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1. 发明授权

US5240747A Process for modifying surfaces of materials 失效
标题翻译：修饰材料表面的工艺
公开(公告)号：US5240747A
公开(公告)日：1993-08-31
申请号：US739353
申请日：1991-08-02
申请人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L33/00 , A61L33/06 , C03C17/28 , C03C17/32 , C03C17/34 , C04B41/46 , C04B41/48 , C04B41/52 , C04B41/82 , C04B41/83 , C04B41/89 , C07C247/16 , C08J7/04 , C08J7/12 , C12N11/08
CPC分类号： C08J7/047 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0082 , A61L33/06 , C03C17/28 , C03C17/32 , C03C17/3405 , C04B41/46 , C04B41/4857 , C04B41/52 , C04B41/82 , C04B41/83 , C04B41/89 , C07C247/16 , C08J7/12 , C12N11/08 , C08J2425/00 , C08J2433/00
摘要： A process for modifying the surface of a material such as plastics, metals, glasses and ceramics which comprises the steps of (1) coating a compound having at least one azido group on the surface of the material to be modified, (2) making a modifier substance to be fixed for the modification exist on or in the coated surface, and (3) irradiating ultraviolet rays to the coated surface to fix the modifier substance to the coated surface, wherein various compounds can be used as the modifier for converting the characteristics of the material surface to the desired characteristics without previously treating them, and various materials can be easily modified with a firm fixing of the modifier.
摘要翻译：一种改性材料如塑料，金属，玻璃和陶瓷的表面的方法，其包括以下步骤：（1）在待改性材料的表面上涂覆具有至少一个叠氮基的化合物，（2）为了改变而要固定的改性剂物质存在于涂布表面上或涂布表面上，（3）向涂布表面照射紫外线以将改性物质固定在涂布表面上，其中可以使用各种化合物作为转化特性的改性剂的材料表面达到所需的特性，而不预先处理它们，并且可以用改性剂的牢固固定容易地改变各种材料。

2. 发明授权

US5202227A Control of cell arrangement 失效
标题翻译：细胞安排的控制
公开(公告)号：US5202227A
公开(公告)日：1993-04-13
申请号：US531596
申请日：1990-06-01
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： C12M3/04 , C12N5/00 , C12N5/071 , G03F7/00 , G03F7/008
CPC分类号： G03F7/008 , C12N5/0068 , C12N5/069 , G03F7/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.

3. 发明授权

US5593814A Control of cell arrangement 失效
标题翻译：细胞排列控制
公开(公告)号：US5593814A
公开(公告)日：1997-01-14
申请号：US308204
申请日：1994-09-19
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： C12M3/04 , C12N5/00 , C12N5/071 , G03F7/00 , G03F7/008 , G03F7/012
CPC分类号： G03F7/008 , C12N5/0068 , C12N5/069 , G03F7/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.
摘要翻译：一种用于控制细胞排列的装置，其具有由细胞粘合剂表面和细胞非粘合剂表面组成的图案，其具有良好的细胞粘附选择性，并且可以通过以常规方式培养细胞而以高分辨率提供细胞图案。该装置通过一种方法制备，该方法包括将光敏，细胞粘合剂或细胞非粘合性聚合物施加到具有与施加的聚合物相反的反电池粘附性的表面，并将光图案照射到感光性聚合物层，随后显影 ; 包括将UV或辐射图案化地照射到细胞非粘合剂表面以在照射部分中产生诸如羧基或氨基的细胞粘附官能团的方法; 或包括以下步骤：将UV或辐射图案化地照射到由塑料制成的细胞粘合剂或非粘合剂表面，以在照射部分中产生聚合起始部位，并将至少一种具有反电池粘附性的单体接枝聚合到塑料表面以在塑料表面的照射部分上产生聚合物。

4. 发明授权

US5128170A Method for manufacturing medical device having a highly biocompatible surface 失效
标题翻译：用于制造具有高生物量表面的医疗装置的方法
公开(公告)号：US5128170A
公开(公告)日：1992-07-07
申请号：US520902
申请日：1990-05-09
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L33/06
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/06
摘要： A medical device having a highly biocompatible surface wherein hydrophilic polymer is bonded onto a surface of the medical device covalently through a nitrogen atom, and a method for manufacturing a medical device having a highly biocompatible surface comprising the steps of applying a hydrophilic polymer having azido group and/or a composition comprising a compound having at least two azido group and a hydrophilic polymer onto the surface of the medical device, and irradiating the biocompatible material with light so that the hydrophilic polymer is bonded to the medical device surface. The device has sufficient biocompatibility, medical functional capability and economical efficiency. The method easily provides a medical device with sufficient biocompatibility without impairing the device's medical functional capability and economical efficiency.

5. 发明授权

US5898000A Substrate for controlling growth direction of nerve fibers and process for preparing the same, method for controlling growth direction of nerve fibers and artificial neuronal network by the same 失效
标题翻译：用于控制神经纤维生长方向的底物及其制备方法，用于控制神经纤维生长方向和人造神经网络的方法
公开(公告)号：US5898000A
公开(公告)日：1999-04-27
申请号：US712823
申请日：1991-06-10
申请人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue
发明人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue
IPC分类号： C12M1/00 , C12M3/00 , C12N5/00 , C12N5/0793
CPC分类号： C12N5/0068 , C12N5/0619 , C12N2533/54 , C12N2535/10
摘要： A substrate for controlling the growth direction of serve fibers charcterized in that a nerve cell adhesive substance is fixed in the form of a desired pattern and a process for preparing the substrate, a method for controlling the growth direction of nerve fibers and a neuronal network.According to this invention, precise control of nerve fibers' growth direction is achieved.
摘要翻译：用于控制服用纤维的生长方向的底物是神经细胞粘附物质以所需图案的形式和制备基质的方法固定，控制神经纤维的生长方向和神经元网络的方法。根据本发明，可以精确控制神经纤维的生长方向。

6. 发明授权

US5763504A Photcurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof 失效
标题翻译：光电性糖胺聚糖衍生物，交联糖胺聚糖及其生产方法
公开(公告)号：US5763504A
公开(公告)日：1998-06-09
申请号：US476236
申请日：1995-06-07
申请人： Takehisa Matsuda , Minoo J. Moghaddam , Katsukiyo Sakurai
发明人： Takehisa Matsuda , Minoo J. Moghaddam , Katsukiyo Sakurai
IPC分类号： A61K47/36 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/737 , A61K47/48 , A61L27/00 , A61L27/20 , A61L31/04 , A61L33/00 , A61L33/08 , A61L33/10 , A61P43/00 , C08B37/00 , C08B37/08 , C08B37/10 , C08F251/00 , C08L5/00 , C08L5/08 , C08L5/10 , C08L51/02 , C08G64/00 , A61K9/50 , C08G69/08 , C08G73/10
CPC分类号： B82Y5/00 , A61K47/48961 , A61L27/20 , A61L31/042 , A61L33/08 , C08B37/0063
摘要： Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.
摘要翻译：可光固化的糖胺聚糖（GAG）衍生物和交联的糖胺聚糖，其是高度安全和生物相容的，制备这种可光固化的GAG衍生物的方法，其易于通过在需要时使用溶剂浇铸而成型，由此可以容易地消除引起不利影响的未反应物质，以及提供了基于可光固化的GAG衍生物或交联的GAG生产交联的GAG和医疗材料的方法。可光固化的GAG衍生物包含糖胺聚糖和结合到其上的光反应性化合物，并且可以例如通过使糖胺聚糖的羟基或羧基与光反应性化合物分别进行酯化反应或酰胺化反应来制备。交联的GAG通过与其结合的光反应性化合物的分子间交联衍生自可光固化的GAG衍生物。

7. 发明授权

US5192301A Closing plug of a defect for medical use and a closing plug device utilizing it 失效
标题翻译：关闭医疗用途的缺陷和使用其的闭合插管装置
公开(公告)号：US5192301A
公开(公告)日：1993-03-09
申请号：US754163
申请日：1991-09-03
申请人： Tetsuro Kamiya , Shigeyuki Echigo , Takehisa Matsuda , Ryuichiro Yoda , Nobuko Satoh
发明人： Tetsuro Kamiya , Shigeyuki Echigo , Takehisa Matsuda , Ryuichiro Yoda , Nobuko Satoh
IPC分类号： A61B17/00 , A61B17/12 , A61B19/00 , A61F2/00 , A61F2/01
CPC分类号： A61B17/0057 , A61B2017/00579 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B90/39 , A61F2002/3008 , A61F2250/0098
摘要： The closing plug and the closing plug device are used for closing a body defect percutaneously. During the insertion into the defect, the closing plug can be deformed to a smaller size to facilitate the insertion operation and recovered to its original larger shape after it is fitted to the defect, to thereby close the defect. The closing plug device facilitates the insertion of the closing plug into the defect. The closing plug has a flange or an enlarged portion at least at one end thereof and is made of a shape memory polymer having a shape recovery temperature in the range of 20.degree. C. to 70.degree. C. The closing plug device comprises a closing plug, a catheter and a guide wire or a pushing wire to aid in insertion of the closing plug to a defect.
摘要翻译：关闭塞子和闭塞装置用于经皮闭合身体缺陷。在插入缺陷期间，封闭塞可以变形为更小的尺寸以便于插入操作，并且在闭合塞被装配到缺陷之后恢复到其原始较大的形状，从而闭合缺陷。闭合塞装置便于将闭塞塞插入到缺陷中。封闭塞至少在其一端具有凸缘或扩大部分，并且由形状恢复温度在20℃至70℃范围内的形状记忆聚合物制成。封闭塞装置包括封闭塞，导管和引导线或推动线，以帮助将闭塞塞插入缺陷。

8. 发明申请

US20060228344A1 Cell-containing preparations 审中-公开
标题翻译：含细胞的制剂
公开(公告)号：US20060228344A1
公开(公告)日：2006-10-12
申请号：US10559835
申请日：2004-01-23
申请人： Takehisa Matsuda
发明人： Takehisa Matsuda
IPC分类号： A61K48/00 , C12N15/86
CPC分类号： A61K38/1833 , Y02A50/465 , A61K2300/00
摘要： The present invention provides a cell-containing preparation comprising cells containing a DNA having a base sequence represented by SEQ ID NO:1 or 2, or a DNA hybridizable with a DNA having a base sequence represented by SEQ ID NO:1 or 2 under stringent conditions, and a fibrous protein. The cell-containing preparation of the present invention makes it possible to more efficiently supply NK4 having an inhibitory action against the growth or metastasis of cancers to cancer cells.
摘要翻译：本发明提供一种含有细胞的制剂，其含有含有由SEQ ID NO：1或2表示的碱基序列的DNA的细胞，或者与具有由SEQ ID NO：1或2表示的碱基序列的DNA杂交的DNA在严格条件下条件和纤维蛋白。本发明的含细胞的制剂使得可以更有效地提供对癌细胞的生长或转移具有抑制作用的NK4。

9. 发明授权

US5718723A Artificial blood vessel and process for producing the same 失效
标题翻译：人造血管及其制造方法
公开(公告)号：US5718723A
公开(公告)日：1998-02-17
申请号：US305377
申请日：1994-09-13
申请人： Takehisa Matsuda , Nobuyuki Nakajima , Hiroyuki Kito
发明人： Takehisa Matsuda , Nobuyuki Nakajima , Hiroyuki Kito
IPC分类号： A61L27/00 , A61F2/06 , A61L27/34 , A61L27/50 , A61L33/00 , A61L33/08 , A61L33/12 , A61F2/04
CPC分类号： A61L33/124 , A61L27/34 , A61L27/507 , A61L33/08 , A61F2/06 , Y10S623/921
摘要： This invention provides a more functionalized artificial blood vessel which can be organized by independently designing its inner and outer surfaces and endowing them with respectively different biocompatibilities, as well as a process for producing the same. The artificial blood vessel comprises a tubular support having a layer of photogelled cinnamic acid-bound chondroitin sulfate coated on the inner surface thereof and a layer of photogelled coumarin-bound gelatin coated on the outer surface thereof. The process for producing the above artificial blood vessel comprises coating a layer of coumarin-bound gelatin on the outer surface of a tubular support and a layer of cinnamic acid-bound chondroitin sulfate on the inner surface of the support and irradiating each of the layers with light.
摘要翻译：本发明提供了一种更具功能化的人造血管，其可以通过独立地设计其内表面和外表面并赋予它们分别具有不同的生物相容性以及其制造方法来组织。人造血管包括管状支持体，其具有涂覆在其内表面上的光凝胶状肉桂酸结合的硫酸软骨素层和涂覆在其外表面上的光凝胶化香豆素结合明胶层。制造上述人造血管的方法包括在支撑体的内表面上在管状载体的外表面上涂布香豆素结合的明胶层，并在载体的内表面上涂布肉桂酸结合的硫酸软骨素层，并用光。

10. 发明授权

US5348873A Immobilization of an anti-thrombogenic substance with a photo-reactive azide and a photo-crosslinking material 失效
标题翻译：用光反应性叠氮化物和光交联材料固定抗血栓形成物质
公开(公告)号：US5348873A
公开(公告)日：1994-09-20
申请号：US963089
申请日：1992-10-19
申请人： Takehisa Matsuda , Yasuhide Nakayama , Takashi Sugawara
发明人： Takehisa Matsuda , Yasuhide Nakayama , Takashi Sugawara
IPC分类号： A61L33/00 , A61M25/00 , C12N11/04 , C12N11/08 , A61F13/00 , C12N11/06
CPC分类号： C12N11/04 , A61L33/0029 , C12N11/08 , Y10S514/822
摘要： An anti-thrombogenic substance is immobilized on a base of a medical device to impart anti-thrombogenic properties to the medical device. The method comprises the steps of applying a photo-reactive azide derivative macromolecular material to a base to form a bonding layer, coating the bonding layer with a macromolecular layer composed of a water-soluble photo-crosslinking macromolecular material containing the anti-thrombogenic substance, and irradiating the base with ultraviolet light with the bonding layer and the macromolecular layer formed thereon to develop inter-molecular covalent bonding in the bonding layer. The macromolecular layer containing the anti-thrombogenic substance is thus fixed onto the base. Concurrently, the anti-thrombogenic substance is immobilized in the macromolecular layer which is crosslinked. The azide derivative can be poly-m-azidostyrene, copolymers, of poly-m-aziodstyrene with styrene and copolymers of poly-m-azidostyrene with methyl methacrylate. The water-soluble photo-crosslinking macromolecular material can be a copolymer of a photo-dimeric monomer with a water-soluble monomer or a copolymer of a photo-reactive azide with a water-soluble monomer.
摘要翻译：将抗血栓形成物质固定在医疗装置的基底上，以向医疗装置赋予抗血栓形成性质。该方法包括以下步骤：将光反应性叠氮化物衍生物高分子材料施加到基底上以形成结合层，用包含抗血栓形成物质的水溶性光交联性高分子材料构成的高分子层涂覆粘合层，并用形成在其上的接合层和高分子层的紫外线照射基底，以在接合层中形成分子间共价键。因此将含有抗血栓形成物质的大分子层固定在基底上。同时，抗血栓形成物质固定在交联的高分子层中。叠氮衍生物可以是聚 - 间 - 叠氮基苯乙烯，聚 - 间 - 偶氮苯乙烯与苯乙烯的共聚物和聚 - 叠氮基苯乙烯与甲基丙烯酸甲酯的共聚物。水溶性光交联高分子材料可以是光二聚单体与水溶性单体或光反应性叠氮化物与水溶性单体的共聚物的共聚物。

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