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1. 发明授权

US5240747A Process for modifying surfaces of materials 失效
标题翻译：修饰材料表面的工艺
公开(公告)号：US5240747A
公开(公告)日：1993-08-31
申请号：US739353
申请日：1991-08-02
申请人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L33/00 , A61L33/06 , C03C17/28 , C03C17/32 , C03C17/34 , C04B41/46 , C04B41/48 , C04B41/52 , C04B41/82 , C04B41/83 , C04B41/89 , C07C247/16 , C08J7/04 , C08J7/12 , C12N11/08
CPC分类号： C08J7/047 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0082 , A61L33/06 , C03C17/28 , C03C17/32 , C03C17/3405 , C04B41/46 , C04B41/4857 , C04B41/52 , C04B41/82 , C04B41/83 , C04B41/89 , C07C247/16 , C08J7/12 , C12N11/08 , C08J2425/00 , C08J2433/00
摘要： A process for modifying the surface of a material such as plastics, metals, glasses and ceramics which comprises the steps of (1) coating a compound having at least one azido group on the surface of the material to be modified, (2) making a modifier substance to be fixed for the modification exist on or in the coated surface, and (3) irradiating ultraviolet rays to the coated surface to fix the modifier substance to the coated surface, wherein various compounds can be used as the modifier for converting the characteristics of the material surface to the desired characteristics without previously treating them, and various materials can be easily modified with a firm fixing of the modifier.
摘要翻译：一种改性材料如塑料，金属，玻璃和陶瓷的表面的方法，其包括以下步骤：（1）在待改性材料的表面上涂覆具有至少一个叠氮基的化合物，（2）为了改变而要固定的改性剂物质存在于涂布表面上或涂布表面上，（3）向涂布表面照射紫外线以将改性物质固定在涂布表面上，其中可以使用各种化合物作为转化特性的改性剂的材料表面达到所需的特性，而不预先处理它们，并且可以用改性剂的牢固固定容易地改变各种材料。

2. 发明授权

US5593814A Control of cell arrangement 失效
标题翻译：细胞排列控制
公开(公告)号：US5593814A
公开(公告)日：1997-01-14
申请号：US308204
申请日：1994-09-19
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： C12M3/04 , C12N5/00 , C12N5/071 , G03F7/00 , G03F7/008 , G03F7/012
CPC分类号： G03F7/008 , C12N5/0068 , C12N5/069 , G03F7/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.
摘要翻译：一种用于控制细胞排列的装置，其具有由细胞粘合剂表面和细胞非粘合剂表面组成的图案，其具有良好的细胞粘附选择性，并且可以通过以常规方式培养细胞而以高分辨率提供细胞图案。该装置通过一种方法制备，该方法包括将光敏，细胞粘合剂或细胞非粘合性聚合物施加到具有与施加的聚合物相反的反电池粘附性的表面，并将光图案照射到感光性聚合物层，随后显影 ; 包括将UV或辐射图案化地照射到细胞非粘合剂表面以在照射部分中产生诸如羧基或氨基的细胞粘附官能团的方法; 或包括以下步骤：将UV或辐射图案化地照射到由塑料制成的细胞粘合剂或非粘合剂表面，以在照射部分中产生聚合起始部位，并将至少一种具有反电池粘附性的单体接枝聚合到塑料表面以在塑料表面的照射部分上产生聚合物。

3. 发明授权

US5128170A Method for manufacturing medical device having a highly biocompatible surface 失效
标题翻译：用于制造具有高生物量表面的医疗装置的方法
公开(公告)号：US5128170A
公开(公告)日：1992-07-07
申请号：US520902
申请日：1990-05-09
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L33/06
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/06
摘要： A medical device having a highly biocompatible surface wherein hydrophilic polymer is bonded onto a surface of the medical device covalently through a nitrogen atom, and a method for manufacturing a medical device having a highly biocompatible surface comprising the steps of applying a hydrophilic polymer having azido group and/or a composition comprising a compound having at least two azido group and a hydrophilic polymer onto the surface of the medical device, and irradiating the biocompatible material with light so that the hydrophilic polymer is bonded to the medical device surface. The device has sufficient biocompatibility, medical functional capability and economical efficiency. The method easily provides a medical device with sufficient biocompatibility without impairing the device's medical functional capability and economical efficiency.

4. 发明授权

US5202227A Control of cell arrangement 失效
标题翻译：细胞安排的控制
公开(公告)号：US5202227A
公开(公告)日：1993-04-13
申请号：US531596
申请日：1990-06-01
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： C12M3/04 , C12N5/00 , C12N5/071 , G03F7/00 , G03F7/008
CPC分类号： G03F7/008 , C12N5/0068 , C12N5/069 , G03F7/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.

5. 发明授权

US5302393A Method for inhibiting biological degradation of implantation polymeric material, inhibitor thereof and implantation polymeric material containing the inhibitor 失效
标题翻译：用于抑制植入聚合物材料的生物降解的方法，其抑制剂和含有抑制剂的植入聚合材料
公开(公告)号：US5302393A
公开(公告)日：1994-04-12
申请号：US910809
申请日：1992-07-09
申请人： Hiroshi Matsumoto , Kensuke Kondo , Kazuhiko Inoue , Nobutaka Tani
发明人： Hiroshi Matsumoto , Kensuke Kondo , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： A61K31/505 , A61L17/00 , A61L27/50 , A61L29/14 , A61L33/00 , A61M39/00 , A61K31/74 , A61L27/00
CPC分类号： A61L27/505 , A61K31/505 , A61L17/005 , A61L29/143 , A61L33/0041 , A61L2300/204 , A61L2300/42 , Y10S623/92
摘要： A method for inhibiting decomposition and/or degradation of an implantation polymeric material in the living body, which comprises allowing dipyridamole and/or a salt or a derivative thereof as an active component to exist in the vicinity of an implantation polymeric material implanted in the living body; an inhibitor effective for inhibiting biological decomposition and/or degradation of a polymeric material implanted in the living body, which comprises dipyridamole and/or a salt or a derivative thereof as an active component; and an implantation polymeric material which contains dipyridamole and/or a salt or a derivative thereof as an active component.
摘要翻译：一种用于抑制活体中植入聚合物材料的分解和/或降解的方法，其包括使双嘧达莫和/或其盐或其衍生物作为活性成分存在于植入生物体内的植入聚合材料附近身体; 一种有效抑制植入生物体中的聚合材料的生物分解和/或降解的抑制剂，其包括双嘧达莫和/或其作为活性组分的盐或其衍生物; 以及含有双嘧达莫和/或其作为活性组分的盐或其衍生物的植入聚合材料。

6. 发明申请

US20120264687A1 MODIFIED ERYTHROPOIETIN TO WHICH WATER-SOLUBLE LONG-CHAIN MOLECULE IS ADDED 审中-公开
标题翻译：添加了可溶性长链分子的改良的红细胞膜蛋白
公开(公告)号：US20120264687A1
公开(公告)日：2012-10-18
申请号：US13395534
申请日：2010-09-15
申请人： Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
发明人： Nobutaka Tani , Toshihide Fujii , Hiroyuki Watanabe , Hirofumi Maeda
IPC分类号： A61K38/18 , A61P7/06
CPC分类号： A61K9/0019 , A61K38/1816 , A61K47/60
摘要： An object of the invention is to provide a pharmaceutical composition that contains erythropoietin as the active ingredient and has, when administered in humans and/or animals, a hematopoietic effect that lasts for not less than seven days. The invention provides a pharmaceutical composition containing, in an amount equal to not less than 50% of the total erythropoietin, erythropoietin to which two or more water-soluble long-chain molecules are added. The invention also provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a molecular weight of not less than 30 kDa. The invention further provides a pharmaceutical composition containing erythropoietin to which a water-soluble long-chain molecule is added, wherein the water-soluble long-chain molecule has a branched chain.
摘要翻译：本发明的目的是提供一种含有促红细胞生成素作为活性成分并且在人和/或动物中施用时持续不少于7天的造血作用的药物组合物。本发明提供一种药物组合物，其含量等于不少于总促红细胞生成素的50％，红细胞生成素，其中加入了两种或更多种水溶性长链分子。本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中水溶性长链分子的分子量不小于30kDa。本发明还提供含有促红细胞生成素的药物组合物，其中加入水溶性长链分子，其中所述水溶性长链分子具有支链。

7. 发明授权

US6133431A Adsorbent for immunoglobulins and complexes thereof, adsorption method, and adsorption device 有权
标题翻译：免疫球蛋白吸附剂及其配合物，吸附方法和吸附装置
公开(公告)号：US6133431A
公开(公告)日：2000-10-17
申请号：US117233
申请日：1998-10-20
申请人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
发明人： Takamune Yasuda , Osamu Odawara , Eiji Ogino , Michio Nomura , Takahisa Nakai , Takashi Asahi , Nobutaka Tani
IPC分类号： A61K35/14 , A61M1/36 , B01J20/32 , C07K17/00 , C07K17/02 , A61K39/00
CPC分类号： C07K17/02 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3282 , C07K17/00 , A61M1/3679 , A61M2202/0417
摘要： An adsorbent that exhibits a high specificity in adsorbing immunoglobulins and/or complexes thereof, is extremely reduced in the lowering of the adsorption characteristic during sterilization or storage, is highly stable and safe, and is prepared by immobilizing on a water-insoluble support either a peptide derivative which has undergone at least one of the deletion, substitution, insertion, or addition of amino acids in a peptide having a specified amino acid sequence or an amino acid sequence, or the above peptide derivative which has undergone the addition of Lyn or Cys at the amino and/or carboxyl terminal thereof; a device for adsorption and removal made by packing the adsorbent in a vessel equipped with effluent preventing means; and a method of adsorbing and removing immunoglobulins and/or complexes thereof contained in the blood, plasma or other body fluids with the adsorbent.
摘要翻译： PCT No.PCT / JP97 / 00161 Sec。 371日期：1998年10月20日 102（e）日期1998年10月20日PCT 1997年1月24日PCT公布。第WO97 / 26930号公报日期1997年7月31日在吸附免疫球蛋白和/或其复合物中显示高特异性的吸附剂在灭菌或储存期间吸附特性的降低极度降低，是高度稳定和安全的，并且通过固定在水上制备 - 不溶性支持已经在具有特定氨基酸序列或氨基酸序列的肽中经历了氨基酸的缺失，取代，插入或添加中的至少一个的肽衍生物，或上述已经经历在其氨基和/或羧基末端添加Lyn或Cys; 用于通过将吸附剂包装在装有流出物防止装置的容器中而进行吸附和除去的装置; 以及利用吸附剂吸收和除去血液，血浆或其他体液中所含的免疫球蛋白和/或其复合物的方法。

8. 发明授权

US6037458A Adsorbent for serum amyloid protein 失效
标题翻译：血清淀粉样蛋白用吸附剂
公开(公告)号：US6037458A
公开(公告)日：2000-03-14
申请号：US948470
申请日：1992-09-22
申请人： Fumiyasu Hirai , Nobutaka Tani
发明人： Fumiyasu Hirai , Nobutaka Tani
IPC分类号： A61M1/34 , A61M1/36 , B01D15/00 , B01J20/32 , A23J1/00 , A61K35/14 , A61M37/00
CPC分类号： A61M1/3486 , B01D15/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3274 , B01J20/328 , A61M1/3679
摘要： An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.
摘要翻译：一种血清淀粉样蛋白的吸附剂，其包含水不溶性载体和选自具有阴离子官能团的化合物，具有多于一个阴离子官能团的聚阴离子化合物，苯胺和苯胺衍生物，所述化合物被固定在所述载体上，或下式-NR 1 R 2基团，其中R 1是氢原子，甲基或乙基，R 2是满足log P值的原子团，其中P是分布在水 - 辛醇体系中，式R2H的化合物的系数为0至3.2，所述基团键合到所述载体上，以及通过使用上述吸附剂的去除装置从体液中除去血清淀粉样蛋白的方法。根据本发明，SA蛋白质，特别是SAA蛋白质和SAP蛋白质可以选择性地从体液中除去而不会大大降低HDL。此外，可以以低成本提供吸附剂。

9. 发明授权

US5902877A Adsorbent of interleukins, process for removing the same, and adsorber for the same 失效
标题翻译：白细胞介素的吸附剂，其除去方法和吸附剂
公开(公告)号：US5902877A
公开(公告)日：1999-05-11
申请号：US646266
申请日：1996-05-20
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
IPC分类号： B01J20/26 , B01J20/32 , C07K14/54 , A23J1/00
CPC分类号： B01J20/3212 , B01J20/26 , B01J20/3204 , B01J20/321 , B01J20/3251 , C07K14/54
摘要： The present invention relates to an adsorbent being capable of efficiently adsorbing and removing interleukins in a body fluid and to a method for adsorbing and removing, if necessary, and recovering interleukins in a body fluid with the above-mentioned adsorbent. According to the present invention, there are provided an adsorbent of interleukins which comprises a water-insoluble carrier having an anionic functional group, a method for adsorbing, removing and recovering interleukins using the same and an adsorber using the same.
摘要翻译： PCT No.PCT / JP95 / 01859 Sec。 371日期：1996年5月20日 102（e）日期1996年5月20日PCT提交1995年9月18日PCT公布。出版物WO96 / 09115 日期：1996年3月28日本发明涉及能够有效吸附和去除体液中的白细胞介素的吸附剂，如果需要，涉及吸附和除去体液中的白细胞介素的方法。根据本发明，提供一种白细胞介素的吸附剂，其包含具有阴离子官能团的水不溶性载体，使用其的吸附，除去和回收白细胞介素的方法和使用该吸附剂的吸附剂。

10. 发明授权

US5854368A Adjuvant for pharmaceutical preparations 失效
公开(公告)号：US5854368A
公开(公告)日：1998-12-29
申请号：US774492
申请日：1996-12-30
申请人： Koji Iritani , Tetsuya Kawasaki , Nobutaka Tani , Shigeki Masuda , Yoshiaki Yano
发明人： Koji Iritani , Tetsuya Kawasaki , Nobutaka Tani , Shigeki Masuda , Yoshiaki Yano
IPC分类号： A61K9/28 , A61K9/32 , C08G63/16 , C08G63/672 , C08G69/44 , C08G63/668
CPC分类号： C08G69/44 , A61K9/2853 , C08G63/16 , C08G63/672
摘要： A polyester represented by the following general formula (I) and a copolymer which comprises two structural units represented by the following general formulae (I') and (II). ##STR1## and a coating material for use in large intestine-selective drug release pharmaceutical preparations, which contains the above polyester and/or copolymer. The polyester and copolymer of the present invention contain a saccharide residue which is hydrolyzed and/or assimilated specifically in the large intestine, drugs contained in solid oral pharmaceutical administration pharmaceutical preparations coated with the coating material of the present invention are not decomposed or absorbed by digestive organs other than the large intestine, but instead are released selectively and therefore in a high concentration in the large intestine.

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