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1. 发明授权

US5514815A Succinimide derivatives and process for preparing the same 失效
标题翻译：琥珀酰亚胺衍生物及其制备方法
公开(公告)号：US5514815A
公开(公告)日：1996-05-07
申请号：US33804
申请日：1993-03-18
申请人： Tameo Iwasaki , Takashi Nishitani , Akio Ohtani , Masanori Inamasu
发明人： Tameo Iwasaki , Takashi Nishitani , Akio Ohtani , Masanori Inamasu
IPC分类号： A61K31/225 , A61K31/40 , C07C235/34 , C07C243/32 , C07D207/02 , C07D401/06 , A61K31/44 , A61K31/535 , C07D207/40 , C07D413/06
CPC分类号： C07D207/02 , A61K31/225 , A61K31/40 , C07C235/34 , C07C243/32 , C07D401/06
摘要： Novel succinimide derivatives of formula I!: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula:>N--R.sup.3or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: --NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.
摘要翻译：式[I]的新型琥珀酰亚胺衍生物：其中环A是三低级烷氧基苯基，其中R 1和R 2相互结合形成下式的基团：其中R 1和R 2之一较低烷氧基，另一个为式-NHR 3基团，其中R 3为氢，取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的氨基，羟基或吡啶基羰基或其盐，这些化合物具有优异的抗血栓形成活性，作为抗血栓药物或合成中间体用于制备其他抗血栓药物。

2. 发明授权

US5639789A Butadiene derivatives and process for using the same 失效
标题翻译：丁二烯衍生物和使用方法相同
公开(公告)号：US5639789A
公开(公告)日：1997-06-17
申请号：US436564
申请日：1995-05-08
申请人： Tameo Iwasaki , Takashi Nishitani , Akio Ohtani , Masanori Inamasu
发明人： Tameo Iwasaki , Takashi Nishitani , Akio Ohtani , Masanori Inamasu
IPC分类号： A61K31/225 , A61K31/40 , C07C235/34 , C07C243/32 , C07D207/02 , C07D401/06 , A61K31/44
CPC分类号： C07D207/02 , A61K31/225 , A61K31/40 , C07C235/34 , C07C243/32 , C07D401/06
摘要： Novel butadiene derivatives of the formula [I]: ##STR1## wherein Ring A is tri-lower alkoxyphenyl, R.sup.1 and R.sup.2 combine each other to form a group of the formula: ##STR2## or one of R.sup.1 and R.sup.2 is lower alkoxy, and the other is group of the formula: -NHR.sup.3, in which R.sup.3 is hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkoxy, substituted or unsubstituted amino, hydroxy or pyridylcarbonyl, or salts thereof, these compounds have excellent antithrombotic activity and are useful as antithrombotic drug, or synthetic intermediate for preparing other antithrombotic drug.
摘要翻译：式[I]的新型丁二烯衍生物：其中环A是三低级烷氧基苯基，R 1和R 2相互结合形成下式的基团：其中R 1和R 2之一较低烷氧基，另一个为式-NHR 3基团，其中R 3为氢，取代或未取代的低级烷基，取代或未取代的低级烷氧基，取代或未取代的氨基，羟基或吡啶基羰基或其盐，这些化合物具有优异的抗血栓形成活性，作为抗血栓药物或合成中间体用于制备其他抗血栓药物。

3. 发明授权

US07448631B2 Braiding yarn made of expanded graphite, and gland packing 有权
标题翻译：由膨胀石墨制成的编织纱线，以及压盖包装
公开(公告)号：US07448631B2
公开(公告)日：2008-11-11
申请号：US11093064
申请日：2005-03-29
申请人： Masao Shimizu , Seiichi Yamashita , Takahisa Ueda , Masaru Fujiwara , Akio Ohtani
发明人： Masao Shimizu , Seiichi Yamashita , Takahisa Ueda , Masaru Fujiwara , Akio Ohtani
IPC分类号： F16J15/22 , D02G3/36
CPC分类号： F16J15/22 , D02G3/447 , D04C1/12 , D10B2505/06
摘要： In a braiding yarn made of expanded graphite 1, a reinforcing wire member 3 made of a stainless steel wire which is easily plastically deformed, and having a diameter of 0.05 to 0.2 mm is spirally wound around the outer periphery of a twisted expanded graphite base member 2 having a width of 3 mm and a thickness of 0.38 mm, at a narrow pitch P of 0.5 to 5 mm without slack. Alternatively, the reinforcing wire member is wound so as to be embedded in the inner side of and along an edge 4 of an expanded graphite tape which is spirally exposed from the outer surface of the expanded graphite base member 2.
摘要翻译：在由膨胀石墨1制成的编织纱中，由扭曲的膨胀石墨基材的外周螺旋地卷绕由容易塑性变形的直径为0.05〜0.2mm的不锈钢丝制成的加强丝构件3， 2，宽度为3mm，厚度为0.38mm，间距P为0.5〜5mm，没有松弛。或者，加强线构件被卷绕成嵌入在从膨胀石墨基底构件2的外表面螺旋状地露出的膨胀石墨带的边缘4的内侧。

4. 发明申请

US20050218604A1 Braiding yarn made of expanded graphite, and gland packing 有权
标题翻译：由膨胀石墨制成的编织纱线，以及压盖包装
公开(公告)号：US20050218604A1
公开(公告)日：2005-10-06
申请号：US11093064
申请日：2005-03-29
申请人： Masao Shimizu , Seiichi Yamashita , Takahisa Ueda , Masaru Fujiwara , Akio Ohtani
发明人： Masao Shimizu , Seiichi Yamashita , Takahisa Ueda , Masaru Fujiwara , Akio Ohtani
IPC分类号： F16J15/22 , F16J15/20
CPC分类号： F16J15/22 , D02G3/447 , D04C1/12 , D10B2505/06
摘要： In a braiding yarn made of expanded graphite 1, a reinforcing wire member 3 made of a stainless steel wire which is easily plastically deformed, and having a diameter of 0.05 to 0.2 mm is spirally wound around the outer periphery of a twisted expanded graphite base member 2 having a width of 3 mm and a thickness of 0.38 mm, at a narrow pitch P of 0.5 to 5 mm without slack. Alternatively, the reinforcing wire member is wound so as to be embedded in the inner side of and along an edge 4 of an expanded graphite tape which is spirally exposed from the outer surface of the expanded graphite base member 2.
摘要翻译：在由膨胀石墨1制成的编织纱中，由扭曲的膨胀石墨基材的外周螺旋地卷绕由容易塑性变形的直径为0.05〜0.2mm的不锈钢丝制成的加强丝构件3， 2，宽度为3mm，厚度为0.38mm，间距P为0.5〜5mm，没有松弛。或者，加强线构件被卷绕成嵌入在从膨胀石墨基底构件2的外表面螺旋状地露出的膨胀石墨带的边缘4的内侧。

5. 发明授权

US4806950A Image recording apparatus for heat generation type 失效
标题翻译：用于发热型的图像记录装置
公开(公告)号：US4806950A
公开(公告)日：1989-02-21
申请号：US063073
申请日：1987-06-17
申请人： Kiyoshi Sekine , Akio Ohtani
发明人： Kiyoshi Sekine , Akio Ohtani
IPC分类号： B41J2/36 , B41J2/38 , B41M5/382 , H04N1/40 , H04N1/405 , G01D15/10
CPC分类号： H04N1/40031 , B41J2/38 , H04N1/4056
摘要： An image recording apparatus of a type using a heat sensitive record paper including a thermal head having a number of heat generating resistors aligned in a line extending in a width direction of the record paper which is fed under the thermal head at a constant speed, and a driving and controlling circuit for supplying heating currents to respective resistors in accordance with an image signal to be recorded. The driving and controlling circuit generates pre-heat pulses whose pulse width is changed in accordance with desired background level of an image to be formed, and record signals for reproducing gray levels of respective dots in the image. Each record signal is composed of a plurality of record pulses having different pulse widths corresponding to weights of digits of a binary image signal.
摘要翻译：一种使用热敏记录纸的类型的图像记录装置，该热敏记录纸包括具有多个发热电阻器的热敏头，所述热敏头具有以在恒定速度下供给在热敏头下的记录纸的宽度方向上延伸的线排列的热发生电阻;以及驱动和控制电路，用于根据要记录的图像信号向各个电阻器供应加热电流。驱动和控制电路产生脉冲宽度根据要形成的图像的期望背景水平而改变的预热脉冲，并记录用于再现图像中各个点的灰度级的信号。每个记录信号由对应于二进制图像信号的位数的权重的具有不同脉冲宽度的多个记录脉冲组成。

6. 发明授权

US06248743B1 Butadiene derivatives and process for preparing thereof 失效
标题翻译：丁二烯衍生物及其制备方法
公开(公告)号：US06248743B1
公开(公告)日：2001-06-19
申请号：US09143358
申请日：1998-08-28
申请人： Hiroshi Ohmizu , Akio Ohtani , Tsuyoshi Ohgiku , Hiroshi Sai , Jun Murakami
发明人： Hiroshi Ohmizu , Akio Ohtani , Tsuyoshi Ohgiku , Hiroshi Sai , Jun Murakami
IPC分类号： A61K31495
CPC分类号： C07D207/02 , C07C69/734 , C07C235/34 , C07C2601/08 , C07D211/58 , C07D213/40 , C07D213/55 , C07D213/56 , C07D213/75 , C07D213/89 , C07D231/12 , C07D231/38 , C07D231/40 , C07D233/56 , C07D239/42 , C07D249/08 , C07D261/14 , C07D317/60 , C07D401/06 , C07D405/12
摘要： A novel butadiene derivative of the formula: wherein Ring A is heterocycle, or benzene being optionally substituted by lower alkyl, alkoxy, nitro, hydroxy, substituted or unsubstituted amino or halogen, Ring B is heterocycle, or benzene being optionally substituted by lower alkoxy, lower alkylenedioxy or di-lower alkylamino, R1 and R2 are each H or lower alkyl, one of —COR32 and —COR42 is carboxyl, and the other is carboxyl being optionally esterified, or the corresponding amide or pyrrolidine derivatives, or a pharmaceutically acceptable salt thereof. Said compounds show excellent PAI-1 inhibitory activity and are useful in the prophylaxis or treatment of various thromboses such as myocardial infarction, intra-atrial thrombus in atrial fibrillation, cerebral infarction, angina pectoris, stroke, pulmonary infarction, deep venous thrombus (DVT), disseminated intravascular coagulation syndrome (DIC), diabetic complications, restenosis after percutaneous transluminal coronary angioplasty (PTCA), etc.
摘要翻译：一种下式的新型丁二烯衍生物：其中环A是杂环，或任选被低级烷基，烷氧基，硝基，羟基，取代或未取代的氨基或卤素取代的苯，环B是杂环，或任选被低级烷氧基取代的苯，低级亚烷基二氧基或二低级烷基氨基，R 1和R 2各自为H或低级烷基，-COR 32和-COR 42中的一个为羧基，另一个为任选被酯化的羧基，或相应的酰胺或吡咯烷衍生物或其药学上可接受的盐其中。所述化合物显示优异的PAI-1抑制活性，可用于预防或治疗心肌梗死，心房颤动，脑梗死，心绞痛，中风，肺梗死，深静脉血栓（DVT）等心血管栓塞，，弥漫性血管内凝血综合征（DIC），糖尿病并发症，经皮腔内冠状动脉成形术（PTCA）后再狭窄等。

7. 发明授权

US4786634A Method for treating arteriosclerosis 失效
标题翻译：治疗动脉硬化的方法
公开(公告)号：US4786634A
公开(公告)日：1988-11-22
申请号：US49169
申请日：1987-05-12
申请人： Hitoshi Iwasaki , Kazuyuki Kitamura , Akio Ohtani
发明人： Hitoshi Iwasaki , Kazuyuki Kitamura , Akio Ohtani
IPC分类号： C07D281/10 , A61K31/55 , A61K31/554 , A61P9/10
CPC分类号： A61K31/55 , Y10S514/824
摘要： There are disclosed a prophylactic and curing composition for arteriosclerosis, comprising as an active ingredient an 8-chloro-1,5-benzothiazepine derivative represented by the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represent lower alkyl groups, or a pharmaceutically acceptable salt thereof, and a method of treatment of arteriosclerosis.
摘要翻译：公开了一种用于动脉硬化的预防和治疗组合物，其包含作为活性成分的由下式表示的8-氯-1,5-苯并硫氮因衍生物：其中R 1，R 2，R 3和R 4各自代表低级烷基基团或其药学上可接受的盐，以及治疗动脉硬化的方法。

8. 发明授权

US5323181A Apparatus for recording image having size larger than television image of one frame 失效
标题翻译：用于记录尺寸大于一帧的电视图像的图像的装置
公开(公告)号：US5323181A
公开(公告)日：1994-06-21
申请号：US662726
申请日：1991-02-28
申请人： Akio Ohtani , Yuji Nagura , Hideaki Iwase
发明人： Akio Ohtani , Yuji Nagura , Hideaki Iwase
IPC分类号： B41J2/00 , B41J2/32 , G03B42/02 , H04N1/10 , H04N1/193 , H04N1/203 , H04N5/76
CPC分类号： H04N1/2038 , B41J2/32 , H04N1/1004 , H04N1/193 , H04N1/203 , H04N2201/0404 , H04N2201/0426
摘要： An apparatus for recording an image having a size larger than a television image of one frame including a thermal head having a length which is equal to the longitudinal length of the television image of one frame. An image signal to be recorded is supplied to the thermal head, while a heat sensitive record paper unwound from a paper roll is fed through the thermal head at a constant speed. In this manner an elongated image having a width equal to the longitudinal length of the television image of one frame and a length longer than the lateral length of the television image of one frame is recorded on the heat sensitive record paper. The length of the recorded image is limited only by length of the heat sensitive record paper. In a preferred embodiment, the length of the thermal head is made equal to three times the longitudinal length of the television image of one frame and the image signal to be recorded is stored in a memory. Pixel signals of corresponding scanning lines of three television images of one frame arranged side by side are simultaneously read out and the read out pixel signals are supplied to heater elements of the thermal head.
摘要翻译：一种用于记录尺寸大于一帧的电视图像的图像的装置，包括具有等于一帧的电视图像的纵向长度的长度的热敏头。要记录的图像信号被提供给热敏头，而从纸卷展开的热敏记录纸以恒定速度馈送通过热敏头。以这种方式，具有等于一帧的电视图像的纵向长度的宽度和长于一帧的电视图像的横向长度的长度的细长图像被记录在热敏记录纸上。记录图像的长度仅受限于热敏记录纸的长度。在优选实施例中，热头的长度等于一帧的电视图像的纵向长度的三倍，并且要记录的图像信号被存储在存储器中。并排布置的一帧的三个电视图像的相应扫描线的像素信号被同时读出，读出的像素信号被提供给热敏头的加热元件。

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