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1. 发明授权

US08293190B2 Polymer compound for biomedical use and biochip substrate using such a polymer compound 有权
公开(公告)号：US08293190B2
公开(公告)日：2012-10-23
申请号：US13306240
申请日：2011-11-29
申请人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
发明人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
IPC分类号： G01N33/52
CPC分类号： C08J7/047 , C08F220/28 , C08F220/30 , C08F220/36 , C08F220/38 , C08F2220/286 , C08F2220/306 , C08J2365/00 , C08J2443/00 , G01N33/54393 , Y10T428/31504 , Y10T428/31938
摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

2. 发明授权

US08088340B2 Polymer compound for biomedical use and biochip substrate using such a polymer compound 有权
标题翻译：用于生物医学用途的高分子化合物和使用这种高分子化合物的生物芯片底物
公开(公告)号：US08088340B2
公开(公告)日：2012-01-03
申请号：US11908170
申请日：2006-03-14
申请人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
发明人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
IPC分类号： G01N33/52
CPC分类号： C08J7/047 , C08F220/28 , C08F220/30 , C08F220/36 , C08F220/38 , C08F2220/286 , C08F2220/306 , C08J2365/00 , C08J2443/00 , G01N33/54393 , Y10T428/31504 , Y10T428/31938
摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.
摘要翻译：一种生物芯片基板，当用于检测或分析蛋白质，核酸等时，能够通过限制待检测物质的非特异性吸附或结合来实现高检测精度。生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯属不饱和可聚合单体和具有亚烷基二醇残基的烯键式不饱和可聚合单体共聚得到的聚合物，用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

3. 发明申请

US20090176298A1 Polymer Compound For Medical Material, And Biochip Substrate Using The Polymer Compound 有权
标题翻译：医用材料用高分子化合物及使用高分子化合物的生物芯片基板
公开(公告)号：US20090176298A1
公开(公告)日：2009-07-09
申请号：US11920560
申请日：2006-05-18
申请人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
发明人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
IPC分类号： C12M1/34 , C08F230/08 , C08L83/04
CPC分类号： G01N33/54393 , C08F2/38 , C08F220/36 , C08F290/06 , C08F290/062 , C08G65/3322 , C08G65/33379 , C08G65/33396 , C08G65/336 , C08L2203/02 , C09D133/00 , C09D155/005 , G01N2035/00158
摘要： A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface.The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.
摘要翻译：本发明的主要目的是提供一种具有优异的固定生物活性物质的能力的药物用高分子化合物，具有化学物质在洗涤工序中溶解性差或劣化的化学/物理稳定性，特别是可以适用于塑料基材表面。本发明提供一种医用材料用高分子化合物，其为含有具有固定生物活性物质的官能团的烯属不饱和可聚合单体（a）的重复单元的聚合物，其中，聚合物在至少一个末端具有反应性官能团以及在基材表面上形成含有高分子化合物的层的生物芯片基板，从而达到目的。

4. 发明授权

US09046515B2 Polymer compound for medical material, and biochip substrate using the polymer compound 有权
标题翻译：用于医疗材料的高分子化合物和使用该高分子化合物的生物芯片基材
公开(公告)号：US09046515B2
公开(公告)日：2015-06-02
申请号：US11920560
申请日：2006-05-18
申请人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
发明人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
IPC分类号： B05D3/00 , C12M1/00 , G01N33/543 , C08F2/38 , C08F290/06 , C08G65/332 , C08G65/333 , C08G65/336 , C09D133/00 , C09D155/00 , C08F220/36 , G01N35/00
CPC分类号： G01N33/54393 , C08F2/38 , C08F220/36 , C08F290/06 , C08F290/062 , C08G65/3322 , C08G65/33379 , C08G65/33396 , C08G65/336 , C08L2203/02 , C09D133/00 , C09D155/005 , G01N2035/00158
摘要： A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface.The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.
摘要翻译：本发明的主要目的是提供一种具有优异的固定生物活性物质的能力的药物用高分子化合物，具有化学物质在洗涤工序中溶解性差或劣化的化学/物理稳定性，特别是可以适用于塑料基材表面。本发明提供一种医用材料用高分子化合物，其为含有具有固定生物活性物质的官能团的烯属不饱和可聚合单体（a）的重复单元的聚合物，其中，聚合物在至少一个末端具有反应性官能团以及在基材表面上形成含有高分子化合物的层的生物芯片基板，从而达到目的。

5. 发明申请

US20080175758A1 Polymer Compound For Biomedical Use and Biochip Substrate Using Such a Polymer Compound 有权
标题翻译：用于生物医学用途的聚合物化合物和使用这种聚合物化合物的生物芯片底物
公开(公告)号：US20080175758A1
公开(公告)日：2008-07-24
申请号：US11908170
申请日：2006-03-14
申请人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
发明人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
IPC分类号： B01J19/00 , C08F120/26 , C08F120/10 , C08F116/34 , C08F124/00 , B32B27/32 , B32B27/00 , B05D3/00 , C08F128/02 , C08F130/08 , C09D133/04
CPC分类号： C08J7/047 , C08F220/28 , C08F220/30 , C08F220/36 , C08F220/38 , C08F2220/286 , C08F2220/306 , C08J2365/00 , C08J2443/00 , G01N33/54393 , Y10T428/31504 , Y10T428/31938
摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.
摘要翻译：一种生物芯片基板，当用于检测或分析蛋白质，核酸等时，能够通过限制待检测物质的非特异性吸附或结合来实现高检测精度。生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯属不饱和可聚合单体和具有亚烷基二醇残基的烯键式不饱和可聚合单体共聚得到的聚合物，用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

6. 发明申请

US20110039736A1 METHOD OF IMMOBILIZING BIOLOGICALLY ACTIVE SUBSTANCE 审中-公开
标题翻译：固定生物活性物质的方法
公开(公告)号：US20110039736A1
公开(公告)日：2011-02-17
申请号：US12921664
申请日：2008-03-11
申请人： Sohei Funaoka , Midori Abe
发明人： Sohei Funaoka , Midori Abe
IPC分类号： C40B50/18 , C08F8/00
CPC分类号： G01N33/531 , B05D3/00 , C07K17/00 , C08F290/046 , C09D133/10 , C12N15/1006 , C12Q2565/50 , G01N33/54393
摘要： An object of the present invention is to provide a method of immobilizing the biologically active substance which has an excellent capability of immobilizing a target biologically active substance, and exhibits low nonspecific adsorption of the biologically active substance to provide a high S/N ratio, without using a functional group for fixing the biologically active substance and without having a process of inactivating the functional group for fixing the biologically active substance after immobilizing the biologically active substance. The above object is achieved by a method of immobilizing a biologically active substance comprising the step of: bringing a solution into contact with a compound-side surface of an immobilizing substrate to immobilize the biologically active substance on a surface of the immobilizing substrate, the solution being prepared by dissolving the biologically active substance in a phosphate buffer having a phosphate concentration of 0.1 M or more, and the immobilizing substrate comprising a substrate and a compound containing a hydrophilic group inhibiting nonspecific adsorption on a surface of the substrate.
摘要翻译：本发明的目的是提供一种固定化生物活性物质固定化能力优异的生物活性物质的方法，并且生物活性物质的非特异性吸附低，提供高的S / N比，而没有使用固定生物活性物质的官能团，并且在固定生物活性物质之后没有使用于固定生物活性物质的官能团失活的方法。上述目的是通过固定生物活性物质的方法实现的，包括以下步骤：使溶液与固定基质的化合物侧表面接触，将生物活性物质固定在固定基材的表面上，溶液通过将生物活性物质溶解在磷酸盐浓度为0.1M以上的磷酸盐缓冲液中，将含有底物的固定化基质和含有抑制非特异性吸附的亲水基团的化合物在基材的表面上进行制备。

7. 发明申请

US20100062475A1 PARTICLE FOR MEDICAL USE, PARTICLE FOR ANLAYSIS AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：用于医疗用途的颗粒，用于环境的颗粒及其生产方法
公开(公告)号：US20100062475A1
公开(公告)日：2010-03-11
申请号：US12448681
申请日：2008-01-11
申请人： Yuzo Hamaguchi , Sohei Funaoka , Yoshiaki Fukunishi , Tayuki Matsumoto
发明人： Yuzo Hamaguchi , Sohei Funaoka , Yoshiaki Fukunishi , Tayuki Matsumoto
IPC分类号： C12Q1/02 , B32B5/16 , B05D7/00
CPC分类号： A61K47/32 , A61K9/167 , C08F230/08 , C08F257/02 , C08F265/00 , C08F265/04 , C08F289/00 , C08F291/00 , C08F292/00 , C08F2220/287 , C08F2220/306 , C08L51/003 , C08L51/10 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998 , C08L2666/02
摘要： The object of the present invention is to provide a particle for medical use which has an excellent capability of fixing a biologically active substance and such a chemical/physical stability that the particle is less dissolved or deteriorated in a washing step, and a particle for analysis which has an excellent capability of capturing a biomolecule and such a chemical/physical stability that the particle is less dissolved or deteriorated in a washing step.The object of the present invention is achieved by a particle for medical use which has on the surface thereof a polymer-containing layer formed by introducing a polymerizable functional group or a chain-transfer group to the surface of a core particle, mixing the resultant particle with a polymerizable component containing a polymerizable monomer having a functional group for fixing a biologically active substance, and causing the mixture to develop polymerization reaction The object of the present invention is also achieved by a particle for analysis of the interaction of biomolecules, which particle having on the surface thereof a polymer-containing layer formed by introducing a polymerizable functional group or a chain-transfer group to the surface of a core particle, mixing the resultant particle with a polymerizable component containing a polymerizable monomer having a functional group for fixing a biologically active substance, and causing the mixture to develop, polymerization reaction, wherein the biologically active substance is fixed through the functional group for fixing a biologically active substance in the polymer-containing layer.
摘要翻译：本发明的目的是提供一种医疗用颗粒，其具有优异的固定生物活性物质的能力和在洗涤步骤中颗粒较少溶解或劣化的化学/物理稳定性和用于分析的颗粒其具有捕获生物分子的优异能力和在洗涤步骤中颗粒较少溶解或劣化的化学/物理稳定性。本发明的目的是通过一种用于医疗用途的颗粒来实现的，其表面上具有通过将可聚合官能团或链转移基团引入核心颗粒的表面而形成的含聚合物层，将所得颗粒具有可聚合单体，其含有具有用于固定生物活性物质的官能团的可聚合单体，并使混合物产生聚合反应本发明的目的还通过用于分析生物分子的相互作用的颗粒来实现，该颗粒具有在其表面上形成通过将可聚合官能团或链转移基团引入核心颗粒的表面而形成的含聚合物层，将所得颗粒与可聚合单元混合，所述可聚合组分含有用于固定生物学的官能团的可聚合单体活性物质，并使混合物发生聚合反应，其中通过用于将生物活性物质固定在含聚合物的层中的官能团固定生物活性物质。

8. 发明申请

US20100311958A1 CARRIER, METHOD AND REAGENT FOR OBTAINING SMALL RNA 审中-公开
标题翻译：载体，用于获得小RNA的方法和试剂
公开(公告)号：US20100311958A1
公开(公告)日：2010-12-09
申请号：US12744797
申请日：2008-11-27
申请人： Takahiro Nishibu , Sohei Funaoka , Yuzo Yamaguchi
发明人： Takahiro Nishibu , Sohei Funaoka , Yuzo Yamaguchi
IPC分类号： C07H1/06 , B01J20/26
CPC分类号： C12N15/1006 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/141 , C12Q1/6813 , G01N33/5308 , C12Q2525/207
摘要： An object of the present invention is to provide a carrier which enables to obtain a small RNA in high yield yet in high purity, a simple method for obtaining a small RNA and/or a target nucleic acid of small RNA using the same, and a reagent and a kit comprising the above-described carrier.The present invention relates to (1) a carrier for obtaining a small RNA produced by introducing a polymerizable functional group or a chain transfer group to the surface of a core particle, mixing said particle with a polymerizable monomer, then promoting polymerization reaction to form a layer comprising a polymer compound on the surface of said particle, and immobilizing a physiologically active substance having affinity to a small RNA-binding protein on the surface of the particle; (2) a method for obtaining a small RNA, characterized by using the above-described carrier; (3) a reagent for obtaining a small RNA and/or a target nucleic acid of small RNA, comprising the above-described carrier; (4) a reagent kit for obtaining a small RNA and/or a target nucleic acid of small RNA, comprising said reagent; and (5) a method for obtaining a target nucleic acid of small RNA, characterized by using the above-described carrier.
摘要翻译：本发明的目的是提供能够以高产率而高纯度获得小RNA的载体，使用该载体获得小RNA的RNA和/或靶核酸的简单方法，以及试剂和包含上述载体的试剂盒。本发明涉及（1）一种用于获得通过将可聚合官能团或链转移基团引入核心颗粒表面而获得的小RNA的载体，将所述颗粒与可聚合单体混合，然后促进聚合反应以形成在所述颗粒的表面上包含聚合物化合物的层，并且将对小的RNA结合蛋白具有亲和力的生理活性物质固定在所述颗粒的表面上; （2）获得小RNA的方法，其特征在于使用上述载体; （3）包含上述载体的用于获得小RNA的小RNA和/或靶核酸的试剂; （4）包含所述试剂的用于获得小RNA的小RNA和/或靶核酸的试剂盒; 和（5）获得小RNA靶核酸的方法，其特征在于使用上述载体。

9. 发明申请

US20150005180A9 Biochip 审中-公开
标题翻译：生物芯片
公开(公告)号：US20150005180A9
公开(公告)日：2015-01-01
申请号：US10572332
申请日：2004-09-17
申请人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
发明人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
IPC分类号： C40B30/04 , C40B60/12 , C40B40/08 , C40B40/12 , C40B50/18 , C40B99/00 , C40B40/10
CPC分类号： C12Q1/003
摘要： A biochip is provided that suppresses nonspecific adsorption or bonding of a detection target substance without coating with an adsorption inhibitor and that has excellent detection sensitivity. The constitution is such that it has a macromolecular substance containing a phosphorylcholine group and an active ester group on a substrate surface of a biochip substrate.
摘要翻译：提供一种生物芯片，其抑制检测对象物质的非特异性吸附或结合而不用吸附抑制剂涂覆并且具有优异的检测灵敏度。其结构是在生物芯片基板的基板表面上具有含有磷酰胆碱基和活性酯基的大分子物质。

10. 发明申请

US20100222226A1 Biochip 审中-公开
标题翻译：生物芯片
公开(公告)号：US20100222226A1
公开(公告)日：2010-09-02
申请号：US10572332
申请日：2004-09-17
申请人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
发明人： Kazuhiko Ishihara , Sohei Funaoka , Kanehisa Yokoyama
IPC分类号： C40B30/04 , C40B99/00 , C40B60/12 , C40B40/08 , C40B40/10 , C40B40/12 , C40B50/18
CPC分类号： C12Q1/003
摘要： To provide an electronic component mounting system and an electronic component mounting method which can prevent a mounting failure due to positional error in a height direction of a substrate and ensure mounting quality. The electronic component mounting system includes a plurality of electronic component mounting devices connected to one another and mounts an electronic component on a substrate to manufacture a mounting substrate. A print test device for testing the substrate after solder printing measures a height position of a height measurement point set on the upper surface of the substrate 4 by a height measuring machine 22 and outputs a measurement result as substrate height data. In a component placing step using an electronic component placing device, a control parameter for controlling a component placing operation of the placing head 32 is updated. Accordingly, it is possible to correct a variation of the height position of an individual substrate and to prevent a mounting failure due to positional error in the height direction of the substrate.
摘要翻译：提供一种能够防止由于基板的高度方向上的位置误差引起的安装故障并确保安装质量的电子部件安装系统和电子部件安装方法。电子部件安装系统包括彼此连接的多个电子部件安装装置，并将电子部件安装在基板上以制造安装基板。用于在焊接印刷之后测试基板的印刷测试装置通过高度测量机22测量设置在基板4的上表面上的高度测量点的高度位置，并输出测量结果作为基板高度数据。在使用电子部件放置装置的部件放置步骤中，更新用于控制放置头32的部件放置操作的控制参数。因此，可以校正单个基板的高度位置的变化，并且可以防止由于基板的高度方向上的位置误差引起的安装故障。

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