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1. 发明授权

US5254766A Process for producing alkyl-substituted aromatic hydrocarbon using heteropolyacid salts 失效
标题翻译：使用杂多酸盐生产烷基取代芳烃的方法
公开(公告)号：US5254766A
公开(公告)日：1993-10-19
申请号：US773264
申请日：1991-10-09
申请人： Terunori Fujita , Kazunori Takahata , Hiroyasu Ohno , Masayasu Ishibashi , Hideo Oikawa
发明人： Terunori Fujita , Kazunori Takahata , Hiroyasu Ohno , Masayasu Ishibashi , Hideo Oikawa
IPC分类号： C07C2/70
CPC分类号： C07C2/70 , C07C2527/18
摘要： A process for producing an alkyl-substituted aromatic hydrocarbon, which comprises alkylating an aromatic hydrocarbon with an alkylating agent in the presence of a heteropoly-acid or a salt thereof such as phosphorus tungstate and silicon tungstate as a catalyst. The process is particularly useful for preparing alkyl-substituted naphthalene or naphthalene derivatives.

2. 发明授权

US5068455A 3-(2-hydroperoxy-2-propyl)phenol and method of producing resorcinol using the same 失效
标题翻译： 3-（2-羟基-2-丙醛）酚及其使用方法
公开(公告)号：US5068455A
公开(公告)日：1991-11-26
申请号：US578206
申请日：1990-09-06
申请人： Kiyotaka Yorozu , Hiroyasu Ohno
发明人： Kiyotaka Yorozu , Hiroyasu Ohno
IPC分类号： C07C37/08 , C07C39/08 , C07C409/08
CPC分类号： C07C409/08 , C07C37/08
摘要： There is provided a novel organic hydroperoxide, 3-(2-hydroperoxy-2-propyl)phenol. The hydroperoxide is produced by oxidizing 3-(2-hydroxy-2-propyl)phenol or m-isopropenylphenol with hydrogen peroxide in the presence of an acid catalyst.There is further provided a method of producing resorcinol which comprises decomposing the 3-(2-hydroperoxy-2-propyl)phenol in the presence of an acid catalyst.

3. 发明授权

US06872858B2 Diphenol and process for producing the same 有权
标题翻译：二苯酚及其制备方法
公开(公告)号：US06872858B2
公开(公告)日：2005-03-29
申请号：US10467187
申请日：2002-02-07
申请人： Kouji Muragaki , Tadashi Hiramine , Hiroyasu Ohno
发明人： Kouji Muragaki , Tadashi Hiramine , Hiroyasu Ohno
IPC分类号： C07C37/06 , C07C37/52 , C07C39/15 , C07C39/17 , C07C39/23 , C07L39/12
CPC分类号： C07C39/23 , C07C37/003 , C07C37/06 , C07C37/20 , C07C37/52 , C07C39/15 , C07C39/17 , C07C2601/14 , C07C2601/16
摘要： The invention provides a diphenol represented by the general formula (I) wherein X is a divalent cyclic hydrocarbon group selected from 1-cyclohexene-1,4-ylene group, 1,4-cyclohexylene group and p-phenylene group, R is an alkyl group of 1-4 carbon atoms, n is 0 or an integer of 1-3 when X is 1-cyclohexene-1,4-ylene group and an integer of 1-3 when X is 1,4-cyclohexylene group or p-phenylene group. The invention further provides a process for the production of the same.
摘要翻译：本发明提供由通式（I）表示的二酚，其中X为选自1-环己烯-1,4-亚基，1,4-亚环己基和对亚苯基的二价环状烃基，R为烷基 1-4个碳原子的基团，当X是1-环己烯-1,4-亚基时，n是0或1-3的整数，当X是1,4-亚环己基或对 - 亚苯基。本发明还提供了一种制备该方法的方法。

4. 发明授权

US5565609A Method of purifying aromatic dicarboxylic acids 失效
标题翻译：芳香族二羧酸的纯化方法
公开(公告)号：US5565609A
公开(公告)日：1996-10-15
申请号：US313184
申请日：1994-11-22
申请人： Noriyuki Hirowatari , Hiroyasu Ohno , Kenji Shimamoto
发明人： Noriyuki Hirowatari , Hiroyasu Ohno , Kenji Shimamoto
IPC分类号： C07C51/487 , C07C51/42
CPC分类号： C07C51/487
摘要： There is provided a method of purifying a crude aromatic dicarboxylic acid which comprises purifying an aqueous solution of an organic amine salt of the crude aromatic dicarboxylic acid, and then thermally decomposing the organic amine salt whereby to recover the thus highly purified aromatic dicarboxylic acid.
摘要翻译： PCT No.PCT / JP94 / 00197 Sec。 371日期：1994年11月22日 102（e）1994年11月22日PCT PCT 1994年2月9日PCT公布。 WO94 / 18152 PCT公开号日本1994年8月18日提供了一种纯化粗芳族二羧酸的方法，其包括纯化粗芳族二羧酸的有机胺盐水溶液，然后热分解有机胺盐，由此回收如此高纯度芳族二羧酸。

5. 发明授权

US4959368A Therapeutic agent for neurological diseases 失效
标题翻译：神经系统疾病治疗剂
公开(公告)号：US4959368A
公开(公告)日：1990-09-25
申请号：US130533
申请日：1987-10-22
申请人： Akira Awaya , Takuo Nakano , Hisashi Kobayashi , Ken E. Tan , Kazutoshi Horikomi , Tadayuki Sasaki , Keiichi Yokoyama , Hiroyasu Ohno , Kozi Kato , Takumi Kitahara , Ikuo Tomino , Shigeru Isayama
发明人： Akira Awaya , Takuo Nakano , Hisashi Kobayashi , Ken E. Tan , Kazutoshi Horikomi , Tadayuki Sasaki , Keiichi Yokoyama , Hiroyasu Ohno , Kozi Kato , Takumi Kitahara , Ikuo Tomino , Shigeru Isayama
IPC分类号： A61K31/505 , A61K31/506 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/70 , C07D239/84 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
CPC分类号： C07D239/42 , A61K31/505 , A61K31/506 , C07D239/47 , C07D239/48 , C07D239/70 , C07D239/84 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04
摘要： A pharmaceutical composition comprising a pyrimidine represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom, an acyl group having 2 to 4 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms, an alkoxycarbonylmethyl group having 3 to 5 carbon atoms, a 3,4-dimethoxybenzoyl group or a 3,4-methylenedioxybenzyl group,R.sup.2 represents a hydrogen atom, an amino group, a monoalkylamino group having 1 to 4 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an alkoxycarbonyl group having 2 to 4 carbon atoms,R.sup.3 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 4 carbon atoms, a dialkylaminocarbonyl group having 1 to 9 carbon atoms in each alkyl moiety, an alkoxy group having 1 to 5 carbon atoms, or a hydroxyethyl group, R.sup.2 and R.sup.3, together with the carbon atoms to which they are bonded, may form a 5- to 7-membered carbocyclic ring or a heterocyclic ring having N, O or S as the hetero atom, and R.sup.4 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkylthio group having 1 to 4 carbon atoms,or a pharmaceutically acceptable salt thereof. The above active compound has activities of promoting growth of nerve cells, forming neurites, and restoring motor functions, and is useful as an agent for treating diseases of peripheral and central nerves.

6. 发明授权

US4734418A Quinazoline compounds and antihypertensives 失效
标题翻译：喹唑啉化合物和抗高血压药
公开(公告)号：US4734418A
公开(公告)日：1988-03-29
申请号：US805905
申请日：1985-12-06
申请人： Keiichi Yokoyama , Koji Kato , Takumi Kitahara , Hiroyasu Ohno , Takashi Nishina , Mikio Kumakura , Akira Awaya , Takuo Nakano , Kazuyuki Watanabe , Sakae Saruta
发明人： Keiichi Yokoyama , Koji Kato , Takumi Kitahara , Hiroyasu Ohno , Takashi Nishina , Mikio Kumakura , Akira Awaya , Takuo Nakano , Kazuyuki Watanabe , Sakae Saruta
IPC分类号： C07D239/95 , C07D401/12 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/55 , A61K31/505 , C07D401/04 , C07D403/14
CPC分类号： C07D401/12 , C07D239/95 , C07D471/04 , C07D487/04 , C07D495/04
摘要： Disclosed herein is an antihypertensive preparation containing, as an active component, a novel quinazoline derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sup.100 means a hydrogen atom or methoxy group, R.sup.200 and R.sup.300 denote individually a hydrogen atom or lower alkoxy group, R.sup.400 is a hydrogen atom or amino group, l stands for 2 or 3, and Het is a specific hetero ring group.
摘要翻译：本文公开了一种抗高血压制剂，其含有作为活性成分的由以下通式表示的新型喹唑啉衍生物或其盐：其中R100表示氢原子或甲氧基，R200和R300分别表示氢原子或低级烷氧基，R400为氢原子或氨基，l为2或3，Het为特定的杂环基。

7. 发明授权

US5475157A Process for producing aromatic hydroxylic compound 失效
标题翻译：制备芳香族羟基化合物的方法
公开(公告)号：US5475157A
公开(公告)日：1995-12-12
申请号：US256245
申请日：1994-09-02
申请人： Shintaro Araki , Hiroshi Iwasaki , Hiroyasu Ohno , Isao Hashimoto , Teruaki Mukaiyama
发明人： Shintaro Araki , Hiroshi Iwasaki , Hiroyasu Ohno , Isao Hashimoto , Teruaki Mukaiyama
IPC分类号： C07C37/08 , C07C45/53
CPC分类号： C07C37/08 , Y02P20/52
摘要： There is disclosed a process for producing an aromatic hydroxylic compound by acid decomposition of a hydroperoxide having the general formula (I) ##STR1## wherein Ar represents an aromatic hydrocarbon group having a valence of n; and n represents an integer of 1 or 2, in the presence of an acid catalyst, thereby to provide an aromatic hydroxylic compound having the general formula (II)Ar--(OH)n (II)wherein Ar and n are the same as above defined, characterized in that tetrafluoroboric acid, hexafluorosilicic acid or hexafluorophosphoric acid is used as the acid catalyst. According to this process, the aromatic hydroxylic compound is obtained in a high yield while the by-production of hydroxyacetone is effectively suppressed. In paricular, a more effective suppression of by-production of hydroxyacetone and a higher yield of the target compound can be achieved by carrying out the acid decomposition reaction in two stages wherein the first stage of the reaction is carried out in the first reactor at a temperature of 50.degree.-95.degree. C., the resultant reaction mixture is sent to the second reactor, and the second stage of the reaction is then carried out in the second reactor at a temperature of 80.degree.-120.degree. C.
摘要翻译： PCT No.PCT / JP93 / 01586 Sec。 371日期：1994年9月2日 102（e）1994年9月2日PCT 1993年11月1日PCT公布。公开号WO94 / 10115 PCT 日本公报1994年5月11日。公开了通过酸分解具有通式（I）c的化合价n为n的烃基的氢过氧化物制备芳族羟基化合物的方法。并且n表示1或2的整数，在酸催化剂的存在下，由此提供具有通式（II）的Ar-（OH）n（II）的芳族羟基化合物，其中Ar和n与上述相同其特征在于使用四氟硼酸，六氟硅酸或六氟磷酸作为酸催化剂。根据该方法，以高产率获得芳族羟基化合物，同时有效抑制羟基丙酮的副产物。在这种情况下，可以通过在两个阶段中进行酸分解反应来实现对羟基丙酮的副产物的更有效抑制和目标化合物的较高产率，其中反应的第一阶段在第一反应器中以温度为50-95℃，将所得反应混合物送至第二反应器，然后在第二反应器中在80-120℃的温度下进行第二阶段反应。

8. 发明授权

US5030767A 3-(2-hydroperoxy-2-propyl)phenol and method of producing resorcinol using the same 失效
标题翻译： 3-（2-氢过氧-2-丙基）苯酚和使用其制备间苯二酚的方法
公开(公告)号：US5030767A
公开(公告)日：1991-07-09
申请号：US305185
申请日：1989-02-02
申请人： Kiyotaka Yorozu , Hiroyasu Ohno
发明人： Kiyotaka Yorozu , Hiroyasu Ohno
IPC分类号： C07C37/08 , C07C39/08 , C07C409/08
CPC分类号： C07C409/08 , C07C37/08
摘要： There is provided a novel organic hydroperoxide, 3-(2-hydroperoxy-2-propyl)phenol. The hydroperoxide is produced by oxidizing 3-(2-hydroxy-2-propyl)phenol or m-isopropenylphenol with hydrogen peroxide in the presence of an acid catalyst.There is further provided a method of producing resorcinol which comprises decomposing the 3-(2-hydroperoxy-2-propyl)phenol in the presence of an acid catalyst.

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