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1. 发明授权

US10112045B2 Implantable medical device fixation 有权
公开(公告)号：US10112045B2
公开(公告)日：2018-10-30
申请号：US13284761
申请日：2011-10-28
申请人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
发明人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
IPC分类号： A61B5/02 , A61N1/05 , A61N1/372 , A61N1/375 , A61N1/362
摘要： An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.

2. 发明申请

US20120172690A1 IMPLANTABLE MEDICAL DEVICE FIXATION 审中-公开
标题翻译：可植入医疗器械固定
公开(公告)号：US20120172690A1
公开(公告)日：2012-07-05
申请号：US13284761
申请日：2011-10-28
申请人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
发明人： Thomas A. Anderson , Douglas D. Nippoldt , Richard W. Swenson, III , Vladimir Grubac , Matthew D. Bonner , Raymond W. Usher , Arshad A. Alfoqaha
IPC分类号： A61B5/145 , A61B19/00 , A61N1/36 , A61N1/365 , A61B5/04 , A61N1/05
CPC分类号： A61N1/0573 , A61N1/362 , A61N1/37205 , A61N1/37518 , A61N1/3756
摘要： An assembly includes an implantable medical device (IMD) including a conductive housing, and a fixation element assembly attached to the IMD. The fixation element assembly includes a set of active fixation tines and an insulator to electrically isolate the set of active fixation tines from the conductive housing of the implantable medical device. The active fixation tines in the set are deployable from a spring-loaded position in which distal ends of the active fixation tines point away from the implantable medical device to a hooked position in which the active fixation tines bend back towards the implantable medical device. The active fixation tines are configured to secure the implantable medical device to a patient tissue when deployed while the distal ends of the active fixation tines are positioned adjacent to the patient tissue.
摘要翻译：组件包括可植入医疗装置（IMD），其包括导电外壳和连接到IMD的固定元件组件。固定元件组件包括一组主动固定齿和绝缘体，用于将一组主动固定齿与可植入医疗装置的导电外壳电隔离。组合中的主动固定齿可从弹簧加载位置展开，其中主动固定尖端的远端尖端远离可植入医疗装置指向钩状位置，在该位置，主动固定齿可向着可植入医疗装置弯回。主动固定齿构造成在展开时将可植入医疗装置固定到患者组织，同时活动固定齿的远端定位成与患者组织相邻。

3. 发明授权

US07294312B2 Test cartridge holder for blood samples 有权
标题翻译：用于血液样品的测试盒支架
公开(公告)号：US07294312B2
公开(公告)日：2007-11-13
申请号：US10371351
申请日：2003-02-20
申请人： Michael M. Green , Douglas D. Nippoldt , William D. Zillmann , Brent E. Wallace , Jeff N. Rejent
发明人： Michael M. Green , Douglas D. Nippoldt , William D. Zillmann , Brent E. Wallace , Jeff N. Rejent
IPC分类号： G01N1/10 , B01L9/00
CPC分类号： B01L9/00 , B01L3/0293 , B01L3/508 , B01L2200/026 , B01L2300/0654 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： Improved methods and apparatus that make more accurate and reduces risk of filling reaction chambers of cartridge cells with blood samples to conduct blood coagulation tests of the type employing the plunger technique are disclosed. A cartridge holder is provided that secures a test cartridge in a fixed upright position and deflects the plunger flag of each cartridge cell to enable manual insertion of a blood dispenser deeply into the reaction chamber to fill the reaction chamber and avoid contamination of surfaces of the cartridge outside the reaction chamber. Preferably, the cartridge holder provides illumination of the reaction chamber during filling, so that the user can judge when the reaction chamber is properly filled with blood dispensed from the blood dispenser. The cartridge holder may incorporate image magnification to facilitate viewing of the reaction chamber as it is filled.
摘要翻译：公开了改进的方法和装置，其使得更准确并降低了使用血液样品填充细胞的反应室的风险以进行使用柱塞技术的类型的凝血试验。提供了一种盒式存储器，其将测试盒固定在固定的直立位置，并使每个盒式电池的柱塞标志偏转，使得血液分配器可以深入人工插入反应室以填充反应室，并避免对盒的表面的污染在反应室外。优选地，盒保持器在填充期间提供反应室的照明，使得用户可以判断反应室何时被适当地填充从血液分配器分配的血液。墨盒保持器可以包括图像放大率以便于在填充反应室时观察反应室。

4. 发明授权

US08903497B2 Conformal antenna for implantable medical device and implantable medical device with such antenna 有权
标题翻译：用于可植入医疗设备的保形天线和具有这种天线的可植入医疗设备
公开(公告)号：US08903497B2
公开(公告)日：2014-12-02
申请号：US12895083
申请日：2010-09-30
申请人： Clark B. Norgaard , Michael W. Barror , Douglas D. Nippoldt , Tony A. Ulrich
发明人： Clark B. Norgaard , Michael W. Barror , Douglas D. Nippoldt , Tony A. Ulrich
IPC分类号： A61N1/372 , A61B5/00 , H01F5/02
CPC分类号： A61N1/37229 , A61B5/0031 , A61N1/37205 , H01F5/02 , Y10T29/49016
摘要： System and method for making an antenna. An implantable medical device has a housing, a bobbin and a coil. The housing has an interior generally tubular cross-section with a longitudinal axis, the housing having a lateral portion of a segment of the tubular cross-section along the longitudinal axis. The bobbin has a first side nearest to the interior of the housing and a second side opposite the first side. The coil, wound around the bobbin on a winding axis orthogonal to the longitudinal axis of the tubular cross-section, has a greater number of complete turns proximate the second side of the bobbin than proximate the first side of the bobbin, with the coil having a cross-sectional shape selected for a space between the bobbin and the interior of the housing in the lateral portion of the segment of the tubular cross-section along the longitudinal axis of the housing.
摘要翻译：制造天线的系统和方法。可植入医疗装置具有壳体，线轴和线圈。壳体具有内部具有纵向轴线的大致管状的横截面，壳体具有沿着纵向轴线的管状横截面的一部分的横向部分。线轴具有最靠近壳体内部的第一侧和与第一侧相对的第二侧。线圈缠绕在与管状横截面的纵向轴线正交的绕线轴上的线轴上，靠近线轴第二侧的完整匝数比靠近线轴的第一侧更多，线圈具有所述截面形状被选择为所述筒管和所述壳体内部之间的空间，所述横截面形状沿着所述壳体的纵向轴线在所述管状横截面的所述段的横向部分的横向部分中。

5. 发明授权

US07439069B2 Blood coagulation test cartridge, system, and method 失效
标题翻译：血液凝固试验盒，系统和方法
公开(公告)号：US07439069B2
公开(公告)日：2008-10-21
申请号：US11047026
申请日：2005-01-31
申请人： Douglas D. Nippoldt , Cynthia T. Clague , Daniel G. Ericson
发明人： Douglas D. Nippoldt , Cynthia T. Clague , Daniel G. Ericson
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/2575
摘要： A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood receptacle that is open to the atmosphere into which a blood sample is to be deposited, a vacuum port that is open to atmosphere, and a spiral capillary within the test cartridge having a capillary length and cross-section area, a first capillary end of the spiral capillary open to the blood receptacle and a second capillary end of the spiral capillary open to the vacuum port, whereby the spiral capillary is closed to atmosphere. When a blood sample is deposited in the blood receptacle, a vacuum is drawn through the vacuum port and the blood is drawn through the spiral capillary until coagulation occurs. A pressure change is detected, and the coagulation time is measured.
摘要翻译：公开了一种用于确定沉积在测试盒中的血液样品的凝固时间，例如凝血酶时间，PT，aPTT和ACT的系统和方法。测试盒包括对要沉积血液样本的大气开放的血液容器，对大气开放的真空端口以及具有毛细管长度和横截面面积的测试盒内的螺旋毛细管，螺旋毛细管的第一毛细管端部通向血液容器，并且螺旋毛细管的第二毛细管端部通向真空端口，由此螺旋毛细管关闭到大气。当血液样本沉积在血液容器中时，真空通过真空口抽出，血液通过螺旋毛细管吸入，直到发生凝血。检测到压力变化，并测量凝固时间。

6. 发明申请

US20090248126A1 Integrated Conductive Sensor Package Having Conductor Bypass, Distal Electrode, Distal Adapter and Custom Molded Overlay 有权
标题翻译：导体绕组，远端电极，远端适配器和定制模压叠层的集成导电传感器封装
公开(公告)号：US20090248126A1
公开(公告)日：2009-10-01
申请号：US12411124
申请日：2009-03-25
申请人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
发明人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
IPC分类号： A61N1/05 , A61B5/02 , B23P25/00
CPC分类号： A61N1/056 , A61B5/02158 , A61B5/042 , A61B2562/12 , A61N1/3702 , Y10T29/49982
摘要： This disclosure relates to implantable medical devices (IMDs); in particular, to medical electrical leads having an integrated sensor disposed in a hermetic package and said sensor package accommodates a torque coil and an elongated cable conductor extending therethrough. The integrated sensor can include a pressure sensor, an accelerometer, and the like. The coil and the cable can couple to pacing and sensing electrode coupled to the lead distal to the sensor package. The sensor package is compact, substantially circular in cross section and robust, in that the overall design promote mechanical stability.
摘要翻译：本公开涉及可植入医疗器械（IMD）; 具体地，涉及具有设置在密封包装中的集成传感器的医疗电引线，并且所述传感器封装容纳扭矩线圈和延伸穿过其中的细长电缆导体。集成传感器可以包括压力传感器，加速度计等。线圈和电缆可以耦合到起搏和感测电极，其耦合到远离传感器封装的引线。传感器封装紧凑，横截面基本圆形，坚固耐用，因为整体设计提升了机械稳定性。

7. 发明授权

US07422905B2 Blood coagulation test cartridge, system, and method 有权
标题翻译：血液凝固试验盒，系统和方法
公开(公告)号：US07422905B2
公开(公告)日：2008-09-09
申请号：US10826994
申请日：2004-04-19
申请人： Cynthia T. Clague , Daniel S. Cheek , Douglas D. Nippoldt
发明人： Cynthia T. Clague , Daniel S. Cheek , Douglas D. Nippoldt
IPC分类号： G01N33/86
CPC分类号： G01N11/162 , G01N11/14 , G01N15/042 , G01N15/05 , G01N33/4905 , G01N2015/0092 , Y10T436/111666
摘要： A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chamber pivot element and is provided with a cartridge port for introducing a test sample into the test chamber. Ferromagnetic agitator vane leaflets extend from an agitator pivot element supported by the test chamber pivot element intermediate the upper and lower major sides for rotational motion. The agitator vane leaflets can be swept, in response to an external magnetic field, through the test sample in the absence of coagulation. A timer is started when the agitator movement is commenced whereupon the agitator moves freely. Resistance to agitator movement due to coagulation is detected, and the coagulation time is measured.
摘要翻译：公开了一种用于确定沉积在测试盒中的测试样品的凝固时间（例如TT，PT，aPTT和ACT）的系统和方法。具有上下侧和下侧壁的盒壳体包围具有测试室枢转元件的测试室，并且设置有用于将测试样品引入测试室的盒端口。铁磁搅拌器叶片叶片从由测试室枢转元件支撑的搅拌器枢轴元件延伸，位于上，下三个主要侧面以用于旋转运动。在不存在凝结的情况下，搅拌器叶片叶片可以响应于外部磁场扫过测试样品。当搅拌器运动开始时，搅拌器自由移动，启动定时器。检测到由于凝结而产生的搅拌器运动阻力，测定凝固时间。

8. 发明授权

US08849424B2 Integrated conductive sensor package having conductor bypass, distal electrode, distal adapter and custom molded overlay 有权
标题翻译：具有导体旁路，远端电极，远端适配器和定制模制覆盖层的集成导电传感器封装
公开(公告)号：US08849424B2
公开(公告)日：2014-09-30
申请号：US12411124
申请日：2009-03-25
申请人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
发明人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
IPC分类号： A61N1/00 , A61N1/05 , A61B5/0215 , A61N1/37 , A61B5/042
CPC分类号： A61N1/056 , A61B5/02158 , A61B5/042 , A61B2562/12 , A61N1/3702 , Y10T29/49982
摘要： This disclosure relates to implantable medical devices (IMDs); in particular, to medical electrical leads having an integrated sensor disposed in a hermetic package and said sensor package accommodates a torque coil and an elongated cable conductor extending therethrough. The integrated sensor can include a pressure sensor, an accelerometer, and the like. The coil and the cable can couple to pacing and sensing electrode coupled to the lead distal to the sensor package. The sensor package is compact, substantially circular in cross section and robust, in that the overall design promote mechanical stability.
摘要翻译：本公开涉及可植入医疗器械（IMD）; 具体地，涉及具有设置在密封包装中的集成传感器的医疗电引线，并且所述传感器封装容纳扭矩线圈和延伸穿过其中的细长电缆导体。集成传感器可以包括压力传感器，加速度计等。线圈和电缆可以耦合到起搏和感测电极，其耦合到远离传感器封装的引线。传感器封装紧凑，横截面基本圆形，坚固耐用，因为整体设计提升了机械稳定性。

9. 发明申请

US20090248117A1 ROBUST HIGH POWER AND LOW POWER CARDIAC LEADS HAVING INTEGRATED SENSORS 审中-公开
标题翻译：具有集成传感器的稳定的高功率和低功率电源引线
公开(公告)号：US20090248117A1
公开(公告)日：2009-10-01
申请号：US12411058
申请日：2009-03-25
申请人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
发明人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
IPC分类号： A61N1/08 , A61N1/05
CPC分类号： A61N1/056 , A61B5/02152 , A61B5/02158 , A61B2562/0247 , A61B2562/187
摘要： A lead of an implantable medical device system having an elongated lead body and a sensor coupled to the lead body and extending from a proximal end to a distal end. The sensor includes a first portion extending from a top to a bottom, and from a proximal end to a distal end and a second portion engaged against the first portion and extending from a top to a bottom, the top of the second portion extending from a proximal end to a distal end. A first flange extends proximally relative to the proximal end of the top of the second portion to a first flange end, and a second flange extends distally relative to the distal end of the top of the second portion to a second flange end, wherein the first flange end is aligned with the proximal end of the first portion and the second flange end is aligned with the distal end of the first portion.
摘要翻译：可植入医疗装置系统的引线，其具有细长的引线主体和耦合到引线主体并从近端延伸到远端的传感器。传感器包括从顶部延伸到底部以及从近端延伸到远端的第一部分和与第一部分接合并且从顶部延伸到底部的第二部分，第二部分的顶部从近端到远端。第一凸缘相对于第二部分的顶部的近端向近侧延伸到第一凸缘端，并且第二凸缘相对于第二部分的顶部的远端向远侧延伸到第二凸缘端，其中第一凸缘凸缘端与第一部分的近端对准，第二凸缘端与第一部分的远端对准。

10. 发明申请

US20090248108A1 Robust High Power and Low Power Cardiac Leads Having Integrated Sensors 有权
标题翻译：具有集成传感器的强大功率和低功率心脏线索
公开(公告)号：US20090248108A1
公开(公告)日：2009-10-01
申请号：US12411082
申请日：2009-03-25
申请人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
发明人： Douglas D. Nippoldt , Thomas D. Brostrom , Richard J. O'Brien , Michael A. Schugt , Scott J. Davis , Yaling Fan
IPC分类号： A61N1/375 , A61N1/05
CPC分类号： A61N1/056 , A61B5/02152 , A61B5/02158 , A61B2562/0247 , A61B2562/187
摘要： A lead of an implantable medical device system having an elongated lead body, a sensor coupled to the lead body and extending from a proximal end to a distal end, and a distal lead adaptor having a first arm extending distally from the distal end of the sensor to a first arm end, a second arm extending distally from the distal end of the sensor to a second arm end, and a third arm extending between the first arm end and the second arm end, wherein the first arm, the second arm, and the third arm form an open portion.
摘要翻译：具有细长引线体的可植入医疗装置系统的引线，耦合到引线主体并从近端延伸到远端的传感器以及远端引线适配器，其具有从传感器的远端向远端延伸的第一臂到第一臂端，从传感器的远端向远端延伸到第二臂端的第二臂，以及在第一臂端和第二臂端之间延伸的第三臂，其中第一臂，第二臂和第三臂形成开放部分。

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