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1. 发明授权

US4330527A Wound treatment agent 失效
标题翻译：伤口治疗剂
公开(公告)号：US4330527A
公开(公告)日：1982-05-18
申请号：US93530
申请日：1979-11-13
申请人： Teruo Arima , Kenji Machii , Nobumoto Chikazawa , Tetsuya Takeuchi , Setsuro Fujii
发明人： Teruo Arima , Kenji Machii , Nobumoto Chikazawa , Tetsuya Takeuchi , Setsuro Fujii
IPC分类号： A61K38/45 , A61K37/48
CPC分类号： A61K38/45 , Y10S435/824
摘要： A new wound treatment agent which contains as an effective ingredient a fraction containing nucleoside phosphotransferase produced by a nucleoside phosphotransferase producing bacterium belonging to the genus Clostridium, solely or in combination with zinc oxide.
摘要翻译：一种新的伤口治疗剂，其单独或与氧化锌组合，其中含有由属于梭菌属的核苷磷酸转移酶产生细菌产生的含有核苷磷酸转移酶的级分作为有效成分。

2. 发明授权

US4604234A Protein having cell growth stimulating action, composition thereof and method for producing the same 失效
标题翻译：具有细胞生长刺激作用的蛋白质，其组合物及其制备方法
公开(公告)号：US4604234A
公开(公告)日：1986-08-05
申请号：US584335
申请日：1984-02-28
申请人： Setsuro Fujii , Nobumoto Chikazawa , Teruo Arima , Masakazu Fukushima
发明人： Setsuro Fujii , Nobumoto Chikazawa , Teruo Arima , Masakazu Fukushima
IPC分类号： C12P21/00 , A61K31/714 , A61K33/30 , A61K35/74 , A61K38/00 , A61P1/04 , A61P1/16 , A61P17/00 , A61P43/00 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/28 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/41 , C12R1/01 , C12R1/07 , C12R1/125 , C12R1/145 , C12R1/15 , C12R1/185 , C12R1/19 , C12R1/20 , C12R1/37 , C12R1/38 , C12R1/42 , C12R1/425 , C12R1/43 , C12R1/44 , C12R1/445 , C12R1/45 , C12R1/46 , C07K15/04 , A61K37/00
CPC分类号： C07K14/34 , A61K33/30 , C07K14/195 , C07K14/21 , C07K14/212 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/28 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , A61K38/00 , Y10S435/823 , Y10S435/839 , Y10S435/842 , Y10S435/843 , Y10S435/849 , Y10S435/879 , Y10S435/88 , Y10S435/884 , Y10S435/885
摘要： A protein effective in stimulating cell growth activity. The protein has a molecular weight of from 5,000 to about 160,000, is composed predominantly of neutral and acidic amino acids, contains a significant amount of glutamic acid and aspartic acid, and is substantially free of nucleoside phosphotransferase. The protein is useful as wound treatment agent and as promoting agent in the synthesis of DNA. A method of producing the protein and compositions containing the same are also disclosed.
摘要翻译：有效刺激细胞生长活性的蛋白质。该蛋白质具有5,000至约160,000的分子量，主要由中性和酸性氨基酸组成，含有显着量的谷氨酸和天冬氨酸，并且基本上不含核苷磷酸转移酶。该蛋白质可用作伤口治疗剂，并用作DNA合成中的促进剂。还公开了生产蛋白质的方法和含有该蛋白质的组合物。

3. 发明授权

US4550076A Rapid assaying method for guanase 失效
标题翻译： guanase快速检测方法
公开(公告)号：US4550076A
公开(公告)日：1985-10-29
申请号：US424182
申请日：1982-09-27
申请人： Nobumoto Chikazawa , Toshiharu Muraoka , Setsuro Fujii
发明人： Nobumoto Chikazawa , Toshiharu Muraoka , Setsuro Fujii
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/34
CPC分类号： C12Q1/28 , C12Q1/34 , G01N2333/978
摘要： The guanase activity in body fluids such as blood serum can be rapidly and accurately assayed by (I) decomposing guanine with the guanase in the specimen to xanthine and ammonia at pH 7-9, preferably at pH 8, (II) decomposing the xanthine formed by former step I with xanthine oxidase to uric acid and hydrogen peroxide, (III) reacting the reactant solution of the former step II with 3-methyl-2-benzothiazolinonehydrazone, an aniline derivative such as N,N-di-lower-alkylaniline and peroxidase, and finally measuring the optical absorption of the reactant solution of the step III at 570-600 nm. The all steps can be completed within 15 minutes. Therefore, this assay is adoptable for automatic assay of guanase on usual clinically available automatic analyzers.
摘要翻译：通过（I）将样品中的鸟嘌呤分解为黄嘌呤和氨，pH7-9，优选pH8，（II）分解形成的黄嘌呤的鸟嘌呤，可快速准确地测定体液如血清中的鸟苷酸活性通过前一步骤I将黄嘌呤氧化酶与尿酸和过氧化氢反应，（III）使前一步骤II的反应物溶液与3-甲基-2-苯并噻唑酮腙，苯胺衍生物如N，N-二低级烷基苯胺和过氧化物酶，最后在570-600nm测量步骤III的反应物溶液的光吸收。所有步骤可在15分钟内完成。因此，该测定法可用于通常临床可用的自动分析仪上的鸟苷酸的自动测定。

4. 发明授权

US4788141A Automatic analyzer for guanase activity 失效
标题翻译：自动分析仪进行鸟类活动
公开(公告)号：US4788141A
公开(公告)日：1988-11-29
申请号：US078009
申请日：1987-07-24
申请人： Seiichiro Yamasaki , Setsuro Fujii , Isao Nakagawa , Nobumoto Chikazawa , Toshiharu Muraoka
发明人： Seiichiro Yamasaki , Setsuro Fujii , Isao Nakagawa , Nobumoto Chikazawa , Toshiharu Muraoka
IPC分类号： G01J5/60 , A61K35/14 , C12Q1/34 , G01N33/483 , G01N33/80 , G01N35/04
CPC分类号： C12Q1/34 , G01N2333/978
摘要： An automatic analyzer comprising a plurality of sample containers for accommodating different blood samples individually, specific sample container moving means, a plurality of reagent containers for accommodating at least a reagent for an assay of guanase activity, a specific reagent container holding means, a plurality of reaction containers, specific reaction container moving means, specific sample pouring means, specific cleaning vessels, specific stirring means, specific measuring means, specific cleaning means, a specific analog-digital converter, specific counting-calculating means, a specific display means, and specific operation control means, so that the display means produces a signal for excluding the measured blood sample corresponding to a display value when the display value is above a predetermined reference value of guanase activity.
摘要翻译：一种自动分析装置，其特征在于，包括分别容纳不同的血液样本的多个检体容器，特定的检体容器移动机构，至少容纳用于检测动物活动的试剂的多个试剂容器，特定试剂容器保持机构，反应容器，特定反应容器移动装置，特定的样品注入装置，特定的清洁容器，特定的搅拌装置，特定的测量装置，特定的清洁装置，特定的模拟数字转换器，特定的计数计算装置，特定的显示装置和特定的操作控制装置，使得当显示值高于动画活动的预定参考值时，显示装置产生用于排除与显示值相对应的测量血样的信号。

5. 发明授权

US5162305A Polypeptide derivatives 失效
标题翻译：多肽衍生物
公开(公告)号：US5162305A
公开(公告)日：1992-11-10
申请号：US314018
申请日：1989-02-23
申请人： Setsuro Fujii , Yoshihito Yamamoto , Fumio Shimizu , Masatoshi Inai , Mitsuru Hirohashi
发明人： Setsuro Fujii , Yoshihito Yamamoto , Fumio Shimizu , Masatoshi Inai , Mitsuru Hirohashi
IPC分类号： A61K38/23 , A61K38/00 , A61P5/12 , C07K7/06 , C07K14/575 , C07K14/585
CPC分类号： C07K14/585 , A61K38/00
摘要： Novel synthetic polypeptide derivatives, i.e., novel calcitonin derivatives, having improved basic physiological activities of the corresponding natural calcitonins, i.e., the activity for lowering the blood level of calcium, the activity as an analgesic, as well as the activity for inhibiting the secretion of the gastric juice. Thus these synthetic calcitonins are effective as agents for curing hypercalcemia, analgetic agents, anti-ulcerative agents and the like.

6. 发明授权

US5047521A 5-fluorouracil derivatives 失效
标题翻译： 5-氟尿嘧啶衍生物
公开(公告)号：US5047521A
公开(公告)日：1991-09-10
申请号：US150407
申请日：1988-02-09
申请人： Setsuro Fujii , Mitsuru Hirohashi , Yoshihito Yamamoto , Yutaka Kojima
发明人： Setsuro Fujii , Mitsuru Hirohashi , Yoshihito Yamamoto , Yutaka Kojima
IPC分类号： A61K31/505 , A61K31/70 , C07D239/54 , C07D239/553 , C07D401/12 , C07D409/06 , C07D409/14 , C07H19/06 , C07H19/073 , H01S4/00
CPC分类号： C07D239/553 , C07D401/12 , C07D409/14 , C07H19/06
摘要： This invention relates to a novel 5-fluorouracil derivative represented by the formula ##STR1## wherein R.sup.y is a hydrogen atom or a specific acyl group, Z is a phenyl-lower alkoxy-lower alkyl group, thienyl-lower alkyl group optionally substituted with halogen atom on the thienyl ring, or a group ##STR2## wherein R.sup.1 and R.sup.2 are each a hydrogen atom, a specific acyl group, phenyl-lower alkyl group having a group R.sup.x OCO-- on the phenyl ring, or a group --(A).sub.n B, R.sup.x being a specific organic group, A being a lower alkylene group, n being 0 or 1, and B being a 5- or 6-membered unsaturated heterocyclic group having 1 to 4 hetero-atoms selected from N, O and S and optionally having a benzene ring, naphthalene ring or pyridine ring condensed therewith, with the proviso that R.sup.1 and R.sup.2 are not hydrogen atoms or specific acyl groups at the same time; to a process for preparing the same; and to an anticancer composition comprising the same as an effective ingredient.
摘要翻译： PCT No.PCT / JP87 / 00275 Sec。 371日期1988年2月9日 102（e）1988年2月9日PCT PCT公开1987年4月30日PCT公布。公开号WO87 / 06582 日本公开日：1987年11月5日。本发明涉及由式（1）表示的新型5-氟尿嘧啶衍生物，其中R y为氢原子或特定酰基，Z为苯基 - 低级烷氧基 - 低级烷基任选被噻吩基环上的卤素原子取代的噻吩基 - 低级烷基，或其中R 1和R 2各自为氢原子，特定酰基，具有基团R xOCO-的苯基 - 低级烷基基团环，或基团 - （A）nB，Rx是特定的有机基团，A是低级亚烷基，n是0或1，B是具有1〜4个杂原子的5或6元不饱和杂环基，选自N，O和S且任选具有苯环的原子，萘环或与其缩合的吡啶环，条件是R1和R2不同时为氢原子或特定酰基; 一个制备它的过程; 以及包含其作为有效成分的抗癌组合物。

7. 发明授权

US4652570A Anti-cancer composition for delivering 5-fluorouracil 失效
标题翻译：用于递送5-氟尿嘧啶的抗癌组合物
公开(公告)号：US4652570A
公开(公告)日：1987-03-24
申请号：US645165
申请日：1984-08-28
申请人： Setsuro Fujii , Norio Unemi , Setsuo Takeda
发明人： Setsuro Fujii , Norio Unemi , Setsuo Takeda
IPC分类号： A61K31/505 , C07D239/54 , C07D239/553
CPC分类号： C07D239/553 , A61K31/505 , Y10S514/922
摘要： An anti-cancer composition for treating cancers sensitive to 5-fluorouracil therapy in warm-blooded animals, comprising 5-fluorouracil and uracil.
摘要翻译：一种用于治疗温血动物中对5-氟尿嘧啶治疗敏感的癌症的抗癌组合物，其包含5-氟尿嘧啶和尿嘧啶。

8. 发明授权

US4570006A Amidine compound, process for producing same and anti-complement agent comprising same 失效
标题翻译：脒化合物，其制备方法和包含其的抗补体剂
公开(公告)号：US4570006A
公开(公告)日：1986-02-11
申请号：US664261
申请日：1984-10-24
申请人： Setsuro Fujii , Takashi Yaegashi , Toyoo Nakayama , Yojiro Sakurai , Shigeki Nunomura , Toshiyuki Okutome
发明人： Setsuro Fujii , Takashi Yaegashi , Toyoo Nakayama , Yojiro Sakurai , Shigeki Nunomura , Toshiyuki Okutome
IPC分类号： A61K31/155 , A61K31/215 , A61K31/24 , C07C45/54 , C07C271/06 , C07C271/22 , C07C279/18 , C07C335/22 , C07D317/68 , C07C119/00 , A61K31/22 , A61K31/235
CPC分类号： C07C255/00 , C07C271/22 , C07C279/18 , C07C335/22 , C07C45/54 , C07D317/68
摘要： Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsine, anti-plasmin, anti-kallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)R.sub.1 --COOH (II)with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof. ##STR2##
摘要翻译：由式（I）表示的脒基化合物及其药学上可接受的酸加成盐是新型化合物，可用作强抗胰蛋白酶，抗纤溶酶，抗激肽释放酶和抗凝血酶剂。具有强大的抗Cl（Cl＆upbar＆r，Cl＆upbar＆s）活性和抗补体活性，它们也可用作抗补体剂。这些脒基化合物通过通式（II）R 1 -COOH（II）表示的羧酸化合物与脒基苯酚化合物（III）的酯化反应制备，如果需要，可以将其转化为其药学上可接受的酸加成盐。（三）

9. 发明授权

US4532255A Amidine compounds and anticomplement agent comprising same 失效
标题翻译：脒化合物和包含其的抗补体剂
公开(公告)号：US4532255A
公开(公告)日：1985-07-30
申请号：US572269
申请日：1984-01-20
申请人： Setsuro Fujii , Toshiyuki Okutome , Toyoo Nakayama , Takashi Yaegashi , Masateru Kurumi
发明人： Setsuro Fujii , Toshiyuki Okutome , Toyoo Nakayama , Takashi Yaegashi , Masateru Kurumi
IPC分类号： C07C249/02 , A61K31/155 , C07C257/18 , C07C279/18 , C07D317/68 , C07C101/00 , A61K31/34 , C07C101/48
CPC分类号： C07D317/68 , C07C279/18
摘要： Amidino compounds represented by the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and antithrombin agents. Having strong anti-C1 (C1r, C1s) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula ##STR2## with 6-amidino-2-naphthol and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof.

10. 发明授权

US4514416A Amidine compound, process for producing same and anti-complement agent comprising same 失效
标题翻译：脒化合物，其制备方法和包含其的抗补体剂
公开(公告)号：US4514416A
公开(公告)日：1985-04-30
申请号：US611937
申请日：1984-05-21
申请人： Setsuro Fujii , Takashi Yaegashi , Toyoo Nakayama , Yojiro Sakurai , Shigeki Nunomura , Toshiyuki Okutome
发明人： Setsuro Fujii , Takashi Yaegashi , Toyoo Nakayama , Yojiro Sakurai , Shigeki Nunomura , Toshiyuki Okutome
IPC分类号： A61K31/155 , A61K31/215 , A61K31/24 , C07C45/54 , C07C271/06 , C07C271/22 , C07C279/18 , C07C335/22 , C07D317/68 , C07C119/00 , A61K31/22 , A61K31/235
CPC分类号： C07C255/00 , C07C271/22 , C07C279/18 , C07C335/22 , C07C45/54 , C07D317/68
摘要： Amidino compounds represented by the formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful antitrypsine, antiplasmin, antikallikrein and anti-thrombin agents. Having strong anti-Cl (Clr, Cls) activities and an anticomplement activity, they are also useful as anticomplement agents. These amidino compounds are prepared by usual esterification of carboxylic acid compounds represented by the formula (II)R.sub.1 --COOH (II)with amidinophenol compound (III) and, if necessary, can be transformed into pharmaceutically acceptable acid addition salts thereof. ##STR2##
摘要翻译：由式（I）表示的脒基化合物及其药学上可接受的酸加成盐是新的化合物，可用作强效的抗胰蛋白酶，抗血纤维蛋白酶，抗激肽释放酶和抗凝血酶剂。具有强大的抗Cl（Cl＆upbar＆r，Cl＆upbar＆s）活性和抗补体活性，它们也可用作抗补体剂。这些脒基化合物通过通式（II）R 1 -COOH（II）表示的羧酸化合物与脒基苯酚化合物（III）的酯化反应制备，如果需要，可以将其转化为其药学上可接受的酸加成盐。（三）

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