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1. 发明申请

US20140039166A1 SILICA NANOPARTICLE FOR DIAGNOSTIC IMAGING, METHOD FOR PRODUCING THE SAME, AND BIOSUBSTANCE LABELING AGENT 审中-公开
标题翻译：用于诊断成像的二氧化硅纳米颗粒，其生产方法和生物利用度标记物
公开(公告)号：US20140039166A1
公开(公告)日：2014-02-06
申请号：US14005741
申请日：2012-03-15
申请人： Takuji Aimiya , Naoko Furusawa , Yasushi Nakano
发明人： Takuji Aimiya , Naoko Furusawa , Yasushi Nakano
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , A61K49/0093 , A61K49/0423 , B82Y5/00
摘要： A silica nanoparticle for diagnostic imaging that may be capable of use for X-ray CT, fluorescent imaging, or the like, and have high emission intensity. A method for producing such a silica nanoparticle for diagnostic imaging is provided. Also, a biosubstance labeling agent using the silica nanoparticle for diagnostic imaging is provided. The silica nanoparticle for diagnostic imaging encapsulates an organic fluorescent dye and a metal complex, wherein a ligand of the metal complex form a covalent bond with constituent molecules of the silica nanoparticle.
摘要翻译：用于诊断成像的二氧化硅纳米颗粒，其可以用于X射线CT，荧光成像等，并且具有高发射强度。提供了一种用于诊断成像的二氧化硅纳米粒子的制造方法。另外，提供了使用二氧化硅纳米粒子进行诊断成像的生物体标记剂。用于诊断成像的二氧化硅纳米颗粒包封有机荧光染料和金属络合物，其中金属络合物的配体与二氧化硅纳米颗粒的组成分子形成共价键。

2. 发明申请

US20130157895A1 TISSUE STAINING METHOD, TISSUE EVALUATION METHOD AND BIOSUBSTANCE DETECTION METHOD 审中-公开
公开(公告)号：US20130157895A1
公开(公告)日：2013-06-20
申请号：US13819574
申请日：2011-03-15
申请人： Takuji Aimiya , Hideki Gouda , Hisatake Okada , Yasushi Nakano , Kohsuke Gonda , Motohiro Takeda , Noriaki Ohuchi
发明人： Takuji Aimiya , Hideki Gouda , Hisatake Okada , Yasushi Nakano , Kohsuke Gonda , Motohiro Takeda , Noriaki Ohuchi
IPC分类号： G01N1/30 , G01N33/74
摘要： A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances accumulated therein; in the stained tissue, counting fluorescent points or measuring fluorescent brightness; and evaluating the expression level of a biosubstance, which matches the biosubstance recognition site, in the aforesaid tissue on the basis of the number of the fluorescent points or fluorescent brightness that was measured.

3. 发明授权

US10809167B2 Tissue staining method with staining agent containing particle holding plural phosphors 有权
公开(公告)号：US10809167B2
公开(公告)日：2020-10-20
申请号：US13819574
申请日：2011-03-15
申请人： Takuji Aimiya , Hideki Gouda , Hisatake Okada , Yasushi Nakano , Kohsuke Gonda , Motohiro Takeda , Noriaki Ohuchi
发明人： Takuji Aimiya , Hideki Gouda , Hisatake Okada , Yasushi Nakano , Kohsuke Gonda , Motohiro Takeda , Noriaki Ohuchi
IPC分类号： G01N1/30 , B82Y30/00 , B82Y15/00 , G01N33/58 , G01N21/64 , G01N33/74
摘要： A tissue staining method which comprises: staining a tissue with a staining reagent wherein a biosubstance recognition site is bonded to particles carrying multiple fluorescent substances accumulated therein; in the stained tissue, counting fluorescent points or measuring fluorescent brightness; and evaluating the expression level of a biosubstance, which matches the biosubstance recognition site, in the aforesaid tissue on the basis of the number of the fluorescent points or fluorescent brightness that was measured.

4. 发明申请

US20120252140A1 FLUORESCENT SUBSTANCE-CONTAINING SILICA NANOPARTICLES AND BIOSUBSTANCE LABELING AGENT 有权
标题翻译：含荧光物质的二氧化硅纳米颗粒和生物体标记物
公开(公告)号：US20120252140A1
公开(公告)日：2012-10-04
申请号：US13517271
申请日：2010-11-04
申请人： Takuji Aimiya , Hideki Hoshino
发明人： Takuji Aimiya , Hideki Hoshino
IPC分类号： G01N21/76
CPC分类号： G01N33/587 , B82Y30/00 , C01B33/12 , C01B33/18 , C01P2004/64 , C09B67/0097 , C09B67/0098 , C09K11/02 , C09K11/06 , C09K11/883
摘要： Disclosed are fluorescent substance-containing silica nanoparticles containing a fluorescent substance therein featured in that the surface of the silica nanoparticles is coated with a material having a bulk refractive index of from 1.60 to 4.00. The invention can provide fluorescent substance-containing silica nanoparticles excellent in long term storage stability and a biosubstance labeling agent employing the same.
摘要翻译：公开了含有荧光物质的含荧光物质的二氧化硅纳米粒子，其特征在于二氧化硅纳米颗粒的表面涂覆有体积折射率为1.60至4.00的材料。本发明可以提供长期保存稳定性优异的含荧光物质的二氧化硅纳米粒子和使用其的生物体标记剂。

5. 发明申请

US20120045850A1 SILICA NANOPARTICLE EMBEDDING QUANTUM DOTS, PREPARATION METHOD THEREOF AND BIOSUBSTANCE LABELING AGENT BY USE THEREOF 有权
标题翻译：二氧化硅纳米颗粒嵌入量，其制备方法及其使用的生物体标记物
公开(公告)号：US20120045850A1
公开(公告)日：2012-02-23
申请号：US13318177
申请日：2010-03-01
申请人： Takuji Aimiya , Masaru Takahashi
发明人： Takuji Aimiya , Masaru Takahashi
IPC分类号： G01N33/53 , B82Y5/00 , B82Y99/00
CPC分类号： C01B33/18 , B82Y15/00 , C09K11/02 , C09K11/59 , C09K11/62 , G01N33/588 , Y10S977/773 , Y10S977/779
摘要： Disclosed is a quantum dot-embedded silica nanoparticle having plural quantum dots embedded within the silica nanoparticle, wherein the number of quantum dots existing in a concentric area within 10% of a radius from a center of the silica nanoparticle accounts for 10 to 70% of the number of total quantum dots embedded in the silica nanoparticle.
摘要翻译：公开了一种量子点嵌入二氧化硅纳米颗粒，其具有嵌入二氧化硅纳米颗粒内的多个量子点，其中存在于距离二氧化硅纳米颗粒的中心的半径的10％以内的同心区域中的量子点的数量占二氧化硅纳米颗粒的10至70％嵌入二氧化硅纳米颗粒中的总量子点的数量。

6. 发明授权

US09023659B2 Silica nanoparticle embedding quantum dots, preparation method thereof and biosubstance labeling agent by use thereof 有权
标题翻译：嵌入量子点的二氧化硅纳米颗粒，其制备方法和生物物质标记剂
公开(公告)号：US09023659B2
公开(公告)日：2015-05-05
申请号：US13318177
申请日：2010-03-01
申请人： Takuji Aimiya , Masaru Takahashi
发明人： Takuji Aimiya , Masaru Takahashi
IPC分类号： G01N33/552 , C01B33/18 , B82Y15/00 , G01N33/58 , C09K11/02 , C09K11/59 , C09K11/62
CPC分类号： C01B33/18 , B82Y15/00 , C09K11/02 , C09K11/59 , C09K11/62 , G01N33/588 , Y10S977/773 , Y10S977/779
摘要： Disclosed is a quantum dot-embedded silica nanoparticle having plural quantum dots embedded within the silica nanoparticle, wherein the number of quantum dots existing in a concentric area within 10% of a radius from a center of the silica nanoparticle accounts for 10 to 70% of the number of total quantum dots embedded in the silica nanoparticle.
摘要翻译：公开了一种量子点嵌入二氧化硅纳米颗粒，其具有嵌入二氧化硅纳米颗粒内的多个量子点，其中存在于距离二氧化硅纳米颗粒的中心的半径的10％以内的同心区域中的量子点的数量占二氧化硅纳米颗粒的10至70％嵌入二氧化硅纳米颗粒中的总量子点的数量。

7. 发明授权

US08513031B2 Fluorescent substance-containing silica nanoparticles with coating having high bulk refractive index 有权
$Fluorescent substance-containing silica nanoparticles with coating having high bulk refractive index$
标题翻译：含有具有高体积折射率的涂层的含荧光物质的二氧化硅纳米粒子
公开(公告)号：US08513031B2
公开(公告)日：2013-08-20
申请号：US13517271
申请日：2010-11-04
申请人： Takuji Aimiya , Hideki Hoshino
发明人： Takuji Aimiya , Hideki Hoshino
IPC分类号： G01N33/552 , G01N33/553
CPC分类号： G01N33/587 , B82Y30/00 , C01B33/12 , C01B33/18 , C01P2004/64 , C09B67/0097 , C09B67/0098 , C09K11/02 , C09K11/06 , C09K11/883
摘要： Disclosed are fluorescent substance-containing silica nanoparticles containing a fluorescent substance therein featured in that the surface of the silica nanoparticles is coated with a material having a bulk refractive index of from 1.60 to 4.00. The invention can provide fluorescent substance-containing silica nanoparticles excellent in long term storage stability and a biosubstance labeling agent employing the same.
摘要翻译：公开了含有荧光物质的含荧光物质的二氧化硅纳米粒子，其特征在于二氧化硅纳米颗粒的表面涂覆有体积折射率为1.60至4.00的材料。本发明可以提供长期保存稳定性优异的含荧光物质的二氧化硅纳米粒子和使用其的生物体标记剂。

8. 发明申请

US20110111233A1 INORGANIC NANOPARTICLE LABELING AGENT 审中-公开
标题翻译：无机纳米材料标签代理
公开(公告)号：US20110111233A1
公开(公告)日：2011-05-12
申请号：US13002491
申请日：2009-02-26
申请人： Kazuya Tsukada , Takuji Aimiya
发明人： Kazuya Tsukada , Takuji Aimiya
IPC分类号： C09K11/00 , B05D5/00 , B82Y5/00 , B82Y15/00 , B82Y40/00
CPC分类号： G01N33/587 , C09K11/02 , C09K11/59 , C09K11/592 , C09K11/66 , C09K11/661 , Y10T428/2991 , Y10T428/2993
摘要： An inorganic nanoparticle labeling agent having adaptability for being employed as a labeled material in the field of biology and medical science and capable of emitting fluorescence at a stable emission intensity is disclosed, comprising inorganic nanoparticles which were surface-modified with an organic compound, wherein the inorganic nanoparticles exhibit an average particle size of 1 to 10 nm, the organic compound is a compound containing a polyethylene glycol chain, the average particle size D of the inorganic nanoparticle labeling agent is from 8 to 25 nm; and an amount M (mol) of the organic compound per inorganic nanoparticle and a length L (nm) of the organic compound measured from an inorganic nanoparticle surface meet the relationship represented by the following formula (I): (M×1022)×L/D=1.0−4.5 Formula (I)
摘要翻译：公开了一种具有适用于在生物学和医学领域中用作标记材料并且能够以稳定发射强度发射荧光的适应性的无机纳米颗粒标记剂，其包括用有机化合物进行表面改性的无机纳米颗粒，其中无机纳米粒子的平均粒径为1〜10nm，有机化合物为含有聚乙二醇链的化合物，无机纳米粒子标记剂的平均粒径D为8〜25nm，无机纳米粒子的有机化合物的M（摩尔）和无机纳米粒子表面的有机化合物的长度L（nm）满足下式（I）所示的关系：（M×1022）×L / D = 1.0-4.5式（I）

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