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1. 发明授权

US06815449B2 LK6-A derivatives 失效
标题翻译： LK6-A衍生物
公开(公告)号：US06815449B2
公开(公告)日：2004-11-09
申请号：US10289317
申请日：2002-11-07
申请人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
发明人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
IPC分类号： A61K314745
CPC分类号： C07D471/06
摘要： Compounds having immunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. are represented by formula I: and pharmaceutically acceptable salts thereof.
摘要翻译：具有免疫抑制活性，细胞生长抑制活性，抗肿瘤活性等的化合物由式I表示：及其药学上可接受的盐。

2. 发明授权

US06613774B1 Pyrrolo [4,3,2-de] quinoline derivatives 失效
标题翻译：吡咯并[4,3,2-de]喹啉衍生物
公开(公告)号：US06613774B1
公开(公告)日：2003-09-02
申请号：US09720900
申请日：2001-01-02
申请人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
发明人： Tsutomu Akama , Hiroyuki Nagata , Atsuhiro Hasegawa , Harumi Ue , Isami Takahashi , Yutaka Saitoh , Kenichi Mochida , Shun-ichi Ikeda , Yutaka Kanda
IPC分类号： A61K314745
CPC分类号： C07D471/06
摘要： LK6-A derivatives which have immmunosuppressive activity, cell growth inhibitory activity, anti-tumor activity, etc. and which are represented by general formula (I): as defined herein, and pharmaceutically acceptable salts thereof.
摘要翻译： LK6-A衍生物，其具有免疫抑制活性，细胞生长抑制活性，抗肿瘤活性等，并且由通式（I）表示：如本文所定义，及其药学上可接受的盐。

3. 发明授权

US06869971B1 UCS1025 derivatives 失效
标题翻译： UCS1025衍生品
公开(公告)号：US06869971B1
公开(公告)日：2005-03-22
申请号：US10110964
申请日：2000-10-19
申请人： Tsutomu Akama , Akira Asai , Tsutomu Agatsuma , Shinji Nara , Yoshinori Yamashita , Tamio Mizukami , Shun-ichi Ikeda , Yutaka Saitoh , Yutaka Kanda
发明人： Tsutomu Akama , Akira Asai , Tsutomu Agatsuma , Shinji Nara , Yoshinori Yamashita , Tamio Mizukami , Shun-ichi Ikeda , Yutaka Saitoh , Yutaka Kanda
IPC分类号： A61P31/04 , A61P35/00 , C07D487/04 , C07D487/14 , C07D487/16 , C07D491/14 , C07D491/147 , C07D491/16 , C07D498/08 , A61K31/403 , A61K31/4453 , C07D209/52 , C07D401/06
CPC分类号： C07D487/04 , C07D487/14 , C07D491/14
摘要： UCS 1025 derivatives having antitumor activity or antibacterial activity which are represented by formula (I): wherein R1 represents hydrogen, lower alkyl, etc.; R2 represents hydrogen, or is combined with R3 to represent a bond, etc., or is combined with R4 to represent —O(C═O)—, etc.; R3 represents hydrogen, etc., or is combined with R2 to represent a bond, etc.; R4 represents hydrogen, etc., or is combined with R2 to represent —(C═O)O—, etc.; R5 represents hydrogen or is combined with R6 to represent a bond; R6 represents hydrogen, etc., or is combined with R5 to represent a bond; R7 represents hydrogen or is combined with R8 to represent ═O; R8 represents hydroxy or is combined with R7 to represent ═O; ---- represents a single bond or a double bond, and a represents a single bond (two carbon atoms to which a is bound are combined to form a single bond) or an oxygen atom, or pharmaceutically acceptable salts thereof.
摘要翻译：由式（I）表示的具有抗肿瘤活性或抗菌活性的UCS 1025衍生物：其中R 1表示氢，低级烷基等; R 2表示氢，或与R 3结合以表示键等，或与R 4结合以表示-O（C = O） - 等; R 3表示氢等，或与R 2结合以表示键等; R 4表示氢等，或与R 2结合代表 - （C = O）O-等; R 5表示氢或与R 6结合以表示键; R 6表示氢等，或与R 5结合以表示键; R 7表示氢或与R 8结合以代表= O; R 8表示羟基或与R 7结合代表= O; ----表示单键或双键，a表示单键（被结合形成单键的两个碳原子）或氧原子，或其药学上可接受的盐。

4. 发明授权

US5977165A Radicicol derivatives 失效
标题翻译：蓝霉素衍生物
公开(公告)号：US5977165A
公开(公告)日：1999-11-02
申请号：US958285
申请日：1997-10-27
申请人： Tsutomu Agatsuma , Yutaka Saitoh , Yoshinori Yamashita , Tamio Mizukami , Shiro Akinaga , Katsushige Gomi , Kazuhito Akasaka , Isami Takahashi
发明人： Tsutomu Agatsuma , Yutaka Saitoh , Yoshinori Yamashita , Tamio Mizukami , Shiro Akinaga , Katsushige Gomi , Kazuhito Akasaka , Isami Takahashi
IPC分类号： C07D313/00 , A61K31/335
CPC分类号： C07D313/00
摘要： The present invention relates to radicicol derivatives represented by the following formula (I) or pharmacologically acceptable salts thereof: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; (1) when X represents halogen, Y represents an oxygen atom or R.sup.4 --O--N (wherein R.sup.4 represents hydrogen or substituted or unsubstituted lower alkyl); and R.sup.3 represents hydrogen, alkanoyl, alkenoyl or the like; and (2) when X and R.sup.3 are combined with each other to represent a single bond; Y represents R.sup.4B --O--N (wherein R.sup.4B has the same meaning as R.sup.4). The radicicol derivatives of the present invention demonstrate tyrosine kinase inhibition activity and pharmacological activities such as antitumor, antimicrobial or immunosuppression effects.
摘要翻译：本发明涉及由下式（I）表示的根赤壳菌素衍生物或其药理学上可接受的盐：其中R1和R2相同或不同，各自代表氢，烷酰基，烯酰基或叔丁基二甲基甲硅烷基; （1）当X表示卤素时，Y表示氧原子或R4-O-N（其中R4表示氢或取代或未取代的低级烷基）; 和R3表示氢，烷酰基，烯酰基等; 和（2）当X和R 3相互结合以表示单键时; Y表示R4B-O-N（其中R4B与R4相同）。本发明的根皮霉素衍生物显示出酪氨酸激酶抑制活性和药理活性，如抗肿瘤，抗微生物或免疫抑制作用。

5. 发明授权

US5733924A DC 107 derivatives and treatment methods 失效
标题翻译： DC 107衍生物和处理方法
公开(公告)号：US5733924A
公开(公告)日：1998-03-31
申请号：US776938
申请日：1997-04-17
申请人： Yutaka Kanda , Yutaka Saitoh , Hiromitsu Saito , Tadashi Ashizawa , Kazuyo Sugiyama , Katsushige Gomi , Shingo Kakita , Yuichi Takahashi , Chikara Murakata
发明人： Yutaka Kanda , Yutaka Saitoh , Hiromitsu Saito , Tadashi Ashizawa , Kazuyo Sugiyama , Katsushige Gomi , Shingo Kakita , Yuichi Takahashi , Chikara Murakata
IPC分类号： C07D513/08 , A61K37/00
CPC分类号： C07D513/08
摘要： DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, �wherein R.sup.1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4 or the like; R.sup.2 represents hydrogen or COR.sup.5 ; R.sup.3 represents lower alkyl, lower alkenyl, aralkyl which may be substituted with substituted or unsubstituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, substituted or unsubstituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxyalkyl, alicyclic alkanoyloxyalkyl or the like, or bonds to Y to represent a single bond; Y bonds to R.sup.3 to represent a single bond, or bonds to Z to represent a single bond; Z represents hydrogen or bonds to Y to represent a single bond; W represents oxygen or NR.sup.6, with the proviso that the compound wherein R.sup.1, R.sup.2 and Z each represents hydrogen, R.sup.3 bonds to Y to represent a single bond, and W represents oxygen (DC107) is excluded.!
摘要翻译： PCT No.PCT / JP96 / 01646 Sec。 371日期1997年04月17日 102（e）1997年4月17日PCT PCT 1996年6月14日PCT公布。出版物WO97 / 00260 PCT 日本1997年3月1日由式（I）代表的DC107衍生物：其中R1为氢，低级烷氧基烷基，芳烷氧基烷基，低级烷氧基烷氧基烷基，低级烷氧基烷氧基烷氧基烷基，芳烷基，四氢吡喃基，COR4或类似; R2表示氢或COR5; R3代表低级烷基，低级烯基，可被取代或未取代的芳基取代的芳烷基，低级烷氧基烷基，芳烷氧基烷基，取代或未取代的芳氧基烷基，低级烷氧基羰基烷基，低级烷酰氧基烷基，脂环族烷酰氧基烷基等，或与Y键合以表示单键 ; Y键合到R3表示单键，或键合到Z表示单键; Z表示氢或与Y键合以表示单键; W表示氧或NR 6，条件是其中R1，R2和Z各自表示氢，R3与Y键合以表示单键，W表示氧（DC107）的化合物。

6. 发明授权

US5925641A Farnesyltransferase inhibitor 失效
标题翻译：法呢基转移酶抑制剂
公开(公告)号：US5925641A
公开(公告)日：1999-07-20
申请号：US912870
申请日：1997-08-19
申请人： Yutaka Kanda , Yutaka Saitoh , Kazuhito Akasaka , Tamio Mizukami , Hirofumi Nakano
发明人： Yutaka Kanda , Yutaka Saitoh , Kazuhito Akasaka , Tamio Mizukami , Hirofumi Nakano
IPC分类号： A61K31/495 , A61K31/54 , C07D241/08 , C07D513/08
CPC分类号： C07D513/08 , A61K31/495 , A61K31/54 , C07D241/08
摘要： The present invention relates to a farnesyltransferase inhibitor and an antitumor agent comprising, as an active ingredient, a piperazinedione derivative represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent lower alkyl, lower alkoxyalkyl, substituted or unsubstituted aryl, or aralkyl; R.sup.3 and R.sup.4 independently represent mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio, or aryloxycarbonylthio, or alternatively R.sup.3 and R.sup.4 are combined together to form disulfide; and R.sup.5 and R.sup.6 independently represent hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl, or aralkyl.
摘要翻译：本发明涉及法呢基转移酶抑制剂和抗肿瘤剂，其包含作为活性成分的由式（I）表示的哌嗪二酮衍生物：其中R1和R2独立地表示低级烷基，低级烷氧基烷基，取代或未取代的芳基或芳烷基; R3和R4独立地表示巯基，低级烷酰硫基，芳酰硫基，低级烷氧基羰基硫基或芳氧基羰基硫基，或者R3和R4组合在一起形成二硫化物; R 5和R 6独立地表示氢，低级烷基，低级烷氧基烷基，羟烷基，低级烷酰氧基烷基，芳氧基烷基，芳烷氧基烷基或芳烷基。

7. 发明授权

US5728830A Farnesyltransferase inhibitor 失效
标题翻译：法呢基转移酶抑制剂
公开(公告)号：US5728830A
公开(公告)日：1998-03-17
申请号：US436458
申请日：1995-05-22
申请人： Yutaka Kanda , Yutaka Saitoh , Kazuhito Akasaka , Tamio Mizukami , Hirofumi Nakano
发明人： Yutaka Kanda , Yutaka Saitoh , Kazuhito Akasaka , Tamio Mizukami , Hirofumi Nakano
IPC分类号： A61K31/495 , A61K31/54 , C07D241/08 , C07D513/08 , C07D285/15
CPC分类号： C07D513/08 , A61K31/495 , A61K31/54 , C07D241/08
摘要： The present invention relates to a farnesyltransferase inhibitor and an antitumor agent comprising, as an active ingredient, a piperazinedione derivative represented by formula (I): ##STR1## wherein R.sup.1 and R.sup.2 independently represent lower alkyl, lower alkoxyalkyl, substituted or unsubstituted aryl, or aralkyl; R.sup.3 and R.sup.4 independently represent mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio, or aryloxycarbonylthio, or alternatively R.sup.3 and R.sup.4 are combined together to form disulfide; and R.sup.5 and R.sup.6 independently represent hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl, or aralkyl.
摘要翻译： PCT No.PCT / JP94 / 01543 Sec。 371日期：1995年5月22日 102（e）日期1995年5月22日PCT 1994年9月20日PCT公布。出版物WO95 / 08542 日期：1995年3月30日本发明涉及法呢基转移酶抑制剂和抗肿瘤剂，其包含作为活性成分的式（I）表示的哌嗪二酮衍生物：其中R 1和R 2独立地表示低级烷基，低级烷氧基烷基，取代或未取代的芳基或芳烷基; R3和R4独立地表示巯基，低级烷酰硫基，芳酰硫基，低级烷氧基羰基硫基或芳氧基羰基硫基，或者R3和R4组合在一起形成二硫化物; R 5和R 6独立地表示氢，低级烷基，低级烷氧基烷基，羟烷基，低级烷酰氧基烷基，芳氧基烷基，芳烷氧基烷基或芳烷基。

8. 发明授权

US07787915B2 Folding type portable wireless unit 失效
标题翻译：折叠型便携式无线单元
公开(公告)号：US07787915B2
公开(公告)日：2010-08-31
申请号：US11571747
申请日：2005-07-12
申请人： Hiroyuki Uejima , Yutaka Isoda , Nobuharu Mashima , Masayoshi Hirai , Nobuhiro Iwai , Yutaka Saitoh , Kenichi Maeda
发明人： Hiroyuki Uejima , Yutaka Isoda , Nobuharu Mashima , Masayoshi Hirai , Nobuhiro Iwai , Yutaka Saitoh , Kenichi Maeda
IPC分类号： H04M1/00
CPC分类号： H01Q1/243 , H01Q9/285 , H01Q9/42 , H04M1/0216
摘要： In a folding mobile radio device, a gain is lowered considerably in its close state under such a condition that an upper case is excited directly in its open state to aim at a wide band and a high gain is used as an antenna. A folding mobile radio device includes a first case, a second case, a jointing portion for connecting the first case and the second case to open/close, a conductor element arranged in the first case, and a feeding element arranged in the second case. Then, in an open state via the jointing portion, the conductor element and the feeding element come close to each other and are coupled magnetically at a time of feeding a power whereas, in a close state via the jointing portion, the conductor element and the feeding element are apart from each other rather than the open state and are not coupled magnetically at a time of feeding a power.
摘要翻译：在折叠式移动无线电设备中，在大气体在其打开状态下被直接激发以对准宽带并且高增益被用作天线的条件下，在其接近状态下，增益显着降低。折叠移动无线电设备包括第一壳体，第二壳体，用于连接第一壳体和第二壳体以打开/关闭的接合部分，布置在第一壳体中的导体元件和布置在第二壳体中的馈送元件。然后，通过接合部处于断开状态，导体元件和馈电元件彼此接近并且在馈电时磁耦合，而在接合状态下，通过接合部分导体元件和馈电元件彼此分开而不是打开状态，并且在馈送电力时不会磁耦合。

9. 发明申请

US20070109581A1 Information processing device and preview displaying method 审中-公开
标题翻译：信息处理装置和预览显示方法
公开(公告)号：US20070109581A1
公开(公告)日：2007-05-17
申请号：US11593590
申请日：2006-11-07
申请人： Yutaka Saitoh
发明人： Yutaka Saitoh
IPC分类号： G06F3/12
CPC分类号： G06F3/1285 , G06F3/1208 , G06F3/1245 , G06F3/1256 , G06F3/1284
摘要： An information processing device converts input document data into print data used to control a printer, and displays a print preview before outputting the print data to the printer. In the information processing device, a document data storing unit stores the input document data as intermediate data. A layout determining unit determines a layout of image data of the document data on an output sheet based on a specified printing method, so that layout information is created. A preview displaying unit displays a print preview on a computer screen based on the stored document data. A print data creating unit converts the input document data into the print data.
摘要翻译：信息处理设备将输入的文档数据转换为用于控制打印机的打印数据，并在将打印数据输出到打印机之前显示打印预览。在信息处理设备中，文档数据存储单元将输入的文档数据存储为中间数据。布局确定单元基于指定的打印方法在输出页上确定文档数据的图像数据的布局，从而创建布局信息。预览显示单元基于存储的文档数据在计算机屏幕上显示打印预览。打印数据创建单元将输入的文档数据转换成打印数据。

10. 发明申请

US20060052987A1 Wireless measuring device 有权
标题翻译：无线测量设备
公开(公告)号：US20060052987A1
公开(公告)日：2006-03-09
申请号：US11206157
申请日：2005-08-18
申请人： Shozo Katsuki , Yutaka Saitoh , Tsutomu Tanaka , Akira Ohnishi , Sumitaka Tachikawa
发明人： Shozo Katsuki , Yutaka Saitoh , Tsutomu Tanaka , Akira Ohnishi , Sumitaka Tachikawa
IPC分类号： G06F15/00 , H03F1/26 , H04B15/00
CPC分类号： H04Q9/00
摘要： A wireless measuring device 1 is provided which includes a plurality of child units 2 and a parent unit 3 to receive data measured by these child units 2 by wireless communication. Each of the child units 2 has a controlling section 20 that can move to a standby state, a measuring section 21, a signal receiving section 22 to receive a measurement instructing signal from the parent unit 3, and a signal transmitting section 23 to transmit the measured data by wireless communication. The parent unit 3 has a signal transmitting section to transmit the measurement instructing signal to each of the child units 2 and a measured data receiving section 32 to receive measured data to be transmitted from the signal transmitting section 23.
摘要翻译：提供一种无线测量装置1，其包括多个子单元2和母单元3，以通过无线通信来接收由这些子单元2测量的数据。每个子单元2具有可以移动到待机状态的控制部分20，测量部分21，用于接收来自母单元3的测量指令信号的信号接收部分22以及信号发送部分23，通过无线通信测量数据。母单元3具有信号发送部分，用于将测量指示信号发送到每个子单元2和测量数据接收部分32，以接收从信号发送部分23发送的测量数据。

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