基本信息:
- 专利标题： INORGANIC NANOPARTICLE LABELING AGENT
- 专利标题（中）：无机纳米材料标签代理
- 申请号：US13002491 申请日：2009-02-26
- 公开(公告)号：US20110111233A1 公开(公告)日：2011-05-12
- 发明人： Kazuya Tsukada , Takuji Aimiya
- 申请人： Kazuya Tsukada , Takuji Aimiya
- 优先权： JP2008-176748 20080707
- 国际申请： PCT/JP2009/053534 WO 20090226
- 主分类号： C09K11/00
- IPC分类号： C09K11/00 ; B05D5/00 ; B82Y5/00 ; B82Y15/00 ; B82Y40/00
摘要：
An inorganic nanoparticle labeling agent having adaptability for being employed as a labeled material in the field of biology and medical science and capable of emitting fluorescence at a stable emission intensity is disclosed, comprising inorganic nanoparticles which were surface-modified with an organic compound, wherein the inorganic nanoparticles exhibit an average particle size of 1 to 10 nm, the organic compound is a compound containing a polyethylene glycol chain, the average particle size D of the inorganic nanoparticle labeling agent is from 8 to 25 nm; and an amount M (mol) of the organic compound per inorganic nanoparticle and a length L (nm) of the organic compound measured from an inorganic nanoparticle surface meet the relationship represented by the following formula (I): (M×1022)×L/D=1.0−4.5 Formula (I)
摘要（中）：
公开了一种具有适用于在生物学和医学领域中用作标记材料并且能够以稳定发射强度发射荧光的适应性的无机纳米颗粒标记剂，其包括用有机化合物进行表面改性的无机纳米颗粒，其中 无机纳米粒子的平均粒径为1〜10nm，有机化合物为含有聚乙二醇链的化合物，无机纳米粒子标记剂的平均粒径D为8〜25nm， 无机纳米粒子的有机化合物的M（摩尔）和无机纳米粒子表面的有机化合物的长度L（nm）满足下式（I）所示的关系：（M×1022）×L / D = 1.0-4.5式（I）