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1. 发明授权

US09265781B2 Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid 有权
标题翻译：制备包含无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物的方法
公开(公告)号：US09265781B2
公开(公告)日：2016-02-23
申请号：US13980223
申请日：2012-03-07
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18 , A61K31/7048 , C07H17/04 , C12P19/60 , A61K9/16
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译：本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高到86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

2. 发明授权

US09206215B2 Hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, particulate composition comprising the same, their preparation and uses 有权
标题翻译：含水结晶的2-O-α-D-葡糖基-L-抗坏血酸，包含它们的颗粒组合物，它们的制备和用途
公开(公告)号：US09206215B2
公开(公告)日：2015-12-08
申请号：US13821498
申请日：2011-09-06
申请人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
发明人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
IPC分类号： C07H17/04 , A61K31/7048 , C07H19/01 , A23L1/302 , A61K8/60 , A61Q19/00 , A61K9/14 , A61Q19/02
CPC分类号： C07H19/01 , A23L33/15 , A61K8/602 , A61K9/145 , A61K31/7048 , A61K2800/10 , A61Q19/00 , A61Q19/02 , C07H17/04
摘要： The present invention has objects to provide a novel crystalline 2-O-α-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, and their production processes and uses.
摘要翻译：本发明的目的是提供一种新的结晶2-O-α-葡萄糖基-L-抗坏血酸及其制备方法和用途，并通过提供含水结晶的2-O-α-葡糖基-L-抗坏血酸来解决上述目的包含含水结晶2-O-α-葡糖基-L-抗坏血酸的颗粒组合物及其制备方法和用途。

3. 发明申请

US20150040889A1 Process for producing a particulate composition comprising crystalline trehalose dihydrate 有权
标题翻译：制备包含结晶海藻糖二水合物的颗粒组合物的方法
公开(公告)号：US20150040889A1
公开(公告)日：2015-02-12
申请号：US14346410
申请日：2012-09-12
申请人： Takashi Shibuya , Seisuke Izawa
发明人： Takashi Shibuya , Seisuke Izawa
IPC分类号： C12P19/12 , C12P19/20 , C13K13/00
CPC分类号： C07H3/04 , C07H1/00 , C12N9/1074 , C12P19/12 , C12P19/14 , C12P19/18 , C12P19/20 , C12Y204/01019 , C13K13/007
摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.
摘要翻译：提供一种能够生产含有结晶海藻糖二水合物的颗粒组合物的方法。包括使α-糖基海藻糖形成酶作用于源自节杆菌属微生物的液化淀粉和源自节杆菌属微生物的海藻糖释放酶以及淀粉脱支酶和环麦芽糖糊精葡聚糖转移酶; 使葡糖淀粉酶作用于所得混合物，得到含α，α-海藻糖的糖溶液; 从上述糖溶液中沉淀出结晶α，α-海藻糖二水合物; 通过离心机收集沉淀的结晶α，α-海藻糖二水合物; 并老化并干燥收集的晶体。来自Paenibacillus属的微生物的环糊精葡聚糖转移酶或其突变酶用于将干燥固体的糖溶液中的α，α-海藻糖含量提高至86.0重量％以上，而不经过分馏步骤柱层析。

4. 发明授权

US09657045B2 Process for producing a particulate composition comprising crystalline trehalose dihydrate 有权
公开(公告)号：US09657045B2
公开(公告)日：2017-05-23
申请号：US14346410
申请日：2012-09-12
申请人： Takashi Shibuya , Seisuke Izawa
发明人： Takashi Shibuya , Seisuke Izawa
IPC分类号： C13K13/00 , C07H3/04 , C12P19/12 , C12P19/18 , C07H1/00 , C12P19/14 , C12N9/10 , C12P19/20
CPC分类号： C07H3/04 , C07H1/00 , C12N9/1074 , C12P19/12 , C12P19/14 , C12P19/18 , C12P19/20 , C12Y204/01019 , C13K13/007
摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.

5. 发明授权

US08765416B2 Particulate composition containing anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof 有权
标题翻译：含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其制备方法及其用途
公开(公告)号：US08765416B2
公开(公告)日：2014-07-01
申请号：US12875786
申请日：2010-09-03
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/44
CPC分类号： C12P19/60 , A23L33/10 , A23L33/15 , A61K8/0241 , A61K8/676 , A61K8/732 , A61K31/7048 , A61K2800/57 , A61K2800/654 , A61Q19/02 , C07H17/04 , Y10T428/2982
摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.
摘要翻译：本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上; 并提供其制造方法及其用途。

6. 发明申请

US20140178943A9 PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
标题翻译：生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
公开(公告)号：US20140178943A9
公开(公告)日：2014-06-26
申请号：US13980223
申请日：2012-03-07
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译：本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

7. 发明申请

US20130195941A1 PULLULAN-CONTAINING POWDER, METHOD FOR PRODUCING THE SAME AND USE THEREOF 审中-公开
标题翻译：含PULLULAN的粉末，其生产方法及其用途
公开(公告)号：US20130195941A1
公开(公告)日：2013-08-01
申请号：US13704814
申请日：2011-06-17
申请人： Takashi Shibuya , Seisuke Izawa , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Toshio Miyake
IPC分类号： C12P19/10 , A61K8/73 , A23L1/03 , A61K47/36
CPC分类号： C12P19/10 , A61K8/022 , A61K8/73 , A61K47/36 , A61K2800/10 , A61Q19/00 , C08B37/0018 , C08L5/00 , C12R1/645
摘要： The present invention aims to provide a particulate composition containing pullulan, which can be produced without employing any complicated purification step such as solvent precipitation and, when formed into a film, exhibits a higher rupture strength compared to conventional ones; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing pullulan which is produced from a culture obtained by culturing a mutant of a microorganism of the species Aureobasidium pullulans in a culture medium containing glucose and maltose as carbon sources, without employing a step of removing concomitant saccharides; contains a pullulan fraction and a concomitant saccharide fraction that are respectively insoluble and soluble in 75% by volume of methanol in water; has a percentage of 3% by weight or lower of the content of concomitant saccharides contained in the concomitant saccharide fraction against the content of total saccharides contained in the whole particulate composition, when determined based on the anthrone sulfuric acid method; and contains mannitol; and by providing the process of the same and uses thereof.
摘要翻译：本发明的目的在于提供一种含有支链淀粉的颗粒组合物，其可以在不使用任何复杂的纯化步骤如溶剂沉淀的情况下制备，并且当形成膜时，与常规的相比，具有更高的断裂强度; 其制造方法; 及其用途。本发明通过提供一种含有支链淀粉的颗粒组合物，其中所述组合物由通过培养含有葡萄糖和麦芽糖作为碳源的培养基中的优质链霉菌种的微生物的突变体获得的培养物而得到，而不采用以下步骤：去除伴随的糖类; 含有不溶于75％（体积）甲醇的水中的支链淀粉部分和伴随的糖类部分。当根据蒽酮硫酸法测定时，伴随糖类成分中所含的伴随糖含量相对于全部颗粒组合物中所含的总糖含量为3重量％以下的百分比; 并含有甘露醇; 并通过提供相同的方法和使用它们。

8. 发明申请

US20130172542A1 HYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PARTICULATE COMPOSITION COMPRISING THE SAME, THEIR PREPARATION AND USES 有权
标题翻译：水溶性结晶2-O-α-D-葡萄糖-L-抗坏血酸，包含它们的颗粒组合物，其制备和用途
公开(公告)号：US20130172542A1
公开(公告)日：2013-07-04
申请号：US13821498
申请日：2011-09-06
申请人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
发明人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
IPC分类号： C07H19/01
CPC分类号： C07H19/01 , A23L33/15 , A61K8/602 , A61K9/145 , A61K31/7048 , A61K2800/10 , A61Q19/00 , A61Q19/02 , C07H17/04
摘要： The present invention has objects to provide a novel crystalline 2-O-α-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, and their production processes and uses.
摘要翻译：本发明的目的是提供一种新的结晶2-O-α-葡糖基-L-抗坏血酸及其制备方法和用途，并通过提供含水结晶的2-O-α-葡糖基-L-抗坏血酸来解决上述目的包含含水结晶的2-O-α-葡糖基-L-抗坏血酸的颗粒组合物及其制备方法和用途。

9. 发明申请

US20130295618A1 PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
标题翻译：生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
公开(公告)号：US20130295618A1
公开(公告)日：2013-11-07
申请号：US13980223
申请日：2012-03-07
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译：本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

10. 发明申请

US20110091726A1 PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF 有权
标题翻译：包含无水晶体2-O-α-D-葡糖醛酸-L-抗坏血酸的颗粒组合物，其生产方法及其用途
公开(公告)号：US20110091726A1
公开(公告)日：2011-04-21
申请号：US12875786
申请日：2010-09-03
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： B32B5/00 , C07H19/01 , C12P19/60
CPC分类号： C12P19/60 , A23L33/10 , A23L33/15 , A61K8/0241 , A61K8/676 , A61K8/732 , A61K31/7048 , A61K2800/57 , A61K2800/654 , A61Q19/02 , C07H17/04 , Y10T428/2982
摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25° C. under a relative humidity of 35% by weight for 12 hours after removal water in the particulate composition under nitrogen gas stream; and by providing a process for producing the same and uses thereof.
摘要翻译：本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上时，基于颗粒组合物的粉末X射线衍射分析曲线和动态蒸气当在氮气流下除去颗粒组合物中的水后，在25℃相对湿度35重量％下保持12小时，吸附水平为0.01重量％以下; 并提供其制造方法及其用途。

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