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1. 发明授权

US07422905B2 Blood coagulation test cartridge, system, and method 有权
标题翻译：血液凝固试验盒，系统和方法
公开(公告)号：US07422905B2
公开(公告)日：2008-09-09
申请号：US10826994
申请日：2004-04-19
申请人： Cynthia T. Clague , Daniel S. Cheek , Douglas D. Nippoldt
发明人： Cynthia T. Clague , Daniel S. Cheek , Douglas D. Nippoldt
IPC分类号： G01N33/86
CPC分类号： G01N11/162 , G01N11/14 , G01N15/042 , G01N15/05 , G01N33/4905 , G01N2015/0092 , Y10T436/111666
摘要： A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chamber pivot element and is provided with a cartridge port for introducing a test sample into the test chamber. Ferromagnetic agitator vane leaflets extend from an agitator pivot element supported by the test chamber pivot element intermediate the upper and lower major sides for rotational motion. The agitator vane leaflets can be swept, in response to an external magnetic field, through the test sample in the absence of coagulation. A timer is started when the agitator movement is commenced whereupon the agitator moves freely. Resistance to agitator movement due to coagulation is detected, and the coagulation time is measured.
摘要翻译：公开了一种用于确定沉积在测试盒中的测试样品的凝固时间（例如TT，PT，aPTT和ACT）的系统和方法。具有上下侧和下侧壁的盒壳体包围具有测试室枢转元件的测试室，并且设置有用于将测试样品引入测试室的盒端口。铁磁搅拌器叶片叶片从由测试室枢转元件支撑的搅拌器枢轴元件延伸，位于上，下三个主要侧面以用于旋转运动。在不存在凝结的情况下，搅拌器叶片叶片可以响应于外部磁场扫过测试样品。当搅拌器运动开始时，搅拌器自由移动，启动定时器。检测到由于凝结而产生的搅拌器运动阻力，测定凝固时间。

2. 发明授权

US07439069B2 Blood coagulation test cartridge, system, and method 失效
标题翻译：血液凝固试验盒，系统和方法
公开(公告)号：US07439069B2
公开(公告)日：2008-10-21
申请号：US11047026
申请日：2005-01-31
申请人： Douglas D. Nippoldt , Cynthia T. Clague , Daniel G. Ericson
发明人： Douglas D. Nippoldt , Cynthia T. Clague , Daniel G. Ericson
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/4905 , Y10T436/2575
摘要： A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood receptacle that is open to the atmosphere into which a blood sample is to be deposited, a vacuum port that is open to atmosphere, and a spiral capillary within the test cartridge having a capillary length and cross-section area, a first capillary end of the spiral capillary open to the blood receptacle and a second capillary end of the spiral capillary open to the vacuum port, whereby the spiral capillary is closed to atmosphere. When a blood sample is deposited in the blood receptacle, a vacuum is drawn through the vacuum port and the blood is drawn through the spiral capillary until coagulation occurs. A pressure change is detected, and the coagulation time is measured.
摘要翻译：公开了一种用于确定沉积在测试盒中的血液样品的凝固时间，例如凝血酶时间，PT，aPTT和ACT的系统和方法。测试盒包括对要沉积血液样本的大气开放的血液容器，对大气开放的真空端口以及具有毛细管长度和横截面面积的测试盒内的螺旋毛细管，螺旋毛细管的第一毛细管端部通向血液容器，并且螺旋毛细管的第二毛细管端部通向真空端口，由此螺旋毛细管关闭到大气。当血液样本沉积在血液容器中时，真空通过真空口抽出，血液通过螺旋毛细管吸入，直到发生凝血。检测到压力变化，并测量凝固时间。

3. 发明授权

US07909762B2 Vein harvesting system including dilator shaft and removable retractor housing 有权
标题翻译：静脉收获系统包括扩张器轴和可拆卸牵开器外壳
公开(公告)号：US07909762B2
公开(公告)日：2011-03-22
申请号：US11522866
申请日：2006-09-18
申请人： Raymond W. Usher , Cynthia T. Clague
发明人： Raymond W. Usher , Cynthia T. Clague
IPC分类号： A61B17/00
CPC分类号： A61B17/00008 , A61B2017/00778
摘要： The invention provides a system and method for harvesting a vessel section. The system comprises an endoscope, at least one harvesting tool, and an elongated instrument comprising a shaft and a housing. The shaft includes a viewable region along a length of the shaft and a lumen to slidably receive the endoscope. The housing is releasably engaged with the shaft and includes an elongated opening to provide a working area adjacent to a vessel for the harvesting tool. The method includes making an incision at a point corresponding to the proximal end of the vessel section to be harvested. A shaft is inserted through the incision and adjacent to the vessel section. A housing is slidably engaged with the inserted shaft. Harvesting operations are performed in a working area defined by sidewalls of the housing. The harvesting operations are visually monitored through the shaft.
摘要翻译：本发明提供了一种收集血管部分的系统和方法。该系统包括内窥镜，至少一个收获工具和包括轴和壳体的细长器械。轴包括沿着轴的长度的可视区域和可滑动地容纳内窥镜的内腔。壳体可释放地与轴接合并且包括细长的开口以提供与用于收获工具的容器相邻的工作区域。该方法包括在与要收获的血管部分的近端相对应的点处进行切口。轴穿过切口并与血管部分相邻。壳体与插入的轴可滑动地接合。在由壳体的侧壁限定的工作区域中进行收获操作。收割操作通过轴进行视觉监控。

4. 发明申请

US20080161843A1 Vessel support device and method of vessel harvesting 审中-公开
标题翻译：船舶支持装置和船舶采收方法
公开(公告)号：US20080161843A1
公开(公告)日：2008-07-03
申请号：US11974922
申请日：2007-10-16
申请人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
发明人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
IPC分类号： A61B17/32 , A61M5/00 , A61M31/00 , A61M5/178 , A61B19/00
CPC分类号： A61B17/32 , A61B17/00008 , A61B17/3205 , A61B17/32053 , A61B2017/320064
摘要： Embodiments of the invention provide a vessel support system and a method of vessel harvesting. The system can include a cutting device, a catheter adapted to be inserted into a section of the vessel in order to support the vessel as the cutting device is advanced over the vessel, and a cannula adapted to be coupled to the vessel and adapted to receive the catheter as the catheter is inserted into the section of the vessel. The method can include orienting a cutting device coaxially with the cannula and the catheter and advancing the cutting device over the cannula, the catheter, and the section of the vessel in order to core out the section of the vessel and a portion of the surrounding tissue.
摘要翻译：本发明的实施例提供了一种血管支持系统和血管收集方法。该系统可以包括切割装置，适于插入到容器的一部分中的导管，以便当切割装置前进在容器上时支撑容器，以及适于联接到容器并适于接收的套管作为导管的导管插入血管的部分。该方法可以包括将切割装置与套管和导管同轴定向，并将切割装置推进套管，导管和容器的部分，以便将血管的一部分和周围组织的一部分。

5. 发明申请

US20080161841A1 Cutting device and method of vessel harvesting 审中-公开
标题翻译：切割装置和采集方法
公开(公告)号：US20080161841A1
公开(公告)日：2008-07-03
申请号：US11974914
申请日：2007-10-16
申请人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
发明人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
IPC分类号： A61B17/3205
CPC分类号： A61B17/32 , A61B17/00008 , A61B17/3205 , A61B17/32053 , A61B2017/320064
摘要： Embodiments of the invention provide a cutting device and method of vessel harvesting. The cutting device can include at least one tubular member, a cutting element, and a centering member. The cutting device can include at least one tubular member with a flexible section and a cutting element. The method of vessel harvesting can include spacing a cutting element of the cutting device from the vessel as the cutting element is advanced over the vessel.
摘要翻译：本发明的实施例提供一种切割装置和容器收获方法。切割装置可以包括至少一个管状构件，切割元件和定心构件。切割装置可以包括具有柔性部分和切割元件的至少一个管状部件。当切割元件在容器上前进时，容器收集的方法可以包括将切割装置的切割元件与容器间隔开。

6. 发明授权

US07762951B2 Vein harvesting system including dilator shaft and removable retractor housing 有权
标题翻译：静脉收获系统包括扩张器轴和可拆卸牵开器外壳
公开(公告)号：US07762951B2
公开(公告)日：2010-07-27
申请号：US11147927
申请日：2005-06-08
申请人： Raymond W. Usher , Cynthia T. Clague
发明人： Raymond W. Usher , Cynthia T. Clague
IPC分类号： A61B1/32
CPC分类号： A61B17/00008 , A61B2017/00778
摘要： The invention provides a system and method for harvesting a vessel section. The system includes an endoscope, at least one harvesting tool, and an elongated instrument including a shaft and a housing. The shaft includes a viewable region along a length of the shaft and a lumen to slidably receive the endoscope. The housing is releasably engaged with the shaft and includes an elongated opening to provide a working area adjacent to a vessel for the harvesting tool. The method includes making an incision at a point corresponding to the proximal end of the vessel section to be harvested. A shaft is inserted through the incision and adjacent to the vessel section. A housing is slidably engaged with the inserted shaft. Harvesting operations are performed in a working area defined by sidewalls of the housing. The harvesting operations are visually monitored through the shaft.
摘要翻译：本发明提供了一种收集血管部分的系统和方法。该系统包括内窥镜，至少一个收获工具和包括轴和壳体的细长器械。轴包括沿着轴的长度的可视区域和可滑动地容纳内窥镜的内腔。壳体可释放地与轴接合并且包括细长的开口以提供与用于收获工具的容器相邻的工作区域。该方法包括在与要收获的血管部分的近端相对应的点处进行切口。轴穿过切口并与血管部分相邻。壳体与插入的轴可滑动地接合。在由壳体的侧壁限定的工作区域中进行收获操作。收割操作通过轴进行视觉监控。

7. 发明申请

US20100121362A1 VESSEL SUPPORT DEVICE AND METHOD OF VESSEL HARVESTING 审中-公开
标题翻译：船舶支持装置和船舶收集方法
公开(公告)号：US20100121362A1
公开(公告)日：2010-05-13
申请号：US12689357
申请日：2010-01-19
申请人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
发明人： Cynthia T. Clague , Michael J. Hobday , Raymond W. Usher , Roderick E. Briscoe , Katherine S. Olig , Ana R. Menk , Christopher P. Olig , Eric A. Meyer , Steven C. Christian , Thomas P. Daigle , Robert H. Reetz , Jeffrey D. Sandstrom , James R. Keogh , Matthew D. Bonner , Scott E. Jahns , Philip J. Haarstad
IPC分类号： A61B17/22 , A61M25/00
CPC分类号： A61B17/32 , A61B17/00008 , A61B17/3205 , A61B17/32053 , A61B2017/320064
摘要： Embodiments of the invention provide a vessel support system and a method of vessel harvesting. The system can include a cutting device, a catheter adapted to be inserted into a section of the vessel in order to support the vessel as the cutting device is advanced over the vessel, and a cannula adapted to be coupled to the vessel and adapted to receive the catheter as the catheter is inserted into the section of the vessel. The method can include orienting a cutting device coaxially with the cannula and the catheter and advancing the cutting device over the cannula, the catheter, and the section of the vessel in order to core out the section of the vessel and a portion of the surrounding tissue.
摘要翻译：本发明的实施例提供了一种血管支持系统和血管收集方法。该系统可以包括切割装置，适于插入到容器的一部分中的导管，以便当切割装置前进在容器上时支撑容器，以及适于联接到容器并适于接收的套管作为导管的导管插入血管的部分。该方法可以包括将切割装置与套管和导管同轴定向，并将切割装置推进套管，导管和容器的部分，以便将血管的一部分和周围组织的一部分。

8. 发明申请

US20090137900A1 Methods and Apparatus for Locating Body Vessels and Occlusions in Body Vessels 审中-公开
标题翻译：用于定位体内血管和闭塞的方法和装置
公开(公告)号：US20090137900A1
公开(公告)日：2009-05-28
申请号：US12362658
申请日：2009-01-30
申请人： Mathew D. Bonner , Cynthia T. Clague , Scott E. Jahns , James R. Keogh
发明人： Mathew D. Bonner , Cynthia T. Clague , Scott E. Jahns , James R. Keogh
IPC分类号： A61B5/05
CPC分类号： A61B5/06 , A61B5/062 , A61B2017/00022 , A61B2017/00243 , A61B2017/00252 , A61B2017/22001 , A61B2090/061
摘要： Methods and apparatus employed to locate body vessels and occlusions in body vessels finding particular utility in cardiac surgery, particularly minimally invasive cardiac surgery to locate cardiac arteries and occlusions in cardiac arteries are disclosed. An elongated vessel lumen probe incorporating a lumen probe element at or near the elongated vessel lumen probe distal end is advanced into the vessel lumen. A vessel surface probe manipulated by the surgeon and having a surface probe element sensor is employed to detect the lumen probe element and to follow the progress of the vessel lumen probe element as it approaches and is advanced through or is blocked by an occlusion. In the location of a coronary artery, the surface probe element sensor is moved about against the epicardium over the suspected location of the artery of interest until a surface probe element sensor of the present invention at the surface probe distal end interacts with the lumen probe element of the vessel lumen probe.
摘要翻译：公开了用于定位身体血管和身体血管闭塞的方法和装置，其在心脏手术中特别有用，特别是在心脏动脉中定位心脏动脉和闭塞的微创心脏手术。在细长血管腔探针末端处或其附近并入管腔探针元件的细长血管腔探针被推入血管内腔。由外科医生操作并具有表面探针元件传感器的血管表面探针被用于检测内窥镜元件，并且随着血管腔探针元件的进入而进入并被阻塞阻塞。在冠状动脉的位置，表面探针元件传感器在目标动脉的疑似位置上靠近心外膜移动，直到本发明的表面探针元件传感器在表面探针远端与内腔探针元件相互作用的血管腔探针。

9. 发明授权

US07189231B2 Electrosurgical methods and apparatus for making precise incisions in body vessels 有权
公开(公告)号：US07189231B2
公开(公告)日：2007-03-13
申请号：US10917755
申请日：2004-08-13
申请人： Cynthia T. Clague , Philip J. Haarstad , Scott E. Jahns , James R. Keogh , Christopher P. Olig , Raymond W. Usher
发明人： Cynthia T. Clague , Philip J. Haarstad , Scott E. Jahns , James R. Keogh , Christopher P. Olig , Raymond W. Usher
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B18/1482 , A61B2018/00386 , A61B2018/1407 , A61B2090/034 , A61B2090/036
摘要： Methods and apparatus employed in surgery involving making precise incisions in vessels of the body, particularly cardiac blood vessels in coronary revascularization procedures conducted on the stopped or beating heart are disclosed. Such incisions are created by applying an elongated electrosurgical cutting electrode to the outer surface of the vessel wall in substantially parallel alignment with the body vessel axis, the elongated electrosurgical cutting electrode having a predetermined cutting electrode length exceeding the cutting electrode width. RF energy is applied between the electrosurgical cutting electrode and the ground electrode at an energy level and for a duration sufficient to cut an elongated slit through the vessel wall where the elongated electrosurgical cutting electrode is applied to the surface of the vessel wall.

10. 发明授权

US5971023A Junction for shear sensitive biological fluid paths 失效
标题翻译：剪切敏感生物流体路径的结
公开(公告)号：US5971023A
公开(公告)日：1999-10-26
申请号：US800904
申请日：1997-02-12
申请人： Cynthia T. Clague , Frank D. Dorman , Robert C. Hamlen , Donald W. Hegeman, III , Timothy A. Miller , Joseph E. Poissant , Richard T. Stone , Michael P. Sullivan
发明人： Cynthia T. Clague , Frank D. Dorman , Robert C. Hamlen , Donald W. Hegeman, III , Timothy A. Miller , Joseph E. Poissant , Richard T. Stone , Michael P. Sullivan
IPC分类号： A61M5/142 , A61M1/10 , A61M39/10 , F15C1/16
CPC分类号： A61M39/10 , F04D29/428 , A61M1/101 , A61M2202/0413 , A61M2206/10 , Y10S415/90 , Y10T137/2104 , Y10T137/2109 , Y10T137/2115
摘要： A biological fluid transport device comprises a cutwater at the junction of at least two blood flow paths. The cutwater is substantially straight, substantially vertical, or both. At least one of the fluid paths may be tubular, and in some embodiments all of the fluid paths are tubular. The shear sensitive fluid may be, without limitation, blood, blood-based combinations, cell culture media, cell suspensions, proteins, and microcapsule suspensions. The device may be part of an extracorporeal circuit (e.g., blood during heart-lung bypass procedures or blood processing), but it need not be. Preferred embodiments of the device include, without limitation, kinetic pumps, mass transfer devices, filters, reservoirs, and heat exchangers.
摘要翻译：生物流体输送装置包括在至少两个血流路径的交界处的切割水。切割水基本上是直的，基本垂直的，或两者都是。流体路径中的至少一个可以是管状的，并且在一些实施例中，所有流体路径都是管状的。剪切敏感流体可以是但不限于血液，基于血液的组合，细胞培养基，细胞悬浮液，蛋白质和微胶囊悬浮液。该装置可以是体外循环的一部分（例如在心肺旁路手术或血液处理期间的血液），但是不需要。装置的优选实施例包括但不限于动力泵，传质装置，过滤器，储存器和热交换器。

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