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    • 3. 发明授权
    • Optical fiber based fluorescent immunoassay apparatus
    • 基于光纤的荧光免疫测定仪
    • US5449625A
    • 1995-09-12
    • US98394
    • 1993-08-16
    • Takeshi KobayashiShinji IijimaYasunori SakaiKen-ichi Shimada
    • Takeshi KobayashiShinji IijimaYasunori SakaiKen-ichi Shimada
    • G01N21/64G01N33/53G01N33/543G01N33/58
    • G01N33/54366G01N33/5302G01N33/582Y10S435/968Y10S435/969Y10S436/80Y10S436/807
    • The present invention relates to an apparatus for performing a fluoroimmunoassay, the apparatus comprising an excitation light source, a fluorescence detector, an optical fiber for an excitation light from the excitation light source to which an antigen or antibody is bound, and a spectroscope, in which the mentioned antigen or antibody is bound to an outgoing end surface of the optical fiber for the excitation light. In the apparatus the spectroscope is constructed so that it introduces the excitation light emitted from the excitation light source to a incident end surface of the optical fiber for the excitation light and introduces a fluorescence emitted from a fluorescence-labeled antibody or antigen which forms an immunological complex with the antigen or antibody to the fluorescence detector. In the apparatus the outgoing end surface of the optical fiber for the excitation light has a transmittance for the excitation light from the excitation light source. The invention also relates to a sensing chip which is used in the apparatus for performing a fluoroimmunoassay therewith.
    • PCT No.PCT / JP92 / 01652 Sec。 371日期:1993年8月16日 102(e)日期1993年8月16日PCT提交1992年12月17日PCT公布。 公开号WO93 / 13418 日期:1993年7月8日。本发明涉及一种用于进行荧光免疫测定的装置,该装置包括激发光源,荧光检测器,用于来自激发光源的激发光的光纤,抗原或抗体 所述抗原或抗体结合到所述光纤的出射端表面用于激发光。 在该装置中,分光镜被构造成使得从激发光源发射的激发光引入用于激发光的光纤的入射端面,并引入从形成免疫学的荧光标记的抗体或抗原发射的荧光 与荧光检测器的抗原或抗体复合。 在该装置中,用于激发光的光纤的出射端面对于来自激发光源的激发光具有透射率。 本发明还涉及用于与其进行荧光免疫测定的装置中的感测芯片。