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1. 发明授权

US07273702B2 Apparatus for purifying nucleic acid and method of purifying nucleic acid 有权
标题翻译：核酸纯化装置及核酸纯化方法
公开(公告)号：US07273702B2
公开(公告)日：2007-09-25
申请号：US10478096
申请日：2002-05-24
申请人： Teruhisa Akashi , Yukiko Ikeda , Yoshihiro Nagaoka , Naruo Watanabe , Yuji Miyahara
发明人： Teruhisa Akashi , Yukiko Ikeda , Yoshihiro Nagaoka , Naruo Watanabe , Yuji Miyahara
IPC分类号： C12Q1/68 , C12M1/00 , C12M3/00 , C07H21/02
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2300/0803 , B01L2300/0867 , B01L2300/1827 , B01L2400/0409 , B01L2400/0694 , G01N35/00069 , G01N2030/381
摘要： A nucleic acid refining apparatus, being ease in automation thereof, keeping high in contacting frequency between nucleic acid within a sample and a solid phase during nucleic acid capture processing, thereby proving high capturing rate, comprises: means for separating a liquid containing the nucleic acid therein from said sample through centrifugal force; means for transferring a reagent through the centrifugal force; means for producing a mixture liquid of said reagent transferred through the centrifugal force and a solution containing said nucleic acid therein; a carrier for capturing said nucleic acid; means for transferring said mixture liquid to said carrier through the centrifugal force; heating means for heating said carrier; and a holding means for separating and holding the reagent containing said nucleic acid eluting from said carrier, separating from other reagent, through different centrifugal.
摘要翻译：一种核酸精制装置，其易于自动化，在核酸捕获处理期间保持样品内的核酸与固相之间的接触频率高，从而证明高捕获率，包括：用于分离含有核酸的液体的装置其中从所述样品通过离心力; 用于通过离心力转移试剂的装置; 用于生产通过离心力转移的所述试剂的混合液体的装置和其中含有所述核酸的溶液; 用于捕获所述核酸的载体; 用于通过离心力将所述混合液转移到所述载体的装置; 用于加热所述载体的加热装置; 以及用于分离并保持含有从所述载体洗脱的所述核酸的试剂的保持装置，通过不同的离心与其它试剂分离。

2. 发明授权

US08801412B2 Screw compressor 有权
标题翻译：螺杆压缩机
公开(公告)号：US08801412B2
公开(公告)日：2014-08-12
申请号：US13248110
申请日：2011-09-29
申请人： Yukiko Ikeda , Kazuaki Shiinoki , Masakatsu Okaya , Natsuki Kawabata , Masahiro Kawamura , Iwao Aoki
发明人： Yukiko Ikeda , Kazuaki Shiinoki , Masakatsu Okaya , Natsuki Kawabata , Masahiro Kawamura , Iwao Aoki
IPC分类号： F04C29/00
CPC分类号： C10M169/04 , F01C1/14 , F04C18/084 , F04C18/16 , F04C2230/91 , F04C2280/04 , F05C2225/10 , F05C2251/14
摘要： In order to prevent deterioration in performance of an oil-free screw compressor and scuffing caused by rust, surfaces of both male and female rotors are coated with heat-resistance coatings containing a solid lubricant.A coating contains Polyimide resin to which Molybdenum disulfide, as a solid lubricant, and Aluminum oxide and Titanium oxide, as additives, are added. Accordingly, it is possible to realize a coating that is higher in heat resistance and longer in lifetime than a conventional one.
摘要翻译：为了防止无油螺杆式压缩机的性能下降，由锈蚀造成的磨损，两个阳转子和阴转子的表面均涂有含有固体润滑剂的耐热涂层。涂料含有聚酰亚胺树脂，其中加入作为固体润滑剂的二硫化钼和作为添加剂的氧化铝和氧化钛。因此，可以实现比传统的更高的耐热性和更长的寿命的涂层。

3. 发明授权

US06808633B1 Centrifugal separator and sample preparation device using the separator 失效
标题翻译：离心分离器和使用分离器的样品制备装置
公开(公告)号：US06808633B1
公开(公告)日：2004-10-26
申请号：US10018430
申请日：2001-12-20
申请人： Kazunori Okano , Katsuji Murakawa , Shinichi Fukuzono , Yukiko Ikeda
发明人： Kazunori Okano , Katsuji Murakawa , Shinichi Fukuzono , Yukiko Ikeda
IPC分类号： B01D1100
CPC分类号： B01L3/5021 , B04B1/02 , B04B5/0407 , B04B5/0442 , B04B5/10 , B04B7/08 , Y10T436/111666 , Y10T436/25375 , Y10T436/255
摘要： A centrifugal separator of the invention has a centrifugal rotor (10-1), with symmetric rotation axes, having single sample separation chamber in it for centrifuging samples contained in sample solutions, an upper opening passing through to said sample separation chamber in the upper part, members of frameworks capable of being coupled to said upper opening, a rotation driving means, assuming that the direction of said symmetric rotation axis is the first direction, for driving said centrifugal rotor around said rotation axis in the first direction, wherein assuming that two directions intersecting with said first direction are the second and third directions, the length of said sample preparation chamber in said third direction is longer than the length of said sample preparation chamber in said second direction. Since one kind of sample is handled in one centrifugal rotor, the centrifugal separator of the invention allows discrete treatment (sequential treatment) suitable for the flow system, in which individual samples can be treated independently, making easy automation of sample preparation revolving centrifugation.
摘要翻译：本发明的离心分离机具有对称旋转轴的离心转子（10-1），在其中具有单个样品分离室，用于离心样品溶液中包含的样品，上部开口穿过上部样品分离室假定所述对称旋转轴的方向为第一方向的旋转驱动装置，用于沿所述第一方向围绕所述旋转轴驱动所述离心转子，其中，假定所述两个与第一方向相交的方向是第二和第三方向，所述样品制备室在所述第三方向上的长度比所述第二方向上的样品制备室的长度长。由于在一个离心转子中处理了一种样品，本发明的离心分离器允许适用于流动系统的独立处理（顺序处理），其中可以独立地处理各个样品，从而容易地自动进行样品制备旋转离心。

4. 发明授权

US06249403B1 Magnetic hard disk drive and process for producing the same 失效
公开(公告)号：US06249403B1
公开(公告)日：2001-06-19
申请号：US09080417
申请日：1998-05-18
申请人： Hiromitsu Tokisue , Sunao Yonekawa , Nobuyuki Ishii , Yasuyuki Horiguchi , Yoshishige Endo , Yasuhiro Yoshimura , Yutaka Ito , Osamu Narisawa , Hiroshi Yuyama , Youichi Inoue , Yukiko Ikeda
发明人： Hiromitsu Tokisue , Sunao Yonekawa , Nobuyuki Ishii , Yasuyuki Horiguchi , Yoshishige Endo , Yasuhiro Yoshimura , Yutaka Ito , Osamu Narisawa , Hiroshi Yuyama , Youichi Inoue , Yukiko Ikeda
IPC分类号： G11B5255
CPC分类号： G11B5/6005 , G11B5/10 , G11B5/40 , G11B5/41
摘要： A magnetic hard disk drive comprising a magnetic disk and a magnetic head slider, characterized in that said magnetic head slider is coated with a layer having a contact angle of 50° or more when measured by using a lubricant coated on the magnetic disk, is free from start failure due to stiction caused by adhesion of the lubricant to the slider surface.

5. 发明授权

US5450931A Vibration control apparatus 失效
标题翻译：振动控制装置
公开(公告)号：US5450931A
公开(公告)日：1995-09-19
申请号：US216718
申请日：1994-03-23
申请人： Hiromitsu Masuda , Taichi Sato , Kihachiro Tanaka , Yukiko Ikeda
发明人： Hiromitsu Masuda , Taichi Sato , Kihachiro Tanaka , Yukiko Ikeda
IPC分类号： D06F19/00 , F16F9/30 , F16F13/08
CPC分类号： F16F13/08 , F16F9/303
摘要： A thixotropic material is charged in a container. The container also holds a movable member which is placed in the thixotropic material so as to stir the thixotropic material. A force transmitting element is connected to the movable member. When an object, the vibration of which is to be controlled, is out of resonance, the amplitude of vibration is so small that the thixotropic material is in a gel state, thus presenting a comparatively large spring constant for the vibration control apparatus. As the excitation frequency is increased towards the resonance range, the amplitude of vibration is increased correspondingly, so that the movable member stirs the thixotropic material to generate stress in the latter, whereby the phase of the thixotropic material is changed from gel to sol. Consequently, the natural frequency of the vibration system, including the object and the vibration control apparatus, is lowered, thus averting resonance. It is thus possible to obtain vibration restraining or control effect over a wide range of excitation frequencies.
摘要翻译：将触变材料装入容器中。容器还保持放置在触变材料中的可动件，以搅拌触变材料。力传递元件连接到可动件。当要控制其振动的物体不共振时，振动的振幅如此之小，使得触变材料处于凝胶状态，因此对于振动控制装置呈现较大的弹簧常数。随着激发频率向共振范围增加，振动幅度相应增加，使得可动件搅动触变材料，从而在后者中产生应力，从而使触变材料的相位从凝胶变为溶胶。因此，包括物体和振动控制装置的振动系统的固有频率降低，从而避免共振。因此，可以在宽范围的激励频率上获得振动抑制或控制效果。

6. 发明授权

US06329023B2 Process for producing a magnetic head slider 有权
标题翻译：制造磁头滑块的方法
公开(公告)号：US06329023B2
公开(公告)日：2001-12-11
申请号：US09784218
申请日：2001-02-16
申请人： Hiromitsu Tokisue , Sunao Yonekawa , Nobuyuki Ishii , Yasuyuki Horiguchi , Yoshishige Endo , Yasuhiro Yoshimura , Yutaka Ito , Osamu Narisawa , Hiroshi Yuyama , Youichi Inoue , Yukiko Ikeda
发明人： Hiromitsu Tokisue , Sunao Yonekawa , Nobuyuki Ishii , Yasuyuki Horiguchi , Yoshishige Endo , Yasuhiro Yoshimura , Yutaka Ito , Osamu Narisawa , Hiroshi Yuyama , Youichi Inoue , Yukiko Ikeda
IPC分类号： B05D512
CPC分类号： G11B5/6005 , G11B5/10 , G11B5/40 , G11B5/41
摘要： A magnetic hard disk drive comprising a magnetic disk and a magnetic head slider, characterized in that said magnetic head slider is coated with a layer having a contact angle of 50° or more when measured by using a lubricant coated on the magnetic disk, is free from start failure due to stiction caused by adhesion of the lubricant to the slider surface.
摘要翻译：一种包括磁盘和磁头滑块的磁性硬盘驱动器，其特征在于，当通过使用涂覆在磁盘上的润滑剂进行测量时，所述磁头滑块涂覆有接触角为50°或更大的层，是免费的由于润滑剂粘附到滑块表面引起的静摩擦起始故障。

7. 发明授权

US06326189B1 Nucleic acid separating vessel, a method of manufacturing the nucleic acid separating vessel, and a method for separating the nucleic acid 失效
标题翻译：核酸分离容器，制造核酸分离容器的方法和分离核酸的方法
公开(公告)号：US06326189B1
公开(公告)日：2001-12-04
申请号：US09518172
申请日：2000-03-02
申请人： Shinichi Fukuzono , Tetsuo Yokoyama , Yukiko Ikeda , Yoshishige Endo
发明人： Shinichi Fukuzono , Tetsuo Yokoyama , Yukiko Ikeda , Yoshishige Endo
IPC分类号： C12M134
CPC分类号： C12N15/1006 , B01L3/50255 , C12Q1/6806 , C12Q2565/137
摘要： The sample vessel 1 comprises plurality of vessels 1a. The vessel 1a comprises an opening for sample inlet 3, a liquid sample outlet 4, and a silicon oxide composite particles structural body 2 is arranged at the bottom of the vessel 1a, i.e. the liquid sample outlet 4. The silicon oxide composite particles structural body 2 is a structural body composed of a composite made of plural silicon oxide particles having smaller diameter combined with a resin particle having larger diameter. Accordingly, even if the diameter of the silicon oxide particles 7 is set small in order to maintain the nucleic acid combination ability high, the presence of the resin particles 6 having a large diameter makes it possible to ensure the liquid conduction path, and the nucleic acid separating vessel, which is capable of suppressing decrease of the B/F separating velocity with maintaining the nucleic acid combining ability high can be realized.
摘要翻译：样品容器1包括多个容器1a。容器1a包括用于样品入口3的开口，液体样品出口4和氧化硅复合颗粒结构体2布置在容器1a的底部，即液体样品出口4.氧化硅复合颗粒结构体 2是由具有较小直径的多个氧化硅颗粒与具有较大直径的树脂颗粒组合的复合体构成的结构体。因此，为了保持核酸组合能力，即使将氧化硅粒子7的直径设定得较小，直径大的树脂粒子6的存在也可以确保液体传导路径，核酸可以实现能够在保持核酸结合能力的同时抑制B / F分离速度的降低的酸分离容器。

8. 发明授权

US6162356A Chip for use in nucleic acid separation, structural element and process for forming the structural element 无效
标题翻译：用于核酸分离的芯片，用于形成结构元件的结构元件和工艺
公开(公告)号：US6162356A
公开(公告)日：2000-12-19
申请号：US272353
申请日：1999-03-19
申请人： Yukiko Ikeda , Yoshishige Endo , Yasuhiro Yoshimura , Takao Terayama , Kenji Yasuda , Toshinari Sakurai , Tetsuo Yokoyama , Takanori Aono
发明人： Yukiko Ikeda , Yoshishige Endo , Yasuhiro Yoshimura , Takao Terayama , Kenji Yasuda , Toshinari Sakurai , Tetsuo Yokoyama , Takanori Aono
IPC分类号： B01D15/08 , C03C11/00 , C07H1/08
CPC分类号： B01J20/2803 , B01J20/103 , B01J20/28026 , B01J20/283 , B01J20/3234
摘要： Composite particles formed from resin particles and silica particles (amount of silica particles: 0.2 to 10 wt. % on the basis of the resin particles) in an apparatus for formation of composite particles are placed in a PTFE mold and heat treated to weld the resin particles to one another, thereby forming a structural element, which is dipped in an ethyl silicate solution containing monodispersed silica particles, then taken out of the solution and subjected to further heat treatment to form an ultimate structural element, which is sealed in a tip case, whereby a tip can be produced at a low cost and used to separate nucleic acid from a liquid sample for a short time at a high recovery rate without any defects such as breaking, etc.
摘要翻译：在复合颗粒形成装置中由树脂颗粒和二氧化硅颗粒形成的复合颗粒（二氧化硅颗粒的数量（基于树脂颗粒的0.2至10重量％））放置在PTFE模具中并进行热处理以使树脂从而形成结构元件，将其浸入含有单分散二氧化硅颗粒的硅酸乙酯溶液中，然后从溶液中取出并进行进一步的热处理以形成最终结构元件，其密封在尖端壳体从而可以以低成本生产尖端，并且用于以高回收率将液体样品中的核酸与液体样品分离短时间而没有诸如破裂等缺陷。

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