专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08431603B2 3-phenylpyrazolo[5,1-b]thiazole compounds 有权
标题翻译： 3-苯基吡唑并[5,1-b]噻唑化合物
公开(公告)号：US08431603B2
公开(公告)日：2013-04-30
申请号：US12421182
申请日：2009-04-09
申请人： Hisashi Shibata , Kodo Shikata , Akira Inomata , Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda
发明人： Hisashi Shibata , Kodo Shikata , Akira Inomata , Kogyoku Shin , Taro Terauchi , Yoshinori Takahashi , Minako Hashizume , Kunitoshi Takeda
IPC分类号： A61K31/4439 , C07D513/02
CPC分类号： C07D513/04
摘要： A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine.
摘要翻译：由下式（I）表示的化合物或其盐表现出优异的CRF受体拮抗作用，作为药物具有充分的药理活性，安全性和药代动力学性质。其中R1表示式-A11-A12; R2表示四氢呋喃基甲基，四氢吡喃基甲基或四氢吡喃基; A11表示单键，亚甲基或1,2-亚乙基; A12表示C1-6烷基，C3-6环烷基或具有甲基的C3-6环烷基; R3表示甲氧基，氰基，环丁氧基甲基，甲氧基甲基或乙氧基甲基; R4表示甲氧基或氯。

2. 发明申请

US20090181985A1 IMIDAZO[1,2-b]PYRIDAZINE COMPOUND 失效
标题翻译：咪唑并[1,2-b]吡啶化合物
公开(公告)号：US20090181985A1
公开(公告)日：2009-07-16
申请号：US12397132
申请日：2009-03-03
申请人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Matsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Yoshinori Takahashi , Yorihisa Hoshino , Koichi Kikuchi , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Matsuko Ono , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： A61K31/519 , C07D487/02 , A61P25/18 , A61P25/22
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula or a salt thereof. Wherein R1 denotes a hydrogen atom, a C1-6 alkyl group, a C1-6 alkoxy group and the like; R2 denotes a halogen atom, a cyano group, a nitro group, a C1-10 alkyl group, a C2-10 alkenyl group, C2-10 alkynyl group and the like; R3 denotes a C6-14 aromatic hydrocarbon cyclic group or a 5- to 14-membered aromatic heterocyclic group, each of which may have a substituent; and X, Y and X are independent of each other and each denotes N or CR4 (wherein R4 denotes a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally halogenated C1-6 alkyl group and the like) and, in this case, at least two of X, Y and Z denote CR4.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物或其盐。其中R1表示氢原子，C1-6烷基，C1-6烷氧基等; R2表示卤素原子，氰基，硝基，C1-10烷基，C2-10烯基，C2-10炔基等; R3表示可以具有取代基的C 6-14芳族烃环状基团或5〜14元芳香族杂环基团。 X，Y和X彼此独立地表示N或CR4（其中R4表示氢原子，卤素原子，氰基，硝基，任意卤代的C 1-6烷基等）和在这种情况下，X，Y和Z中的至少两个表示CR 4。

3. 发明授权

US07176216B2 7-phenylpyrazolopyridine compounds 有权
标题翻译： 7-苯基吡唑并吡啶化合物
公开(公告)号：US07176216B2
公开(公告)日：2007-02-13
申请号：US10689088
申请日：2003-10-21
申请人： Shigeki Hibi , Yorihisa Hoshino , Koichi Kikuchi , Kogyoku Shin , Yoshinori Takahashi , Masae Fujisawa , Hisashi Shibata , Mitsuhiro Ino
发明人： Shigeki Hibi , Yorihisa Hoshino , Koichi Kikuchi , Kogyoku Shin , Yoshinori Takahashi , Masae Fujisawa , Hisashi Shibata , Mitsuhiro Ino
IPC分类号： A61K31/44
CPC分类号： C07D471/04 , C07F5/025 , C07F7/1804
摘要： A compound represented by the formula: [wherein R1 is methoxy, methylthio, ethyl, etc.; R5 and R6 are each independently cyclopropylmethyl, (4-tetrahydropyranyl)methyl, etc.; and two of R40, R41 and R42 are C1-6 alkoxy while the remaining one is methoxymethyl, etc.], a salt thereof, or a hydrate of the foregoing. This compound has excellent antagonism against corticotropin-releasing factor receptor.
摘要翻译：由下式表示的化合物[其中R 1是甲氧基，甲硫基，乙基等; R 5和R 6各自独立地为环丙基甲基，（4-四氢吡喃基）甲基等; R 40，R 41和R 42中的两个是C 1-6烷氧基，而剩余的一个是甲氧基甲基等]，其盐或上述的水合物。该化合物对促肾上腺皮质激素释放因子受体具有优异的拮抗作用。

4. 发明授权

US07091215B2 Pyrazolo[1,5-a]pyridines and medicines containing the same 失效
标题翻译：吡唑并[1,5-a]吡啶和含有它们的药物
公开(公告)号：US07091215B2
公开(公告)日：2006-08-15
申请号：US10250693
申请日：2002-04-25
申请人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
发明人： Shigeki Hibi , Koichi Kikuchi , Yorihisa Hoshino , Motohiro Soejima , Tatsuya Yoshiuchi , Kogyoku Shin , Mutsuko Ono , Yoshinori Takahashi , Hisashi Shibata , Mitsuhiro Ino , Tetsuya Hirakawa
IPC分类号： C07D471/02 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , C07F5/025 , C07F7/2208
摘要： Compounds represented by the general formula: [wherein R1 represents methoxy, ethyl, methylthio, etc., R2, R3 and R4 each represent hydrogen, a halogen, etc., R5 and R6 each represent —X5—X6—X7 (wherein X5 represents a single bond or —CO—, X6 represents a single bond, —NR3a, etc. and X7 and R3a each represent hydrogen, C1-10 alkyl, etc.), and Ar represents phenyl, pyridyl, etc.], salts thereof and hydrates of the foregoing.
摘要翻译：由以下通式表示的化合物：其中R 1表示甲氧基，乙基，甲硫基等，R 2，R 3和R 3， SUP> 4 各自表示氢，卤素等，R 5和R 6各自表示-X 5〜其中X 5表示单键或-CO-，X 6表示单键键，-NR 3a等，X 7和R 9各自表示氢，C 1-10烷基，烷基等），Ar表示苯基，吡啶基等]，其盐和上述的水合物。

5. 发明申请

US20050004159A1 Tricyclic fused heterocyclic compound, process for preparing it and medicament comprising it 失效
标题翻译：三环稠合杂环化合物，其制备方法和包含它的药物
公开(公告)号：US20050004159A1
公开(公告)日：2005-01-06
申请号：US10903387
申请日：2004-08-02
申请人： Shigeki Hibi , Yorihisa Hoshino , Tatsuya Yoshiuchi , Kogyoku Shin , Kouichi Kikuchi , Motohiro Soejima , Mutsuko Tabata , Yoshinori Takahashi , Hisashi Shibata , Takayuki Hida , Tetsuya Hirakawa , Mitsuhiro Ino
发明人： Shigeki Hibi , Yorihisa Hoshino , Tatsuya Yoshiuchi , Kogyoku Shin , Kouichi Kikuchi , Motohiro Soejima , Mutsuko Tabata , Yoshinori Takahashi , Hisashi Shibata , Takayuki Hida , Tetsuya Hirakawa , Mitsuhiro Ino
IPC分类号： A61P1/04 , A61P1/08 , A61P1/10 , A61P1/12 , A61P1/14 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , C07D471/14 , C07D487/14 , C07D491/14 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/14 , C07D487/14 , C07D491/14
摘要： The present invention provides a novel compound having an excellent corticotrophin-releasing-factor receptor antagonistic activity. That is, it provides a compound represented by the following formula, a pharmacologically acceptable salt thereof or hydrates thereof. Wherein A, B and D are the same as or different from each other and each represents a group represented by the formula —(CR1R2)m— (wherein R1 and R2 are the same as or different from each other and each represents a C1-6 alkyl group etc.), —NR3— (wherein R3 represetns hydrogen etc.) etc.; E and G are the same as or different from each other and each represents a group represented by the formula —(CR6R7)p— (wherein R6 and R7 are the same as or different from each other and each represents hydrogen etc.; and p represents an integer of 0, 1 or 2); J represents a carbon atom or nitrogen atom, each substituted with C1-6 alkyl group optionally substituted with a halogen atom, etc.; K and L are the same as or different from each other and each represents carbon atom or nitrogen atom; M means hydrogen, a halogen atom, an optionally substituted C1-6 alkyl group etc.; and the partial structure means a single or double bond.
摘要翻译：本发明提供具有优异的促肾上腺皮质激素释放因子受体拮抗活性的新型化合物。也就是说，它提供由下式表示的化合物，其药理学上可接受的盐或其水合物。其中A，B和D彼此相同或不同，并且各自表示由式 - （CR 1 R 2）m - 表示的基团（其中R 1和R 2为相同或不同，各自表示C1-6烷基等），-NR 3 - （其中R 3表示氢等）等; E和G彼此相同或不同，并且各自表示由下式表示的基团 - （CR 6 R 7）p - （其中R 6和R 7与彼此不同，各自表示氢等; p表示0,1或2的整数）; J表示碳原子或氮原子，各自被任选被卤素原子取代的C 1-6烷基取代; K和L彼此相同或不同，各自表示碳原子或氮原子; M表示氢，卤原子，任意取代的C 1-6烷基等; 并且部分结构表示单键或双键。

6. 发明授权

US5840910A Pyridine derivatives having anti-ulcerative activity 无效
标题翻译：具有抗溃疡活性的吡啶衍生物
公开(公告)号：US5840910A
公开(公告)日：1998-11-24
申请号：US354726
申请日：1994-12-06
申请人： Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人： Shigeru Souda , Norihiro Ueda , Shuhei Miyazawa , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/54 , A61P1/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Pyridine derivatives useful for preventing or treating peptic ulcers, pharmaceutical preparations and methods of treating peptic ulcers are disclosed.
摘要翻译：公开了用于预防或治疗消化性溃疡的吡啶衍生物，药物制剂和治疗消化性溃疡的方法。

7. 发明授权

US5512579A Aminobenzoic acid derivatives 失效
标题翻译：氨基苯甲酸衍生物
公开(公告)号：US5512579A
公开(公告)日：1996-04-30
申请号：US275704
申请日：1994-07-18
申请人： Shuhei Miyazawa , Yorohisa Hoshino , Hisashi Shibata , Kazuo Hirota , Takaaki Kameyama , Shinya Abe , Takashi Yamanaka
发明人： Shuhei Miyazawa , Yorohisa Hoshino , Hisashi Shibata , Kazuo Hirota , Takaaki Kameyama , Shinya Abe , Takashi Yamanaka
IPC分类号： A61K31/40 , A61K31/403 , A61K31/435 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K31/535 , A61K31/55 , A61K31/625 , A61P1/00 , A61P1/08 , A61P1/12 , A61P1/14 , A61P25/20 , A61P25/22 , A61P43/00 , C07D207/14 , C07D209/00 , C07D211/58 , C07D221/22 , C07D221/24 , C07D223/32 , C07D451/02 , C07D451/04 , C07D451/14 , C07D471/08 , C07D471/18 , C07D491/08 , C07D498/08 , C07D295/04
CPC分类号： C07D451/02 , C07D207/14 , C07D211/58 , C07D221/24 , C07D451/04 , C07D451/14 , C07D471/08 , C07D491/08 , C07D498/08
摘要： To provide a compound which exhibits a serotonin antagonism and an acetylcholine release accelerating activity at a well-balanced activity ratio. An aminobenzoic acid derivative represented by the general formula (I) or (II) or a pharmacologically acceptable salt thereof: ##STR1## wherein R.sup.1 represents a group represented by the formula: ##STR2## {wherein A represents a group represented by formula --CH.sub.2 --X--CH.sub.2 -- (wherein X represents O, >N--R.sup.6 or >CHR.sup.7 (wherein R.sup.6 represents lower alkyl and R.sup.7 represents hydrogen or lower alkoxy)), etc.; D and E each represents a group represented by formula --(CH.sub.2).sub.3 --, etc., and R.sup.2 represents lower alkyl. etc.}; R.sup.9 represents alkynyl; R.sup.10 represents amino, etc.; R.sup.11 represents halogen; R.sup.12 and R.sup.13 each represent lower alkyl; a is an integer of 1 to 5; and b is an integer of 0 to 5!.
摘要翻译：提供以良好平衡的活性比表现出5-羟色胺拮抗作用和乙酰胆碱释放促进活性的化合物。（I）或（II）表示的氨基苯甲酸衍生物或其药理学上可接受的盐：其中R1表示由下式表示的基团：其中A表示由式-CH 2 -X-CH 2 - （其中X表示O，> N-R 6或> CHR 7（其中R 6表示低级烷基，且R 7表示氢或低级烷氧基））等表示的基团。 D和E各自表示由式 - （CH 2）3 - 等表示的基团，并且R 2表示低级烷基。等等。}; R9代表炔基; R10表示氨基等。 R11表示卤素; R 12和R 13各自表示低级烷基; a为1〜5的整数， b为0〜5的整数]。

8. 发明授权

US5239079A Pyridinium salt and pharmacological composition containing the same 失效
标题翻译：吡啶鎓盐及其药物组合物
公开(公告)号：US5239079A
公开(公告)日：1993-08-24
申请号：US928742
申请日：1992-08-13
申请人： Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
发明人： Shigeru Souda , Shuhei Miyazawa , Norihiro Ueda , Katsuya Tagami , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Masatoshi Fujimoto , Manabu Murakami , Kiyoshi Oketani , Hideaki Fujisaki , Hisashi Shibata , Tsuneo Wakabayashi
IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
CPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D417/14 , C07D513/14
摘要： A pyridinium salt is useful as an antiulcer and is defined by the following formula. It includes a sulphenamide compound and a pyridinium compound. J is benzoimidazole, K is --S-- or --SSR, Z is hydroxy or oxyalkyl. ##STR1##
摘要翻译：吡啶鎓盐可用作抗溃疡剂并由下式定义。它包括苯丙胺化合物和吡啶鎓化合物。 J为苯并咪唑，K为-S-或-SSR，Z为羟基或烷氧基。

9. 外观设计

USD328087S Combined video tape recorder and camera 失效
公开(公告)号：USD328087S
公开(公告)日：1992-07-21
申请号：US532513
申请日：1990-06-04
申请人： Hisashi Shibata , Yuichi Kosukegawa , Takanori Nishiyama , Akira Takahashi , Seiji Nomura
设计人： Hisashi Shibata , Yuichi Kosukegawa , Takanori Nishiyama , Akira Takahashi , Seiji Nomura

10. 发明申请

US20070053685A1 Camera module 失效
标题翻译：相机模块
公开(公告)号：US20070053685A1
公开(公告)日：2007-03-08
申请号：US11495474
申请日：2006-07-28
申请人： Hisashi Shibata , Toshihiko Sato
发明人： Hisashi Shibata , Toshihiko Sato
IPC分类号： G03B17/00
CPC分类号： G03B17/02 , G02B5/003 , G02B13/001 , G02B27/0018 , G03B29/00 , H04N5/2253 , H04N5/2254
摘要： A camera module is composed from a lens unit including at least one lens, a barrel provided with the lens and having a barrel opening, and a lens holder for holding the barrel; and an image pickup device portion provided under the lens unit and having an image pickup device housing space in which an image pickup device is hermetically provided. The barrel opening of the barrel has an annular edge which serves as a diaphragm, and the annular edge of the barrel opening has a lower annular corner portion which is located on the side of the lens, wherein the lower annular corner portion of the annular edge is formed so as to have a rounded cross-sectional shape and staining is formed on the lower annular corner portion.
摘要翻译：相机模块由透镜单元组成，该透镜单元包括至少一个透镜，设置有透镜的镜筒并具有镜筒开口，以及用于保持镜筒的镜头保持器; 以及设置在透镜单元下方并且具有图像拾取装置容纳空间的图像拾取装置部分，其中密封摄像装置。枪管的枪管开口具有用作隔膜的环形边缘，并且枪管开口的环形边缘具有位于透镜侧的下环形角部，其中环形边缘的下环形角部形成为具有圆形横截面形状，并且在下环形角部上形成有缎纹。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式