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1. 发明申请

US20100184981A1 2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES 审中-公开
标题翻译： 2,3-二氢 - 咪唑啉衍生物
公开(公告)号：US20100184981A1
公开(公告)日：2010-07-22
申请号：US12688756
申请日：2010-01-15
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
IPC分类号： C07D403/14 , C07D417/14 , C07D405/14
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof, has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，特别优异的凝血因子VIIa抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。其中R 1表示氢，R 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等

2. 发明授权

US07807690B2 2,3-dihydro-iminoisoindole derivatives 失效
标题翻译： 2,3-二氢 - 亚氨基异吲哚衍生物
公开(公告)号：US07807690B2
公开(公告)日：2010-10-05
申请号：US12234116
申请日：2008-09-19
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimiyo Tabata
IPC分类号： A61K31/506 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/4196 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D249/12
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.].
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，对凝血因子VIIa特别优异的抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。 [其中R1表示氢，R2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等]。

3. 发明授权

US06841265B2 Titanium alloy vacuum and vacuum part 有权
标题翻译：钛合金真空和真空部分
公开(公告)号：US06841265B2
公开(公告)日：2005-01-11
申请号：US10312701
申请日：2002-03-18
申请人： Hiroki Kurisu , Mitsuru Matsuura , Setsuo Yamamoto , Masaki Hesaka , Atsushi Takemura
发明人： Hiroki Kurisu , Mitsuru Matsuura , Setsuo Yamamoto , Masaki Hesaka , Atsushi Takemura
IPC分类号： B01J3/00 , B01J3/03 , C22C14/00 , C23C8/12 , C23C8/16 , C23C16/44 , B23P15/00
CPC分类号： C23C8/16 , C22C14/00 , Y10S428/923 , Y10T428/12993
摘要： The objective of the present invention is to provide a titanium alloy vacuum container and vacuum parts that can easily achieve an ultra-high vacuum in a short time through vacuum evacuation.The titanium alloy of the titanium alloy vacuum container and vacuum parts has a compact structure composed of fine grains, each having a size of approximately not more than 10 μm, with a surface that is exposed to at least vacuum being set to have a surface roughness of not more than 50 nm; and in this structure, preferably, the surface roughness thereof may be set to not more than 10 nm, the titanium alloy may have a hardness in a range of not less than 230 Hv to not more than 310 Hv, and the titanium alloy may have a passivity surface film made by a thin titanium oxide layer or nitride layer that is formed on the surface thereof. The titanium alloy, which is desirably used in such titanium alloy vacuum container and vacuum parts, contains 0.3 wt. % to 0.5 wt. % of iron and 0.3 wt. % to 0.5 wt. % of oxygen, and the remainder thereof is made from Ti obligatory impurities.
摘要翻译：本发明的目的是提供一种钛合金真空容器和真空部件，其可以通过真空排气在短时间内容易地实现超高真空。钛合金真空容器和真空部件的钛合金具有紧凑的结构由细颗粒组成，每个细颗粒具有大约不超过10μm的尺寸，其中至少暴露于真空的表面被设定为具有不大于50nm的表面粗糙度; 在该结构中，优选其表面粗糙度可以设定为不大于10nm，钛合金的硬度可以在230Hv以上且不高于310Hv的范围内，并且钛合金可以具有由形成在其表面上的薄氧化钛层或氮化物层制成的无源表面膜。希望用于这种钛合金真空容器和真空部件中的钛合金含有0.3wt。％至0.5wt。铁含量为0.3％％至0.5wt。的氧气，其余部分由Ti强制性杂质制成。

4. 发明授权

US06594162B2 Inverter device 失效
公开(公告)号：US06594162B2
公开(公告)日：2003-07-15
申请号：US10075447
申请日：2002-02-15
申请人： Hisanobu Shinoda , Yoshio Kayumi , Tetsuro Shigemizu , Masato Goto , Atsushi Takemura
发明人： Hisanobu Shinoda , Yoshio Kayumi , Tetsuro Shigemizu , Masato Goto , Atsushi Takemura
IPC分类号： H02M112
CPC分类号： H02M7/53873 , H02P27/06
摘要： The inverter device includes an inverse conversion circuit which converts a supplied direct-current electricity into a alternating-current electricity having a predetermined frequency, and is designed to drive a motor for a rotary machine, at various speeds, in which the switching control of the inverse conversion circuit is performed by a digital processor. In this inverter device, a timer interrupt process having an independent constant processing cycle which is not directly related to the processing cycle of the system control in the digital processor is assigned. In the timer interrupt process, whether or not switching of the inverse conversion circuit is required is determined, and the switching control is carried out on the basis of the determination.

5. 发明申请

US20090270433A1 2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES 失效
标题翻译： 2,3-二氢 - 咪唑啉衍生物
公开(公告)号：US20090270433A1
公开(公告)日：2009-10-29
申请号：US12234116
申请日：2008-09-19
申请人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
发明人： Richard Clark , Atsushi Takemura , Nobuhisa Watanabe , Osamu Asano , Tadashi Nagakura , Kimlyo Tabata
IPC分类号： A61K31/506 , C07D413/14 , C07D405/14 , A61K31/427
CPC分类号： C07D417/14 , C07D209/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]
摘要翻译：由以下通式（1）表示的化合物或其盐具有丝氨酸蛋白酶抑制活性，对凝血因子VIIa特别优异的抑制活性。该化合物或其盐可用作与血栓形成相关的疾病的治疗和/或预防剂。 [其中R 1表示氢，R 2表示任选取代的苯基等，R 3表示任选取代的C 6-10芳基等]

6. 发明授权

US08436009B2 Prodrug of triazolone compound 有权
标题翻译：三唑酮化合物的前药
公开(公告)号：US08436009B2
公开(公告)日：2013-05-07
申请号：US13695665
申请日：2011-05-18
申请人： Richard Clark , Fumiyoshi Matsuura , Masanobu Shinoda , Shinsuke Hirota , Kazunobu Kira , Hiroshi Azuma , Atsushi Takemura , So Yasui , Kazutomi Kusano , Masaki Mikamoto , Takao Omae
发明人： Richard Clark , Fumiyoshi Matsuura , Masanobu Shinoda , Shinsuke Hirota , Kazunobu Kira , Hiroshi Azuma , Atsushi Takemura , So Yasui , Kazutomi Kusano , Masaki Mikamoto , Takao Omae
IPC分类号： A61K31/506 , C07D239/42
CPC分类号： C07D401/14 , C07D403/04
摘要： By oral administration of a compound represented by the following Formula (I): the blood level of Compound (IV): which has an excellent inhibitory action against blood coagulation factor VIIa and the anticoagulant action, reaches a level sufficient for expression of its pharmacological actions. Therefore, the compound of the present invention is useful as a therapeutic and/or prophylactic agent for diseases caused by thrombus formation.
摘要翻译：通过口服给药由下式（I）表示的化合物：对血液凝固因子VIIa具有优异抑制作用的化合物（IV）的血液水平和抗凝血作用达到足以表达其药理作用的水平。因此，本发明的化合物可用作由血栓形成引起的疾病的治疗和/或预防剂。

7. 发明申请

US20130053563A1 PRODRUG OF TRIAZOLONE COMPOUND 有权
标题翻译：三唑酮化合物的制备
公开(公告)号：US20130053563A1
公开(公告)日：2013-02-28
申请号：US13695665
申请日：2011-05-18
申请人： Richard Clark , Fumiyoshi Matsuura , Masanobu Shinoda , Shinsuke Hirota , Kazunobu Kira , Hiroshi Azuma , Atsushi Takemura , So Yasui , Kazutomi Kusano , Masaki Mikamoto , Takao Omae
发明人： Richard Clark , Fumiyoshi Matsuura , Masanobu Shinoda , Shinsuke Hirota , Kazunobu Kira , Hiroshi Azuma , Atsushi Takemura , So Yasui , Kazutomi Kusano , Masaki Mikamoto , Takao Omae
IPC分类号： C07D403/04 , C07D401/14
CPC分类号： C07D401/14 , C07D403/04
摘要： By oral administration of a compound represented by the following Formula (I): the blood level of Compound (IV): which has an excellent inhibitory action against blood coagulation factor VIIa and the anticoagulant action, reaches a level sufficient for expression of its pharmacological actions. Therefore, the compound of the present invention is useful as a therapeutic and/or prophylactic agent for diseases caused by thrombus formation.
摘要翻译：通过口服给药由下式（I）表示的化合物：对血液凝固因子VIIa具有优异抑制作用的化合物（IV）的血液水平和抗凝血作用达到足以表达其药理作用的水平。因此，本发明的化合物可用作由血栓形成引起的疾病的治疗和/或预防剂。

8. 发明授权

US5885375A High strength titanium alloy, product made of the titanium alloy and method for producing the product 失效
标题翻译：高强度钛合金，钛合金制品及其制造方法
公开(公告)号：US5885375A
公开(公告)日：1999-03-23
申请号：US952511
申请日：1997-11-28
申请人： Atsushi Takemura , Hachiro Kushida , Norio Hashimoto , Tadao Enomoto , Hideo Taguchi
发明人： Atsushi Takemura , Hachiro Kushida , Norio Hashimoto , Tadao Enomoto , Hideo Taguchi
IPC分类号： C22C14/00 , C22F1/18
CPC分类号： C22F1/183 , C22C14/00
摘要： The present invention provides a high strength titanium alloy useful as a material for products such as ornaments, products such as ornaments made of the titanium alloy, and a method for producing the products using the titanium alloy as a material. The high strength titanium alloy is capable of attaining high machinability, and the product made of the titanium alloy is excellent in beauty and decorativeness while being hard to made flawed or concaved. According to the present invention, the titanium alloy includes iron of 0.20 to 0.8 mass percent and oxygen of 0.20 to 0.6 mass percent, or iron of 0.2 to 1.0 mass percent, oxygen of 0.15 to 0.6 mass percent and silicon of 0.20 to 1.0 mass percent, with the balance of titanium and inevitable impurities. A method for producing a product using the titanium alloy as a material includes a steps of hot forging the titanium alloy at a temperature of (.beta.-transformation temperature -200.degree. C.) or higher, and then cooling it, thereby giving a high strength to the product.
摘要翻译： PCT No.PCT / JP97 / 01023 Sec。 371日期1997年11月28日 102（e）日期1997年11月28日PCT 1997年3月26日PCT公布。第WO97 / 37049号公报日期：1997年10月9日本发明提供可用作诸如装饰品的产品的材料的高强度钛合金，以及由钛合金制成的饰品等制品，以及使用该钛合金作为材料的制品的制造方法。高强度钛合金能够获得高切削性，并且由钛合金制成的产品在美观和装饰性方面优异，同时难以制造有缺陷或凹陷。根据本发明，钛合金含有0.20〜0.8质量％的铁，0.20〜0.6质量％的氧，0.2〜1.0质量％的铁，0.15〜0.6质量％的氧，0.20〜1.0质量％的硅，，余量为钛和不可避免的杂质。使用钛合金作为材料的产品的制造方法包括在（β-转变温度-200℃）以上的温度下热锻钛合金的工序，然后冷却，得到高强度到产品。

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