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1. 发明授权

US08333769B2 Apparatus and methods for introducing portals in bone 有权
标题翻译：将门户引入骨骼的装置和方法
公开(公告)号：US08333769B2
公开(公告)日：2012-12-18
申请号：US12745557
申请日：2008-12-05
申请人： Gregory Vincent Browne , Werner Reinhard Simbeck , Christopher Grant Denny , David Brian Bonar , Terence Gilhuly
发明人： Gregory Vincent Browne , Werner Reinhard Simbeck , Christopher Grant Denny , David Brian Bonar , Terence Gilhuly
IPC分类号： A61B17/16
CPC分类号： A61B17/1604 , A61B17/16 , A61B17/1615 , A61B17/1624 , A61B17/1691 , A61B17/17 , A61B17/1764 , A61B17/1789 , A61B17/3472 , A61B17/3494 , A61B90/03 , A61B2017/00539 , A61B2017/00544 , A61B2017/00548 , A61B2017/3407 , A61B2017/347 , A61B2090/032 , A61B2090/034 , A61B2090/08021 , A61B2217/005 , A61B2217/007 , A61M5/158 , A61M25/04 , A61M39/0247 , A61M2005/1585 , A61M2039/025 , A61M2039/0291
摘要： An apparatus and method for introducing portals into bone is described herein. An example apparatus for introducing portals into bone includes a handle, a base, and a driving member. The driving member can be made to project past the base by operating the handle. The base is detachable from the handle. The apparatus also includes a guide coupled at a first end to the handle and at a second end to the base. The base is detachably coupled to the guide. A base coupling detachably coupling the base to the guide includes an actuating member movable between a coupled configuration wherein the base is coupled to the guide and an uncoupled configuration wherein the base is released from the guide. The actuating member is arranged so that motion of the handle toward the base moves the actuating member from the coupled configuration to the uncoupled configuration.
摘要翻译：本文描述了将入口引入骨中的装置和方法。用于将门户引入骨骼的示例性装置包括手柄，基座和驱动构件。可以通过操作手柄使驱动构件突出通过基座。底座可从手柄上拆下。该装置还包括在第一端处连接到手柄并且在第二端处连接到基座的引导件。基座可拆卸地联接到引导件。将基座可拆卸地联接到引导件的基座联接器包括致动构件，其可在联接构造之间移动，其中基座联接到引导件，并且非耦合构造，其中基座从引导件释放。致动构件被布置成使得手柄朝向基座的运动将致动构件从联接构造移动到非耦合构造。

2. 发明授权

US08292891B2 Apparatus having release mechanism for introducing bone portals and related methods 有权
标题翻译：具有用于引入骨门的释放机构的装置和相关方法
公开(公告)号：US08292891B2
公开(公告)日：2012-10-23
申请号：US12851545
申请日：2010-08-05
申请人： Gregory Vincent Browne , Werner Reinhard Simbeck , Christopher Grant Denny , David Brian Bonar , Terence Gilhuly
发明人： Gregory Vincent Browne , Werner Reinhard Simbeck , Christopher Grant Denny , David Brian Bonar , Terence Gilhuly
IPC分类号： A61B17/00
CPC分类号： A61B17/1604 , A61B17/16 , A61B17/1615 , A61B17/1624 , A61B17/1691 , A61B17/17 , A61B17/1764 , A61B17/1789 , A61B17/3472 , A61B17/3494 , A61B90/03 , A61B2017/00539 , A61B2017/00544 , A61B2017/00548 , A61B2017/3407 , A61B2017/347 , A61B2090/032 , A61B2090/034 , A61B2090/08021 , A61B2217/005 , A61B2217/007 , A61M5/158 , A61M25/04 , A61M39/0247 , A61M2005/1585 , A61M2039/025 , A61M2039/0291
摘要： Some introducer tools for bone portals have a handle coupled to a driving member by a force-limiting coupling. A bone portal comprising a bone-penetrating portion and a bone stop may be driven to a desired depth in bone when the force-limiting coupling allows application of force to the bone portal that is sufficient to drive the bone-penetrating portion of the portal into the bone but not sufficient to drive the bone stop significantly into the bone. Bone portals of various types are described herein. Various configurations for stylets suitable for use in introducing bone portals or otherwise penetrating bone and methods for inserting bone portals are also described herein.
摘要翻译：用于骨门入口的一些导引器工具具有通过限制力联接器联接到驱动构件的手柄。包括骨穿透部分和骨块的骨质入口可以被驱动到骨骼中期望的深度，当限制力联接允许施加力到骨入口足以驱动入口的骨穿透部分骨骼但不足以驱动骨头显着地进入骨骼。本文描述了各种类型的骨门户。本文还描述了适用于引入骨入口或以其他方式穿透骨的样式的各种配置以及插入骨门的方法。

3. 发明申请

US20100081963A1 Improved sensors and sensing for monitoring neuromuscular blockade 有权
标题翻译：改进的传感器和传感器用于监测神经肌肉阻滞
公开(公告)号：US20100081963A1
公开(公告)日：2010-04-01
申请号：US12311105
申请日：2007-09-14
申请人： Terence Gilhuly
发明人： Terence Gilhuly
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0002 , A61B5/01 , A61B5/02055 , A61B5/1106 , A61B5/4821 , A61B5/72 , A61B5/746 , A61M2005/14208 , G05B17/02 , G06F19/00 , G06F19/3456 , G16H50/50 , Y02A90/26
摘要： Improved sensors and sensing methods for detection of Neuromuscular Blockade (NMB), for example to improve monitoring generally, as well as facilitate automated NMB drug administration. The methods, systems, devices, etc., herein can increase the quantity and quality of data available. The methods, etc., include translation between commonly available sensing types, use of partially saturated sensor measurements, use of a model of neurotransmitter storage and release and sophisticated use of more than one sensor simultaneously. These methods are aided by new sensors and methods of decreasing electrical noise. An implementation of the methods, systems, devices, etc., herein is automated drug delivery for NMB, whether through an advisor system or through with full computer control.
摘要翻译：改进的用于检测神经肌肉阻滞（NMB）的传感器和感测方法，例如通常改善监测，以及促进自动NMB药物给药。这里的方法，系统，设备等可以增加可用数据的数量和质量。方法等包括通常可用的感测类型之间的翻译，部分饱和传感器测量的使用，神经递质储存和释放的模型的使用以及同时多个传感器的复杂使用。这些方法得到了新的传感器和降低电噪声的方法的帮助。这里的方法，系统，设备等的实现是NMB的自动化药物递送，无论是通过顾问系统还是通过全面的计算机控制。

4. 发明申请

US20050234526A1 Systems and methods for detection of disease including oral scopes and ambient light management systems (ALMS) 审中-公开
标题翻译：用于检测疾病的系统和方法，包括口腔范围和环境光线管理系统（ALMS）
公开(公告)号：US20050234526A1
公开(公告)日：2005-10-20
申请号：US11016567
申请日：2004-12-16
申请人： Terence Gilhuly , Peter Whitehead
发明人： Terence Gilhuly , Peter Whitehead
IPC分类号： A61B1/00 , A61B1/24 , A61B1/32 , A61B5/00 , A61B5/107 , A61H21/00 , G01N21/64
CPC分类号： A61B5/0077 , A61B1/00128 , A61B1/00142 , A61B1/00193 , A61B1/043 , A61B1/0615 , A61B1/0646 , A61B1/24 , A61B1/32 , A61B5/0071 , A61B5/0088 , A61B5/107 , A61B5/411 , A61B5/444 , A61B2560/0456
摘要： Methods and systems related to detecting disease, such as oral cancer, in a patient, using a viewing scope to investigate a patient's tissues. The systems and methods excite and detect fluorescence from the tissue. The fluorescence can then be evaluated, and the possibility of certain diseases such as cancer can be determined. The devices include an ambient light management system (ALMS, often referred to as a “vestibular device”) that manages background light in the health practitioner's office. This device can be used with scope systems for fluorescence based detection of abnormal tissue.
摘要翻译：与患者中检测疾病如口腔癌相关的方法和系统，使用观察范围来调查患者的组织。系统和方法激发和检测来自组织的荧光。然后可以评估荧光，并且可以确定某些疾病如癌症的可能性。这些装置包括管理卫生从业员办公室背景光的环境光管理系统（ALMS，通常称为“前庭装置”）。该装置可用于荧光检测异常组织的示波器系统。

5. 发明申请

US20180221611A1 BETTER BITE BLOCK 审中-公开
公开(公告)号：US20180221611A1
公开(公告)日：2018-08-09
申请号：US15888073
申请日：2018-02-04
申请人： Terence Gilhuly
发明人： Terence Gilhuly
IPC分类号： A61M16/04
CPC分类号： A61M16/0493 , A61M16/0688 , A61M16/085 , A61M2205/0216 , A61M2230/432
摘要： Patients undergoing general anesthetics frequently experience emergence clenching where the patient may bite onto their breathing tube and may clench their teeth. These activities lead to dental damage and negative pressure pulmonary edema. The invention of this patent is a simpler, better bite block that may be used to prevent these injuries. The bite block presented comprises a deformable material used as a core around which a bite-resistant material is wrapped to prevent damage to the core by patient biting. The bite-resistant material may be formed into a distal tail that the user can pull to retain or retrieve the device. It may also have a patch of adhesive to attach the bite block to locations including the patient, the surgical drapes and the patient's breathing airway, and thereby prevent loss of the bite block.

6. 发明申请

US20140196721A1 Pressure release means and placement indicator for inflatable catheter or respiratory gas supply retention means 审中-公开
标题翻译：用于充气导管或呼吸气体供应保持装置的压力释放装置和放置指示器
公开(公告)号：US20140196721A1
公开(公告)日：2014-07-17
申请号：US13740183
申请日：2013-01-12
申请人： Terence Gilhuly
发明人： Terence Gilhuly
IPC分类号： A61M16/04 , A61M25/00
CPC分类号： A61M16/044 , A61M16/0409 , A61M16/0434 , A61M16/209
摘要： Under- and overinflation of retention balloons and cuffs for catheters including Foley catheters, and for endotracheal tubes, tracheostomy tubes, laryngeal mask airways and similar devices is correlated with hospital acquired infections and with patient injury. In this patent, a solution that correctly inflates inflatable retention devices is taught, whereby a pressure release means is incorporated into the inflation pathway from the fluid input syringe to the retention means while inflating. This pressure release means can be set to open at or near the optimal fluid pressure so that overinflation can be prevented by releasing any pressure above the optimal pressure and underinflation can be prevented by a user pressurizing the cuff until the valve is noticed to open. As well, observation of fluid leaked through the pressure relief means can indicate misplacement of the retention means, allowing the user to reposition it before patient injury occurs. The invention is presented as a standalone part and in a format whereby the invention is integrated into existing airway cuff inflation designs.
摘要翻译：用于导管（包括Foley导管）和气管内导管，气管造口管，喉罩气道和类似装置的保留气囊和袖带的欠充和过度充气与医院获得性感染和患者损伤相关。在该专利中，教导了可充气保持装置正确膨胀的解决方案，由此在膨胀期间将压力释放装置并入到从流体输入注射器到保持装置的充气路径中。该压力释放装置可以被设置为在最佳流体压力处或接近最佳流体压力下打开，从而可以通过释放高于最佳压力的任何压力来防止过度充气，并且可以通过用户对袖带的压力来防止欠充气，直到阀被注意到打开。同样，观察通过压力释放装置泄漏的流体可以指示保持装置的错位，允许使用者在患者发生伤害之前重新定位它。本发明被呈现为独立的部分，并且以将本发明整合到现有的气道袖带充气设计的格式中呈现。

7. 发明授权

US08229872B2 Modeling and control for highly variable and nonlinear systems 有权
标题翻译：高度可变和非线性系统的建模与控制
公开(公告)号：US08229872B2
公开(公告)日：2012-07-24
申请号：US12311104
申请日：2007-09-14
申请人： Terence Gilhuly
发明人： Terence Gilhuly
IPC分类号： G06F17/00 , G06N5/02
CPC分类号： A61B5/05 , A61B5/0002 , A61B5/01 , A61B5/02055 , A61B5/1106 , A61B5/4821 , A61B5/72 , A61B5/746 , A61M2005/14208 , G05B17/02 , G06F19/00 , G06F19/3456 , G16H50/50 , Y02A90/26
摘要： The present invention relates generally to methods of modeling and handling of nonlinearities for application of automatic control to systems with high inter-process variance and nonlinearities. The variance and nonlinearities make these systems difficult to control. Variance is accounted for by replacing the mathematical model of the system with a more representative model from a modelset that may or may not be chosen based on characteristics of the system under test, and then adapting using recursive estimation techniques. Nonlinearities defined by threshold to response and maximal responses are incorporated into linear models relating accumulated inputs to response. Example implementations in relation to automated drug delivery for neuromuscular blocking drugs through warning, advisory and closed-loop control systems are discussed.
摘要翻译：本发明一般涉及用于将自动控制应用于具有高过程间变化和非线性的系统的非线性建模和处理的方法。方差和非线性使得这些系统难以控制。通过用可能或可能不会根据被测系统的特性来选择的模型组中的更具代表性的模型来替代系统的数学模型，然后使用递归估计技术进行调整来解释差异。由阈值响应和最大响应定义的非线性被并入到将累积输入与响应相关联的线性模型中。讨论了通过警告，咨询和闭环控制系统与神经肌肉阻滞药物自动化药物递送有关的实例。

8. 发明申请

US20140012157A1 Monobody Sensors for Monitoring Neuromuscular Blockade 审中-公开
标题翻译：用于监测神经肌肉阻滞的单体传感器
公开(公告)号：US20140012157A1
公开(公告)日：2014-01-09
申请号：US13934235
申请日：2013-07-03
申请人： Terence Gilhuly
发明人： Terence Gilhuly
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0002 , A61B5/01 , A61B5/02055 , A61B5/1106 , A61B5/4821 , A61B5/72 , A61B5/746 , A61M2005/14208 , G05B17/02 , G06F19/3456 , G16H50/50 , Y02A90/26
摘要： Improved sensors and sensing methods for detection of Neuromuscular Blockade (NMB), for example to improve monitoring generally, as well as facilitate automated NMB drug administration. The methods, systems, devices, etc., herein can increase the quantity and quality of data available. The methods, etc., include translation between commonly available sensing types, use of partially saturated sensor measurements, use of a model of neurotransmitter storage and release and sophisticated use of more than one sensor simultaneously. These methods are aided by new sensors and methods of decreasing electrical noise. An implementation of the methods, systems, devices, etc., herein is automated drug delivery for NMB, whether through an advisor system or through with full computer control.
摘要翻译：改进的用于检测神经肌肉阻滞（NMB）的传感器和感测方法，例如通常改善监测，以及促进自动NMB药物给药。这里的方法，系统，设备等可以增加可用数据的数量和质量。方法等包括通常可用的感测类型之间的翻译，部分饱和传感器测量的使用，神经递质储存和释放的模型的使用以及同时多个传感器的复杂使用。这些方法得到了新的传感器和降低电噪声的方法的帮助。这里的方法，系统，设备等的实现是NMB的自动化药物递送，无论是通过顾问系统还是通过全面的计算机控制。

9. 发明申请

US20100312246A1 APPARATUS AND METHODS FOR INTRODUCING PORTALS IN BONE 有权
公开(公告)号：US20100312246A1
公开(公告)日：2010-12-09
申请号：US12745557
申请日：2008-12-05
申请人： Gregory Vincent Browne , Werner Reinhard Simbeck , Christopher Grant Denny , David Brian Bonar , Terence Gilhuly
发明人： Gregory Vincent Browne , Werner Reinhard Simbeck , Christopher Grant Denny , David Brian Bonar , Terence Gilhuly
IPC分类号： A61B17/56
CPC分类号： A61B17/1604 , A61B17/16 , A61B17/1615 , A61B17/1624 , A61B17/1691 , A61B17/17 , A61B17/1764 , A61B17/1789 , A61B17/3472 , A61B17/3494 , A61B90/03 , A61B2017/00539 , A61B2017/00544 , A61B2017/00548 , A61B2017/3407 , A61B2017/347 , A61B2090/032 , A61B2090/034 , A61B2090/08021 , A61B2217/005 , A61B2217/007 , A61M5/158 , A61M25/04 , A61M39/0247 , A61M2005/1585 , A61M2039/025 , A61M2039/0291
摘要： Some introducer tools for bone portals have a handle coupled to a driving member by a force-limiting coupling. A bone portal comprising a bone-penetrating portion and a bone stop may be driven to a desired depth in bone when the force-limiting coupling allows application of force to the bone portal that is sufficient to drive the bone-penetrating portion of the portal into the bone but not sufficient to drive the bone stop significantly into the bone. Bone portals of various types are described herein. Various configurations for stylets suitable for use in introducing bone portals or otherwise penetrating bone and methods for inserting bone portals are also described herein.

10. 发明申请

US20080045799A1 Multipurpose diseased tissue detection devices, systems, and methods 审中-公开
标题翻译：多用途病变组织检测装置，系统和方法
公开(公告)号：US20080045799A1
公开(公告)日：2008-02-21
申请号：US11786462
申请日：2007-04-10
申请人： Peter Whitehead , Terence Gilhuly , Pierre Lane
发明人： Peter Whitehead , Terence Gilhuly , Pierre Lane
IPC分类号： A61B1/06
CPC分类号： A61B5/444 , A61B1/06 , A61B5/0059 , A61B5/0071 , A61B5/0088 , A61B2560/0443
摘要： An autofluorescence light examination system having a plurality of modular parts includes a main body, a light source, and at least two detachable instruments. The main body is configured to deliver light to a target tissue and contains at least one optical element configured so that a user can directly view the target tissue through the main body while the target tissue is illuminated by the light source. The main body is further configured to accept at least two detachable instruments that are configured to deliver light to at least two different target tissues located at at least two different areas of the body and configured such that a user can directly view the target tissue through the main body while the target tissue is illuminated by the light source.
摘要翻译：具有多个模块化部件的自发荧光检查系统包括主体，光源和至少两个可拆卸的装置。主体被配置为将光传送到目标组织并且包含至少一个光学元件，其被配置为使得当目标组织被光源照射时，用户可以通过主体直接观看目标组织。主体还被配置为接受至少两个可分离的仪器，其被配置为将光传送到位于身体的至少两个不同区域的至少两个不同的目标组织，并且被配置为使得用户可以直接观察目标组织主体，而目标组织被光源照射。

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