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1. 发明授权

US08712702B2 Measuring apparatus for measuring a physical property of a sample 有权
标题翻译：用于测量样品的物理性质的测量装置
公开(公告)号：US08712702B2
公开(公告)日：2014-04-29
申请号：US13167585
申请日：2011-06-23
申请人： Takeshi Takagi , Koji Okumura , Tatsuo Kamata
发明人： Takeshi Takagi , Koji Okumura , Tatsuo Kamata
IPC分类号： G06F19/00 , G01N1/10
CPC分类号： G01N1/38 , B01L3/502715 , B01L2200/10 , B01L2300/0654 , B01L2300/0816 , B01L2300/087 , B01L2300/0877 , B01L2300/0883 , B01L2300/0887 , B01L2400/0406 , G01N27/3271 , G01N2021/054 , G01N2035/1018
摘要： A measuring apparatus for measuring a predetermined physical property of a liquid measuring sample comprises a preparing unit in which a plurality of materials including at least a liquid material are mixed; a supply route which supplies the liquid material to the preparing unit; a withdrawing unit which withdraws the measuring sample from the preparing unit into the supply route, the measuring sample being prepared to contain the liquid material supplied to the preparing unit via the supply route; and a measuring unit which measures the predetermined physical property of the measuring sample withdrawn into the supply route by the withdrawing unit.
摘要翻译：用于测量液体测量样品的预定物理性能的测量装置包括其中混合至少包含液体材料的多种材料的制备单元; 将液体材料供给到制备单元的供给路径; 所述取出单元将所述测量样品从所述准备单元抽出到所述供给路径中，所述测量样品准备容纳经由所述供给路径供给到所述准备单元的液体材料; 以及测量单元，其测量由所述抽出单元抽出到所述供给路径中的所述测量样本的预定物理属性。

2. 发明申请

US20100200432A1 METHOD AND APPARATUS FOR DETERMINING SUBSTRATE CONCENTRATION AND REAGENT FOR DETERMINING SUBSTRATE CONCENTRATION 审中-公开
标题翻译：用于确定底物浓度和测定底物浓度的试剂的方法和装置
公开(公告)号：US20100200432A1
公开(公告)日：2010-08-12
申请号：US12449732
申请日：2008-02-24
申请人： Tatsuo Kamata , Takeshi Takagi
发明人： Tatsuo Kamata , Takeshi Takagi
IPC分类号： G01N27/26 , C01B21/08
CPC分类号： C12Q1/006 , C12Q1/28
摘要： The present invention relates to a method, a reagent and an apparatus for determining a substrate concentration based on an amount of hydrogen peroxide generated from a substrate. In the present invention, a suppressing agent for suppressing a reaction between the hydrogen peroxide and an inhibitor is added. As the suppressing agent, an azide compound such as sodium azide or a nitrite compound such as sodium nitrite is used. In the invention, a supporting electrolyte, such as sodium chloride or potassium chloride may be further added.
摘要翻译：本发明涉及一种基于从基底产生的过氧化氢量来确定底物浓度的方法，试剂和装置。在本发明中，添加抑制过氧化氢与抑制剂的反应的抑制剂。作为抑制剂，可以使用叠氮化钠等叠氮化合物，亚硝酸钠等亚硝酸酯化合物。在本发明中，可以进一步添加氯化钠或氯化钾等担载电解质。

3. 发明授权

US09429579B2 Blood analysis apparatus 有权
标题翻译：血液分析仪
公开(公告)号：US09429579B2
公开(公告)日：2016-08-30
申请号：US12311175
申请日：2007-09-20
申请人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
发明人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
IPC分类号： G01N33/00 , G01N35/00 , G01N33/66 , G01N33/72 , G01N35/02 , A61B5/145 , G01N30/88
CPC分类号： G01N33/66 , A61B5/14532 , G01N33/723 , G01N35/026 , G01N2030/8822 , G01N2800/042
摘要： The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.
摘要翻译：血液分析装置技术领域本发明涉及用于测定血液中葡萄糖和糖血红蛋白浓度的血液分析装置X. 血液分析装置X构成为通过血液13的一次取样来进行葡萄糖和糖血红蛋白的浓度测定。血液分析装置X优选同时进行葡萄糖和糖血红蛋白的浓度测定用样品制剂1 样品制备。血液分析装置X可以被配置为执行用于测量糖血红蛋白的血液样品的稀释和用于使用相同的稀释剂测量葡萄糖的血液样品的稀释。

4. 发明授权

US08535510B2 Method for measuring substrate concentration and apparatus for measuring substrate concentration 有权
标题翻译：测量底物浓度的方法和测量底物浓度的装置
公开(公告)号：US08535510B2
公开(公告)日：2013-09-17
申请号：US12450775
申请日：2008-04-15
申请人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
发明人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B2560/0223
摘要： This invention provides a substrate concentration measuring method for measuring a concentration of a substrate included in a specimen based on an output for measurement from an enzyme electrode when the enzyme electrode and the substrate are reacted with each other, the substrate concentration is calculated using an output for correction from the enzyme electrode obtained when a reference solution whose substrate concentration is known and the enzyme electrode are reacted with each other before or after the enzyme electrode and the substrate are reacted with each other. For example, the output for correction is measured by each specimen. In this method, the substrate concentration may be calculated using the output for correction for the specimen to be measured and an output for correction corresponding to the at least one other specimen and measured prior to the output for correction.
摘要翻译：本发明提供一种基板浓度测量方法，用于当酶电极和基板彼此反应时，基于酶电极的测量输出测量样品中包含的基板的浓度，基板浓度使用输出用于当酶底物浓度已知的参比溶液和酶电极在酶电极和底物之间彼此反应之前彼此反应的酶电极获得的酶电极校正。例如，用于校正的输出由每个样本测量。在该方法中，可以使用待测试样本的校正输出和与至少一个其他样本相对应的校正输出并在校正输出之前测量来计算衬底浓度。

5. 发明申请

US20100299072A1 SUBSTRATE CONCENTRATION MEASUREMENT METHOD AND SUBSTRATE CONCENTRATION MEASUREMENT APPARATUS 审中-公开
标题翻译：基板浓度测量方法和基板浓度测量装置
公开(公告)号：US20100299072A1
公开(公告)日：2010-11-25
申请号：US12451085
申请日：2008-04-25
申请人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
发明人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
IPC分类号： G06F19/00 , G01N33/50
CPC分类号： G01N27/3274 , G01N30/8606 , G01N33/5438 , G01N33/721 , G01N33/96 , G01N2030/146 , G01N2030/8411 , G01N2030/8822
摘要： This invention is a method for a substrate concentration measurement method including measuring a concentration of a substrate in a blood specimen containing hemoglobin. In the method, the substrate concentration is calculated by using a measurement value correlating with a substrate concentration influenced by hemoglobin, and a hemoglobin concentration or a value correlating with the hemoglobin concentration. A substrate concentration is calculated by correcting the measurement value Re correlating with the substrate concentration based on the following Formulae 1 and 2: [Formula 1] Corrected value=100×Re/V (%), wherein V (%) represents a value with respect to plasma (a ratio of a measurement value influenced by hemoglobin with respect to a measurement value obtained by measuring plasma), and Re represents the measurement value correlating with the substrate concentration influenced by hemoglobin; [Formula 2] Value with respect to plasma V (%)=(Vmax×Re)/(Km+Re)+B, wherein Vmax represents a value obtained by subtracting an intercept (B) from the value (V) with respect to plasma which is maintained constant even when the measurement value influenced by hemoglobin increases, Km represents a value of Re at which the value V (%) with respect to plasma becomes Vmax/2, and B represents a value (constant) of V (%) with respect to plasma when Re is 0.
摘要翻译：本发明是一种测定含有血红蛋白的血液标本中的基质浓度的基板浓度测定方法。在该方法中，通过使用与受血红蛋白影响的底物浓度相关的测定值和血红蛋白浓度或与血红蛋白浓度相关的值来计算底物浓度。通过基于以下公式1和2校正与底物浓度相关的测量值Re来计算底物浓度：[式1]校正值= 100×Re / V（％），其中V（％）表示与对血浆的影响（由血红蛋白影响的测定值相对于通过测定血浆得到的测定值的比例），Re表示与由血红蛋白影响的底物浓度相关的测定值; [式2]相对于等离子体V（％）=（Vmax×Re）/（Km + Re）+ B的值，其中Vmax表示通过从相对于（V）的值（V）减去截距（B）即使当受血红蛋白影响的测量值增加时，也保持恒定的等离子体，Km表示相对于等离子体的值V（％）为Vmax / 2的Re值，B表示V（％）的值（常数））相对于等离子体。

6. 发明申请

US20120094367A1 Blood analysis apparatus 有权
标题翻译：血液分析仪
公开(公告)号：US20120094367A1
公开(公告)日：2012-04-19
申请号：US12311175
申请日：2007-09-20
申请人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
发明人： Koji Sugiyama , Tatsuo Kamata , Takeshi Takagi
IPC分类号： C12M1/40
CPC分类号： G01N33/66 , A61B5/14532 , G01N33/723 , G01N35/026 , G01N2030/8822 , G01N2800/042
摘要： The present invention relates to a blood analysis apparatus X for measuring concentrations of glucose and glycohemoglobin in blood. The blood analysis apparatus X is configured to perform the concentration measurement of the glucose and the glycohemoglobin by one sampling of blood 13. The blood analysis apparatus X is preferably configured to simultaneously carry out sample preparations for concentration measurement of the glucose and the glycohemoglobin by one sample preparation. The blood analysis apparatus X may be configured to perform dilution of a blood sample for measuring the glycohemoglobin and dilution of a blood sample for measuring the glucose using the same diluent.
摘要翻译：血液分析装置技术领域本发明涉及用于测定血液中葡萄糖和糖血红蛋白浓度的血液分析装置X. 血液分析装置X构成为通过血液13的一次取样来进行葡萄糖和糖血红蛋白的浓度测定。血液分析装置X优选同时进行葡萄糖和糖血红蛋白的浓度测定用样品制剂1 样品制备。血液分析装置X可以被配置为执行用于测量糖血红蛋白的血液样品的稀释和用于使用相同的稀释剂测量葡萄糖的血液样品的稀释。

7. 发明申请

US20120015388A1 Diluent for Preparing Analytical Sample 审中-公开
标题翻译：稀释剂用于制备分析样品
公开(公告)号：US20120015388A1
公开(公告)日：2012-01-19
申请号：US13166575
申请日：2011-06-22
申请人： Takeshi Takagi , Toshikatsu Sakai , Chiaki Miyamoto , Takefumi Asami , Tatsuo Kamata , Takuya Yotani , Takayuki Oka
发明人： Takeshi Takagi , Toshikatsu Sakai , Chiaki Miyamoto , Takefumi Asami , Tatsuo Kamata , Takuya Yotani , Takayuki Oka
IPC分类号： C12Q1/54 , C12M1/40
CPC分类号： C12Q1/006 , G01N33/66 , G01N33/723 , G01N33/726
摘要： The ionic strength of a diluent for preparing an analytical sample is set to be 0.06 to 0.16. The analytical sample prepared by using the diluent having the ionic strength within this range can be subjected to both for analyzing a first object in a test sample by electrode method and for analyzing a second object in the test sample by liquid chromatography method, and high-precision measurement can be attained. The analytical sample is especially useful for preparing a sample for measurement used both for measuring glucose concentration in a blood sample by enzyme electrode method and for measuring glycohemoglobin concentration in the blood sample by liquid chromatography method.
摘要翻译：用于制备分析样品的稀释剂的离子强度设定为0.06至0.16。通过使用离子强度在该范围内的稀释剂制备的分析样品可以通过电极法分析测试样品中的第一个物体，并通过液相色谱法分析测试样品中的第二个物体，可以进行精度测量。分析样品特别适用于制备用于通过酶电极法测量血液样品中的葡萄糖浓度并通过液相色谱法测量血液样品中的糖血红蛋白浓度的测量样品。

8. 发明申请

US20100288650A1 METHOD FOR MEASURING SUBSTRATE CONCENTRATION AND APPARATUS FOR MEASURING SUBSTRATE CONCENTRATION 有权
标题翻译：用于测量基板浓度的方法和用于测量基板浓度的装置
公开(公告)号：US20100288650A1
公开(公告)日：2010-11-18
申请号：US12450775
申请日：2008-04-15
申请人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
发明人： Tatsuo Kamata , Takeshi Takagi , Yuki Ito
IPC分类号： G01N27/27
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/1495 , A61B2560/0223
摘要： This invention provides a substrate concentration measuring method for measuring a concentration of a substrate included in a specimen based on an output for measurement from an enzyme electrode when the enzyme electrode and the substrate are reacted with each other, the substrate concentration is calculated using an output for correction from the enzyme electrode obtained when a reference solution whose substrate concentration is known and the enzyme electrode are reacted with each other before or after the enzyme electrode and the substrate are reacted with each other. For example, the output for correction is measured by each specimen. In this method, the substrate concentration may be calculated using the output for correction for the specimen to be measured and an output for correction corresponding to the at least one other specimen and measured prior to the output for correction.
摘要翻译：本发明提供一种基板浓度测量方法，用于当酶电极和基板彼此反应时，基于酶电极的测量输出测量样品中包含的基板的浓度，基板浓度使用输出用于当酶底物浓度已知的参比溶液和酶电极在酶电极和底物之间彼此反应之前彼此反应的酶电极获得的酶电极校正。例如，用于校正的输出由每个样本测量。在该方法中，可以使用待测试样本的校正输出和与至少一个其他样本相对应的校正输出并在校正输出之前测量来计算衬底浓度。

9. 发明授权

US09142289B2 Method for driving variable resistance element, and nonvolatile memory device 有权
标题翻译：用于驱动可变电阻元件的方法和非易失性存储器件
公开(公告)号：US09142289B2
公开(公告)日：2015-09-22
申请号：US13883075
申请日：2012-06-11
申请人： Takeshi Takagi , Koji Katayama
发明人： Takeshi Takagi , Koji Katayama
IPC分类号： G11C11/21 , G11C13/00
CPC分类号： G11C13/0007 , G11C13/0064 , G11C13/0069 , G11C2013/0073 , G11C2013/009 , G11C2013/0092 , G11C2213/15 , G11C2213/32
摘要： A driving method for driving a variable resistance element and a nonvolatile memory device, which achieves stable storage operation. In a low resistance write process, a low resistance writing voltage pulse having the negative polarity is applied once to a variable resistance layer included in a variable resistance element while in a high resistance write process, a high resistance writing voltage pulse having the positive polarity is applied more than twice to the same variable resistance layer. Here, when a voltage value of one of the high resistance writing voltage pulses is VH1 and a voltage value of the other high resistance writing voltage pulse applied subsequently is VH2, VH1>VH2 is satisfied.
摘要翻译：用于驱动可变电阻元件和非易失性存储器件的驱动方法，其实现稳定的存储操作。在低电阻写入处理中，具有负极性的低电阻写入电压脉冲在包括在可变电阻元件中的可变电阻层上施加一次，而在高电阻写入处理中，具有正极性的高电阻写入电压脉冲是施加两倍以上的同一可变电阻层。这里，当高电阻写入电压脉冲之一的电压值为VH1，随后施加的另一个高电阻写入电压脉冲的电压值为VH2时，满足VH1> VH2。

10. 发明授权

US08796660B2 Nonvolatile memory element comprising a resistance variable element and a diode 有权
标题翻译：非易失性存储元件包括电阻可变元件和二极管
公开(公告)号：US08796660B2
公开(公告)日：2014-08-05
申请号：US12375881
申请日：2007-09-21
申请人： Takeshi Takagi , Takumi Mikawa
发明人： Takeshi Takagi , Takumi Mikawa
IPC分类号： H01L29/02 , H01L47/00 , H01L29/04 , H01L29/06 , H01L29/08 , H01L31/0352 , H01L45/00 , H01L27/24 , H01L27/10 , H01L21/00 , G11C11/00
CPC分类号： H01L45/04 , H01L27/101 , H01L27/2409 , H01L27/2418 , H01L27/2463 , H01L45/1233 , H01L45/1273 , H01L45/146 , H01L45/1683
摘要： A nonvolatile memory element (20) of the present invention comprises a resistance variable element (14) and a diode (18) which are formed on a substrate (10) such that the resistance variable element (14) has a resistance variable layer (11) sandwiched between a lower electrode (12) and an upper electrode (13), and the diode (18) which is connected in series with the resistance variable element (14) in the laminating direction and has an insulating layer or semiconductor layer (15) sandwiched between a first electrode (16) at the lower side and a second electrode (17) at the upper side. The resistance variable layer (11) is embedded in a first contact hole (21) formed on the lower electrode (12). A first area (22) where insulating layer or semiconductor layer (15) of the diode (18) is in contact with a first electrode (16) of the diode (18) is larger than at least one of a second area (23) where the resistance variable layer (11) is in contact with the upper electrode (13) and a third area (24) where the resistance variable layer (11) is in contact with the lower electrode (12).
摘要翻译：本发明的非易失性存储元件（20）包括形成在基板（10）上的电阻可变元件（14）和二极管（18），使得电阻可变元件（14）具有电阻变化层（11 ）和位于下电极（12）和上电极（13）之间的二极管（18），以及与电阻可变元件（14）在层叠方向上串联连接并具有绝缘层或半导体层（15）的二极管）夹在下侧的第一电极（16）和上侧的第二电极（17）之间。电阻变化层（11）嵌入形成在下电极（12）上的第一接触孔（21）中。二极管（18）的绝缘层或半导体层（15）与二极管（18）的第一电极（16）接触的第一区域（22）大于第二区域（23）中的至少一个，其中电阻变化层（11）与上电极（13）接触，电阻变化层（11）与下电极（12）接触的第三区域（24）。

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