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2. 发明申请

US20020134907A1 Polymer-based platform for microfluidic systems 有权
标题翻译：用于微流体系统的基于聚合物的平台
公开(公告)号：US20020134907A1
公开(公告)日：2002-09-26
申请号：US10107933
申请日：2002-03-26
申请人： The Regents of the University of California
发明人： William Benett , Peter Krulevitch , Mariam Maghribi , Julie Hamilton , Klint Rose , Amy W. Wang
IPC分类号： B29C033/40
CPC分类号： B29C39/10 , B29C33/3842 , B29C39/34 , B29K2083/00 , B29K2083/005 , B29L2031/24 , B29L2031/756
摘要： A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure. Microdevices may be embedded within the cast polymer-based platform, or bonded to the platform structure subsequent to molding, to create an integrated microfluidic system. In this manner, the new microfluidic platform is versatile and capable of quickly generating prototype systems, and could easily be adapted to a manufacturing setting.
摘要翻译：使用从一组可互连网络构建块（例如线，引脚，块和互连）中选择的网络构建块形成基于聚合物的微流体系统平台的方法。所选择的构建块可互连地组装并且固定地定位在模具框架的模腔中的精确位置中，以构建优选具有中尺度尺寸的微流体流路网络的三维模型构造。然后将可硬化液体（例如聚（二甲基硅氧烷））引入模腔中并硬化以形成平台结构以及模制具有通道，储存器和端口的微流体流路网络。预制的弯头，T型和其他接头用于将各种构件块元件相互连接起来。在将液体硬化之后，将构建块从平台结构上移除，以使平台结构内的通道，空腔和端口可用。微型设备可以嵌入在基于浇铸聚合物的平台内，或者在模制之后结合到平台结构，以形成集成的微流体系统。以这种方式，新的微流体平台是通用的，能够快速生成原型系统，并且可以容易地适应于制造设置。

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