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1. 发明授权

US6054484A Transparent aqueous solution of diclofenac sodium and medicinal compositions with the use of the same 失效
标题翻译：透明的双氯芬酸钠水溶液和药用组合物使用相同
公开(公告)号：US6054484A
公开(公告)日：2000-04-25
申请号：US125011
申请日：1998-08-07
申请人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa , Takaaki Matsumoto
发明人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa , Takaaki Matsumoto
IPC分类号： A61K9/70 , A61K31/196 , A61K47/18 , A61K31/195
CPC分类号： A61K9/7023 , A61K31/196 , A61K47/18 , A61K9/0014
摘要： Disclosed are a clear aqueous solution of diclofenac sodium dissolved in a mixed solvent of a fatty acid dialkylolamide and water; an anti-inflammatory analgesic composition excellent in percutaneous absorption, which comprises the clear aqueous solution and a higher unsaturated aliphatic alcohol contained in the solution; and a self-adhesive cataplasm comprising a cataplasm base and the clear aqueous solution, polybutene and gelatin added in the base. The clear aqueous solution of diclofenac sodium contains, in particular, diclofenac sodium, a fatty acid dialkylolamide and water at a ratio falling within a hexagonal region formed by linking the points A, B, C, D, E and F in the figure.
摘要翻译： PCT No.PCT / JP97 / 00293 Sec。 371日期：1998年8月7日 102（e）日期1998年8月7日PCT提交1997年2月6日PCT公布。公开号WO97 / 28794 日期1997年8月14日公开是溶解在脂肪酸二烷基酰胺和水的混合溶剂中的透明的双氯芬酸钠水溶液; 具有优异的经皮吸收的抗炎止痛组合物，其包含所述溶液中所含的透明水溶液和较高级不饱和脂肪醇; 以及在基底中添加有悬滴剂碱和透明水溶液，聚丁烯和明胶的自粘性粘膜。双氯芬酸钠的透明水溶液特别包含双氯芬酸钠，脂肪酸二烷基酰胺和水，其比率落在通过连接图中的点A，B，C，D，E和F形成的六边形区域内。

2. 发明授权

US5795916A Composition of external preparation 失效
标题翻译：外用制剂的组成
公开(公告)号：US5795916A
公开(公告)日：1998-08-18
申请号：US776700
申请日：1997-04-21
申请人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa
发明人： Takashi Sekine , Eiji Ogura , Shinichi Ota , Kazuyuki Ishikawa
IPC分类号： A61K31/196 , A61K47/18 , A61K31/19 , A61K31/16
CPC分类号： A61K31/196 , A61K47/18 , A61K9/0014
摘要： Disclosed herein is an external preparation composition, in a liquid preparation, cream, ointment or cataplasm plaster, characterized in that the composition contains a water-soluble salt of diclofenac, such as diclofenac sodium, water, and a fatty acid dialkylolamide and/or its polyoxyethylene adduct. The external preparation composition according to this invention is excellent in the percutaneous absorption of the water-soluble salt of diclofenac, which has high solubility and stability in the preparation.
摘要翻译： PCT No.PCT / JP95 / 01576第 371日期1997年04月21日 102（e）1997年4月21日PCT PCT 1995年8月8日PCT公布。公开号WO96 / 04902 日期1996年2月22日本文公开了一种外用制剂组合物，其在液体制剂，霜剂，软膏或糊剂膏药中，其特征在于组合物含有双氯芬酸的水溶性盐，例如双氯芬酸钠，水和脂肪酸二烷基酰胺和/或其聚氧乙烯加合物。根据本发明的外用制剂组合物在制备中溶解性和稳定性高的双氯芬酸盐的水溶性盐的经皮吸收性优异。

3. 发明授权

US5968899A Medicinal compositions of peptides with EACA or tranexamic acid for enhanced mucosal absorption 失效
标题翻译：具有EACA或氨甲环酸的肽的药物组合物用于增强粘膜吸收
公开(公告)号：US5968899A
公开(公告)日：1999-10-19
申请号：US737930
申请日：1996-12-02
申请人： Takashi Sekine , Kazuyuki Ishikawa , Takayoshi Kimura , Yoshinobu Nakai
发明人： Takashi Sekine , Kazuyuki Ishikawa , Takayoshi Kimura , Yoshinobu Nakai
IPC分类号： A61K38/23 , A61K47/10 , A61K47/18 , A61K38/17 , A61K38/09 , A61K38/10 , A61K38/16
CPC分类号： A61K47/183 , A61K38/23 , A61K47/10 , A61K9/0019 , Y10S514/802
摘要： Disclosed is a medicinal composition, which comprises a peptide as an effective ingredient and as bases, epsilon aminocaproic acid or tranexamic acid and an ethylene oxide-propylene oxide block copolymer represented by the following formula (I):HO(C.sub.2 H.sub.4 O).sub.a --(C.sub.3 H.sub.6 O).sub.b --(C.sub.2 H.sub.4 O).sub.c H (I)wherein a, b and c stand for integers of 1 or greater, respectively. According to this medicinal composition, the peptide can be absorbed at a high rate through the mucosa and further, its pharmacological effects are prolonged over for a long time.
摘要翻译： PCT No.PCT / JP95 / 01085 Sec。 371日期1996年12月2日第 102（e）日期1996年12月2日PCT归档1995年6月2日PCT公布。 WO95 / 33474 PCT公开号日期：1995年12月14日公开是药物组合物，其包含作为有效成分的肽和作为碱的ε氨基己酸或氨甲环酸和由下式（I）表示的环氧乙烷 - 环氧丙烷嵌段共聚物：HO（C 2 H 4 O ）a-（C 3 H 6 O）b - （C 2 H 4 O）c H（I）其中a，b和c分别表示1或更大的整数。根据该药物组合物，可以通过粘膜以高速率吸收肽，并且其药理作用长时间延长。

4. 发明授权

US09579297B2 Pharmaceutical composition for application to nail 有权
标题翻译：用于指甲的药物组合物
公开(公告)号：US09579297B2
公开(公告)日：2017-02-28
申请号：US12159591
申请日：2006-12-26
申请人： Tomohiro Ishima , Mamoru Naruse , Hideo Kaneda , Kazuo Kanai , Takashi Sekine , Shinichi Ota , Tomonari Yoshimura
发明人： Tomohiro Ishima , Mamoru Naruse , Hideo Kaneda , Kazuo Kanai , Takashi Sekine , Shinichi Ota , Tomonari Yoshimura
IPC分类号： A61K31/00 , A61F13/10 , A61K9/70 , A61K31/4178 , A61K45/06 , A61F13/00
CPC分类号： A61K9/7061 , A61F13/02 , A61F13/105 , A61F2013/00906 , A61K9/0014 , A61K31/00 , A61K31/4174 , A61K31/4178 , A61K45/06 , A61K47/10 , A61K47/22 , A61K47/32 , A61K47/38 , A61M35/00
摘要： Since treatment effects of conventional external preparations were not satisfactory, it is aimed to provide a novel external preparation that is excellent in drug permeability to nail, capable of fully exhibiting effects of an antifungal drug, and effective for treatments of diseases such as nail mycosis and nail candidiasis, particularly, treatments for nail tinea. The external preparation of this invention is a pharmaceutical composition for nail characterized by containing an antifungal drug, alkylpyrrolidone or a derivative thereof, and a crosslinking hydrogel.
摘要翻译：由于常规外用制剂的治疗效果不能令人满意，目的在于提供一种能够充分发挥抗真菌药物效果，能够有效治疗诸如甲型真菌病等疾病的指甲药物渗透性优异的外用制剂，指甲念珠菌病，特别是指甲癣的治疗。本发明的外用制剂是用于指甲的药物组合物，其特征在于含有抗真菌药物，烷基吡咯烷酮或其衍生物和交联水凝胶。

5. 发明申请

US20130288514A1 ELECTRICAL CONNECTION TERMINAL AND CONNECTOR USING SAME 有权
标题翻译：电气连接端子和连接器使用相同
公开(公告)号：US20130288514A1
公开(公告)日：2013-10-31
申请号：US13819502
申请日：2012-01-11
申请人： Takashi Sekine , Kenichi Yamaguchi
发明人： Takashi Sekine , Kenichi Yamaguchi
IPC分类号： H01R4/10
CPC分类号： H01R4/10 , F21K9/232 , F21V3/00 , F21V19/004 , F21V23/06 , F21Y2115/10 , H01R4/24 , H01R4/2404 , H01R4/4818 , H01R12/515 , H01R12/721
摘要： An electrical connection terminal for securely retaining a connection object without degrading connection reliability, and a connector using the electrical connection terminal. A first contacting portion adapted to cut into a lead wire of a cable to restrict displacement thereof in a counter-insertion direction is provided in the leading-end corner of a first contact piece of a terminal, and a second contacting portion with which the lead wire slidably makes contact is provided on the leading end of a second contact piece of the terminal. Disconnection of the lead wire is prevented by means of the first contacting portion and securing a sufficient area of connect with the lead wire by the second contacting portion. The second contacting portion is formed by chamfering the leading-end corner of the second contact piece. Accordingly, the leading-end side of the second contact piece need not be bent to form a curved-surface contacting portion.
摘要翻译：一种用于牢固地保持连接对象而不降低连接可靠性的电连接端子，以及使用该电连接端子的连接器。在端子的第一接触片的前端角部和第二接触部分中设置适于切割成电缆的引线以限制其沿反向插入方向的位移的第一接触部分，在端子的第二接触片的前端设有可滑动地接触的线。通过第一接触部分防止引线的断开，并且通过第二接触部分确保与引线的足够的连接区域。第二接触部分通过倒角第二接触片的前端角形成。因此，第二接触片的前端侧不需要弯曲而形成曲面接触部。

6. 发明授权

US08038511B2 Method for machining chamfer portion of semiconductor wafer and method for correcting groove shape of grinding stone 有权
标题翻译：半导体晶片的倒角部分的加工方法及修磨砂轮的形状的方法
公开(公告)号：US08038511B2
公开(公告)日：2011-10-18
申请号：US12086330
申请日：2006-12-13
申请人： Eiichi Yamazaki , Takashi Sekine
发明人： Eiichi Yamazaki , Takashi Sekine
IPC分类号： B24B1/00
CPC分类号： H01L21/02021 , B24B9/065 , B24B53/07
摘要： According to the present invention, in a method for subjecting a roughly ground chamfer portion of a semiconductor wafer to helical grinding by relatively inclining the wafer and a second grinding stone to perform precise grinding, an edge portion of a discoid truer is formed into a vertically asymmetrical groove shape of a first grinding stone by using the first grinding stone having a vertically asymmetrical groove formed on a periphery thereof to grind the edge portion of the truer by the groove of the first grinding stone without being relatively inclined, a groove is formed on a periphery of the second grinding stone by relatively inclining the truer and the second grinding stone to subject the second grinding stone to helical grinding, and the chamfer portion of the wafer is precisely ground based on helical grinding by relatively inclining the semiconductor wafer with respect to a direction of the groove formed on the periphery of the second grinding stone. As a result, there is provided the method for machining a chamfer portion of the semiconductor wafer, which can machine the chamfer portion of the wafer into a vertically symmetrical shape when subjecting the chamfer portion of the semiconductor wafer to helical grinding, e.g. a resin grinding stone and the like.
摘要翻译：根据本发明，通过使半导体晶片的大致倒角的倒角部通过相对倾斜晶片进行螺旋磨削和第二研磨石进行精密研磨的方法中，将盘状矫正器的边缘部形成为垂直方向通过使用具有形成在其周边上的垂直不对称槽的第一研磨石，通过第一研磨石的凹槽来研磨修整器的边缘部分而不相对倾斜地在第一研磨石的不对称凹槽形状上形成凹槽，第二研磨石的周边通过相对地倾斜修整器和第二研磨石以使第二研磨石进行螺旋磨削，并且通过相对于半导体晶片相对倾斜相对于螺旋磨削而精确地研磨晶片的倒角部分形成在第二研磨石的周边上的槽的方向。结果，提供了用于加工半导体晶片的倒角部分的方法，当对半导体晶片的倒角部分进行螺旋磨削时，例如可以将晶片的倒角部分加工成垂直对称的形状。树脂研磨石等。

7. 发明申请

US20110048054A1 AIR CONDITIONER 有权
标题翻译：冷气机
公开(公告)号：US20110048054A1
公开(公告)日：2011-03-03
申请号：US12868323
申请日：2010-08-25
申请人： Takashi Sekine
发明人： Takashi Sekine
IPC分类号： F25B13/00 , F25B7/00 , F25B1/10
CPC分类号： F25B13/00 , F25B1/10 , F25B41/046 , F25B2313/007 , F25B2313/0231 , F25B2313/0233 , F25B2313/0253 , F25B2313/02742 , F25B2313/0292 , F25B2400/075
摘要： A triple-pipeline type first outdoor unit 2 provided with a first compressor 20 and a first outdoor heat exchanger 21, a plurality of indoor units 4A to 4D are provided, a second outdoor unit 3 provided with a second compressor 30, a second outdoor heat exchanger 32, and a second expansion valve 33, the first outdoor unit 2 is provided with a first four-way valve 60 that makes a refrigerant discharge pipe 25 of the first compressor 20 and a high-pressure gas pipe 7 capable of communicating with each other and if all the indoor units 4A to 4D perform a cooling operation at the same time, the first four-way valve 60 shuts off the communication between the refrigerant discharge pipe 25 and the high-pressure gas pipe 7, while a third four-way valve 51 is switched so as to connect a gas pipe 35d to the high-pressure gas pipe 7.
摘要翻译：设置有第一压缩机20和第一室外热交换器21，多个室内单元4A〜4D的三管路型第一室外机2，设置有第二压缩机30的第二室外机3，第二室外热交换器32和第二膨胀阀33，第一室外单元2设置有第一四通阀60，其使第一压缩机20的制冷剂排出管25和能够与第一压缩机20连通的高压气体管7 另一方面，如果全部室内机4A〜4D同时进行制冷运转，则第一四通阀60切断制冷剂排出管25与高压气体配管7的连通，切换单向阀51，将气体管道35d与高压气体管道7连接。

8. 发明申请

US20060084316A1 Flat cable coupler and electrical connector assembly 有权
公开(公告)号：US20060084316A1
公开(公告)日：2006-04-20
申请号：US11251153
申请日：2005-10-14
申请人： Kubo Akira , Isao Igarashi , Masata Umehara , Takashi Sekine
发明人： Kubo Akira , Isao Igarashi , Masata Umehara , Takashi Sekine
IPC分类号： H01R12/24
CPC分类号： H01R12/88 , H01R12/772
摘要： An electrical connector assembly comprises a flexible flat cable and a coupler. The flexible flat cable has a tip. A plurality of conductors is provided on a section of the tip between ends thereof. The coupler includes a first holding member mated with a second holding member. The flexible flat cable is positioned between the first and second holding members. The coupler is arranged behind the tip such that both sides of the tip are exposed. The coupler has a width longer than the section of the tip provided with the conductors.

9. 发明申请

US20060057677A1 Organic anion transporter and gene coding for the same 审中-公开
标题翻译：有机阴离子转运蛋白和基因编码相同
公开(公告)号：US20060057677A1
公开(公告)日：2006-03-16
申请号：US11259417
申请日：2005-10-25
申请人： Hitoshi Endou , Yoshikatsu Kanai , Takashi Sekine , Makoto Hosoyamada
发明人： Hitoshi Endou , Yoshikatsu Kanai , Takashi Sekine , Makoto Hosoyamada
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/47
摘要： A protein capable of transporting organic anions having amino acid sequences represented by SEQ ID NO: 1 or 2 or amino acid sequences derived therefrom by deletion, substitution or addition of one or more amino acid residues; and a gene coding for the protein. The protein and gene therefor are useful in vitro analysis of drug release and drug-drug interactions and development of methods for screening drugs useful for preventing nephrotoxicity.
摘要翻译：通过缺失，取代或添加一个或多个氨基酸残基，能够输送具有由SEQ ID NO：1或2表示的氨基酸序列的有机阴离子或其衍生的氨基酸序列的蛋白质; 和编码该蛋白质的基因。其蛋白质和基因可用于药物释放和药物 - 药物相互作用的体外分析以及用于筛选用于预防肾毒性的药物的方法的开发。

10. 发明授权

US09363882B2 Neutron generation target, device, and method 有权
标题翻译：中子生成目标，装置和方法
公开(公告)号：US09363882B2
公开(公告)日：2016-06-07
申请号：US13516112
申请日：2010-12-15
申请人： Takashi Sekine , Toshiyuki Kawashima , Hirofumi Kan , Yoneyoshi Kitagawa , Yoshitaka Mori , Hirozumi Azuma , Tatsumi Hioki , Tomoyoshi Motohiro , Yasushi Miyamoto , Naoki Nakamura
发明人： Takashi Sekine , Toshiyuki Kawashima , Hirofumi Kan , Yoneyoshi Kitagawa , Yoshitaka Mori , Hirozumi Azuma , Tatsumi Hioki , Tomoyoshi Motohiro , Yasushi Miyamoto , Naoki Nakamura
IPC分类号： H05H1/22 , H05H6/00 , G21B1/19 , G21B3/00
CPC分类号： H05H6/00 , G21B1/19 , G21B3/006 , Y02E30/16
摘要： An object is to be capable of inducing a nuclear fusion reaction at a relatively high efficiency and downsize a device. A nuclear fusion device 1 of the present invention includes a nuclear fusion target 7 including a target substrate 7a containing deuterium or tritium and a thin-film layer 7b containing deuterium or tritium stacked on the target substrate 7a, a vacuum container 5 for storing the nuclear fusion target 7, and a laser unit 3 for irradiating two successive first and second pulsed laser lights P1, P2 toward the thin-film layer 7b of the nuclear fusion target 7, and the intensity of the first pulsed laser light P1 is set to a value that is smaller than that of the second pulsed laser light P2 and allows peeling of the thin-film layer 7b from the target substrate 7a.
摘要翻译：目的是能够以相对高的效率诱导核聚变反应并且使装置小型化。本发明的核聚变装置1包括：核聚变靶7，其包含含有氘或氚的靶基板7a和层叠在目标基板7a上的含有氘或氚的薄膜层7b，存储核融合靶7和用于将两个连续的第一和第二脉冲激光P1，P2朝向核聚变靶7的薄膜层7b照射的激光单元3，将第一脉冲激光P1的强度设定为值小于第二脉冲激光P2的值，并允许薄膜层7b从目标衬底7a剥离。

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