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1. 发明授权

US07273702B2 Apparatus for purifying nucleic acid and method of purifying nucleic acid 有权
标题翻译：核酸纯化装置及核酸纯化方法
公开(公告)号：US07273702B2
公开(公告)日：2007-09-25
申请号：US10478096
申请日：2002-05-24
申请人： Teruhisa Akashi , Yukiko Ikeda , Yoshihiro Nagaoka , Naruo Watanabe , Yuji Miyahara
发明人： Teruhisa Akashi , Yukiko Ikeda , Yoshihiro Nagaoka , Naruo Watanabe , Yuji Miyahara
IPC分类号： C12Q1/68 , C12M1/00 , C12M3/00 , C07H21/02
CPC分类号： B01L3/50273 , B01L3/5025 , B01L3/502738 , B01L3/502753 , B01L2200/027 , B01L2300/0803 , B01L2300/0867 , B01L2300/1827 , B01L2400/0409 , B01L2400/0694 , G01N35/00069 , G01N2030/381
摘要： A nucleic acid refining apparatus, being ease in automation thereof, keeping high in contacting frequency between nucleic acid within a sample and a solid phase during nucleic acid capture processing, thereby proving high capturing rate, comprises: means for separating a liquid containing the nucleic acid therein from said sample through centrifugal force; means for transferring a reagent through the centrifugal force; means for producing a mixture liquid of said reagent transferred through the centrifugal force and a solution containing said nucleic acid therein; a carrier for capturing said nucleic acid; means for transferring said mixture liquid to said carrier through the centrifugal force; heating means for heating said carrier; and a holding means for separating and holding the reagent containing said nucleic acid eluting from said carrier, separating from other reagent, through different centrifugal.
摘要翻译：一种核酸精制装置，其易于自动化，在核酸捕获处理期间保持样品内的核酸与固相之间的接触频率高，从而证明高捕获率，包括：用于分离含有核酸的液体的装置其中从所述样品通过离心力; 用于通过离心力转移试剂的装置; 用于生产通过离心力转移的所述试剂的混合液体的装置和其中含有所述核酸的溶液; 用于捕获所述核酸的载体; 用于通过离心力将所述混合液转移到所述载体的装置; 用于加热所述载体的加热装置; 以及用于分离并保持含有从所述载体洗脱的所述核酸的试剂的保持装置，通过不同的离心与其它试剂分离。

2. 发明授权

US07662340B2 Extractor chemical analyzer and chemical analyzing method 有权
标题翻译：提取物化学分析仪和化学分析方法
公开(公告)号：US07662340B2
公开(公告)日：2010-02-16
申请号：US10500385
申请日：2001-12-28
申请人： Yoshihiro Nagaoka , Naruo Watanabe , Teruhisa Akashi , Yuji Miyahara , Kei Takenaka , Tomoki Ohashi
发明人： Yoshihiro Nagaoka , Naruo Watanabe , Teruhisa Akashi , Yuji Miyahara , Kei Takenaka , Tomoki Ohashi
IPC分类号： G01N9/30
CPC分类号： G01N35/025 , B01L3/502738 , B01L2200/0621 , B01L2300/0636 , B01L2300/0816 , B01L2400/0409 , B01L2400/0622 , B01L2400/0694 , G01N21/07 , G01N35/1079 , G01N2035/00504 , G01N2035/0449 , G01N2035/0451 , Y10T436/111666
摘要： The invention is achieved by feeding a reagent using centrifugal force, without providing a valve for controlling the flow rate of the reagent in the reagent flow path.A chemical analyzer is used which comprises a structure that is supported so as to be rotatable, said structure comprising a capturing section for capturing specific chemical substances from a specimen, specimen containers and reagent containers including washing solution containers.The washing solution containers and the other reagent containers comprise a liquid outlet port which is provided at the side opposite to the rotation center side, and the capturing section is held in the structure, closer to the outer periphery side than the specimen container and washing solution and the other reagent containers, and a flow path is provided, with a bent flow path portion which returns to the rotation center side, and which at a particular stage prevents the flow of liquid from the washing solution containers to the capturing section, and at another stage, forms the liquid flow due to the centrifugal force from the rotation of the structure.
摘要翻译：本发明通过使用离心力供给试剂而不设置用于控制试剂流路中的试剂的流量的阀来实现。使用化学分析器，其包括被支撑为可旋转的结构，所述结构包括用于从样品捕获特定化学物质的捕获部分，样本容器和包括洗涤溶液容器的试剂容器。洗涤溶液容器和其他试剂容器包括设置在与旋转中心侧相反的一侧的液体出口，并且捕获部分保持在结构中，比检体容器和洗涤液更靠近外周侧和其他试剂容器以及流路，其具有返回到旋转中心侧的弯曲流路部分，并且在特定阶段防止液体从洗涤溶液容器流向捕获部分，并且在另一个阶段由于结构旋转的离心力而形成液体流动。

3. 发明申请

US20050095172A1 Extractor chemical analyzer and chemical analyzing method 有权
标题翻译：提取物化学分析仪和化学分析方法
公开(公告)号：US20050095172A1
公开(公告)日：2005-05-05
申请号：US10500385
申请日：2001-12-28
申请人： Yoshihiro Nagaoka , Naruo Watanabe , Teruhisa Akashi , Yuji Miyahara , Kei Takenaka , Tomoki Ohashi
发明人： Yoshihiro Nagaoka , Naruo Watanabe , Teruhisa Akashi , Yuji Miyahara , Kei Takenaka , Tomoki Ohashi
IPC分类号： B01D11/04 , G01N1/10 , G01N21/07 , G01N35/00 , G01N35/02 , G01N33/00
CPC分类号： G01N35/025 , B01L3/502738 , B01L2200/0621 , B01L2300/0636 , B01L2300/0816 , B01L2400/0409 , B01L2400/0622 , B01L2400/0694 , G01N21/07 , G01N35/1079 , G01N2035/00504 , G01N2035/0449 , G01N2035/0451 , Y10T436/111666
摘要： The invention is achieved by feeding a reagent using centrifugal force, without providing a valve for controlling the flow rate of the reagent in the reagent flow path. A chemical analyzer is used which comprises a structure that is supported so as to be rotatable, said structure comprising a capturing section for capturing specific chemical substances from a specimen, specimen containers and reagent containers including washing solution containers. The washing solution containers and the other reagent containers comprise a liquid outlet port which is provided at the side opposite to the rotation center side, and the capturing section is held in the structure, closer to the outer periphery side than the specimen container and washing solution and the other reagent containers, and a flow path is provided, with a bent flow path portion which returns to the rotation center side, and which at a particular stage prevents the flow of liquid from the washing solution containers to the capturing section, and at another stage, forms the liquid flow due to the centrifugal force from the rotation of the structure.
摘要翻译：本发明通过使用离心力供给试剂而不设置用于控制试剂流路中的试剂的流量的阀来实现。使用化学分析器，其包括被支撑为可旋转的结构，所述结构包括用于从样品捕获特定化学物质的捕获部分，样本容器和包括洗涤溶液容器的试剂容器。洗涤溶液容器和其他试剂容器包括设置在与旋转中心侧相反的一侧的液体出口，并且捕获部分保持在结构中，比检体容器和洗涤液更靠近外周侧和其他试剂容器以及流路，其具有返回到旋转中心侧的弯曲流路部分，并且在特定阶段防止液体从洗涤溶液容器流向捕获部分，并且在另一个阶段由于结构旋转的离心力而形成液体流动。

4. 发明授权

US07384602B2 Chemical analysis apparatus and genetic diagnostic apparatus 有权
标题翻译：化学分析仪器和遗传诊断仪器
公开(公告)号：US07384602B2
公开(公告)日：2008-06-10
申请号：US10400445
申请日：2003-03-28
申请人： Yoshihiro Nagaoka , Naruo Watanabe , Kei Takenaka , Tomoki Ohashi , Yuji Miyahara
发明人： Yoshihiro Nagaoka , Naruo Watanabe , Kei Takenaka , Tomoki Ohashi , Yuji Miyahara
IPC分类号： C12Q1/68 , G01N15/06 , G01N33/00 , G01N33/48 , G01N35/00
CPC分类号： B01L3/502738 , B01L3/502723 , B01L3/50273 , B01L2200/0621 , B01L2200/10 , B01L2300/0803 , B01L2300/0861 , B01L2400/0409 , B01L2400/0694 , G01N35/00069 , G01N35/025 , G01N2035/00504 , G01N2035/0436 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： In a chemical analysis apparatus for extracting a specific substance, such as nucleic acid, from a sample containing a plurality of chemical substances, solutions remaining in valves are prevented so that a reagent in an earlier step does not contaminate the subsequent steps. Predetermined quantities of solutions are carried and supplied by centrifugal force without providing valves for controlling the flow of the solutions. After perforating the lids of ventilation holes 272, 273, 274 communicated with a detection container 450 and disposal containers 460 and 470 in an analysis disc 2, the analysis disc 2 is rotated to supply and carry a predetermined quantity of the sample.
摘要翻译：在用于从含有多种化学物质的样品中提取特定物质如核酸的化学分析装置中，防止残留在阀中的溶液，使得较早步骤中的试剂不会污染随后的步骤。通过离心力承载和提供预定量的溶液，而不提供用于控制溶液流动的阀。在将分析盘2中的与检测容器450和处置容器460和470连通的通气孔272,273,274的盖子穿孔之后，分析盘2旋转以提供并携带预定量的样品。

5. 发明申请

US20060245972A1 Chemical analyzer and cartridge for chemical analyzer 审中-公开
标题翻译：化学分析仪和化学分析仪盒
公开(公告)号：US20060245972A1
公开(公告)日：2006-11-02
申请号：US11411159
申请日：2006-04-26
申请人： Yasuo Osone , Michihiro Saito , Hiroki Ihara , Noriyo Nishijima , Yoshihiro Nagaoka , Naruo Watanabe , Shigeyuki Sasaki , Nobuyuki Maki
发明人： Yasuo Osone , Michihiro Saito , Hiroki Ihara , Noriyo Nishijima , Yoshihiro Nagaoka , Naruo Watanabe , Shigeyuki Sasaki , Nobuyuki Maki
IPC分类号： G01N35/00
CPC分类号： B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/16 , B01L2300/021 , B01L2300/041 , B01L2300/0672 , B01L2300/0816 , B01L2400/0409 , B01L2400/0677 , B01L2400/0683 , G01N21/07 , G01N35/00069 , G01N2035/00495
摘要： A chemical analyzer has a rotatable holding disk, test cartridges disposed thereon, and a detector. The test cartridge includes a base plate having vessels and flow channels. The base plate is covered with a cover for covering the vessels and flow channels. The holding disk is rotated to generate centrifugal force, causing a fluid to be moved from one vessel at the inner peripheral side with respect to a rotation axis of the holding disk to another vessel at the outer peripheral side with respect to the rotation axis via the flow channel. In the test cartridge, at least one reagent port is formed in the base plate, and a closed vessel containing a reagent is placed in the reagent port. The closed vessel is a microcapsule, a plastic closed vessel, or a screw-in closed vessel, for example.
摘要翻译：化学分析仪具有可旋转的保持盘，设置在其上的测试盒和检测器。测试盒包括具有容器和流动通道的基板。基板覆盖有用于覆盖容器和流动通道的盖。保持盘旋转以产生离心力，使得流体相对于保持盘的旋转轴线从内周侧的一个容器移动到相对于旋转轴的外周侧的另一个容器流通道。在测试盒中，在底板中形成至少一个试剂口，并且将含有试剂的密闭容器放置在试剂口中。密封容器例如是微胶囊，塑料密封容器或螺旋式密闭容器。

6. 发明授权

US07678576B2 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析装置和化学分析盒
公开(公告)号：US07678576B2
公开(公告)日：2010-03-16
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N35/00 , B01F15/02
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译：本发明提供一种容易搅动和加热的化学分析装置。化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。检查筒包括由凹部形成的容器和具有流路的基板。覆盖容器和流路的盖子安装在基板上。通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器的保持盘。检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。

7. 发明申请

US20060159586A1 Chemical analysis apparatus and chemical analysis cartridge 有权
标题翻译：化学分析仪和化学分析盒
公开(公告)号：US20060159586A1
公开(公告)日：2006-07-20
申请号：US11319680
申请日：2005-12-29
申请人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
发明人： Shigeyuki Sasaki , Yoshihiro Nagaoka , Noriyo Nishijima , Naruo Watanabe , Michihiro Saito , Taisaku Seino , Satoshi Takahashi
IPC分类号： G01N31/22
CPC分类号： B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/1816 , B01L2400/0409 , B01L2400/0442 , B01L2400/0475 , G01N21/0332 , G01N21/07 , G01N21/645 , G01N2021/0325 , G01N2035/00148 , G01N2035/00495 , G01N2035/00534 , Y10T436/111666
摘要： The invention provides a chemical analysis apparatus which easily agitates and warms up. A chemical analysis apparatus has a motor, a retaining disc which can be rotated by the motor, a plurality of inspection cartridges which are arranged on the retaining disc, a punching machine for punching the inspection cartridges, a warming apparatus and a detection apparatus. The inspection cartridge includes a container formed by a concave portion and a base plate having a flow path. A cover covering the container and the flow path is installed to the base plate. A liquid solution is moved to the container in an outer peripheral side with respect to a rotation axis from the container in an inner peripheral side with respect to the rotation axis via the flow path, by utilizing a centrifugal force generated on the basis of the rotation of the retaining disc. The inspection cartridge is provided with an agitating means for agitating the liquid solution within the container and a warming means for warming up the liquid solution within the container.
摘要翻译：本发明提供一种容易搅动和加热的化学分析装置。化学分析装置具有电动机，可由电动机旋转的保持盘，设置在保持盘上的多个检查筒，冲压检查筒的冲孔机，加温装置和检测装置。检查筒包括由凹部形成的容器和具有流路的基板。覆盖容器和流路的盖子安装在基板上。通过利用基于旋转产生的离心力，液体溶液在相对于旋转轴线的旋转轴线的相对于旋转轴线的内周侧的外周侧经由流路被移动到容器的保持盘。检查筒设置有用于搅拌容器内的液体溶液的搅拌装置和用于预热容器内的液体溶液的加温装置。

8. 发明授权

US06197255B1 Chemical analyzing apparatus 有权
标题翻译：化学分析仪
公开(公告)号：US06197255B1
公开(公告)日：2001-03-06
申请号：US09398046
申请日：1999-09-17
申请人： Ryo Miyake , Yoshihiro Nagaoka , Akira Koide , Naruo Watanabe , Yasuhiko Sasaki , Hajime Kato , Takao Terayama , Hiroshi Mitsumaki , Hiroyasu Uchida , Takeshi Shibuya , Yasuhiro Yoshimura
发明人： Ryo Miyake , Yoshihiro Nagaoka , Akira Koide , Naruo Watanabe , Yasuhiko Sasaki , Hajime Kato , Takao Terayama , Hiroshi Mitsumaki , Hiroyasu Uchida , Takeshi Shibuya , Yasuhiro Yoshimura
IPC分类号： G01N3502
CPC分类号： G01N35/00663 , B01F11/0283 , G01N35/025 , G01N2035/00673 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A chemical analyzing apparatus comprises a reaction cell holder which holds a plurality of reaction cells that are supplied with samples and reagents at a predetermined position, a measurer for measuring characteristics of the sample, a plurality of reagent containers, a liquid deliverer provided below each of the plurality of reagent containers, one or more sound wave generators provided outside the reaction cells, and storage containers for storing cleansing liquid with different contamination states. The cleansing liquid with different contamination states is reused according to the contamination levels of the reaction cells.
摘要翻译：化学分析装置包括：反应池保持器，其保持在预定位置处供给样品和试剂的多个反应池，用于测量样品特性的测量器，多个试剂容器，下方设置的液体输送器多个试剂容器，设置在反应室外的一个或多个声波发生器和用于存储具有不同污染状态的清洁液的储存容器。具有不同污染状态的清洁液体根据反应池的污染水平重新使用。

9. 发明授权

US07754478B2 Device for cell culture 有权
标题翻译：细胞培养装置
公开(公告)号：US07754478B2
公开(公告)日：2010-07-13
申请号：US10583511
申请日：2004-12-15
申请人： Tsutomu Suzuki , Hiroshi Inomata , Yoshihiro Komori , Hiroshi Tachikui , Naruo Watanabe , Satoshi Ozawa , Yuji Oka , Minoru Ueda , Yasushi Nomura , Masako Nomura, legal representative , Isao Shindo
发明人： Tsutomu Suzuki , Hiroshi Inomata , Yoshihiro Komori , Hiroshi Tachikui , Naruo Watanabe , Satoshi Ozawa , Yuji Oka , Minoru Ueda , Yasushi Nomura , Isao Shindo
IPC分类号： C12M1/02 , C12M1/34
CPC分类号： C12M41/14 , C12M23/22 , C12M27/10 , C12M41/48 , Y10S435/809
摘要： A device for cell culture capable of automatically performing operations for cell culture over several days to several months while minimizing the risk of contamination. A new medicine can be supplied to an incubator means by using a medicine supply means or unnecessary wastewater can be discharged from the incubator means by using a wastewater discharge means without taking out the incubator means disposed in heat insulation box means from a heat insulation box, and the state of the cell culture can be observed with the incubator means formed in the heat insulation box means. Accordingly, the outside air does not enter directly into the incubator means during culturing, and the risk of contamination is completely eliminated. As a result, the culturing operations can be automatically performed over a long period.
摘要翻译：用于细胞培养的装置，其能够在几天至几个月内自动执行细胞培养的操作，同时最小化污染的风险。可以通过使用药物供给装置向培养箱装置提供新药，或者可以通过使用废水排放装置将不需要的废水从培养箱装置排出，而不从隔热箱取出设置在隔热箱装置中的培养箱装置，并且可以用在隔热箱装置中形成的培养箱装置来观察细胞培养的状态。因此，外部空气在培养期间不直接进入培养箱装置，并且完全消除污染的风险。结果，可以长时间自动进行培养操作。

10. 发明授权

US06383452B1 Chemical analyzer and chemical analyzing system 有权
标题翻译：化学分析仪和化学分析系统
公开(公告)号：US06383452B1
公开(公告)日：2002-05-07
申请号：US09526565
申请日：2000-03-16
申请人： Ryo Miyake , Naruo Watanabe , Hajime Katou , Takao Terayama , Yasushi Nomura , Hiroshi Mitsumaki
发明人： Ryo Miyake , Naruo Watanabe , Hajime Katou , Takao Terayama , Yasushi Nomura , Hiroshi Mitsumaki
IPC分类号： G01N3500
CPC分类号： G01N35/1002 , G01N35/0099 , G01N35/028 , Y10T436/2575
摘要： A chemical analyzer for measuring a concentration of components of a sample liquid, by mixing the sample liquid with reagents, so as to react the reagents upon the components thereof. The chemical analyzer includes a carrier which is constructed on a substrate and has an introducing portion through which the sample liquid is injected, distributing flow passages for distributing the sample liquid injected from the introducing portion, and plural reactor portions, each holding the sample liquid therein to be mixed with the reagent, thereby to react. A movable driver portion is provided for mounting the carrier thereon, and a reagent charging device is provided for ejecting the reagents, which are different for the respective reactor portions of the carrier. Further, a detector is provided for detecting the components after mixing the reagents with the sample liquid.
摘要翻译：一种用于通过将样品液体与试剂混合来测量样品液体组分浓度的化学分析仪，以便将试剂与其组分反应。该化学分析装置包括：载体，其构造在基板上，具有引入部，通过该引入部分注入样品液体;分配用于分配从引入部分注入的样品液体的流路;以及多个反应器部分，每个反应器部分将样品液体保持在其中与试剂混合，进行反应。提供了用于将载体安装在其上的可移动的驱动部分，并且提供了用于喷射对于载体的各反应器部分不同的试剂的试剂装料装置。此外，提供了一种用于在将试剂与样品液体混合之后检测组分的检测器。

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