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1. 发明申请

US20100036149A1 METHOD FOR PRODUCING AN OPTICALLY ACTIVE TETRAHYDROQUINOLINE 有权
标题翻译：生产光学活性四氢喹啉的方法
公开(公告)号：US20100036149A1
公开(公告)日：2010-02-11
申请号：US12550948
申请日：2009-08-31
申请人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
发明人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
IPC分类号： C07C227/16
CPC分类号： C07C229/18 , C07C211/49 , C07C229/30 , C07D215/42
摘要： The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a β-ketoester of formula (2) with an amine of formula (3) to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active β-amino acid derivative of formula (5); 3) a step of amidating the optically active β-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) a step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).
摘要翻译：本发明提供了一种工业上有利的式（1）的光学活性四氢喹啉的制备方法，其包括：1）使式（2）的β-酮酯与式（3）的胺反应以产生一种公式（4）; 2）使在1）中获得的上述式（4）的烯氨基酯进行不对称氢化以产生式（5）的光学活性β-氨基酸衍生物的步骤; 3）将2）中得到的光学活性β-氨基酸衍生物（5）酰胺化以制备式（6）的酰胺的步骤; 4）在3）中得到的上述式（6）的酰胺进行烷氧基羰基化以制备式（7）化合物的步骤; 和5）使上述式（7）化合物环化以制备式（1）的光学活性四氢喹啉的步骤。

2. 发明授权

US07601842B2 Method for producing an optically active tetrahydroquinoline 失效
标题翻译：光学活性四氢喹啉的制造方法
公开(公告)号：US07601842B2
公开(公告)日：2009-10-13
申请号：US10545899
申请日：2004-02-17
申请人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
发明人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
IPC分类号： C07D215/38
CPC分类号： C07C229/18 , C07C211/49 , C07C229/30 , C07D215/42
摘要： The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a β-ketoester of formula (2) with an amine of formula (3) to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active β-amino acid derivative of formula (5); 3) a step of amidating the optically active β-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) a step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).
摘要翻译：本发明提供了一种工业上有利的式（1）的光学活性四氢喹啉的制备方法，其包括：1）使式（2）的β-酮酯与式（3）的胺反应以产生一种公式（4）; 2）使在1）中获得的上述式（4）的烯氨基酯进行不对称氢化以产生式（5）的光学活性β-氨基酸衍生物的步骤; 3）将2）中得到的光学活性β-氨基酸衍生物（5）酰胺化以制备式（6）的酰胺的步骤; 4）在3）中得到的上述式（6）的酰胺进行烷氧基羰基化以制备式（7）化合物的步骤; 和5）使上述式（7）化合物环化以制备式（1）的光学活性四氢喹啉的步骤。

3. 发明申请

US20060122225A1 Method for producing an optically active tetrahydroquinoline 失效
公开(公告)号：US20060122225A1
公开(公告)日：2006-06-08
申请号：US10545899
申请日：2004-02-17
申请人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
发明人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
IPC分类号： C07D215/38 , A61K31/4706
CPC分类号： C07C229/18 , C07C211/49 , C07C229/30 , C07D215/42
摘要： The present invention provides an industrially advantageous production method of optically active tetrahydroquinolines of formula (1), which comprises: 1) a step of reacting a β-ketoester of formula (2) with an amine of formula (3) to produce an enaminoester of formula (4); 2) a step of subjecting the enaminoester of formula (4) above obtained in 1) to asymmetric hydrogenation to produce an optically active β-amino acid derivative of formula (5); 3) a step of amidating the optically active β-amino acid derivative (5) above obtained in 2) to produce an amide of formula (6); 4) a step of alkoxycarbonylating the amide of formula (6) above obtained in 3) to produce a compound of formula (7); and 5) a step of subjecting the compound of formula (7) above to cyclization to produce the optically active tetrahydroquinoline of formula (1).

4. 发明授权

US08188307B2 Method for producing an optically active tetrahydroquinoline 有权
标题翻译：光学活性四氢喹啉的制造方法
公开(公告)号：US08188307B2
公开(公告)日：2012-05-29
申请号：US12550948
申请日：2009-08-31
申请人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
发明人： Takashi Moroi , Tsukasa Sotoguchi , Kazuhiko Matsumura , Motonobu Takenaka , Wataru Kuriyama , Toshiyuki Murayama , Hideki Nara , Tohru Yokozawa , Kenji Yagi
IPC分类号： C07C227/16
CPC分类号： C07C229/18 , C07C211/49 , C07C229/30 , C07D215/42
摘要： Disclosed is an industrially advantageous production method of optically active β-amino acid of formula (5a), which includes subjecting an enaminoester of formula (4a) to an asymmetric hydrogenation: wherein * shows an asymmetric carbon atom.
摘要翻译：公开了一种工业上有利的式（5a）的光学活性的（b） - 氨基酸的制备方法，其包括使式（4a）的烯氨基酯进行不对称氢化反应：其中*表示不对称碳原子。

5. 发明授权

US06365755B1 Ammonium 3,5,6-trihydroxyhexanoate derivatives and preparation process thereof 有权
标题翻译：铵3,5,6-三羟基己酸铵衍生物及其制备方法
公开(公告)号：US06365755B1
公开(公告)日：2002-04-02
申请号：US09930263
申请日：2001-08-16
申请人： Kenzo Sumi , Toshiyuki Murayama , Yoshiharu Gonda , Hideki Nara , Takashi Moroi
发明人： Kenzo Sumi , Toshiyuki Murayama , Yoshiharu Gonda , Hideki Nara , Takashi Moroi
IPC分类号： C07D31906
CPC分类号： C07D319/06
摘要： Provided are a novel ammonium (3R,5S)-3,5,6-trihydroxyhexanoate derivative represented by the following formula (I): wherein R1 represents a benzyl group which may have a substituent, a triphenylmethyl group which may have a substituent, an organosilyl group or a C1-5 acyl group; and A means a specific amine; and a preparation process of the derivative.
摘要翻译：提供由下式（I）表示的新型铵（3R，5S）-3,5,6-三羟基己酸衍生物：其中R1表示可具有取代基的苄基，可具有取代基的三苯基甲基，有机甲硅烷基或C 1-5酰基; A表示特定的胺; 和衍生物的制备过程。

6. 发明授权

US5777103A Process for producing cyclohexylazetidinone 失效
标题翻译：环己基氮杂环丁酮的制备方法
公开(公告)号：US5777103A
公开(公告)日：1998-07-07
申请号：US808270
申请日：1997-02-28
申请人： Takaji Matsumoto , Toshiyuki Murayama , Shigeru Mitsuhashi , Takashi Miura
发明人： Takaji Matsumoto , Toshiyuki Murayama , Shigeru Mitsuhashi , Takashi Miura
IPC分类号： C07D205/08 , C07F7/18 , C07B49/00
CPC分类号： C07F7/186 , C07D205/08 , Y02P20/55
摘要： A process for producing cyclohexylazetidinone expressed by the formula(IV) comprises condensing the magnesium enolate compound expressed by the formula (II) with acyloxyazetidinone expressed by the formula (III), wherein Me is a methyl group; R.sup.1 is a hydroxyl-protecting group, R.sup.2 is an acyl group, and X is a halogen atom. ##STR1##
摘要翻译：由式（IV）表示的环己基氮杂环丁酮的制备方法包括将由式（II）表示的烯醇镁化合物与由式（III）表示的酰氧基氮杂环丁酮缩合，其中Me为甲基; R1是羟基保护基，R2是酰基，X是卤素原子。（IMA）>（IV）

7. 发明授权

US5756863A Process for preparing optically active cyclohexanol derivatives 失效
标题翻译：光学活性环己醇衍生物的制备方法
公开(公告)号：US5756863A
公开(公告)日：1998-05-26
申请号：US730021
申请日：1996-10-11
申请人： Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
发明人： Toshiyuki Murayama , Takaji Matsumoto , Takashi Miura
IPC分类号： B01J31/22 , C07B61/00 , C07C29/145 , C07C35/08 , C07C41/26 , C07C43/196
CPC分类号： C07C41/26 , C07C29/145 , C07B2200/07 , C07C2101/14
摘要： A process for producing an optically active cyclohexanol derivative represented by formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 4 carbon atoms, a hydroxyl group, or a protected hydroxyl group, comprising asymmetrically hydrogenating a cyclohexanone derivative in the presence of a catalyst system composed of a transition metal compound (e.g., transition metal complex), a base (e.g., KOH), and a nitrogen compound (e.g., an amine compound).
摘要翻译：制备由式（I）表示的光学活性环己醇衍生物的方法：其中R 1表示具有1至4个碳原子的烷基，羟基或被保护的羟基，包括不对称地氢化环己酮在由过渡金属化合物（例如过渡金属络合物），碱（例如KOH）和氮化合物（例如胺化合物）组成的催化剂体系存在下的衍生物。

8. 发明申请

US20050013588A1 Reproducing apparatus and tracking method 失效
标题翻译：再现设备和跟踪方法
公开(公告)号：US20050013588A1
公开(公告)日：2005-01-20
申请号：US10890600
申请日：2004-07-14
申请人： Toshiyuki Murayama
发明人： Toshiyuki Murayama
IPC分类号： G11B15/467 , H04N5/7826 , H04N5/91
CPC分类号： H04N5/78263
摘要： A reproducing apparatus comprises detecting means 18 and 19 for detecting levels of pilot signals recorded on tracks from reproduced signals reproduced by magnetic heads 1A, 1B, a calculating means 24 for calculating a ratio between levels detected by the detecting means 18 and 19 with respect to the pilot signals recorded on two tracks at both sides of the track traced by the magnetic heads 1A, 1B and a judging means 25 for judging an off-track amount of the magnetic head from the value of the ratio calculated by the calculating means 24, wherein tracking can be effected on the magnetic heads 1A, 1B in response to the off-track amount judged by the judging means 25. In a reproducing apparatus like a VCR (video cassette recorder) in which a magnetic head traces tracks on a tape-like recording medium, tracking can be effected on the magnetic head quickly in a short period of time.
摘要翻译：再现装置包括检测装置18和19，用于检测由磁头1A，1B再现的再现信号记录在磁道上的导频信号的电平;计算装置24，用于计算检测装置18和19相对于记录在由磁头1A，1B跟踪的轨道的两侧的两个轨道上的导频信号和用于根据由计算装置24计算的比率的值来判断磁头的偏离磁道量的判断装置25，其中可以响应于由判断装置25判断的偏离磁道数量对磁头1A，1B进行跟踪。在诸如磁头跟踪磁带上的VCR（录像机）的再现装置中，可以在短时间内快速地对磁头进行跟踪。

9. 发明授权

US5523458A Process for producing optically active diaminohexanone derivative 失效
标题翻译：光学活性二氨基己酮衍生物的制备方法
公开(公告)号：US5523458A
公开(公告)日：1996-06-04
申请号：US229678
申请日：1994-04-19
申请人： Tetsuro Yamasaki , Hidenori Kumobayashi , Noboru Sayo , Toshiyuki Murayama , Noboru Sano , Takero Ishizaki
发明人： Tetsuro Yamasaki , Hidenori Kumobayashi , Noboru Sayo , Toshiyuki Murayama , Noboru Sano , Takero Ishizaki
IPC分类号： B01J31/22 , B01J31/24 , C07B61/00 , C07C215/28 , C07C221/00 , C07C225/16 , C07C231/12 , C07C231/18 , C07C233/36 , C07C233/43 , C07C233/78 , C07C269/06 , C07C271/20 , C07C233/01
CPC分类号： C07C221/00 , C07C231/12 , C07C231/18 , C07C233/36 , C07C233/78 , C07C269/06 , C07C271/20
摘要： Disclosed herein is a process for producing a (2S,5S)-2,5-diamino-1,6-diphenyl-3-hexanone derivative represented by the formula (1): ##STR1## wherein R.sup.1 means a lower alkylcarbonyl group, a halogen-substituted lower alkylcarbonyl group, an arylcarbonyl group or a lower alkoxycarbonyl group, and R.sup.2 and R.sup.3 are identical with or different from each other and denote individually an aryl group or an alkoxy-substituted aryl group, which comprises subjecting a (2S)-2,5-diamino-1,6-diphenyl-4-hexen-3-one derivative represented by the formula (2): ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 have the same meaning as defined above, to a hydrogenation reaction in the presence of a transition metal-containing catalyst.
摘要翻译：本文公开了一种制备由式（1）表示的（2S，5S）-2,5-二氨基-1,6-二苯基-3-己酮衍生物的方法：其中R1表示低级烷基羰基基团，卤素取代的低级烷基羰基，芳基羰基或低级烷氧基羰基，R 2和R 3彼此相同或不同，分别表示芳基或烷氧基取代的芳基，其包括使（ 2S）-2,5-二氨基-1,6-二苯基-4-己烯-3-酮衍生物：其中R1，R2和R3具有与上述相同的含义。在含过渡金属的催化剂存在下进行氢化反应。

10. 发明授权

US08391116B2 Optical disc recording method and optical disc recording apparatus 失效
标题翻译：光盘记录方法和光盘记录装置
公开(公告)号：US08391116B2
公开(公告)日：2013-03-05
申请号：US13326948
申请日：2011-12-15
申请人： Toshiyuki Murayama
发明人： Toshiyuki Murayama
IPC分类号： G11B7/00
CPC分类号： G11B7/1267 , G11B7/14
摘要： An optical disc recording method of determining a disc address when write and read operations are performed for an optical disc during recording power calibration in an optical disc recording apparatus having at least two optical head units including first and second optical head units is disclosed. The method includes: determining a first recording power calibration start address, which is an address at which the first optical head unit starts calibration of the recording power, from a power calibration area provided in advance as an area used to calibrate the recording power; and determining an address obtained by adding a range of the power calibration area used to calibrate the recording power to the first recording power calibration start address as a second recording power calibration start address, which is an address at which the second optical head unit starts calibration of the recording power.
摘要翻译：公开了一种在具有包括第一和第二光学头单元的至少两个光学头单元的光盘记录装置中记录功率校准期间为光盘执行写入和读取操作时确定盘地址的光盘记录方法。该方法包括：从作为用于校准记录功率的区域预先提供的功率校准区域，确定作为第一光学头单元开始记录功率校准的地址的第一记录功率校准起始地址; 以及确定通过将用于校准记录功率的功率校准区域的范围添加到第一记录功率校准开始地址而获得的地址作为第二记录功率校准开始地址，其是第二光学头单元开始校准的地址的记录功率。

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