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    • 5. 发明申请
    • FIBROSIS INHIBITOR
    • 纤维蛋白酶抑制剂
    • US20110015211A1
    • 2011-01-20
    • US12919885
    • 2009-02-26
    • Koji MurakamiTakuya Toramoto
    • Koji MurakamiTakuya Toramoto
    • A61K31/4965C07D241/20A61P35/00A61P17/02A61P25/28A61P13/12A61P1/18A61P19/00
    • C07D241/20A61K31/4965
    • [Object] The main object of the present invention is to provide a fibrosis inhibitor.[Solving Means] The present invention relates to a fibrosis inhibitor containing the heterocyclic derivative represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an active ingredient; In the formula (1), R1 and R2 are the same or different and each represents an optionally substituted aryl; R3 and R4 are the same or different and each represents hydrogen atom or alkyl; R5 represents hydrogen atom, alkyl or halogen atom; Y represents N or N→O; A represents NR6, and R6 represents hydrogen atom, alkyl, etc.; D represents alkylene or alkenylene which is optionally substituted with hydroxy; E represents phenylene or a single bond; G represents O, S, etc.; and Q represents carboxy, alkoxycarbonyl, etc.
    • 本发明的主要目的在于提供纤维化抑制剂。 本发明涉及含有下述通式(1)表示的杂环衍生物或其药学上可接受的盐作为有效成分的纤维化抑制剂。 在式(1)中,R 1和R 2相同或不同,表示任选取代的芳基; R3和R4相同或不同,各自表示氢原子或烷基; R5代表氢原子,烷基或卤素原子; Y表示N或N→O; A表示NR6,R6表示氢原子,烷基等; D表示任选被羟基取代的亚烷基或亚烯基; E表示亚苯基或单键; G代表O,S等; Q表示羧基,烷氧基羰基等。
    • 10. 发明授权
    • N-benzyldioxothiazolidylbenzamide derivatives and process for producing
the same
    • N-苄基二氧代噻唑烷基苯甲酰胺衍生物及其制造方法
    • US6147101A
    • 2000-11-14
    • US482268
    • 2000-01-13
    • Toshio MaedaMasahiro NomuraKatsuya AwanoSusumu KinoshitaHiroya SatohKoji MurakamiMasaki Tsunoda
    • Toshio MaedaMasahiro NomuraKatsuya AwanoSusumu KinoshitaHiroya SatohKoji MurakamiMasaki Tsunoda
    • C07D277/34C07D417/12A61K31/426
    • C07D417/12C07D277/34
    • The present invention provides novel N-benzyldioxothiazolidylbenzamide derivatives that improve the insulin resistance and have potent hypoglycemic and lipid-lowering effects and processes for preparing the same, and relates to N-benzyldioxothiazolidylbenzamide derivatives characterized by being represented by a general formula (1) ##STR1## [wherein R.sup.1 and R.sup.2 denote identically or differently hydrogen atoms, lower alkyl groups with carbon atoms of 1 to 4, lower alkoxy groups with carbon atoms of 1 to 3, lower haloalkyl groups with carbon atoms of 1 to 3, lower haloalkoxy groups with carbon atoms of 1 to 3, halogen atoms, hydroxyl groups, nitro groups, amino groups which may be substituted with lower alkyl group(s) with carbon atoms of 1 to 3 or hetero rings, or R.sup.1 and R.sup.2 link to form a methylenedioxy group, R.sup.3 denotes a lower alkoxy group with carbon atoms of 1 to 3, hydroxyl group or halogen atom, and dotted line indicates double bond or single bond in combination with solid line], and processes for preparing the same.
    • 本发明提供了改善胰岛素抵抗并具有强效降血糖和降脂作用的新型N-苄基二硫代噻唑烷基苯甲酰胺衍生物及其制备方法,涉及以通式(1)表示的N-苄基二硫代噻唑烷基苯甲酰胺衍生物[其中 R1和R2表示相同或不同的氢原子,碳原子数为1〜4的低级烷基,碳原子数1〜3的低级烷氧基,碳原子数1〜3的低级卤代烷基,碳原子数为1〜 1至3,卤素原子,羟基,硝基,可被具有1至3个碳原子的低级烷基取代的氨基或杂环,或R 1和R 2连接形成亚甲二氧基,R 3表示 碳原子数为1〜3的低级烷氧基,羟基或卤素原子,虚线表示双键或单键与实线组合],工序 准备相同。