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1. 发明授权

US06569652B1 Process for preparing optically active 1,2-diols 失效
标题翻译：光学活性1,2-二醇的制备方法
公开(公告)号：US06569652B1
公开(公告)日：2003-05-27
申请号：US09486442
申请日：2000-02-25
申请人： Tamotsu Eguchi , Hideyo Kumazawa , Kenichi Mochida
发明人： Tamotsu Eguchi , Hideyo Kumazawa , Kenichi Mochida
IPC分类号： C12P1302
CPC分类号： C12P7/22
摘要： The present invention relates to a process for producing optically active diols represented by the general formula (II): wherein R1 represents (CH2)n, CH═CH, O, S or NH whereupon n is an integer of 1 to 4, and R2 represents hydrogen, C1-6 alkyl, C1-6 alkoxy, (C1-6 alkoxy)-carbonyl, hydroxy, carboxy, halogen, nitro or amino, which comprises treating compounds represented by the general formula (I): wherein R1 and R2 have the same meanings as defined above, with a culture of a microorganism belonging to the genus Rhodococcus, Bacillus, Brevibacterium or Gordona and being capable of stereoselectively diolating a double bond in ring A, or with a culture of Mortierella vinacea, or with said microorganism itself, or with a treated material from said microorganism.
摘要翻译：本发明涉及由通式（II）表示的光学活性二醇的制备方法：其中R1表示（CH2）n，CH = CH，O，S或NH，其中n为1〜4的整数，R2为代表氢，C 1-6烷基，C 1-6烷氧基，（C 1-6烷氧基） - 羰基，羟基，羧基，卤素，硝基或氨基，其包括处理由通式（I）表示的化合物：其中R1和R2具有与上述定义相同，具有属于红球菌属，芽孢杆菌属，短杆菌属或戈多纳属的微生物的培养物，并且能够立体选择性地使环A中的双键二醇化，或与被孢霉属（Mortierella vinacea）的培养物或与所述微生物本身，或与来自所述微生物的处理物质混合。

2. 发明授权

US4929551A Process for producing L(-)-tetrahydrofolic acid 失效
标题翻译：生产L（ - ） - 四氢叶酸的方法
公开(公告)号：US4929551A
公开(公告)日：1990-05-29
申请号：US393795
申请日：1989-08-15
申请人： Tamotsu Eguchi , Takashi Oshiro , Yukihiro Kuge , Kenichi Mochida , Takayuki Uwajima
发明人： Tamotsu Eguchi , Takashi Oshiro , Yukihiro Kuge , Kenichi Mochida , Takayuki Uwajima
IPC分类号： C12P1/00 , C12P17/18
CPC分类号： C12P17/182 , C12P1/00 , Y10S435/814 , Y10S435/849
摘要： The invention relates to a process for producing L(-)-tetrahydrofolic acid which comprises allowing dihydrofolate reductase to act upon dihydrofolic acid in the presence of (1) NADP or NADPH, and (2) glucose and glucose dehydrogenase. L(-)-tetrahydrofolic acid is useful as the intermediate for L(-)-leucovarin.

3. 发明授权

US6107064A Process for producing xanthine derivatives with bacteria and fungi 失效
标题翻译：用细菌和真菌生产黄嘌呤衍生物的方法
公开(公告)号：US6107064A
公开(公告)日：2000-08-22
申请号：US581533
申请日：1996-01-17
申请人： Junichi Shimada , Tamotsu Eguchi , Kenichi Mochida , Akira Horiguchi , Tohru Yasuzawa , Hideaki Kusaka , Hiromi Nonaka , Fumio Suzuki
发明人： Junichi Shimada , Tamotsu Eguchi , Kenichi Mochida , Akira Horiguchi , Tohru Yasuzawa , Hideaki Kusaka , Hiromi Nonaka , Fumio Suzuki
IPC分类号： C07D473/04 , C07D473/06 , C12P17/18 , C12P17/16
CPC分类号： C07D473/04 , C07D473/06 , C12P17/18
摘要： The present invention relates to a process for producing a xanthine derivative represented by formula (II), comprising converting a xanthine derivative represented by formula (I) {hereinafter, referred to as Compound (I)}: ##STR1## (wherein R.sup.1 and R.sup.2 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl) into a xanthine derivative represented by formula (II) {hereinafter, referred to as Compound (II)}: ##STR2## (wherein R.sup.3 and R.sup.4 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl; R.sup.5 and R.sup.6 independently represent hydrogen, hydroxy, or oxo; with the proviso that R.sup.5 and R.sup.6 are both hydrogen, at least one of R.sup.3 and R.sup.4 is hydroxy-substituted or oxo-substituted lower alkyl; and X and Y both represent hydrogen or are combined with each other to form a single bond) in the presence of an enzyme source for catalyzing hydroxylation or carbonylation of Compound (I) into Compound (II), and collecting the produced Compound (II).
摘要翻译： PCT No.PCT / JP95 / 00929 Sec。 371日期1996年1月17日 102（e）日期1996年1月17日PCT提交1995年5月16日PCT公布。公开号WO95 / 31460 日本特开平9-1252号公报发明内容本发明涉及由式（II）表示的黄嘌呤衍生物的制造方法，其特征在于，将由式（I）表示的黄嘌呤衍生物{以下称为化合物（I）} 和R2独立地表示氢或羟基取代的，取代或未取代的低级烷基）转化为由式（II）表示的黄嘌呤衍生物（以下称为化合物（II）}：（其中R 3和R 4独立地表示氢或羟基取代的，取代或未取代的低级烷基; R 5和R 6独立地表示氢，羟基或氧代;条件是R 5和R 6都是氢，R 3和R 4中的至少一个是羟基取代的或氧代取代的低级烷基; X和Y均表示氢或彼此结合形成单键）在用于催化化合物（I）羟化或羰基化成化合物（II）的酶源的存在下，以及大学将所制备的化合物（II）。

4. 发明授权

US4694001A .beta.-lactam compound and a pharmaceutical composition containing the same 失效
标题翻译： β-内酰胺化合物和含有该β-内酰胺的药物组合物
公开(公告)号：US4694001A
公开(公告)日：1987-09-15
申请号：US674710
申请日：1984-11-26
申请人： Tadashi Hirata , Kenichi Mochida , Chihiro Shiraki , Kiyoshi Sato
发明人： Tadashi Hirata , Kenichi Mochida , Chihiro Shiraki , Kiyoshi Sato
IPC分类号： C07D277/20 , A61K31/435 , A61K31/535 , A61K31/545 , A61K31/546 , A61P31/04 , C07D277/38 , C07D277/40 , C07D277/46 , C07D463/00 , C07D501/20 , C07D501/22 , C07D501/34 , C07D501/59 , C07D505/00 , C07D205/12 , A61K31/395
CPC分类号： C07D505/00 , C07D277/46 , C07D463/22 , Y02P20/55
摘要： .beta.-Lactam compounds represented by the general formula: ##STR1## (wherein X represents CH.sub.2, S or O; Y represents a hydroxyl group, a lower alkanoyloxy group or a lower alkoxycarbonyloxy group; W is a group represented by CH.sub.2, NH, ##STR2## A is a phenyl group, a naphthyl group, or a monocyclic or dicyclic heterocyclic group, respectively substituted by (Y).sub.n ; R.sub.4 and R.sub.5 each are a hydrogen atom, a lower alkyl group, or a cycloalkylidene group with a carbon atom combined therewith; l is 0 or an integer of 1, 2 or 3; m is 0 or 1; n is an integer of 1, 2, 3, 4 or 5; and R.sub.1, R.sub.2 and R.sub.3 are groups often used in the conventional .beta.-lactam compounds) have strong antimicrobial activities against a wide range of Gram positive and negative bacteria; particularly Gram negative bacteria including Pseudomonas aeruginosa, Pseudomonas sepatia and various Enterobacters.
摘要翻译：由以下通式表示的β-内酰胺化合物：其中X表示CH 2，S或O; Y表示羟基，低级烷酰氧基或低级烷氧基羰氧基; W表示为CH 2，NH，图像A是分别被（Y）n取代的苯基，萘基或单环或二环杂环基; R 4和R 5各自为氢原子，低级烷基或具有碳原子的亚环烷基 l是0或1,2或3的整数; m是0或1; n是1,2,3,4或5的整数; R 1，R 2和R 3是通常用于常规的基团 β-内酰胺化合物）对广泛的革兰氏阳性和阴性细菌具有很强的抗微生物活性; 特别是革兰氏阴性细菌，包括铜绿假单胞菌，假单胞菌分离菌和各种肠道特征。

5. 发明授权

US4169942A Fortimicin derivatives and method for production thereof 失效
标题翻译：衍生物衍生物及其生产方法
公开(公告)号：US4169942A
公开(公告)日：1979-10-02
申请号：US899725
申请日：1978-04-25
申请人： Kenichi Mochida , Yasuki Mori
发明人： Kenichi Mochida , Yasuki Mori
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/224 , C07H15/22
CPC分类号： C07H15/224
摘要： 6'-N-methylfortimicin D and 6'-N-methylfortimicin KE are produced by chemically moidifying fortimicin KE. 6'-N-methylfortimicin D is useful as an antibacterial compound; and 6'-N-methylfortimicin KE is useful as an intermediate in the synthesis of the former compound.

6. 发明授权

US4016186A .beta.-Phenoxy or substituted phenoxy ethanol compounds 失效
标题翻译： {62-苯氧基或取代的苯氧基乙醇化合物
公开(公告)号：US4016186A
公开(公告)日：1977-04-05
申请号：US527417
申请日：1974-11-26
申请人： Kiyosi Kondo , Osamu Terada , Kohei Oshima , Yasuki Mori , Kenichi Mochida
发明人： Kiyosi Kondo , Osamu Terada , Kohei Oshima , Yasuki Mori , Kenichi Mochida
IPC分类号： C07C69/003 , C07C69/76
CPC分类号： C07C69/003
摘要： Novel .beta.-phenoxy- or substituted phenoxy-ethanol compounds or esters thereof expressed by the formula ##STR1## wherein R.sup.1 is a hydrogen atom or an alkyl group, R.sup.2 is a hydrogen atom or a substituent, Y is --OH group or group ##STR2## R.sup.3 is an alkyl group, and n is an integer of 1 to 3. These compounds have juvenile hormone activities, and are useful for hormonal pest control and increased production of silkworm cocoons.
摘要翻译：新的β-苯氧基 - 或取代的苯氧基 - 乙醇化合物或其由下式表示的酯其中R 1是氢原子或烷基，R 2是氢原子或取代基，Y是-OH基团或基团 R3为烷基，n为1〜3的整数。

7. 发明授权

US06613774B1 Pyrrolo [4,3,2-de] quinoline derivatives 失效
标题翻译：吡咯并[4,3,2-de]喹啉衍生物
公开(公告)号：US06613774B1
公开(公告)日：2003-09-02
申请号：US09720900
申请日：2001-01-02
申请人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
发明人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
IPC分类号： A61K314745
CPC分类号： C07D471/06
摘要： LK6-A derivatives which have immmunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. and which are represented by general formula (I): as defined herein, and pharmaceutically acceptable salts thereof.
摘要翻译： LK6-A衍生物，其具有免疫抑制活性，细胞生长抑制活性，抗肿瘤活性等，并且由通式（I）表示：如本文所定义，及其药学上可接受的盐。

8. 发明授权

US4237272A Derivatives of fortimicin A 失效
标题翻译： fortimicin A的衍生物
公开(公告)号：US4237272A
公开(公告)日：1980-12-02
申请号：US971438
申请日：1978-12-20
申请人： Kenichi Mochida , Moriyuki Sato , Shigeo Yoshiie , Yasuki Mori
发明人： Kenichi Mochida , Moriyuki Sato , Shigeo Yoshiie , Yasuki Mori
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224 , Y02P20/55
摘要： Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin A.
摘要翻译：半合成抗菌化合物是通过化学改性抗菌复合物强力霉素A.

9. 发明授权

US4226980A Novel derivatives of fortimicin B and process for preparing same 失效
标题翻译： fortimicin B的新型衍生物及其制备方法
公开(公告)号：US4226980A
公开(公告)日：1980-10-07
申请号：US967352
申请日：1978-12-07
申请人： Moriyuki Sato , Kenichi Mochida , Shigeo Yoshiie , Yasuki Mori
发明人： Moriyuki Sato , Kenichi Mochida , Shigeo Yoshiie , Yasuki Mori
IPC分类号： C07H15/224 , A61K31/71 , C07H15/22
CPC分类号： C07H15/224
摘要： Semisynthetic antibacterial compounds are produced by chemically modifying the antibacterial compound fortimicin B.
摘要翻译：半合成抗菌化合物是通过化学修饰抗菌化合物fortimicin B.

10. 发明授权

US06815449B2 LK6-A derivatives 失效
标题翻译： LK6-A衍生物
公开(公告)号：US06815449B2
公开(公告)日：2004-11-09
申请号：US10289317
申请日：2002-11-07
申请人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
发明人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
IPC分类号： A61K314745
CPC分类号： C07D471/06
摘要： Compounds having immunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. are represented by formula I: and pharmaceutically acceptable salts thereof.
摘要翻译：具有免疫抑制活性，细胞生长抑制活性，抗肿瘤活性等的化合物由式I表示：及其药学上可接受的盐。

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