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1. 发明申请

US20070254013A1 Medical Material and Process for Producing the Same 审中-公开
标题翻译：医疗材料及其生产工艺
公开(公告)号：US20070254013A1
公开(公告)日：2007-11-01
申请号：US10588309
申请日：2005-02-01
申请人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Kazuo Tsubota , Naoshi Shinozaki , Shigeto Shimmura , Hideyuki Miyashita
发明人： Tetsushi Taguchi , Hisatoshi Kobayashi , Junzo Tanaka , Kazuo Tsubota , Naoshi Shinozaki , Shigeto Shimmura , Hideyuki Miyashita
IPC分类号： A61F2/14
CPC分类号： A61L27/3804 , A61L27/3604 , A61L27/3641 , A61L27/3687 , A61L27/3839 , A61L2430/16
摘要： [Object] A medical material that improves therapeutic effects in epithelial cells such as keratoconjunctival epithelial cells with the use of an amnion, and a process for producing the same are provided. [Solving Means] A medical material includes an amnion, which is a placental tissue, a polymer film bonded to one surface of the amnion and crosslinked, and cells adhered to the other surface of the amnion. A process for producing the medical material includes the steps of preparing an amnion from which the spongy layer is removed, bonding a biocompatible polymer film to one surface of the amnion followed by crosslinking, adhering epithelial stem cells to the other surface of the amnion, and proliferating epithelial cells from the epithelial stem cells on the surface of the amnion.
摘要翻译：提供了一种使用羊膜改善上皮细胞如角膜结膜上皮细胞治疗效果的医疗材料及其制造方法。 [解决方案]药物材料包括羊膜，羊膜组织，与羊膜的一个表面结合并交联的聚合物膜，以及附着在羊膜的另一表面的细胞。制造医疗材料的方法包括以下步骤：制备从其中除去海绵层的羊膜，将生物相容性聚合物膜粘合到羊膜的一个表面，然后交联，将上皮干细胞粘附到羊膜的另一个表面，以及从羊膜表面的上皮干细胞增殖上皮细胞。

2. 发明申请

US20090047738A1 FEEDER CELL DERIVED FROM TISSUE STEM CELL 审中-公开
标题翻译：从组织干细胞衍生的饲养细胞
公开(公告)号：US20090047738A1
公开(公告)日：2009-02-19
申请号：US12162905
申请日：2007-01-17
申请人： Shigeto Shimmura , Hideyuki Miyashita , Satoru Yoshida , Kazuo Tsubota
发明人： Shigeto Shimmura , Hideyuki Miyashita , Satoru Yoshida , Kazuo Tsubota
IPC分类号： C12N5/02 , C12N5/06 , C12N5/08
CPC分类号： A61K35/28 , A61K35/12 , A61K35/36 , A61K35/44 , C12N5/0621 , C12N5/0623 , C12N5/0656 , C12N2500/25 , C12N2501/11 , C12N2501/39 , C12N2501/81 , C12N2502/03 , C12N2502/08 , C12N2506/08 , C12N2509/00 , C12N2533/56
摘要： It is an object of the present invention to provide a feeder cell with less variation in quality. The present invention relates to a feeder cell derived from a tissue stem and/or progenitor cell. A method of preparation of the feeder cell, a method of preparation of a cultured cell using the feeder cell, and a cell culturing kit are also provided.
摘要翻译：本发明的目的是提供一种质量变化较小的饲养池。本发明涉及源于组织干和/或祖细胞的饲养细胞。还提供了饲养细胞的制备方法，使用饲养细胞的培养细胞的制备方法和细胞培养试剂盒。

3. 发明申请

US20140018416A1 THERAPEUTIC AGENT FOR CORNEAL SENSORY NERVE DAMAGE CONTAINING SEMAPHORIN INHIBITOR AS ACTIVE INGREDIENT 审中-公开
标题翻译：含有作为活性成分的印度尼西亚抑制剂的角膜感觉神经损伤的治疗剂
公开(公告)号：US20140018416A1
公开(公告)日：2014-01-16
申请号：US14001333
申请日：2012-02-23
申请人： Hideyuki Okano , Kazuo Tsubota , Shigeto Shimmura , Masahiro Omoto , Akiyoshi Kishino , Miho Maeda
发明人： Hideyuki Okano , Kazuo Tsubota , Shigeto Shimmura , Masahiro Omoto , Akiyoshi Kishino , Miho Maeda
IPC分类号： C07D311/86
CPC分类号： C07D311/86 , A61K31/352
摘要： A compound represented by formula (1), or a pharmaceutically acceptable salt thereof is effective as a therapeutic agent or a prophylactic agent for a corneal disease or sensory nerve damage due to corneal surgery, and as a regeneration accelerator for corneal sensory nerves: wherein R1 represents a hydrogen atom or a carboxyl group, R2 represents a hydrogen atom or a hydroxy group, R3 represents a hydrogen atom or a carboxyl group, and R4 represents a hydrogen atom or a hydroxy group.
摘要翻译：由式（1）表示的化合物或其药学上可接受的盐作为用于角膜手术的角膜疾病或感觉神经损伤的治疗剂或预防剂，作为角膜感觉神经的再生促进剂是有效的：其中R1 表示氢原子或羧基，R2表示氢原子或羟基，R3表示氢原子或羧基，R4表示氢原子或羟基。

4. 发明申请

US20080255474A1 TEAR MENISCUS TEST DEVICE AND ITS MANUFACTURING METHOD 审中-公开
标题翻译： TEAR MENISCUS测试设备及其制造方法
公开(公告)号：US20080255474A1
公开(公告)日：2008-10-16
申请号：US12099215
申请日：2008-04-08
申请人： Katsushi Ishida , Kazuo Tsubota
发明人： Katsushi Ishida , Kazuo Tsubota
IPC分类号： A61B3/10 , B32B38/04
CPC分类号： A61B5/4514 , A61B3/101 , A61B10/0045 , A61B2010/0006 , A61B2010/0067 , A61B2090/3937 , G01N33/52 , Y10T156/1054
摘要： A tear meniscus test device 1 includes a body part 2 having a elongated shape, which comprises a synthetic resin material or a synthetic rubber material, wherein a groove 3 is formed along the length direction of the elongated shape, and a water absorbing member 4 arranged in the groove 3.
摘要翻译：撕裂弯液面测试装置1包括具有细长形状的主体部分2，其包括合成树脂材料或合成橡胶材料，其中沿着细长形状的长度方向形成有槽3，以及布置成在凹槽3中。

5. 发明申请

US20060188410A1 Sample fluid collecting device 审中-公开
标题翻译：样品流体收集装置
公开(公告)号：US20060188410A1
公开(公告)日：2006-08-24
申请号：US11350700
申请日：2006-02-09
申请人： Katsushi Ishida , Kazuo Tsubota
发明人： Katsushi Ishida , Kazuo Tsubota
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , A61B5/14532 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B10/0051 , A61B10/0064 , A61B2010/0067 , B01L3/021 , B01L2300/028 , B01L2300/0663 , B01L2300/0825 , B01L2300/0838 , B01L2400/0481
摘要： A sample fluid collecting device includes a capillary tube for collecting a sample fluid; and an air reservoir portion 5 having an air hole 10 capable of being closed, which is located at one end of the capillary tube, the capillary tube being formed by two or more supporting members 2, 3 arranged with one or more gap portions 1 being provided in the lengthwise direction; and at least two transparent films 6, 9 lapped on the supporting members 2, 3 so as to cover the gap portion 1.
摘要翻译：样品流体收集装置包括用于收集样品流体的毛细管; 以及位于毛细管的一端的具有能够封闭的通气孔10的储气部5，毛细管由两个以上配置有一个以上间隙部1的支撑部件2,3形成，沿长度方向设置; 并且至少两个透明膜6,9重叠在支撑构件2,3上，以覆盖间隙部分1。

6. 发明授权

US5795912A Therapeutic composition for corneal impairment 失效
标题翻译：角膜损伤的治疗组合物
公开(公告)号：US5795912A
公开(公告)日：1998-08-18
申请号：US815511
申请日：1997-03-12
申请人： Kazuo Tsubota
发明人： Kazuo Tsubota
IPC分类号： A61K31/665 , A61K31/355
CPC分类号： A61K31/683 , A61K31/665 , Y10S514/912
摘要： This invention provides a therapeutic composition for corneal impairment which comprises a phosphoric acid diester compound of the following formula or a pharmacologically acceptable salt thereof, ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a methyl group. The therapeutic composition of this invention is useful for the treatment of electricity-related ophthalmia, snow-related ophthalmia, corneal lesions caused by contact lens wearing, and corneal impairment associated with hypolacrimia.
摘要翻译：本发明提供了一种角膜损伤治疗组合物，其包含下式的磷酸二酯化合物或其药理学上可接受的盐，其中R 1和R 2相同或不同，各自表示氢原子或甲基。本发明的治疗组合物可用于治疗电相关性眼炎，雪相关性眼炎，由隐形眼镜佩戴引起的角膜损伤和与hypolacrimia相关的角膜损伤。

7. 发明申请

US20070008492A1 Method and apparatus for measuring operating visual acuity 有权
标题翻译：用于测量手术视力的方法和装置
公开(公告)号：US20070008492A1
公开(公告)日：2007-01-11
申请号：US11482845
申请日：2006-07-07
申请人： Minako Kaido , Kazuo Tsubota
发明人： Minako Kaido , Kazuo Tsubota
IPC分类号： A61B3/02
CPC分类号： A61B3/028 , A61B3/032
摘要： The present invention provides a method and apparatus for measuring operating vision. An optotype mark is displayed (step 103). A subject's response to the optotype mark is accepted via an input device (step 104). A determination is made as to whether or not the response is correct (step 105). When the current response of the subject is correct and the previous response or one of the previous response and the last-but-one response is incorrect, an optotype mark corresponding to the same visual acuity is presented (step 112). When the previous response is correct or both the previous response and the last-but-one response are correct, an optotype mark corresponding to a visual acuity one level higher is presented (step 110). When the current response is incorrect, an optotype mark corresponding to a visual acuity one level lower is presented (step 111).
摘要翻译：本发明提供了一种用于测量操作视觉的方法和装置。显示视标标记（步骤103）。受试者对视标标记的响应通过输入装置被接受（步骤104）。确定响应是否正确（步骤105）。当对象的当前响应是正确的，并且先前的响应或先前的响应和最后一个响应中的一个不正确时，呈现对应于相同视力的视标（步骤112）。当先前的响应是正确的或者先前的响应和最后一个响应都是正确的时，呈现对应于一个级别更高的视敏度的视标标记（步骤110）。当电流响应不正确时，呈现对应于一级视觉敏锐度的视标标记（步骤111）。

8. 发明授权

US5467442A Image processing apparatus 失效
标题翻译：图像处理装置
公开(公告)号：US5467442A
公开(公告)日：1995-11-14
申请号：US128285
申请日：1993-09-29
申请人： Kazuo Tsubota , Syouichi Tahata
发明人： Kazuo Tsubota , Syouichi Tahata
IPC分类号： G06T15/40 , G06F15/00
CPC分类号： G06T15/40
摘要： In an image processing apparatus, a plurality of different images are displayed simultaneously on a display screen. According to a first feature, a priority circuit determines a display order of images for each dot, the images being supplied from a variety of image generators. In accordance with the priority order, the images are displayed on a screen. According to a second feature, an image processing apparatus includes a register for specifying a key area to be displayed as being transparent. A plurality of images are synthesized in accordance with the data held in the register. According to a third feature, a video display processor (VDP) processes color data of an image to be displayed, and a video encoder unit synthesizes a plurality of images in a predetermined order of a display priority by a cellophane function. The cellophane function is controlled to be turned on and off for each unit of a predetermined data block.
摘要翻译：在图像处理装置中，在显示画面上同时显示多个不同的图像。根据第一特征，优先电路确定每个点的图像的显示顺序，所述图像是从各种图像生成器提供的。按照优先顺序，图像显示在屏幕上。根据第二特征，图像处理装置包括用于指定要显示为透明的关键区域的寄存器。根据保存在寄存器中的数据合成多个图像。根据第三特征，视频显示处理器（VDP）处理要显示的图像的颜色数据，并且视频编码器单元通过玻璃纸功能以预定的显示优先级顺序合成多个图像。玻璃纸功能被控制为预定数据块的每个单元被打开和关闭。

9. 发明授权

US08770743B2 Eyewear 有权
标题翻译：眼镜
公开(公告)号：US08770743B2
公开(公告)日：2014-07-08
申请号：US13299357
申请日：2011-11-18
申请人： Kazuo Tsubota , Hitoshi Tanaka
发明人： Kazuo Tsubota , Hitoshi Tanaka
IPC分类号： G02C11/00 , G02C5/00
CPC分类号： G02C5/001 , A61F9/0008 , G02C11/00
摘要： Eyewear comprising a frame and a liquid storage portion that is disposed within the frame and that includes a cavity for storing liquid. The liquid storage portion includes a gas passing section that allows gas to pass therethrough from the cavity to an inside surface of the frame, which is a surface facing a head of a wearer when the frame is worn on the head, but does not allow liquid to pass therethrough from the cavity to the inside surface of the frame. The liquid storage portion may be disposed such that an outer surface of the liquid storage portion is further inside the frame than an outer surface of the frame.
摘要翻译：眼镜包括框架和液体储存部分，其设置在框架内并且包括用于储存液体的空腔。液体储存部分包括气体通过部分，其允许气体从腔体通过到框架的内表面，该框架是当框架佩戴在头部上时面向佩戴者头部的表面，但不允许液体从腔中通过到框架的内表面。液体储存部可以布置成使得液体存储部分的外表面在框架内部比框架的外表面更进一步。

10. 发明申请

US20130245119A1 THERAPEUTIC OR PROPHYLACTIC AGENT FOR CORNEAL EPITHELIUM DISORDERS AND/OR CONJUNCTIVAL EPITHELIUM DISORDERS 审中-公开
标题翻译：角膜上皮病和/或连续上皮疾病的治疗剂或预防剂
公开(公告)号：US20130245119A1
公开(公告)日：2013-09-19
申请号：US13885826
申请日：2011-11-18
申请人： Akiko Harauma , Fuminori Kawabata , Toru Moriguchi , Tetsuya Kawakita , Kazuo Tsubota
发明人： Akiko Harauma , Fuminori Kawabata , Toru Moriguchi , Tetsuya Kawakita , Kazuo Tsubota
IPC分类号： A61K31/202
CPC分类号： A61K31/202 , A61K9/0053 , A61K31/20 , A61K31/232 , A61K31/661 , A61K35/60 , A61K35/612
摘要： The present invention provides an effective and safe prophylactic and therapeutic pharmaceutical agent and supplement for corneal epithelium disorders and/or conjunctival epithelial disorders. This is a therapeutic and/or prophylactic agent for corneal epithelium disorders and/or conjunctival epithelial disorders comprising eicosapentaenoic acid and/or docosahexaenoic acid, a glycerin ester or phospholipid comprising these fatty acids as constituent fatty acids, or a lower alcohol ester of these fatty acids as active ingredients. These preferably comprise EPA and/or DHA in the form of a refined fish oil or refined krill oil. A total of at least approximately 50 to 5,000 mg of EPA and/or DHA or the esters thereof are taken daily, thereby easing corneal epithelium disorders and/or conjunctival epithelial disorders. In addition, the amount of tears may be recovered.
摘要翻译：本发明提供了一种有效和安全的预防和治疗药剂以及角膜上皮病和/或结膜上皮疾病的补充剂。这是包含二十碳五烯酸和/或二十二碳六烯酸的角膜上皮细胞病和/或结膜上皮病症的治疗和/或预防剂，包含这些脂肪酸作为构成脂肪酸的甘油酯或磷脂，或这些脂肪酸的低级醇酯酸作为活性成分。这些优选包含精制鱼油或精制磷虾油形式的EPA和/或DHA。每天服用至少约50至5,000mg的EPA和/或DHA或其酯，从而缓解角膜上皮病和/或结膜上皮病。此外，眼泪量可以恢复。

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