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1. 发明申请

US20160103094A1 ELECTRO-DIFFUSION ENHANCED BIO-MOLECULE CHARGE DETECTION USING ELECTROSTATIC INTERACTION 有权
公开(公告)号：US20160103094A1
公开(公告)日：2016-04-14
申请号：US14884268
申请日：2015-10-15
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Yang Liu , Robert W. Dutton , Roger T. Howe
IPC分类号： G01N27/414
CPC分类号： G01N33/48721 , C12Q1/68 , G01N27/04 , G01N27/4145 , G01N27/44791 , G01N33/68
摘要： According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width that is not limited by the Debye screening length, along a surface of the substrate. A pair of reservoirs are included in or on the substrate and configured for containing and presenting a sample having bio-molecules for delivery in the channel. A pair of electrodes electrically couple a charge in the sample to enhance ionic current flow therein (e.g., to overcome the electrolyte screening), and a sense electrode is located along the channel for sensing a characteristic of the biological sample by using the electrostatic interaction between the enhanced ionic current flow of the sample and the sense electrode. Actual detection occurs by using a charge-signal processing circuit to process the sensed charge signal and, therefrom, provide an output indicative of a signature for the bio-molecules delivered in the channel.

2. 发明授权

US10385893B2 Electropermanent magnet activated microfluidic droplet size modulation 有权
公开(公告)号：US10385893B2
公开(公告)日：2019-08-20
申请号：US15281535
申请日：2016-09-30
申请人： The Board of Trustees of the Leland Stanford Junior University , Cairo University
发明人： Jose I. Padovani Blanco , Ali Mohamed Ibrahim , Yasser Hussein Anis , Stefanie S. Jeffrey , Roger T. Howe
IPC分类号： B01L3/00 , G01N1/10 , G01N1/18 , F15D1/02 , B01F13/00 , B01F3/08
摘要： An active microfluidic droplet generation device includes a droplet generation junction joining at least one continuous phase channel for carrying a ferrofluid, and a dispersed phase channel for carrying a dispersed phase (e.g., aqueous) flow. A miniature electropermanent magnet (EPM) upstream from the junction generates a magnetic field to modulate a flow rate of a ferrofluid in the continuous phase channel so that dispersed phase droplets are generated with volumes actively controlled on-demand and under continuous flow.

3. 发明授权

US09607815B2 Low work-function, mechanically and thermally robust emitter for thermionic energy converters 有权
公开(公告)号：US09607815B2
公开(公告)日：2017-03-28
申请号：US14485423
申请日：2014-09-12
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Jae Hyung Lee , Igor Bargatin , Bernard Vancil , Roger T. Howe
IPC分类号： H02N10/00 , H01J45/00
CPC分类号： H01J45/00
摘要： Improved thermionic energy converters are provided by electrodes that include a silicon carbide support structure, a tungsten adhesion layer disposed on the silicon carbide support structure, and an activation layer disposed on the tungsten adhesion layer. The activation layer is a material that lowers the electrode work function, such as BaO, SrO and/or CaO.

4. 发明申请

US20170074854A1 ELECTRO-DIFFUSION ENHANCED BIO-MOLECULE CHARGE DETECTION USING ELECTROSTATIC INTERACTION 有权
标题翻译：使用静电相互作用的电扩散增强的生物分子电荷检测
公开(公告)号：US20170074854A1
公开(公告)日：2017-03-16
申请号：US15271014
申请日：2016-09-20
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Yang Liu , Robert W. Dutton , Roger T. Howe
IPC分类号： G01N33/487 , G01N27/414 , G01N27/447
CPC分类号： G01N33/48721 , C12Q1/68 , G01N27/04 , G01N27/4145 , G01N27/44791 , G01N33/68
摘要： According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width that is not limited by the Debye screening length, along a surface of the substrate. A pair of reservoirs are included in or on the substrate and configured for containing and presenting a sample having bio-molecules for delivery in the channel. A pair of electrodes electrically couple a charge in the sample to enhance ionic current flow therein (e.g., to overcome the electrolyte screening), and a sense electrode is located along the channel for sensing a characteristic of the biological sample by using the electrostatic interaction between the enhanced ionic current flow of the sample and the sense electrode. Actual detection occurs by using a charge-signal processing circuit to process the sensed charge signal and, therefrom, provide an output indicative of a signature for the bio-molecules delivered in the channel.
摘要翻译：根据一个方面，本发明涉及一个示例性实施例，其中基于电路的布置包括基于电路的基板，其沿着基板的表面固定具有不受德拜屏蔽长度限制的有效宽度的通道。一对储存器包含在基底中或基底上，并且被配置为容纳和呈现具有用于在通道中递送的生物分子的样品。一对电极将样品中的电荷电耦合以增强其中的离子电流（例如，以克服电解质屏蔽），并且感测电极沿着通道定位，以通过使用样品和感应电极的增强的离子电流流动。通过使用电荷信号处理电路来处理所感测的电荷信号，从而提供指示在通道中递送的生物分子的签名的输出，发生实际检测。

5. 发明申请

US20150325419A1 Low Work-function, Mechanically and Thermally Robust Emitter for Thermionic Energy Converters 有权
标题翻译：用于热电能转换器的低功能，机械和热稳定发射器
公开(公告)号：US20150325419A1
公开(公告)日：2015-11-12
申请号：US14485423
申请日：2014-09-12
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Jae Hyung Lee , Igor Bargatin , Bernard Vancil , Roger T. Howe
IPC分类号： H01J45/00
CPC分类号： H01J45/00
摘要： Improved thermionic energy converters are provided by electrodes that include a silicon carbide support structure, a tungsten adhesion layer disposed on the silicon carbide support structure, and an activation layer disposed on the tungsten adhesion layer. The activation layer is a material that lowers the electrode work function, such as BaO, SrO and/or CaO.
摘要翻译：改进的热电子能量转换器由包括碳化硅支撑结构，设置在碳化硅支撑结构上的钨粘合层和设置在钨粘合层上的活化层的电极提供。活化层是降低电极功能的材料，例如BaO，SrO和/或CaO。

6. 发明授权

US11656192B2 Mesoscale system feedback-induced dissipation and noise suppression 有权
公开(公告)号：US11656192B2
公开(公告)日：2023-05-23
申请号：US17317422
申请日：2021-05-11
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Chaitanya Gupta , Ross M. Walker , Boris Murmann , Roger T. Howe
IPC分类号： G01N27/02 , G01N27/416 , G01N27/327 , G01N27/49
CPC分类号： G01N27/028 , G01N27/3273 , G01N27/416 , G01N27/49
摘要： A high-gain and low-noise negative feedback control (“feedback control”) system can detect charge transfer in quantum systems at room temperatures. The feedback control system can attenuate dissipative coupling between a quantum system and its thermodynamic environment. The feedback control system can be integrated with standard commercial voltage-impedance measurement system, for example, a potentiostat. In one aspect, the feedback control system includes a plurality of electrodes that are configured to electrically couple to a sample, and a feedback mechanism coupled to a first electrode of the plurality of electrodes. The feedback mechanism is configured to detect a potential associated with the sample via the first electrode. The feedback mechanism provides a feedback signal to the sample via a second electrode of the plurality of electrodes, the feedback signal is configured to provide excitation control of the sample at a third electrode of the plurality of electrode.

7. 发明授权

US11035810B2 Mesoscale system feedback-induced dissipation and noise suppression 有权
公开(公告)号：US11035810B2
公开(公告)日：2021-06-15
申请号：US16096893
申请日：2017-04-27
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Chaitanya Gupta , Ross M. Walker , Boris Murmann , Roger T. Howe
IPC分类号： G01N27/416 , G01N27/327 , G01N27/02 , G01N27/49
摘要： A high-gain and low-noise negative feedback control (“feedback control”) system can detect charge transfer in quantum systems at room temperatures. The feedback control system can attenuate dissipative coupling between a quantum system and its thermodynamic environment. The feedback control system can be integrated with standard commercial voltage-impedance measurement system, for example, a potentiostat. In one aspect, the feedback control system includes a plurality of electrodes that are configured to electrically couple to a sample, and a feedback mechanism coupled to a first electrode of the plurality of electrodes. The feedback mechanism is configured to detect a potential associated with the sample via the first electrode. The feedback mechanism provides a feedback signal to the sample via a second electrode of the plurality of electrodes, the feedback signal is configured to provide excitation control of the sample at a third electrode of the plurality of electrode.

8. 发明授权

US10585096B2 Methods and systems for orienting nanomaterials 有权
公开(公告)号：US10585096B2
公开(公告)日：2020-03-10
申请号：US15031793
申请日：2014-10-24
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Sam Emaminejad , Mehdi Javanmard , Chaitanya Gupta , Roger T. Howe
IPC分类号： G01N33/543
摘要： Embodiments of the present disclosure provide for systems of enhancing the signal to noise ratio, methods of orienting a nanomaterial (e.g., an antibody), methods of enhancing the signal to noise ratio in a system (e.g., an assay system), and the like.

9. 发明申请

US20140049135A1 MEMS-Based Integrated Inverter for Wafer-Scale Thermionic Energy Converter 有权
标题翻译：用于晶圆级热电转换器的基于MEMS的集成逆变器
公开(公告)号：US20140049135A1
公开(公告)日：2014-02-20
申请号：US13944570
申请日：2013-07-17
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Igor Bargatin , Roger T. Howe
IPC分类号： H02N3/00
CPC分类号： H02N3/00 , B81B3/0032
摘要： A thermionic energy converter is provided that includes an anode, a cathode, where the anode is disposed opposite the cathode, and a suspension, where a first end of the suspension is connected to the cathode and a second end of the suspension is connected to the anode, where the suspension moveably supports the cathode above the anode to form a variable gap between the anode and the cathode, where the variable gap is capable of enabling a variable thermionic current between the anode and the cathode, where the thermionic converter is capable of an AC power output.
摘要翻译：提供了一种热电子能量转换器，其包括阳极，阴极，其中阳极与阴极相对设置;以及悬架，其中悬架的第一端连接到阴极，并且悬架的第二端连接到阳极，其中悬架可移动地支撑阳极上方的阴极以在阳极和阴极之间形成可变间隙，其中可变间隙能够实现阳极和阴极之间的可变热离子电流，其中热离子转换器能够交流电源输出。

10. 发明申请

US20210341404A1 MESOSCALE SYSTEM FEEDBACK-INDUCED DISSIPATION AND NOISE SUPPRESSION 有权
公开(公告)号：US20210341404A1
公开(公告)日：2021-11-04
申请号：US17317422
申请日：2021-05-11
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Chaitanya Gupta , Ross M. Walker , Boris Murmann , Roger T. Howe
IPC分类号： G01N27/02 , G01N27/327 , G01N27/416 , G01N27/49
摘要： A high-gain and low-noise negative feedback control (“feedback control”) system can detect charge transfer in quantum systems at room temperatures. The feedback control system can attenuate dissipative coupling between a quantum system and its thermodynamic environment. The feedback control system can be integrated with standard commercial voltage-impedance measurement system, for example, a potentiostat. In one aspect, the feedback control system includes a plurality of electrodes that are configured to electrically couple to a sample, and a feedback mechanism coupled to a first electrode of the plurality of electrodes. The feedback mechanism is configured to detect a potential associated with the sample via the first electrode. The feedback mechanism provides a feedback signal to the sample via a second electrode of the plurality of electrodes, the feedback signal is configured to provide excitation control of the sample at a third electrode of the plurality of electrode.

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