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    • 4. 发明授权
    • Applicator for fluid
    • 流体施加器
    • US06491466B1
    • 2002-12-10
    • US09980401
    • 2001-12-03
    • Tamotsu EguchiKenzi SatoMakoto Ono
    • Tamotsu EguchiKenzi SatoMakoto Ono
    • B43K518
    • B43L19/00A45D34/04B43K7/02B43K8/03
    • An applicator includes a reservoir charged with fluid. The reservoir has a discharge-controlling mechanism at one end for applying the fluid. The fluid contains at least one organic solvent, such as mythylcyclohexane, and is charged with a scarcely volatile liquid substance, such as an alkylene oxide adduct of diglycerin, having no compatibility with the applying fluid. The scarcely volatile liquid substance forms a movable plug for an end part of the applying fluid in a contact state and the rear of the plug in the reservoir is released to the atmosphere. The applicator can include writing instruments including a felt tip pen and a ballpoint pen, a corrector, an applicator for adhesive and a dressing instrument.
    • 施加器包括装满流体的储存器。 储存器在一端具有用于施加流体的排出控制机构。 流体含有至少一种有机溶剂,例如乙烯基环己烷,并且与几乎不挥发的液体物质如二甘油的烯化氧加合物一起加载,与施加流体不相容。 几乎不挥发的液体物质形成用于接触状态下的施加流体的端部的可移动塞,并且储存器中的塞子的后部释放到大气中。 涂布器可以包括书写工具,包括毡尖笔和圆珠笔,校正器,粘合剂涂布器和敷料仪器。
    • 5. 发明授权
    • Click type writing implement
    • 点击类型书写工具
    • US06435751B1
    • 2002-08-20
    • US09980790
    • 2001-12-06
    • Makoto OnoHitoshi NakamuraTadashi KorikiTamotsu EguchiSeiichi Kobayashi
    • Makoto OnoHitoshi NakamuraTadashi KorikiTamotsu EguchiSeiichi Kobayashi
    • A46B1102
    • B43K24/082
    • A click type writing implement includes: a ball-pen refill composed of a point assembly at the front end thereof, an ink storage at the rear thereof and a pressurizing mechanism of a pumping type at the rear of the ink storage; an arrangement for holding the refill and engaging it so as to allow the tip of the point assembly to be projected from and retracted into the front end; and a clicking mechanism for keeping the tip of the point assembly projected, the clicking mechanism comprising: a first clicking mechanism for advancing and contracting ink by a short stroke and a second clicking mechanism for advancing and contracting ink by a large stroke, so that the rear end of ink can be pressurized at two levels so as to promote flow of ink toward the point assembly.
    • 点击型书写工具包括:在其前端由点组件,其后部的墨水储存器和在墨水存储器后部的泵送型加压机构组成的圆珠笔填充物; 用于保持再充填并​​将其接合以使点组件的尖端从前端伸出并缩回到前端的装置; 以及用于保持点组件的尖端投影的咔嗒机构,所述咔嗒机构包括:用于通过短行程使油墨前进和收缩的第一咔嗒机构,以及用于大笔画进给和收缩油墨的第二咔嗒机构, 油墨的后端可以被加压到两个水平,以促进油墨朝向点组件的流动。
    • 6. 发明授权
    • Process for producing xanthine derivatives with bacteria and fungi
    • 用细菌和真菌生产黄嘌呤衍生物的方法
    • US6107064A
    • 2000-08-22
    • US581533
    • 1996-01-17
    • Junichi ShimadaTamotsu EguchiKenichi MochidaAkira HoriguchiTohru YasuzawaHideaki KusakaHiromi NonakaFumio Suzuki
    • Junichi ShimadaTamotsu EguchiKenichi MochidaAkira HoriguchiTohru YasuzawaHideaki KusakaHiromi NonakaFumio Suzuki
    • C07D473/04C07D473/06C12P17/18C12P17/16
    • C07D473/04C07D473/06C12P17/18
    • The present invention relates to a process for producing a xanthine derivative represented by formula (II), comprising converting a xanthine derivative represented by formula (I) {hereinafter, referred to as Compound (I)}: ##STR1## (wherein R.sup.1 and R.sup.2 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl) into a xanthine derivative represented by formula (II) {hereinafter, referred to as Compound (II)}: ##STR2## (wherein R.sup.3 and R.sup.4 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl; R.sup.5 and R.sup.6 independently represent hydrogen, hydroxy, or oxo; with the proviso that R.sup.5 and R.sup.6 are both hydrogen, at least one of R.sup.3 and R.sup.4 is hydroxy-substituted or oxo-substituted lower alkyl; and X and Y both represent hydrogen or are combined with each other to form a single bond) in the presence of an enzyme source for catalyzing hydroxylation or carbonylation of Compound (I) into Compound (II), and collecting the produced Compound (II).
    • PCT No.PCT / JP95 / 00929 Sec。 371日期1996年1月17日 102(e)日期1996年1月17日PCT提交1995年5月16日PCT公布。 公开号WO95 / 31460 日本特开平9-1252号公报发明内容本发明涉及由式(II)表示的黄嘌呤衍生物的制造方法,其特征在于,将由式(I)表示的黄嘌呤衍生物{以下称为化合物(I)} 和R2独立地表示氢或羟基取代的,取代或未取代的低级烷基)转化为由式(II)表示的黄嘌呤衍生物(以下称为化合物(II)}:(其中R 3和R 4独立地表示氢 或羟基取代的,取代或未取代的低级烷基; R 5和R 6独立地表示氢,羟基或氧代;条件是R 5和R 6都是氢,R 3和R 4中的至少一个是羟基取代的或 氧代取代的低级烷基; X和Y均表示氢或彼此结合形成单键)在用于催化化合物(I)羟化或羰基化成化合物(II)的酶源的存在下,以及大学 将所制备的化合物(II)。
    • 8. 发明授权
    • Process for preparing optically active 1,2-diols
    • 光学活性1,2-二醇的制备方法
    • US06569652B1
    • 2003-05-27
    • US09486442
    • 2000-02-25
    • Tamotsu EguchiHideyo KumazawaKenichi Mochida
    • Tamotsu EguchiHideyo KumazawaKenichi Mochida
    • C12P1302
    • C12P7/22
    • The present invention relates to a process for producing optically active diols represented by the general formula (II): wherein R1 represents (CH2)n, CH═CH, O, S or NH whereupon n is an integer of 1 to 4, and R2 represents hydrogen, C1-6 alkyl, C1-6 alkoxy, (C1-6 alkoxy)-carbonyl, hydroxy, carboxy, halogen, nitro or amino, which comprises treating compounds represented by the general formula (I): wherein R1 and R2 have the same meanings as defined above, with a culture of a microorganism belonging to the genus Rhodococcus, Bacillus, Brevibacterium or Gordona and being capable of stereoselectively diolating a double bond in ring A, or with a culture of Mortierella vinacea, or with said microorganism itself, or with a treated material from said microorganism.
    • 本发明涉及由通式(II)表示的光学活性二醇的制备方法:其中R1表示(CH2)n,CH = CH,O,S或NH,其中n为1〜4的整数,R2为 代表氢,C 1-6烷基,C 1-6烷氧基,(C 1-6烷氧基) - 羰基,羟基,羧基,卤素,硝基或氨基,其包括处理由通式(I)表示的化合物:其中R1和R2具有 与上述定义相同,具有属于红球菌属,芽孢杆菌属,短杆菌属或戈多纳属的微生物的培养物,并且能够立体选择性地使环A中的双键二醇化,或与被孢霉属(Mortierella vinacea)的培养物或与所述微生物本身 ,或与来自所述微生物的处理物质混合。