148 , A61B2018/00214
摘要： A catheter assembly comprising a elongated, flexible support structure having an axis. The assembly also includes an elongated porous electrode assembly carried by the support structure along the axis for contact with tissue. The elongated porous electrode assembly comprises a wall having an exterior peripherally surrounding an interior area, a lumen to convey a medium containing ions into the interior area, and an element coupling the medium within the interior area to a source of electrical energy. At least a portion of the wall comprising a porous material is sized to allow passage of ions contained in the medium to thereby enable ionic transport of electrical energy through the porous material to the exterior of the wall to form a continuous elongated lesion pattern in tissue contacted by the wall. The support structure can have a curvilinear geometry, e.g., a loop shape, and the elongated porous electrode assembly conforms to the curvilinear geometry.

8. 发明授权

US06197021B1 Systems and methods for controlling tissue ablation using multiple temperature sensing elements 失效
标题翻译：使用多个温度感测元件控制组织消融的系统和方法
公开(公告)号：US06197021B1
公开(公告)日：2001-03-06
申请号：US09154941
申请日：1998-09-17
申请人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
发明人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
IPC分类号： A61B1818
CPC分类号： A61B5/0422 , A61B5/6858 , A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61B18/20 , A61B2017/00088 , A61B2017/00092 , A61B2017/00154 , A61B2017/003 , A61B2018/00083 , A61B2018/00101 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00636 , A61B2018/0066 , A61B2018/0069 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00821 , A61B2018/124 , A61B2018/126 , A61B2018/128 , A61B2018/1435 , A61B2018/1467 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14
摘要： Systems and associated methods place a temperature sensing element in an “edge region” between an energy transmitting electrode and a non-electrically conducting support body, where higher temperatures are likely to exist. Reliable temperature sensing, which is sensitive to variations in temperatures along the electrode, results.
摘要翻译：系统和相关方法将温度感测元件置于能量传输电极和可能存在较高温度的非导电支撑体之间的“边缘区域”中。可靠的温度感测对电极温度的变化敏感。

9. 发明授权

US6076012A Structures for supporting porous electrode elements 失效
标题翻译：用于支撑多孔电极元件的结构
公开(公告)号：US6076012A
公开(公告)日：2000-06-13
申请号：US770572
申请日：1996-12-19
申请人： David K Swanson , Russell B Thompson , Sidney D Fleischman , Dorin Panescu , James G Whayne
发明人： David K Swanson , Russell B Thompson , Sidney D Fleischman , Dorin Panescu , James G Whayne
IPC分类号： A61B18/14 , A61N1/06 , A61N1/30 , A61N1/00 , A61B17/36
CPC分类号： A61N1/06 , A61B18/1492 , A61B2018/00148 , A61B2018/00214
摘要： A catheter assembly comprising a elongated, flexible support structure having an axis. The assembly also includes an elongated porous electrode assembly carried by the support structure along the axis for contact with tissue. The elongated porous electrode assembly comprises a wall having an exterior peripherally surrounding an interior area, a lumen to convey a medium containing ions into the interior area, and an element coupling the medium within the interior area to a source of electrical energy. At least a portion of the wall comprising a porous material is sized to allow passage of ions contained in the medium to thereby enable ionic transport of electrical energy through the porous material to the exterior of the wall to form a continuous elongated lesion pattern in tissue contacted by the wall. The support structure can have a curvilinear geometry, e.g., a loop shape, and the elongated porous electrode assembly conforms to the curvilinear geometry. The assembly also includes comprises a sheath carried by the support structure having a slot extending along the axis of the support structure, wherein the electrode assembly is adapted to bend outwardly through the slot.
摘要翻译：导管组件，其包括具有轴的细长的柔性支撑结构。组件还包括由支撑结构承载的细长多孔电极组件，沿着轴线与组织接触。细长的多孔电极组件包括具有周围围绕内部区域的外部的外壁，用于将含有离子的介质输送到内部区域的内腔，以及将内部区域内的介质耦合到电能源的元件。包含多孔材料的壁的至少一部分的尺寸设定成允许包含在介质中的离子通过，从而使得电能通过多孔材料离子传递到壁的外部，以在组织接触中形成连续的细长损伤图案在墙上。支撑结构可以具有曲线几何形状，例如环形，并且细长多孔电极组件符合曲线几何形状。组件还包括由支撑结构承载的护套，其具有沿着支撑结构的轴线延伸的槽，其中电极组件适于向外弯曲穿过槽。

10. 发明授权

US5810802A Systems and methods for controlling tissue ablation using multiple temperature sensing elements 失效
公开(公告)号：US5810802A
公开(公告)日：1998-09-22
申请号：US788782
申请日：1997-01-24
申请人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
发明人： Dorin Panescu , Sidney D. Fleischman , James G. Whayne , David K. Swanson
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/20 , A61L29/14 , A61L31/10 , A61L31/14 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B17/36
CPC分类号： A61B5/0422 , A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61B5/6858 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , A61B18/20 , A61B2017/00088 , A61B2017/00092 , A61B2017/00154 , A61B2017/003 , A61B2018/00083 , A61B2018/00101 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00636 , A61B2018/0066 , A61B2018/0069 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00821 , A61B2018/124 , A61B2018/126 , A61B2018/128 , A61B2018/1435 , A61B2018/1467
摘要： Systems and associated methods place a temperature sensing element in an "edge region" between an energy transmitting electrode and a non-electrically conducting support body, where higher temperatures are likely to exist. Reliable temperature sensing, which is sensitive to variations in temperatures along the electrode, results.

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