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1. 发明授权

US4902176A Processing apparatus which may be selectively set in two positions in accordance with fluid pressure 失效
标题翻译：可以根据流体压力选择性地设置在两个位置的处理装置
公开(公告)号：US4902176A
公开(公告)日：1990-02-20
申请号：US266005
申请日：1988-11-02
申请人： Takara Sugino , Noboru Kawanishi , Kazuyuki Ishikawa
发明人： Takara Sugino , Noboru Kawanishi , Kazuyuki Ishikawa
IPC分类号： B23Q5/26 , B23B47/22 , B23Q1/70 , B23Q5/32 , B23Q5/52 , B23Q5/58 , F15B20/00 , B23B47/18
CPC分类号： B23Q5/58 , B23Q1/70 , Y10T408/10 , Y10T408/6757 , Y10T409/309352
摘要： A drive shaft rotated by an electric motor is disposed to penetrate through a main body, and a spindle is concentrically mounted at the distal end of the drive shaft so that the rotational force of the drive shaft moving in an axial direction thereof is transmitted to the spindle. A processing drill head is selectively mounted at the distal end of the spindle that is coupled with a piston which is urged to a first position in an axially forward direction of the spindle by the fluid pressure supplied to a cylinder, for executing a processing work and a retreated position at which a hold mode is set. An abutting member is securely fitted to the outer surface of a piston rod, and a ring-shaped magnetic member is further provided to the outer surface of the piston rod in an axially movable manner, this ring-shaped magnetic member always being urged in the retreating direction. The abutting member abuts the ring-shaped magnetic member when it moves together with the piston rod in the forward direction, thereby moving the ring-shaped magnetic member. When the piston rod moves in the retreating direction, the abutting member stops at a second position where it abuts a fixed shockabsorbing member.
摘要翻译：通过电动机旋转的驱动轴被设置成穿过主体，并且主轴同心地安装在驱动轴的远端，使得沿其轴向移动的驱动轴的旋转力被传递到主轴。处理钻头选择性地安装在主轴的远端处，该活塞与活塞联接，该活塞通过供给到气缸的流体压力被推动到主轴的轴向向前的第一位置，用于执行加工工作，设置保持模式的退避位置。抵靠构件牢固地装配到活塞杆的外表面上，并且在轴向移动的方式上在活塞杆的外表面上进一步设置环形磁性构件，该环形磁性构件始终被推向撤退方向。当与活塞杆一起向前移动时，抵靠构件邻接环形磁性构件，从而移动环形磁性构件。当活塞杆沿后退方向移动时，抵接构件停止在与固定的冲击吸收构件抵接的第二位置。

2. 发明授权

US06184753B2 Clock delay circuitry producing clock delays less than the shortest delay element 失效
标题翻译：时钟延迟电路产生小于最短延迟元件的时钟延迟
公开(公告)号：US06184753B2
公开(公告)日：2001-02-06
申请号：US09082474
申请日：1998-05-21
申请人： Kouichi Ishimi , Kazuyuki Ishikawa
发明人： Kouichi Ishimi , Kazuyuki Ishikawa
IPC分类号： H03K5159
CPC分类号： H03K5/135 , G06F1/04 , G06F1/10
摘要： A oscillation circuit has a delay loop with a clock delay circuit for generating a delayed clock signal. The clock delay circuit has a selector and has multiple delay elements with delay times differing from each other. The clock delay circuit may produce a time lag which is less than the delay time of any single delay element, the time lag being based on the difference between the time delays of different delay elements. A phase comparator compares the phase of a signal associated the delay loop to that of a reference clock signal, generating a phase difference clock signal. A delay setting circuit can cause the selector to change the selection of one delayed clock signal according to the phase difference signal from the phase comparator in such a manner as to reduce the phase difference.
摘要翻译：振荡电路具有用于产生延迟时钟信号的时钟延迟电路的延迟环。时钟延迟电路具有选择器并且具有多个具有彼此不同的延迟时间的延迟元件。时钟延迟电路可以产生小于任何单个延迟元件的延迟时间的时滞，该时间延迟基于不同延迟元件的时间延迟之间的差异。相位比较器将与延迟环相关联的信号的相位与参考时钟信号的相位相比较，产生相位差时钟信号。延迟设定电路可以使选择器根据来自相位比较器的相位差信号以减少相位差的方式改变一个延迟时钟信号的选择。

3. 发明授权

US5795916A Composition of external preparation 失效
标题翻译：外用制剂的组成
公开(公告)号：US5795916A
公开(公告)日：1998-08-18
申请号：US776700
申请日：1997-04-21
申请人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa
发明人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa
IPC分类号： A61K31/196 , A61K47/18 , A61K31/19 , A61K31/16
CPC分类号： A61K31/196 , A61K47/18 , A61K9/0014
摘要： Disclosed herein is an external preparation composition, in a liquid preparation, cream, ointment or cataplasm plaster, characterized in that the composition contains a water-soluble salt of diclofenac, such as diclofenac sodium, water, and a fatty acid dialkylolamide and/or its polyoxyethylene adduct. The external preparation composition according to this invention is excellent in the percutaneous absorption of the water-soluble salt of diclofenac, which has high solubility and stability in the preparation.
摘要翻译： PCT No.PCT / JP95 / 01576第 371日期1997年04月21日 102（e）1997年4月21日PCT PCT 1995年8月8日PCT公布。公开号WO96 / 04902 日期1996年2月22日本文公开了一种外用制剂组合物，其在液体制剂，霜剂，软膏或糊剂膏药中，其特征在于组合物含有双氯芬酸的水溶性盐，例如双氯芬酸钠，水和脂肪酸二烷基酰胺和/或其聚氧乙烯加合物。根据本发明的外用制剂组合物在制备中溶解性和稳定性高的双氯芬酸盐的水溶性盐的经皮吸收性优异。

4. 发明授权

US5140546A Adder circuit apparatus 失效
标题翻译：加法器电路装置
公开(公告)号：US5140546A
公开(公告)日：1992-08-18
申请号：US531713
申请日：1990-05-31
申请人： Kazuyuki Ishikawa , Yukihiko Shimazu , Toshiki Fujiyama
发明人： Kazuyuki Ishikawa , Yukihiko Shimazu , Toshiki Fujiyama
IPC分类号： G06F7/50 , G06F7/506 , G06F7/508
CPC分类号： G06F7/508
摘要： An adder circuit includes a Manchester-carry-chain circuit which propagates a carry signal for each block consisting of plural bits, and a carry-look-ahead circuit which selects said carry signal in response to a carry propagation signal being generated by a full adder, and when the carry signal is not generated in the two consecutive blocks, an output from the Manchester-carry-chain circuit is selected by the carry-look-ahead circuit, so that the carry signal being inputted to the low-order block of the two blocks can be propagated as the carry signal to be outputted from the high-order block.
摘要翻译：一个加法器电路包括一个曼彻斯特携带链电路，它传播由多个比特组成的每个块的进位信号，以及一个进位前进电路，其响应于一个全加器产生的进位传播信号选择所述进位信号，并且当在两个连续块中不产生进位信号时，由进位查询电路选择来自曼彻斯特携带链电路的输出，使得进位信号被输入到低位块可以将这两个块作为从高阶块输出的进位信号传播。

5. 发明申请

US20100226994A1 GRANULE, TABLET AND METHODS FOR PRODUCING THE SAME 审中-公开
标题翻译：花纹片，片材及其制造方法
公开(公告)号：US20100226994A1
公开(公告)日：2010-09-09
申请号：US12681559
申请日：2008-10-03
申请人： Nobuaki Hirai , Kazuyuki Ishikawa , Yasutaka Azechi , Yoshitaka Etou
发明人： Nobuaki Hirai , Kazuyuki Ishikawa , Yasutaka Azechi , Yoshitaka Etou
IPC分类号： A61K9/16 , A61K36/889 , A61K31/385 , A61K31/355 , A61K31/07 , A61K31/015 , A61P43/00
CPC分类号： A61K9/1611 , A23L5/44 , A23L33/105 , A23L33/12 , A23L33/155 , A23P10/20 , A23V2002/00 , A61K9/1617 , A61K9/1623 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/015 , A61K31/047 , A61K31/07 , A61K31/19 , A61K31/202 , A61K31/22 , A61K31/23 , A61K31/353 , A61K31/355 , A61K31/381 , A61K36/185 , A61K36/60 , A61K36/73 , A61K36/889 , A23V2250/1628 , A23V2200/21 , A23V2250/2132 , A23V2250/702 , A23V2250/1578
摘要： A granule comprising a carrier composed of porous calcium silicate; a functional substance which is an oily liquid or a low-melting solid and a water-soluble antioxidizing agent, which are adsorbed on the carrier; and a granulating component. The problem to be solved is to improve storage stability of a powdered or tableted functional substance, for example, vitamin A to the level causing no problem in practical use.
摘要翻译：一种颗粒，包括由多孔硅酸钙组成的载体; 作为吸附在载体上的油性液体或低熔点固体和水溶性抗氧化剂的功能性物质，和造粒组分。要解决的问题是将粉状或压片的功能性物质（例如维生素A）的储存稳定性提高到在实际使用中没有问题的水平。

6. 发明授权

US6054484A Transparent aqueous solution of diclofenac sodium and medicinal compositions with the use of the same 失效
标题翻译：透明的双氯芬酸钠水溶液和药用组合物使用相同
公开(公告)号：US6054484A
公开(公告)日：2000-04-25
申请号：US125011
申请日：1998-08-07
申请人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa , Takaaki Matsumoto
发明人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa , Takaaki Matsumoto
IPC分类号： A61K9/70 , A61K31/196 , A61K47/18 , A61K31/195
CPC分类号： A61K9/7023 , A61K31/196 , A61K47/18 , A61K9/0014
摘要： Disclosed are a clear aqueous solution of diclofenac sodium dissolved in a mixed solvent of a fatty acid dialkylolamide and water; an anti-inflammatory analgesic composition excellent in percutaneous absorption, which comprises the clear aqueous solution and a higher unsaturated aliphatic alcohol contained in the solution; and a self-adhesive cataplasm comprising a cataplasm base and the clear aqueous solution, polybutene and gelatin added in the base. The clear aqueous solution of diclofenac sodium contains, in particular, diclofenac sodium, a fatty acid dialkylolamide and water at a ratio falling within a hexagonal region formed by linking the points A, B, C, D, E and F in the figure.
摘要翻译： PCT No.PCT / JP97 / 00293 Sec。 371日期：1998年8月7日 102（e）日期1998年8月7日PCT提交1997年2月6日PCT公布。公开号WO97 / 28794 日期1997年8月14日公开是溶解在脂肪酸二烷基酰胺和水的混合溶剂中的透明的双氯芬酸钠水溶液; 具有优异的经皮吸收的抗炎止痛组合物，其包含所述溶液中所含的透明水溶液和较高级不饱和脂肪醇; 以及在基底中添加有悬滴剂碱和透明水溶液，聚丁烯和明胶的自粘性粘膜。双氯芬酸钠的透明水溶液特别包含双氯芬酸钠，脂肪酸二烷基酰胺和水，其比率落在通过连接图中的点A，B，C，D，E和F形成的六边形区域内。

7. 发明申请

US20100285157A1 GRANULES, TABLETS AND METHOD OF PRODUCING THE SAME 审中-公开
标题翻译：颗粒，片剂及其制备方法
公开(公告)号：US20100285157A1
公开(公告)日：2010-11-11
申请号：US12279980
申请日：2007-02-20
申请人： Nobuaki Hirai , Kazuyuki Ishikawa
发明人： Nobuaki Hirai , Kazuyuki Ishikawa
IPC分类号： A61K36/889 , A61K31/047
CPC分类号： A61K9/1652 , A61K9/1611 , A61K9/1682 , A61K9/2077
摘要： When a light and porous inorganic substance is employed in a large amount as a excipient, it is impossible in the subsequent tabletting step using a tabletting machine to supply a desired amount of the resultant powder into a mortar having a definite diameter. As a result, extremely light tablets are produced. A method of producing the tablet is characterized by including dissolving or dispersing an oily substance, a liquid substance derived from a natural product or a low-melting substance in an organic solvent, allowing a porous calcium silicate powder to adsorb and hold the solution, adding a starch and/or a saccharide thereto, granulating the obtained mixture to give granules having an appropriate loose bulk density, and then compression molding those granules to give tablets.
摘要翻译：当以大量作为赋形剂使用轻质多孔无机物质时，在随后的压片步骤中，使用压片机不可能将所需量的所得粉末供给到具有确定直径的砂浆中。结果，产生极轻的片剂。制备片剂的方法的特征在于将油状物质，衍生自天然产物或低熔点物质的液体物质溶解或分散在有机溶剂中，使多孔硅酸钙粉末吸附并保持溶液，加入淀粉和/或糖，将得到的混合物造粒，得到具有适当松散堆积密度的颗粒，然后压缩那些颗粒以得到片剂。

8. 发明授权

US5968899A Medicinal compositions of peptides with EACA or tranexamic acid for enhanced mucosal absorption 失效
标题翻译：具有EACA或氨甲环酸的肽的药物组合物用于增强粘膜吸收
公开(公告)号：US5968899A
公开(公告)日：1999-10-19
申请号：US737930
申请日：1996-12-02
申请人： Takashi Sekine , Kazuyuki Ishikawa , Takayoshi Kimura , Yoshinobu Nakai
发明人： Takashi Sekine , Kazuyuki Ishikawa , Takayoshi Kimura , Yoshinobu Nakai
IPC分类号： A61K38/23 , A61K47/10 , A61K47/18 , A61K38/17 , A61K38/09 , A61K38/10 , A61K38/16
CPC分类号： A61K47/183 , A61K38/23 , A61K47/10 , A61K9/0019 , Y10S514/802
摘要： Disclosed is a medicinal composition, which comprises a peptide as an effective ingredient and as bases, epsilon aminocaproic acid or tranexamic acid and an ethylene oxide-propylene oxide block copolymer represented by the following formula (I):HO(C.sub.2 H.sub.4 O).sub.a --(C.sub.3 H.sub.6 O).sub.b --(C.sub.2 H.sub.4 O).sub.c H (I)wherein a, b and c stand for integers of 1 or greater, respectively. According to this medicinal composition, the peptide can be absorbed at a high rate through the mucosa and further, its pharmacological effects are prolonged over for a long time.
摘要翻译： PCT No.PCT / JP95 / 01085 Sec。 371日期1996年12月2日第 102（e）日期1996年12月2日PCT归档1995年6月2日PCT公布。 WO95 / 33474 PCT公开号日期：1995年12月14日公开是药物组合物，其包含作为有效成分的肽和作为碱的ε氨基己酸或氨甲环酸和由下式（I）表示的环氧乙烷 - 环氧丙烷嵌段共聚物：HO（C 2 H 4 O ）a-（C 3 H 6 O）b - （C 2 H 4 O）c H（I）其中a，b和c分别表示1或更大的整数。根据该药物组合物，可以通过粘膜以高速率吸收肽，并且其药理作用长时间延长。

9. 发明授权

US5704738A Tool attachment assembly 失效
标题翻译：工具附件总成
公开(公告)号：US5704738A
公开(公告)日：1998-01-06
申请号：US649479
申请日：1996-05-17
申请人： Shigeru Sugino , Kazuyuki Ishikawa
发明人： Shigeru Sugino , Kazuyuki Ishikawa
IPC分类号： B23Q3/12 , B23B31/08 , B23G1/46 , B23F5/14 , B23F1/16
CPC分类号： B23B31/083 , Y10T279/17017 , Y10T279/17965 , Y10T408/03 , Y10T408/95
摘要： A tool attachment assembly having a housing with a central axis, a toolholder with a tool carrying portion and a mounting portion spaced axially from the tool carrying portion, a projection on one of the housing and mounting portion of the tool holder, and a receptacle on the other of the housing and mounting portion of the tool holder for receiving the projection so that the housing and the tool holder reside at least partially, one within the other, with the tool holder in an operative state on the housing. There are axially facing first and second surfaces, one each on the housing and the mounting portion of the tool holder, that extend at least partially around the central axis and are abuttable to each other to limit movement of the tool holder axially towards the housing with the tool holder in the operative state. At least one of the first and second surfaces is other than parallel to a plane that is orthogonal to the central axis.
摘要翻译：具有具有中心轴线的壳体的工具附接组件，具有工具承载部分的工具架和与所述工具承载部分轴向间隔开的安装部分，在所述工具架的壳体和安装部分之一上的突起，以及用于接收突起的工具架的壳体和安装部分中的另一个，使得壳体和工具架至少部分地位于另一个内部，工具保持器处于壳体上的操作状态。具有轴向面对的第一和第二表面，每个在壳体上和工具保持器的安装部分上，其至少部分地围绕中心轴线延伸并且彼此抵靠以限制工具保持器轴向朝向壳体的移动，工具架处于工作状态。第一和第二表面中的至少一个不同于平行于与中心轴线正交的平面。

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