
基本信息:
- 专利标题: Novel Cyclic Amino Benzoic Acid Derivative
- 专利标题(中):新型环状氨基苯甲酸衍生物
- 申请号:US11659854 申请日:2005-08-11
- 公开(公告)号:US20070249580A1 公开(公告)日:2007-10-25
- 发明人: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Takehiro Shinozaki , Shigeki Isogai , Koji Murakami
- 申请人: Masahiro Nomura , Yasuo Takano , Kazuhiro Yumoto , Takehiro Shinozaki , Shigeki Isogai , Koji Murakami
- 优先权: JP2004-234603 20040811
- 国际申请: PCT/JP05/14718 WO 20050811
- 主分类号: A61K31/426
- IPC分类号: A61K31/426 ; A61K31/445 ; A61K31/5375 ; A61K31/55 ; A61P3/10 ; C07D211/36 ; C07D223/00 ; C07D277/02 ; C07D413/00
摘要:
The present invention relates to cyclic amino benzoic acid derivatives which are effective in therapy of lipid metabolism abnormality, diabetes and the like as a human peroxisome proliferators-activated receptor (PPAR) agonist, in particular, as an agonist against human PPARα isoform, and addition salts thereof, and pharmaceutical compositions containing these compounds. A cyclic amino benzoic acid derivative represented by the general formula (1) [wherein a ring Ar represents an aryl group which may have substituent, or the like; Y represents a C1-C4 alkylene, C2-C4 alkenylene, C2-C4 alkynylene, or the like; Z represents an oxygen atom, sulfur atom or —(CH2)n— (n represents 0, 1 or 2); X represents a hydrogen atom, halogen atom, lower alkyl group which may be substituted with a halogen atom, or the like; R represents a hydrogen atom or lower alkyl group, and —COOR substitutes for an ortho position or metha position of binding position of ring W] or a pharmaceutically acceptable salt thereof.
摘要(中):
本发明涉及作为人类过氧化物酶体增殖物激活受体(PPAR)激动剂的脂质代谢异常的治疗有效的环状氨基苯甲酸衍生物,特别是作为对人PPARα同种型的激动剂的添加 其盐,以及含有这些化合物的药物组合物。 由通式(1)表示的环状氨基苯甲酸衍生物[其中环Ar表示可具有取代基的芳基等; Y表示C 1 -C 4亚烷基,C 2 -C 4亚烯基,C 2 C 3 -C 4亚炔基等; Z表示氧原子,硫原子或 - (CH 2 CH 2)n - (n表示0,1或2)。 X表示氢原子,卤素原子,可被卤素原子取代的低级烷基等; R代表氢原子或低级烷基,-COOR代替环W的结合位置的邻位或甲基位置]或其药学上可接受的盐。
公开/授权文献:
- US07902367B2 Cyclic amino benzoic acid derivative 公开/授权日:2011-03-08
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K31/00 | 含有机有效成分的医药配制品 |
--------A61K31/33 | .杂环化合物 |
----------A61K31/335 | ..仅有氧作为环杂原子的,例如制霉色基素 |
------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的,例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
--------------A61K31/425 | ....噻唑 |
----------------A61K31/426 | .....1,3噻唑 |