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1. 发明授权

US06916837B2 Amidino derivatives and anticoagulants and thrombosis therapeutic agents containing them 失效
标题翻译：脒衍生物和含有它们的抗凝血剂和血栓形成治疗剂
公开(公告)号：US06916837B2
公开(公告)日：2005-07-12
申请号：US10294198
申请日：2002-11-14
申请人： Takashi Satoh , Yasushi Okamoto , Osamu Asano , Nobuhisa Watanabe , Tadashi Nagakura , Takao Saeki , Atsushi Inoue , Masahiro Sakurai
发明人： Takashi Satoh , Yasushi Okamoto , Osamu Asano , Nobuhisa Watanabe , Tadashi Nagakura , Takao Saeki , Atsushi Inoue , Masahiro Sakurai
IPC分类号： A61K31/192 , A61K31/194 , A61K31/36 , A61K31/381 , A61K31/4164 , A61K31/472 , A61K31/606 , A61P7/02 , A61P43/00 , C07C257/18 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/14 , C07C317/32 , C07D217/06 , C07D217/22 , C07D233/84 , C07D317/68 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/40 , C07D333/62 , C40B40/04 , A61K31/415 , A61K31/21 , A61K31/24 , A61K31/38
CPC分类号： C07D333/62 , C07C257/18 , C07C275/42 , C07C311/08 , C07C311/21 , C07C311/29 , C07C311/46 , C07C317/14 , C07D217/22 , C07D233/84 , C07D333/22 , C07D333/28 , C07D333/34 , C07D333/38 , C07D333/40
摘要： Amidino derivatives represented by the following general formula (I): {where X is a group represented by R1SO2NR2— (wherein R1 represents optionally substituted C6-14 aryl, etc. and R2 represents hydrogen atom, etc.), etc., Ar1 represents 2,6-naphthylene, etc., R3 represents hydrogen atom, etc. and Y represents carboxyphenyl, etc.} and their pharmacologically acceptable salts or solvates.
摘要翻译：由以下通式（I）表示的脒基衍生物：其中X是由R 1表示的基团SO 2 - （其中 R 1表示任选取代的C 6-14芳基等，R 2表示氢原子等）等，Ar 1， SUP> 1表示2,6-亚萘基等，R 3表示氢原子等，Y表示羧基苯基等}及其药理学上可接受的盐或溶剂化物。

2. 发明授权

US07807690B2 2,3-dihydro-iminoisoindole derivatives 失效
标题翻译： 2,3-二氢 - 亚氨基异吲哚衍生物
公开(公告)号：US07807690B2
公开(公告)日：2010-10-05
申请号：US12234116
申请日：2008-09-19
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4196 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D249/12
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.].
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，对凝血因子VIIa特别优异的抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。 [其中R1表示氢，R2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等]。

3. 发明申请

US20090270433A1 2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES 失效
标题翻译： 2,3-二氢 - 咪唑啉衍生物
公开(公告)号：US20090270433A1
公开(公告)日：2009-10-29
申请号：US12234116
申请日：2008-09-19
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
IPC分类号： A61K31/506 , C07D413/14 , C07D405/14 , A61K31/427
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，对凝血因子VIIa特别优异的抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。 [其中R 1表示氢，R 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等]

4. 发明申请

US20100184981A1 2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES 审中-公开
标题翻译： 2,3-二氢 - 咪唑啉衍生物
公开(公告)号：US20100184981A1
公开(公告)日：2010-07-22
申请号：US12688756
申请日：2010-01-15
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
IPC分类号： C07D403/14 , C07D417/14 , C07D405/14
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof, has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，特别优异的凝血因子VIIa抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。其中R 1表示氢，R 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等

5. 发明授权

US06841549B1 Condensed imidazole compounds and a therapeutic agent for diabetes mellitus 失效
标题翻译：缩合咪唑化合物和糖尿病治疗剂
公开(公告)号：US06841549B1
公开(公告)日：2005-01-11
申请号：US10018688
申请日：2000-06-30
申请人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
发明人： Osamu Asano , Hitoshi Harada , Seiji Yoshikawa , Nobuhisa Watanabe , Takashi Inoue , Tatsuo Horizoe , Nobuyuki Yasuda , Kaya Ohashi , Hiroe Minami , Junsaku Nagaoka , Manabu Murakami , Seiichi Kobayashi , Isao Tanaka , Tsutomu Kawata , Naoyuki Shimomura , Hiroshi Akamatsu , Naoki Ozeki , Toshikazu Shimizu , Kenji Hayashi , Toyokazu Haga , Shigeto Negi , Toshihiko Naito
IPC分类号： A61P3/10 , A61P43/00 , C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40 , A16K31/33 , C07D239/70 , C07D471/00 , C07D487/00 , A16K31/52
CPC分类号： C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40
摘要： The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action.That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I); (wherein R1 represents e.g. an amino group which may be substituted with an alkyl group; R2 represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R3 represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.
摘要翻译：本发明提供了一种基于腺苷A2受体拮抗剂作用的新型糖尿病和糖尿病并发症的预防或治疗剂。即提供了具有腺苷A2受体拮抗剂作用的新颖的缩合咪唑化合物，是有效预防或治疗糖尿病和糖尿病并发症，并由式（I）表示;（其中R 1表示例如可被烷基取代的氨基; R 2表示例如氢原子，可以被羟基取代的烷基，环烷基或烷基，烯基或炔基; R 3表示例如任选取代的烷基，烯基，炔基，芳基，杂芳基，吡啶酮基，嘧啶酮基或哌嗪酮基; Ar表示例如任选取代的芳基或杂芳基; Q和W彼此相同或不同，每个代表 N或CH），其药理学上可接受的盐或其水合物。

6. 发明授权

US07939540B2 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives 有权
标题翻译： 4-（3-苯甲酰氨基苯基）-6,7-二甲氧基-2-甲基氨基喹唑啉衍生物
公开(公告)号：US07939540B2
公开(公告)日：2011-05-10
申请号：US11707904
申请日：2007-02-20
申请人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki , Tomoko Saeki, legal representative , Mai Saeki, legal representative
发明人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki
IPC分类号： C07D239/84 , A61K31/517 , A61P17/04
CPC分类号： C07D239/84
摘要： A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
摘要翻译：由下式（I）表示的化合物，其盐或其水合物可以有效地缓解由特应性疾病等引起的瘙痒：其中R表示羟基，任选被C 1-6烷氧基取代的C 1-6烷氧基或任选的氨基被C 1-6烷基取代。

7. 发明申请

US20070299094A1 4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives 有权
标题翻译： 4-（3-苯甲酰氨基苯基）-6,7-二甲氧基-2-甲基氨基喹唑啉衍生物
公开(公告)号：US20070299094A1
公开(公告)日：2007-12-27
申请号：US11707904
申请日：2007-02-20
申请人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki , Tomoko Saeki , Mai Saeki
发明人： Kazuki Miyazaki , Kazutomi Kusano , Yasutaka Takase , Osamu Asano , Manabu Shirato , Hisashi Wakita , Naoto Ishii , Takao Saeki , Tomoko Saeki , Mai Saeki
IPC分类号： A61K31/517 , A61P17/00 , C07D239/72
CPC分类号： C07D239/84
摘要： A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl.
摘要翻译：由下式（I）表示的化合物，其盐或其水合物可以有效地缓解由特应性疾病等引起的瘙痒：其中R表示羟基，C 1-6烷氧基，其任选被 C 1-6烷氧基或任选被C 1-6烷基取代的氨基。

8. 发明授权

US08368096B2 Solid state image pick-up device and method for manufacturing the same with increased structural integrity 有权
标题翻译：固态摄像装置及其制造方法，具有增加的结构完整性
公开(公告)号：US08368096B2
公开(公告)日：2013-02-05
申请号：US11813242
申请日：2005-12-27
申请人： Osamu Asano , Hitoo Iwasa , Sumio Terakawa , Masami Shouji
发明人： Osamu Asano , Hitoo Iwasa , Sumio Terakawa , Masami Shouji
IPC分类号： H01L33/00
CPC分类号： H01L31/0203 , H01L27/14618 , H01L27/14627 , H01L27/14636 , H01L27/14687 , H01L2224/13 , H04N5/2253
摘要： There are provided image pickup devices capable of significantly increasing production yield and ensuring long-term reliability and a method for manufacturing the image pickup devices. This invention is characterized in that it has a large number of light-receiving portions 2 formed at a surface portion of a wafer 1 and a microlens 3 formed for each of the light-receiving portions, through electrodes 4 for performing supply of power to the light-receiving portions 2 and passing and reception of an electrical signal are provided all over the periphery of the wafer 1, one end of each through electrode 4 is connected to an electrode pad 4a which is connected to a wire leading to a light-receiving element at the surface portion of the wafer 1, the other end is connected to a wire through a back electrode 5, a rib 7 which serves as a partition portion arranged to surround the microlenses 3 on four sides is provided on the surface of the wafer 1, a transparent plate 8 of optical glass or the like is bonded to an upper surface of the rib 7 with adhesive, and a protective frame 10 is provided at a junction between the rib 7 and the transparent plate 8.
摘要翻译：提供能够显着提高产量并确保长期可靠性的图像拾取装置以及用于制造图像拾取装置的方法。本发明的特征在于，具有大量的在晶片1的表面部分形成的光接收部分2和为每个光接收部分形成的微透镜3，通过用于向光接收部分2和电信号的通过和接收被提供在晶片1的整个周边上，每个贯通电极4的一端连接到电极焊盘4a，电极焊盘4a连接到导线的光接收元件在晶片1的表面部分，另一端通过背面电极5连接到电线，在晶片的表面上设置有用作四边周围微透镜3的分隔部分的肋7 如图1所示，光学玻璃等的透明板8用粘合剂粘合到肋7的上表面，并且在肋7和透明板8之间的接合处设置有保护框架10。

9. 发明授权

US07936142B2 Portable drilling device 有权
标题翻译：便携式钻孔装置
公开(公告)号：US07936142B2
公开(公告)日：2011-05-03
申请号：US12159174
申请日：2006-12-13
申请人： Kenji Otsuka , Osamu Asano
发明人： Kenji Otsuka , Osamu Asano
IPC分类号： G05B11/28
CPC分类号： B23B45/02 , B23B2260/062 , B23B2260/122 , B23B2270/32 , B25H1/0071 , G05B19/4062 , G05B2219/37285 , G05B2219/37342 , G05B2219/42286 , G05B2219/42289 , G05B2219/45127 , Y10S388/937 , Y10T408/14
摘要： A drilling device prevents recurrence of an overload condition after occurrence of the overload condition, thereby improving operability and safety in the drilling device. A motor for rotating a drill is connected to an AC power source through a motor control unit, a current detector, and a power switch. A magnet is also connected to the AC power source through the power switch and a full-wave rectifier. The motor control unit rotationally drives the motor on the basis of a signal sent from a main control unit according to a state in which a motor start switch is on. The main control unit controls the motor control unit to gradually reduce a supply voltage to the motor when the motor becomes overloaded, to gradually increase the voltage to the normal power supply condition when the overload condition is vanished, and to stop power supply to the motor if the overload condition continues for a predetermined period.
摘要翻译：钻井装置防止在发生过载状况后再次发生过载状况，从而提高钻井装置的可操作性和安全性。用于旋转钻机的电动机通过电动机控制单元，电流检测器和电源开关连接到AC电源。磁体也通过电源开关和全波整流器连接到交流电源。电动机控制单元根据电动机起动开关接通的状态，根据从主控制单元发送的信号旋转驱动电动机。主控制单元控制电机控制单元，当电机过载时逐渐减小电机的电源电压，当过载状态消失时，逐渐将电压提高到正常供电状态，并停止向电机供电如果过载状态持续一段预定时间。

10. 发明申请

US20060270674A1 Pharmaceutical composition promoting defecation 审中-公开
标题翻译：药物组成促进排便
公开(公告)号：US20060270674A1
公开(公告)日：2006-11-30
申请号：US11500903
申请日：2006-08-09
申请人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
发明人： Masahiro Yasuda , Hitoshi Harada , Shuhei Miyazawa , Seiichi Kobayashi , Kokichi Harada , Takayuki Hida , Hisashi Shibata , Nobuyuki Yasuda , Osamu Asano , Yoshihiko Kotake
IPC分类号： A61K31/5377 , A61K31/506 , C07D413/14 , C07D403/14
CPC分类号： A61K31/506 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/7076 , H04B10/112
摘要： The present invention provides a medicament having a gentle but strong defecation-promoting action without causing diarrhea. That is, it provides a defecation-promoting agent comprising a compound having an adenosine A2receptor antagonism, preferably an adenosine A2b receptor antagonism, or a salt thereof.
摘要翻译：本发明提供一种具有温和但强烈的排便促进作用而不引起腹泻的药物。也就是说，它提供了包含具有腺苷A 2受体拮抗作用的化合物，优选腺苷A 2b受体拮抗剂或其盐的排便促进剂。

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