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1. 发明授权

US5936076A .alpha.galactosylceramide derivatives 失效
标题翻译： α半乳糖神经酰胺衍生物
公开(公告)号：US5936076A
公开(公告)日：1999-08-10
申请号：US450109
申请日：1995-05-25
申请人： Tatsuo Higa , Koji Akimoto , Yasuhiko Koezuka , Teruyuki Sakai , Masahiro Morita , Takenori Natori
发明人： Tatsuo Higa , Koji Akimoto , Yasuhiko Koezuka , Teruyuki Sakai , Masahiro Morita , Takenori Natori
IPC分类号： C07H15/10 , C07H15/00 , A61K31/70
CPC分类号： C07H15/10
摘要： The present invention relates to the novel .alpha.-galactosylceramide represented by the formula (A): ##STR1## wherein R represents ##STR2## where R.sub.2 represents H or OH and X denotes an integer of 0-26, or R represents --(CH.sub.2).sub.7 CH.dbd.CH(CH.sub.2).sub.7 CH.sub.3 and R.sub.1 represents any one of the substituents defined by the following (a)-(e):(a) --CH.sub.2 (CH.sub.2).sub.Y CH.sub.3,(b) --CH(OH)(CH.sub.2).sub.Y CH.sub.3,(c) --CH(OH)(CH.sub.2).sub.Y CH(CH.sub.3).sub.2,(d) --CH.dbd.CH(CH.sub.2).sub.Y CH.sub.3, and(e) --CH(OH)(CH.sub.2).sub.Y CH(CH.sub.3)CH.sub.2 CH.sub.3,wherein Y denotes an integer of 5-17.The present invention also relates to an anti-tumor agent and an immunostimulator comprising one or more of the aforementioned compounds as effective ingredients.
摘要翻译：本发明涉及由式（A）表示的新型α-半乳糖神经酰胺：其中R表示其中R2表示H或OH，X表示0-26的整数，或R表示 - （CH2）7CH = CH（CH2） 7CH 3和R 1表示由以下（a） - （e）定义的任何一个取代基：（a）-CH 2（CH 2）y CH 3，（b）-CH（OH）（CH 2）y CH 3，（c） OH）（CH2）YCH（CH3）2，（d）-CH = CH（CH2）YCH3和（e）-CH（OH）（CH2）YCH（CH3）CH2CH3，其中Y表示5-17 。本发明还涉及包含一种或多种上述化合物作为有效成分的抗肿瘤剂和免疫刺激剂。

2. 发明授权

US5849716A Sphingoglycolipids, their preparation, and therapeutic methods of use 失效
标题翻译：鞘糖脂，其制备方法和治疗方法
公开(公告)号：US5849716A
公开(公告)日：1998-12-15
申请号：US416917
申请日：1995-04-21
申请人： Koji Akimoto , Yasuhiko Koezuka
发明人： Koji Akimoto , Yasuhiko Koezuka
IPC分类号： C07H15/04 , C07H15/10 , A61K31/70 , C07H15/00
CPC分类号： C07H15/04 , C07H15/10
摘要： The present invention relates to a sphingoglycolipid represented by the following formula (I) which is effective at a small dose and has an anti-tumor activity and an immunostimulating effect with few side-effects: ##STR1## wherein X denotes an integer from 10 to 24, Y denotes an integer from 9 to 13, R.sub.1 represents a hexosyl, pentosyl, deoxyhexosyl, aminohexosyl, N-acetylaminohexosyl or a halide thereof or a sialic acid, R.sub.2 represents H or a group OR.sub.2 ', wherein R.sub.2 ' represents H or a galactosyl or glucosyl group, R.sub.3 represents H or a group OR.sub.3 ', wherein R.sub.3 ' represents H or a galactosyl or glucosyl group, R.sub.4 represents a galactosyl group or H, R.sub.5 represents a methyl or isopropyl group, R.sub.6 and R.sub.7 respectively represents H or form a double bond between the two carbon atoms to which R.sub.6 and R.sub.7 are attached, except for the case where R.sub.1 represents .alpha.-galactosyl and R.sub.4 represents H.
摘要翻译： PCT No.PCT / JP93 / 01523 Sec。 371日期1995年04月21日 102（e）日期1995年4月21日PCT提交1993年10月22日PCT公布。第WO94 / 09020号公报日本1994年4月28日本发明涉及以下述式（I）表示的鞘糖脂，其以小剂量有效，具有抗肿瘤活性和少量副作用的免疫刺激作用。其中X表示10〜24的整数，Y表示9〜13的整数，R1表示己糖基，戊糖基，脱氧己糖基，氨基己糖基，N-乙酰氨基己糖基或其卤化物或唾液酸，R2表示H或OR2' 其中R2'表示H或半乳糖基或葡糖基，R3表示H或OR3'，其中R3'表示H或半乳糖基或葡糖基，R4表示半乳糖基或H，R5表示甲基或异丙基， R6和R7分别表示H或R6和R7所连接的两个碳原子之间的双键，除了R1表示α-半乳糖基并且R4表示H的情况。

3. 发明授权

US07336414B2 Optical modulating device 失效
标题翻译：光调制装置
公开(公告)号：US07336414B2
公开(公告)日：2008-02-26
申请号：US10534310
申请日：2004-06-16
申请人： Masamichi Fujiwara , Junichi Kani , Koji Akimoto , Katsumi Iwatsuki
发明人： Masamichi Fujiwara , Junichi Kani , Koji Akimoto , Katsumi Iwatsuki
IPC分类号： H01S3/00
CPC分类号： H04B10/2587 , H04B10/2971 , H04B2210/258 , H04J14/02
摘要： An optical modulation apparatus is provided which implements a stable amplifying function by reducing the effect of reflected light rays form end faces of a bidirectional optical amplifier by imposing a numerical limitation on the relationship between the gain of the bidirectional optical amplifier and the loss of the optical modulator, or by inserting a polarization rotation section in a reflection type optical modulator including the bidirectional optical amplifier or in a multi-wavelength collective optical modulation system combining the multiple optical modulators. An optical modulation apparatus is provided which implements a stable amplifying function and cost reduction by reducing the effect of reflected light rays by interposing optical isolators at every alternate SOAs in a transmission-type optical modulation apparatus including a plurality of semiconductor optical amplifiers (SOAs) connected in a multistage fashion.
摘要翻译：提供一种光调制装置，其通过对双向光放大器的增益与光学损耗之间的关系施加数值限制来减小由双向光放大器的端面反射的反射光的影响来实现稳定的放大功能或者通过在包括双向光放大器的反射型光调制器中插入偏振旋转部分，或者在组合多个光调制器的多波长集合光调制系统中。提供了一种光调制装置，其通过在包括连接的多个半导体光放大器（SOA）的透射型光调制装置中的每个替代的SOA处插入光隔离器来减小反射光线的影响，从而实现了稳定的放大功能和成本降低以多层次的方式。

4. 发明授权

US4613092A Spindle assembly for winding machine 失效
标题翻译：绕线机主轴总成
公开(公告)号：US4613092A
公开(公告)日：1986-09-23
申请号：US710868
申请日：1985-03-12
申请人： Shoji Nakai , Koji Akimoto
发明人： Shoji Nakai , Koji Akimoto
IPC分类号： B65H67/04 , B65H54/20 , B65H54/54 , B65H54/547 , B65H75/30
CPC分类号： B65H54/20 , B65H54/543 , B65H2701/31
摘要： A spindle assembly capable of accomplishing a swing movement of a spindle bearing mechanism to a machine frame, an operation of holding bobbins on and releasing bobbins from a spindle, and an operation of actuating a rotation stopping mechanism by a sliding movement of an operation handle.In the spindle assembly according to the present invention, a first support and a second support are secured to a front end of the spindle rotatably supported at the rear end on the spindle cradle. Bobbin holding members are inserted into slits arranged on circumferential portions of the first support and the second support and moved outwardly or inwardly in the radial direction while a rear end of a sliding cylinder attached to an operation handle, which is capable of freely rotating, is inserted into an inside of the first support and engaged with projections of the bobbin holding members. Since the rear end of the sliding cylinder is formed into a conical shape, when the operation handle is drawn out, the bobbin holding members are moved inward in the radial direction, so that the bobbin can be removed from the spindle.A stop operation of the spindle is performed by engaging a frictional piece moved by rods passing through the first support and the second support by the operation handle with a conical gap of a braking cylinder secured to the spindle cradle.
摘要翻译：一种主轴组件，其能够实现主轴轴承机构向机架的摆动运动，将线轴保持在主轴上并将线筒释放的操作以及通过操作手柄的滑动来致动转动停止机构的操作。在根据本发明的主轴组件中，第一支撑件和第二支撑件固定到主轴的后端处可旋转地支撑在心轴支架上的主轴的前端。梭芯保持构件插入布置在第一支撑件和第二支撑件的圆周部分上的狭缝中，并且在径向方向上向外或向内移动，同时附接到能够自由旋转的操作手柄的滑动筒的后端是插入到第一支撑件的内部并与筒管保持构件的突起接合。由于滑动气缸的后端形成为圆锥形状，所以当拉出操作手柄时，筒管保持构件沿径向向内移动，从而能够使主轴脱开。主轴的停止操作是通过将固定在主轴支架上的制动缸的圆锥形间隙与由操作手柄通过第一支撑件的杆和第二支撑件一起移动的摩擦片接合而进行的。

5. 发明授权

US4530947A Anticorrosive coating composition 失效
标题翻译：防腐涂料组合物
公开(公告)号：US4530947A
公开(公告)日：1985-07-23
申请号：US603396
申请日：1984-04-24
申请人： Hidehiko Kojo , Koji Akimoto
发明人： Hidehiko Kojo , Koji Akimoto
IPC分类号： C09D175/04 , C09D195/00 , C08L63/00 , C08L95/00
CPC分类号： C09D195/00 , C09D175/04
摘要： A coating composition which comprises(A) a polyol resin obtained by the reaction of a prepolymer of epoxy resin and polyhydroxy penolic compound such as(i) poly-nuclear polyhydroxy phenols having adjacent hydroxy groups(ii) polyol esters of polyhydroxy phenolic carboxylic acids having adjacent hydroxy groups, and(iii) a mixture thereof, and one or more compound having one or more amino groups reactive with epoxy group;(B) a compound having more than one isocyanate group or groups which change to isocyanate groups under hardening condition, and(C) a bituminous material and/or its substitute.This coating composition can be coated on rusty metal surfaces.
摘要翻译：一种涂料组合物，其包含（A）通过环氧树脂的预聚物与多羟基化合物反应获得的多元醇树脂，所述多羟基化合物如（i）具有相邻羟基的多核多羟基酚（ii）多羟基酚羧酸的多元醇酯，其具有和（iii）其混合物，以及一种或多种具有一个或多个与环氧基反应的氨基的化合物; （B）具有多于一个异氰酸酯基团的化合物或在硬化条件下变为异氰酸酯基团的基团，和（C）沥青材料和/或其替代物。该涂料组合物可以涂覆在生锈的金属表面上。

6. 发明申请

US20070127113A1 Optical modulation apparatus 失效
标题翻译：光调制装置
公开(公告)号：US20070127113A1
公开(公告)日：2007-06-07
申请号：US11674576
申请日：2007-02-13
申请人： Masamichi Fujiwara , Junichi Kani , Koji Akimoto , Katsumi Iwatsuki
发明人： Masamichi Fujiwara , Junichi Kani , Koji Akimoto , Katsumi Iwatsuki
IPC分类号： H01S3/00
CPC分类号： H04B10/2587 , H04B10/2971 , H04B2210/258 , H04J14/02
摘要： An optical modulation apparatus is provided which implements a stable amplifying function by reducing the effect of reflected light rays from end faces of a bidirectional optical amplifier by imposing a numerical limitation on the relationship between the gain of the bidirectional optical amplifier and the loss of the optical modulator, or by inserting a polarization rotation section in a reflection type optical modulator including the bidirectional optical amplifier or in a multi-wavelength collective optical modulation system combining the multiple optical modulators. An optical modulation apparatus is provided which implements a stable amplifying function and cost reduction by reducing the effect of reflected light rays by interposing optical isolators at every alternate SOAs in a transmission-type optical modulation apparatus including a plurality of semiconductor optical amplifiers (SOAs) connected in a multistage fashion.
摘要翻译：提供一种光调制装置，其通过对双向光放大器的增益与光学损耗之间的关系施加数值限制来降低来自双向光放大器的端面的反射光的影响来实现稳定的放大功能或者通过在包括双向光放大器的反射式光调制器中插入偏振旋转部分，或者在组合多个光调制器的多波长集合光调制系统中。提供了一种光调制装置，其通过在包括连接的多个半导体光放大器（SOA）的透射型光调制装置中的每个替代的SOA处插入光隔离器来减小反射光线的影响，从而实现了稳定的放大功能和成本降低以多层次的方式。

7. 发明授权

US06541541B2 Aqueous resin composition 有权
标题翻译：水性树脂组合物
公开(公告)号：US06541541B2
公开(公告)日：2003-04-01
申请号：US09953947
申请日：2001-09-18
申请人： Kiyoshi Masamune , Naohiro Fujita , Ryo Ogawa , Koji Akimoto
发明人： Kiyoshi Masamune , Naohiro Fujita , Ryo Ogawa , Koji Akimoto
IPC分类号： C08K904
CPC分类号： C08J3/03 , C08G59/3218 , C08J5/08 , C08J2363/00 , C08L63/00 , C08L75/04
摘要： An aqueous resin composition comprising a polyepoxy compound represented by formula (I): wherein n represents a number of from 0.1 to 20; Z represents a single bond, an alkylidene group having 1 to 4 carbon atoms or a sulfone group; and X represents a hydrogen atom or a glycidyl group, provided that at least 10% of nX's represent a glycidyl group, and water.
摘要翻译：一种水性树脂组合物，其包含由式（I）表示的聚环氧化合物：其中n表示0.1至20的数; Z表示单键，碳原子数为1〜4的亚烷基或砜基; 并且X表示氢原子或缩水甘油基，条件是至少10％的nX代表缩水甘油基和水。

8. 发明授权

US5920115A Semiconductor device and display unit using the semiconductor device and notebook-size personal computer 失效
标题翻译：半导体器件和显示单元采用半导体器件和笔记本大小的个人电脑
公开(公告)号：US5920115A
公开(公告)日：1999-07-06
申请号：US962396
申请日：1997-10-31
申请人： Makoto Kimura , Shinji Tojo , Takahiro Fujioka , Akihiko Narisawa , Yoshiyuki Tanigawa , Shinya Kanamitsu , Koji Akimoto , Hiroyuki Mouri
发明人： Makoto Kimura , Shinji Tojo , Takahiro Fujioka , Akihiko Narisawa , Yoshiyuki Tanigawa , Shinya Kanamitsu , Koji Akimoto , Hiroyuki Mouri
IPC分类号： H01L23/50 , G02F1/13 , G09G3/20 , H01L21/3205 , H01L21/60 , H01L23/12 , H01L23/495 , H01L23/52 , G09G3/36 , H01L23/28 , H01L23/48
CPC分类号： H01L24/50 , G09G3/20 , H01L23/49572 , G02F1/13452 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01029 , H01L2924/01033 , H01L2924/01082
摘要： To provide a semiconductor device in which a thin resin film is provided on the whole margin of the principal plane of a semiconductor chip a lead is provided on the thin resin film, the lead is electrically connected with input and output electrode pads of the semiconductor chip, and the electrical joint is covered and sealed with a seal resin.
摘要翻译：为了提供在半导体芯片的主平面的整个边缘上设置薄树脂膜的半导体器件，在薄树脂膜上设置引线，引线与半导体芯片的输入和输出电极焊盘电连接，电接头用密封树脂覆盖并密封。

9. 发明授权

US09925075B2 Stent 有权
公开(公告)号：US09925075B2
公开(公告)日：2018-03-27
申请号：US14349439
申请日：2012-08-22
申请人： Kazuaki Mitsudo , Koji Akimoto
发明人： Kazuaki Mitsudo , Koji Akimoto
IPC分类号： A61F2/915
CPC分类号： A61F2/915 , A61F2002/9155 , A61F2002/91575 , A61F2210/0004 , A61F2230/0054 , A61F2230/0091 , A61F2250/0071
摘要： Provided is a stent of a novel structure with which deflection of a line-shaped body during expansion is prevented and a substantially uniform expansion is achieved over an entire length thereof, and with which, after implantation, stent fracture and damage of body tissue can be prevented by the stent exhibiting a superior pliability and conformability to a shape of a somatic lumen. A stent having a cylindrical peripheral wall formed with a line-shaped body that extends in a helical form in a circumferential direction while reciprocating in an axial direction at a given amplitude. In the stent, connecting parts are formed to link portions of the line-shaped body that are adjacent in the axial direction, and a friable part is provided to rupture itself by being implanted in the somatic lumen and release a link made by the connecting parts.

10. 发明申请

US20060024066A1 Optical modulating device 失效
标题翻译：光调制装置
公开(公告)号：US20060024066A1
公开(公告)日：2006-02-02
申请号：US10534310
申请日：2004-06-16
申请人： Masamichi Fujiwara , Junichi Kani , Koji Akimoto , Katsumi Iwatsuki
发明人： Masamichi Fujiwara , Junichi Kani , Koji Akimoto , Katsumi Iwatsuki
IPC分类号： H04B10/04 , H01S3/00
CPC分类号： H04B10/2587 , H04B10/2971 , H04B2210/258 , H04J14/02
摘要： An optical modulation apparatus is provided which implements a stable amplifying function by reducing the effect of reflected light rays form end faces of a bidirectional optical amplifier by imposing a numerical limitation on the relationship between the gain of the bidirectional optical amplifier and the loss of the optical modulator, or by inserting a polarization rotation section in a reflection type optical modulator including the bidirectional optical amplifier or in a multi-wavelength collective optical modulation system combining the multiple optical modulators. An optical modulation apparatus is provided which implements a stable amplifying function and cost reduction by reducing the effect of reflected light rays by interposing optical isolators at every alternate SOAs in a transmission-type optical modulation apparatus including a plurality of semiconductor optical amplifiers (SOAs) connected in a multistage fashion.
摘要翻译：提供一种光调制装置，其通过对双向光放大器的增益与光学损耗之间的关系施加数值限制来减小由双向光放大器的端面反射的反射光的影响来实现稳定的放大功能或者通过在包括双向光放大器的反射型光调制器中插入偏振旋转部分，或者在组合多个光调制器的多波长集合光调制系统中。提供了一种光调制装置，其通过在包括连接的多个半导体光放大器（SOA）的透射型光调制装置中的每个替代的SOA处插入光隔离器来减小反射光线的影响，从而实现了稳定的放大功能和成本降低以多层次的方式。

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