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1. 发明授权

US08299070B2 Indole compounds and pharmaceutical use thereof 有权
标题翻译：吲哚化合物及其药物用途
公开(公告)号：US08299070B2
公开(公告)日：2012-10-30
申请号：US12954438
申请日：2010-11-24
申请人： Teruhiko Inoue , Tetsudo Kaya , Shinichi Kikuchi , Koji Matsumura , Ritsuki Masuo , Motoya Suzuki , Michihide Maekawa
发明人： Teruhiko Inoue , Tetsudo Kaya , Shinichi Kikuchi , Koji Matsumura , Ritsuki Masuo , Motoya Suzuki , Michihide Maekawa
IPC分类号： A61K31/5355 , A61K31/4523 , A61K31/416 , C07D413/14 , C07D211/00 , C07D231/56
CPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Provided is an agent for the treatment or prophylaxis of inflammatory diseases, allergic diseases, autoimmune diseases, transplant rejection or the like.A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as described in the specification.
摘要翻译：提供了用于治疗或预防炎性疾病，过敏性疾病，自身免疫性疾病，移植排斥反应等的药剂。由下式[I]表示的化合物或其药学上可接受的盐或其溶剂合物：其中每个符号如说明书中所述。

2. 发明申请

US20090048425A1 PROCESS FOR PRODUCTION OF CYCLOOLEFIN 有权
标题翻译：生产环烯醇的方法
公开(公告)号：US20090048425A1
公开(公告)日：2009-02-19
申请号：US11912575
申请日：2006-08-18
申请人： Mitsuo Konishi , Teruhiko Inoue
发明人： Mitsuo Konishi , Teruhiko Inoue
IPC分类号： C08G61/10
CPC分类号： B01J23/46 , B01J23/60 , B01J23/96 , B01J27/053 , B01J38/64 , C07C5/11 , C07C2523/46 , C07C2527/053 , C07C2601/16 , Y02P20/584
摘要： According to the present invention, when cycloolefins are produced by partially hydrogenating a monocyclic aromatic hydrocarbon with hydrogen in the presence of a ruthenium catalyst, water, and a metal sulfate, the decrease in catalytic activity and cycloolefin selectivity is suppressed by reducing the concentration of chloride ions dissolved in the water in which the catalyst is present to 300 wt ppm or less and regenerating a part or all of the catalyst for reuse. Zinc sulfate is preferably used as the metal sulfate. Further, the raw materials and catalyst to be supplied to the reaction preferably have a reduced chloride ion content. This method can suppress the decrease in long-term catalytic activity and cycloolefin selectivity. Furthermore, the catalytic activity and cycloolefin selectivity after catalyst regeneration can be maintained at a high level. As a result, cycloolefins can be efficiently produced for a long period of time.
摘要翻译：根据本发明，当在钌催化剂，水和金属硫酸盐的存在下，通过氢气使单环芳族烃部分氢化制备环烯烃时，通过降低氯化物的浓度来抑制催化活性和环烯选择性的降低溶解在其中存在催化剂的水中的离子为300重量ppm以下，再生部分或全部催化剂用于再利用。硫酸锌优选用作金属硫酸盐。此外，供给反应的原料和催化剂优选具有减少的氯离子含量。该方法可以抑制长期催化活性和环烯烃选择性的降低。此外，催化剂再生后的催化活性和环烯选择性可以保持在高水平。因此，可以长时间有效地制造环烯烃。

3. 发明授权

US07371760B2 Medicinal compositions containing aspirin 有权
公开(公告)号：US07371760B2
公开(公告)日：2008-05-13
申请号：US10600266
申请日：2003-06-20
申请人： Fumitoshi Asai , Atsuhiro Sugidachi , Taketoshi Ogawa , Teruhiko Inoue
发明人： Fumitoshi Asai , Atsuhiro Sugidachi , Taketoshi Ogawa , Teruhiko Inoue
IPC分类号： A61K31/60 , A61K31/4743
摘要： A combination of 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine or a pharmaceutically acceptable salt thereof, and aspirin, which possess excellent inhibitory activity against platelet aggregation and thrombogenesis, and is useful for preventing or treating diseases caused by thrombus or embolus.

4. 发明授权

US07285572B2 CaSR antagonist 失效
标题翻译： CaSR拮抗剂
公开(公告)号：US07285572B2
公开(公告)日：2007-10-23
申请号：US11286378
申请日：2005-11-25
申请人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
发明人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
IPC分类号： A61K31/19 , A61K31/195 , A61K31/185 , C07C61/00 , C07C211/00
CPC分类号： C07D257/04 , C07C217/28 , C07C311/51 , C07D277/56 , C07D285/08 , C07D333/38 , C07F9/3834 , C07F9/4021
摘要： The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the description.
摘要翻译：本发明提供具有钙敏感受体拮抗作用的化合物，含有该化合物，特别是钙受体拮抗剂的药物组合物和用于骨质疏松症的治疗药物。由下式（1）表示的化合物，其药学上可接受的盐或其光学活性形式：其中每个符号如说明书中所定义。

5. 发明申请

US20050032796A1 CaSR antagonist 有权
标题翻译： CaSR拮抗剂
公开(公告)号：US20050032796A1
公开(公告)日：2005-02-10
申请号：US10830480
申请日：2004-04-23
申请人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Kenji Fukuda , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
发明人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Kenji Fukuda , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
IPC分类号： A61P3/14 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , A61P43/00 , C07C217/28 , C07C317/44 , C07C323/62 , C07D215/12 , C07D295/155 , C07D307/79 , A61K31/5377 , A61K31/4025 , A61K31/4439 , A61K31/454 , A61K31/4545 , C07D413/14 , C07D43/14
CPC分类号： C07D213/80 , C07C217/28 , C07C317/44 , C07C323/62 , C07C2601/02 , C07D215/12 , C07D295/155 , C07D307/79
摘要： A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the specification. A compound having a calcium-sensing receptor antagonistic action, a pharmaceutical composition comprising the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis are provided.
摘要翻译：由下式（1）表示的化合物，其药学上可接受的盐或其光学活性形式：其中每个符号如说明书中所定义。提供了具有钙敏感受体拮抗作用的化合物，包含该化合物，特别是钙受体拮抗剂和用于骨质疏松症的治疗药物的药物组合物。

6. 发明授权

US5073556A 4-oxoquinoline-3-carboxylic acid derivatives and their use 失效
标题翻译： 4-氧杂环辛烷-3-羧酸衍生物及其用途
公开(公告)号：US5073556A
公开(公告)日：1991-12-17
申请号：US659829
申请日：1991-02-22
申请人： Masayuki Iwata , Tomio Kimura , Teruhiko Inoue , Yoshimi Fujihara , Tetsushi Katsube
发明人： Masayuki Iwata , Tomio Kimura , Teruhiko Inoue , Yoshimi Fujihara , Tetsushi Katsube
IPC分类号： C07D215/56 , C07D401/04 , C07D521/00
CPC分类号： C07D231/12 , C07D215/56 , C07D233/56 , C07D249/08 , C07D401/04 , Y02P20/55
摘要： Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy; R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.

7. 发明申请

US20070197512A1 Carboxylic Acid Compounds and Use Thereof 审中-公开
标题翻译：羧酸化合物及其用途
公开(公告)号：US20070197512A1
公开(公告)日：2007-08-23
申请号：US11627439
申请日：2007-01-26
申请人： Teruhiko Inoue , Toshihiro Kiguchi , Kazuyuki Hirata , Yuko Shinagawa , Naoki Ogawa , Katsuya Deai
发明人： Teruhiko Inoue , Toshihiro Kiguchi , Kazuyuki Hirata , Yuko Shinagawa , Naoki Ogawa , Katsuya Deai
IPC分类号： A61K31/5415 , A61K31/538 , C07D279/16 , C07D265/36
CPC分类号： C07D265/36 , C07D279/16
摘要： Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: wherein each symbol is as defined in the specification.
摘要翻译：提供一种有效治疗尿酸的病例的高级URAT1活性抑制剂，如高尿酸血症，痛风，急性痛风性关节炎，慢性痛风性关节炎，痛肾，尿结石，肾功能不全，冠心病，缺血性心脏病等。含有下述通式[1]表示的化合物或其药学上可接受的盐或其溶剂合物作为有效成分的URAT1活性抑制剂：其中每个符号如说明书中所定义。

8. 发明申请

US20060135572A1 CaSR antagonist 失效
标题翻译： CaSR拮抗剂
公开(公告)号：US20060135572A1
公开(公告)日：2006-06-22
申请号：US11286378
申请日：2005-11-25
申请人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
发明人： Yuko Shinagawa , Teruhiko Inoue , Toshihiro Kiguchi , Taku Ikenogami , Naoki Ogawa , Takashi Nakagawa , Masanori Shindo , Yuki Soejima
IPC分类号： A61K31/426 , A61K31/381 , A61K31/138 , C07D333/22 , C07D277/22
CPC分类号： C07D257/04 , C07C217/28 , C07C311/51 , C07D277/56 , C07D285/08 , C07D333/38 , C07F9/3834 , C07F9/4021
摘要： The present invention provides a compound having a calcium-sensitive receptor antagonistic action, a pharmaceutical composition containing the compound, particularly a calcium receptor antagonist and a therapeutic drug for osteoporosis. A compound represented by the following formula (1), a pharmaceutically acceptable salt thereof or an optically active form thereof: wherein each symbol is as defined in the description.
摘要翻译：本发明提供具有钙敏感受体拮抗作用的化合物，含有该化合物，特别是钙受体拮抗剂的药物组合物和用于骨质疏松症的治疗药物。由下式（1）表示的化合物，其药学上可接受的盐或其光学活性形式：其中每个符号如说明书中所定义。

9. 发明授权

US6087379A Cyclic amine derivatives 有权
标题翻译：环胺衍生物
公开(公告)号：US6087379A
公开(公告)日：2000-07-11
申请号：US257818
申请日：1999-02-25
申请人： Fumitoshi Asai , Atsuhiro Sugidachi , Toshihiko Ikeda , Hiroyuki Koike , Teruhiko Inoue , Katsunori Takata , Ryo Iwamura , Jun-ichiro Kita , Kenji Yoneda
发明人： Fumitoshi Asai , Atsuhiro Sugidachi , Toshihiko Ikeda , Hiroyuki Koike , Teruhiko Inoue , Katsunori Takata , Ryo Iwamura , Jun-ichiro Kita , Kenji Yoneda
IPC分类号： A61K31/395 , A61K31/397 , A61K31/40 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/46 , A61P7/02 , A61P9/10 , C07D205/04 , C07D205/08 , C07D207/08 , C07D207/12 , C07D211/20 , C07D211/54 , C07D211/72 , C07D213/70 , C07D451/02 , C07D451/04
CPC分类号： C07D213/70 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/20 , C07D211/54 , C07D451/02 , C07D451/04 , Y02P20/55
摘要： A cyclic amine derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted phenyl group, R.sup.2 represents a substituted of unsubstituted C.sub.1 -C.sub.8 aliphatic acyl group, a substituted or unsubstituted benzoyl group or a C.sub.1 -C.sub.4 alkoxycarbonyl group, and R.sup.3 represents a substituted 3 to 7 membered saturated cyclic amino group which may form a fused ring; or pharmaceutically acceptable salts thereof. The compounds and salts have excellent platelet aggregation inhibitory action. They are useful for the treatment and prevention of such diseases as embolism, thrombosis or arteriosclerosis and for the preparation of pharmaceutical compositions for such uses.
摘要翻译：由下式表示的环状胺衍生物：其中，R1表示取代或未取代的苯基，R2表示取代未取代的C1-C8脂肪族酰基，取代或未取代的苯甲酰基或C1〜C4烷氧基羰基，R3表示可以形成稠环的取代的3至7元饱和环氨基; 或其药学上可接受的盐。化合物和盐具有优异的血小板聚集抑制作用。它们可用于治疗和预防诸如栓塞，血栓形成或动脉硬化等疾病以及制备用于此类用途的药物组合物。

10. 发明授权

US5496951A 4-oxoquinoline-3-carboxylic acid derivatives their preparation and their use 失效
标题翻译： 4-氧代喹啉-3-羧酸衍生物的制备及其用途
公开(公告)号：US5496951A
公开(公告)日：1996-03-05
申请号：US379975
申请日：1995-01-27
申请人： Masayuki Iwata , Tomio Kimura , Teruhiko Inoue , Yoshimi Fujihara , Tetsushi Katsube
发明人： Masayuki Iwata , Tomio Kimura , Teruhiko Inoue , Yoshimi Fujihara , Tetsushi Katsube
IPC分类号： C07D215/56 , C07D401/04 , C07D521/00
CPC分类号： C07D231/12 , C07D215/56 , C07D233/56 , C07D249/08 , C07D401/04 , Y02P20/55
摘要： Compounds of formula (I): ##STR1## (in which: R.sup.1 represents fluorinated methoxy: R.sup.2 represents a nitrogen-containing heterocyclic group and R.sup.3 represents hydrogen or amino) and pharmaceutically acceptable salts, esters and amides thereof are valuable antibacterial agents, which may be prepared by reacting a compound similar to that of formula (I) but in which R.sup.2 is replaced by a halogen atom with a compound providing the required group R.sup.2.
摘要翻译：式（I）化合物：其中：R1表示氟化甲氧基：R2表示含氮杂环基，R3表示氢或氨基），其药学上可接受的盐，酯和酰胺是有价值的抗菌剂其可以通过使类似于式（I）的化合物与其中R 2被卤素原子替换的化合物与提供所需基团R2的化合物反应来制备。

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