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1. 发明授权

US07858045B2 Chemical reaction cartridge and method of using same 失效
标题翻译：化学反应筒及其使用方法
公开(公告)号：US07858045B2
公开(公告)日：2010-12-28
申请号：US11528535
申请日：2006-09-28
申请人： Takeo Tanaami , Saya Satou , Hisao Katakura
发明人： Takeo Tanaami , Saya Satou , Hisao Katakura
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/123 , B01L2400/0421 , B01L2400/0481 , G01N27/447 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A cartridge adaptable to various measurement forms is provided. A sample is injected into a well via an injection path. When a roller while kept pressed into contact with the cartridge is rotated rightward, the sample held in the well, and liquid solvent held in a well are caused to reach a well via flow paths, respectively, thereby mixing the sample with the liquid solvent. A mixed liquid is branched into flow paths, respectively, to thereby reach wells, respectively, and reagents pre-held in wells, respectively, are caused to flow into the wells, respectively. Next, temperatures in the wells, respectively, are controlled, thereby executing DNA amplification. Then, PCR by-products as amplified in the wells, respectively, are transferred as far as a position in the vicinity of an electrode via flow paths. Subsequently, a voltage is applied across the electrode as a negative electrode, and an electrode as a positive electrode via a drawing electrode and a drawing electrode, to thereby cause the PCR by-products to undergo electrophoresis.
摘要翻译：提供适用于各种测量形式的盒式磁带。样品通过注射路径注入孔中。当保持按压与筒接触的辊子向右旋转时，将样品保持在井中，并且使保持在孔中的液体溶剂分别通过流动路径到达井，从而将样品与液体溶剂混合。分别将混合液体分支成流路，从而分别到达井，分别将预先保存在井中的试剂流入孔中。接下来，分别控制孔中的温度，从而进行DNA扩增。然后，分别在孔中扩增的PCR副产物通过流路被转移到电极附近的位置。随后，通过拉伸电极和拉伸电极将作为负极的电极和作为正极的电极施加电压，从而使PCR副产物进行电泳。

2. 发明授权

US07854897B2 Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system 有权
标题翻译：化学反应盒，其制造方法和化学反应盒驱动系统
公开(公告)号：US07854897B2
公开(公告)日：2010-12-21
申请号：US10833158
申请日：2004-04-28
申请人： Takeo Tanaami , Hisao Katakura , Saya Satou , Naoki Seki
发明人： Takeo Tanaami , Hisao Katakura , Saya Satou , Naoki Seki
IPC分类号： B01L3/00
CPC分类号： B01L3/502738 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00889 , B01J2219/00891 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/505 , B01L2200/0689 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/1822 , B01L2400/0481 , B01L2400/0655 , G01N33/18
摘要： The present invention describes a disposable chemical reaction cartridge comprising a container formed of a rigid substrate and an elastic body, wherein two or more chambers are linked or configured to be linked through flow paths, and wherein the flow paths, the chambers or both, can be partially closed by applying an external force to the elastic body from outside of the container, to move or block fluids in the flow paths or chambers. The cartridge has a structure protected against viruses or dangerous drugs and facilitates foolproof implementation of prescribed protocols for the samples to be tested.
摘要翻译：本发明描述了一种一次性化学反应盒，其包括由刚性基材和弹性体形成的容器，其中两个或更多个室被连接或构造成通过流动路径连接，并且其中流动路径，室或两者可以通过从容器的外部向弹性体施加外力来移动或阻挡流动路径或腔室中的流体而部分闭合。药筒具有防病毒或危险药物的结构，并且有助于对要测试的样品的规定的协议的实施。

3. 发明申请

US20100151475A1 Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system 审中-公开
标题翻译：化学反应盒，其制造方法和化学反应盒驱动系统
公开(公告)号：US20100151475A1
公开(公告)日：2010-06-17
申请号：US12656770
申请日：2010-02-16
申请人： Takeo Tanaami , Hisao Katakura , Saya Satou , Naoki Seki
发明人： Takeo Tanaami , Hisao Katakura , Saya Satou , Naoki Seki
IPC分类号： C12Q1/68 , C12Q1/54 , C12M1/34 , B01J19/00
CPC分类号： B01L3/502738 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00889 , B01J2219/00891 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/505 , B01L2200/0689 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/1822 , B01L2400/0481 , B01L2400/0655 , G01N33/18
摘要： The present invention makes it possible to realize a chemical reaction cartridge, which enables prescribed protocols to be achieved easily without differences among operators, which is sealed and disposable, and which has a safe structure against viruses or dangerous drugs.This cartridge is intended to be used for performing chemical reaction of samples, comprising a container formed of a rigid substrate and an elastic body, wherein two or more chambers linked or arranged to be able to be linked through flow paths are formed in said container, and wherein said flow paths, said chambers or both are partially closed by applying an external force to said elastic body from outside said container, thereby being able to move or block fluid substance in said flow paths or chambers.
摘要翻译：本发明使得可以实现化学反应盒，其能够容易地实现规定的方案，而不需要密封和一次性的操作者之间的差异，并且具有防病毒或危险药物的安全结构。该墨盒旨在用于进行样品的化学反应，包括由刚性基材和弹性体形成的容器，其中通过流动路径连接或布置成能够通过流动路径连接的两个或更多个室形成在所述容器中，并且其中通过从所述容器外部施加外力将所述流动路径，所述室或两者部分地封闭，从而能够移动或阻挡所述流动路径或室中的流体物质。

4. 发明申请

US20070077170A1 Chemical reaction cartridge and method of using same 失效
标题翻译：化学反应筒及其使用方法
公开(公告)号：US20070077170A1
公开(公告)日：2007-04-05
申请号：US11528535
申请日：2006-09-28
申请人： Takeo Tanaami , Saya Satou , Hisao Katakura
发明人： Takeo Tanaami , Saya Satou , Hisao Katakura
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/123 , B01L2400/0421 , B01L2400/0481 , G01N27/447 , Y10T436/25375 , Y10T436/255 , Y10T436/2575
摘要： A cartridge adaptable to various measurement forms is provided. A sample is injected into a well via an injection path. When a roller while kept pressed into contact with the cartridge is rotated rightward, the sample held in the well, and liquid solvent held in a well are caused to reach a well via flow paths, respectively, thereby mixing the sample with the liquid solvent. A mixed liquid is branched into flow paths, respectively, to thereby reach wells, respectively, and reagents pre-held in wells, respectively, are caused to flow into the wells, respectively. Next, temperatures in the wells, respectively, are controlled, thereby executing DNA amplification. Then, PCR by-products as amplified in the wells, respectively, are transferred as far as a position in the vicinity of an electrode via flow paths. Subsequently, a voltage is applied across the electrode as a negative electrode, and an electrode as a positive electrode via a drawing electrode and a drawing electrode, to thereby cause the PCR by-products to undergo electrophoresis.
摘要翻译：提供适用于各种测量形式的盒式磁带。样品通过注射路径注入孔中。当保持按压与筒接触的辊子向右旋转时，将样品保持在井中，并且使保持在孔中的液体溶剂分别通过流动路径到达井，从而将样品与液体溶剂混合。分别将混合液体分支成流路，从而分别到达井，分别将预先保存在井中的试剂流入孔中。接下来，分别控制孔中的温度，从而进行DNA扩增。然后，分别在孔中扩增的PCR副产物通过流路被转移到电极附近的位置。随后，通过拉伸电极和拉伸电极将作为负极的电极和作为正极的电极施加电压，从而使PCR副产物进行电泳。

5. 发明授权

US09061280B2 Chemical reaction cartridge, its fabrication method, and a chemical reaction cartridge drive system 有权
标题翻译：化学反应盒，其制造方法和化学反应盒驱动系统
公开(公告)号：US09061280B2
公开(公告)日：2015-06-23
申请号：US12656770
申请日：2010-02-16
申请人： Takeo Tanaami , Hisao Katakura , Saya Satou , Naoki Seki
发明人： Takeo Tanaami , Hisao Katakura , Saya Satou , Naoki Seki
IPC分类号： B01L3/00 , B01J19/00 , G01N33/18
CPC分类号： B01L3/502738 , B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01J2219/00889 , B01J2219/00891 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/505 , B01L2200/0689 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/1822 , B01L2400/0481 , B01L2400/0655 , G01N33/18
摘要： The present invention makes it possible to realize a chemical reaction cartridge, which enables prescribed protocols to be achieved easily without differences among operators. The cartridge is sealed and disposable, and has a safe structure against viruses or dangerous drugs. This cartridge is intended to be used for performing chemical reaction of samples. The cartridge comprises a container formed of a rigid substrate and an elastic body, wherein two or more chambers linked or arranged to be able to be linked through flow paths are formed in the container. The flow paths, the chambers or both are partially closed by applying an external force to the elastic body from outside the container, thereby being able to move or block fluid substance in said flow paths or chambers.
摘要翻译：本发明使得可以实现能够容易地实现规定的协议而无需操作者之间的差异的化学反应盒。药筒是密封和一次性的，并且具有防止病毒或危险药物的安全结构。该墨盒旨在用于进行样品的化学反应。盒包括由刚性基底和弹性体形成的容器，其中通过流动路径连接或布置成能够连接的两个或多个腔室形成在容器中。通过从容器的外部向弹性体施加外力，从而能够移动或阻挡所述流动路径或腔室中的流体物质，从而部分地封闭流路，室或两者。

6. 发明申请

US20110280776A1 CAPSULE AND CHEMICAL REACTION CARTRIDGE 有权
标题翻译：胶囊和化学反应盒
公开(公告)号：US20110280776A1
公开(公告)日：2011-11-17
申请号：US13190680
申请日：2011-07-26
申请人： Takeo Tanaami , Hisao Katakura , Nobuyuki Kakuryu , Saya Satou
发明人： Takeo Tanaami , Hisao Katakura , Nobuyuki Kakuryu , Saya Satou
IPC分类号： B01L3/00 , B65D8/04
CPC分类号： B01L3/523 , B01L3/5027 , B01L2200/16 , B01L2300/0867 , B01L2400/0481 , B01L2400/0683 , Y10T428/13
摘要： There are provided a capsule and a chemical reaction cartridge capable of properly handling reagents and so forth. The capsule is formed by laminating two dome-shaped films together at the peripheries thereof. The films are formed by subjecting heat sealable films, to which aluminum vapor deposition is applied, to a drawing process. The films are made of a material (easy-peel material), which can be varied in seal strength by a heating temperature and are thermally welded together at an adhesion area at the peripheries thereof. Thereafter, contents such as reagents and so forth are filled up inside the capsule via a filling section.
摘要翻译：提供了能够适当地处理试剂等的胶囊和化学反应盒。胶囊通过在其周边层叠两个圆顶形膜而形成。通过将施加了铝蒸气沉积的可热封膜进行拉伸加工形成膜。膜由材料（易剥离材料）制成，其可以通过加热温度改变密封强度，并且在其周边的粘合区域处热焊接在一起。此后，通过填充部将诸如试剂等的内容物填充在胶囊内。

7. 发明申请

US20060275813A1 Cartridge for chemical reaction 审中-公开
标题翻译：墨盒用于化学反应
公开(公告)号：US20060275813A1
公开(公告)日：2006-12-07
申请号：US11446225
申请日：2006-06-05
申请人： Takeo Tanaami , Hisao Katakura , Saya Satou
发明人： Takeo Tanaami , Hisao Katakura , Saya Satou
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502715 , B01L7/52 , B01L2300/0636 , B01L2300/0681 , B01L2300/0825 , B01L2300/087 , B01L2300/0877 , B01L2400/0421 , B01L2400/0481
摘要： The cartridge for chemical reaction according to the invention is a cartridge for chemical reaction that causes chemical reaction by feeding an internal liquid by way of deformation caused by external forces. The entirety of a target molecule detecting chip is housed in the cartridge for chemical reaction. According to the cartridge for chemical reaction, the entire target molecule detecting chip is housed in the cartridge for chemical reaction so that it supports various forms of target molecule detecting chips. The target molecule detecting chip may be a penetration type chip that allows a solution including target molecules to penetrate the target molecule detecting chip. In this case, the solution may pass inside the penetration type chip by way of deformation of the cartridge for chemical reaction caused by external forces applied to the cartridge for chemical reaction.
摘要翻译：根据本发明的用于化学反应的药筒是用于通过由外力引起的变形而通过供给内部液体而引起化学反应的化学反应的药筒。靶分子检测芯片的整体容纳在用于化学反应的盒中。根据用于化学反应的盒，整个靶分子检测芯片被容纳在用于化学反应的盒中，从而它支持各种形式的靶分子检测芯片。靶分子检测芯片可以是允许包含靶分子的溶液穿透靶分子检测芯片的穿透型芯片。在这种情况下，溶液可以通过由施加到用于化学反应的盒的外力引起的用于化学反应的盒的变形而穿过穿透型芯片。

8. 发明授权

US09084997B2 Capsule and chemical reaction cartridge 有权
标题翻译：胶囊和化学反应盒
公开(公告)号：US09084997B2
公开(公告)日：2015-07-21
申请号：US13190680
申请日：2011-07-26
申请人： Takeo Tanaami , Hisao Katakura , Nobuyuki Kakuryu , Saya Satou
发明人： Takeo Tanaami , Hisao Katakura , Nobuyuki Kakuryu , Saya Satou
IPC分类号： B01L3/00
CPC分类号： B01L3/523 , B01L3/5027 , B01L2200/16 , B01L2300/0867 , B01L2400/0481 , B01L2400/0683 , Y10T428/13
摘要： There are provided a capsule and a chemical reaction cartridge capable of properly handling reagents and so forth. The capsule is formed by laminating two dome-shaped films together at the peripheries thereof. The films are formed by subjecting heat sealable films, to which aluminum vapor deposition is applied, to a drawing process. The films are made of a material (easy-peel material), which can be varied in seal strength by a heating temperature and are thermally welded together at an adhesion area at the peripheries thereof. Thereafter, contents such as reagents and so forth are filled up inside the capsule via a filling section.
摘要翻译：提供了能够适当地处理试剂等的胶囊和化学反应盒。胶囊通过在其周边层叠两个圆顶形膜而形成。通过将施加了铝蒸气沉积的可热封膜进行拉伸加工形成膜。膜由材料（易剥离材料）制成，其可以通过加热温度改变密封强度，并且在其周边的粘合区域处热焊接在一起。此后，通过填充部将诸如试剂等的内容物填充在胶囊内。

9. 发明申请

US20100124624A1 CAPSULE AND CHEMICAL REACTION CARTRIDGE 审中-公开
标题翻译：胶囊和化学反应盒
公开(公告)号：US20100124624A1
公开(公告)日：2010-05-20
申请号：US12576586
申请日：2009-10-09
申请人： Takeo Tanaami , Hisao Katakura , Nobuyuki Kakuryu , Saya Satou
发明人： Takeo Tanaami , Hisao Katakura , Nobuyuki Kakuryu , Saya Satou
IPC分类号： B01J8/00 , B32B1/08
CPC分类号： B01L3/523 , B01L3/5027 , B01L2200/16 , B01L2300/0867 , B01L2400/0481 , B01L2400/0683 , Y10T428/13
摘要： There are provided a capsule and a chemical reaction cartridge capable of properly handling reagents and so forth. The capsule is formed by laminating two dome-shaped films together at the peripheries thereof. The films are formed by subjecting heat sealable films, to which aluminum vapor deposition is applied, to a drawing process. The films are made of a material (easy-peel material), which can be varied in seal strength by a heating temperature and are thermally welded together at an adhesion area at the peripheries thereof. Thereafter, contents such as reagents and so forth are filled up inside the capsule via a filling section.
摘要翻译：提供了能够适当地处理试剂等的胶囊和化学反应盒。胶囊通过在其周边层叠两个圆顶形膜而形成。通过将施加了铝蒸气沉积的可热封膜进行拉伸加工形成膜。膜由材料（易剥离材料）制成，其可以通过加热温度改变密封强度，并且在其周边的粘合区域处热焊接在一起。此后，通过填充部将诸如试剂等的内容物填充在胶囊内。

10. 发明授权

US07115883B2 Detector calibration method and power measurement instruments using the method 有权
标题翻译：检测器校准方法和功率测量仪器采用该方法
公开(公告)号：US07115883B2
公开(公告)日：2006-10-03
申请号：US10702430
申请日：2003-11-07
申请人： Takeo Tanaami , Yumiko Sugiyama , Saya Satou , Hisao Katakura
发明人： Takeo Tanaami , Yumiko Sugiyama , Saya Satou , Hisao Katakura
IPC分类号： G01N21/64 , G01J5/00
CPC分类号： G01J1/42 , G01J1/16
摘要： Detector calibration methods are described which enable the measurement of absolute power. The method includes using a power meter with traceability to the national standard for optical power to calibrate the power of each photodetector device of a detector with photodetector device arrays arranged in one dimension or two dimensions and to calibrate the output signals of the detector making it possible to measure the spatial distribution of a light source's power and also values of optical power with traceability to the national standard directly from the output signals of the detector.
摘要翻译：描述了能够测量绝对功率的检测器校准方法。该方法包括使用符合国家光功率标准的功率计，以一维或二维布置的光检测器器件阵列来校准检测器的每个光检测器件的功率，并校准检测器的输出信号，使其成为可能用于直接从检测器的输出信号测量光源功率的空间分布以及可追溯到国家标准的光功率值。

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