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1. 发明授权

US4719206A Cephem compounds 失效
公开(公告)号：US4719206A
公开(公告)日：1988-01-12
申请号：US824969
申请日：1986-01-31
申请人： Takao Takaya , Takashi Masugi , Takashi Ogino , Hisashi Takasugi , Hideaki Yamanaka
发明人： Takao Takaya , Takashi Masugi , Takashi Ogino , Hisashi Takasugi , Hideaki Yamanaka
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D213/20 , C07D401/06 , C07D501/18 , C07D501/24 , A61K31/54
CPC分类号： C07D213/20 , C07D401/06
摘要： The invention relates to novel cephem compounds, of high antimicrobial activity, of the formula: ##STR1## wherein R.sup.1 and R.sup.9 are amino or acylamino; andR.sup.9 is a group of the formula: ##STR2## where R.sup.2 is organic group,X is CH or N,Z is acid residueY is CH or N and n is O; orY is N.sup..sym. --R.sup.2 wherein R.sup.2 is as defined above and n is 1,or a group of the formula:--A--N.sup..sym. (R.sup.10).sub.3whereinR.sup.10 is lower alkyl andA is lower alkylene.

2. 发明授权

US4584290A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4584290A
公开(公告)日：1986-04-22
申请号：US556413
申请日：1983-11-30
申请人： Takao Takaya , Takashi Masugi , Takashi Ogino , Hisashi Takasugi , Hideaki Yamanaka
发明人： Takao Takaya , Takashi Masugi , Takashi Ogino , Hisashi Takasugi , Hideaki Yamanaka
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D213/20 , C07D401/06 , C07D501/18 , C07D501/24 , C07D501/38
CPC分类号： C07D213/20 , C07D401/06
摘要： The invention relates to novel compounds of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or acylamino; andR.sup.9 is a group of the formula: ##STR2## wherein R.sup.2 is organic group,X is CH or N,Z is acid residueY is CH or N and n is O; orY is N.sup..sym. --R.sup.2 wherein R.sup.2 is as defined above and n is 1,or a group of the formula:--A--N.sup..sym. (R.sup.10).sub.3whereinR.sup.10 is lower alkyl andA is lower alkylene.
摘要翻译：本发明涉及具有下式的高抗微生物活性的新化合物：其中R1是氨基或酰氨基; 并且R 9是下式的基团：其中R 2是有机基团，X是CH或N，Z是酸残基，Y是CH或N，n是0; 或Y是N（+） - R 2，其中R 2如上定义并且n是1，或下式基团-A-N（+）（R 10）3，其中R 10是低级烷基，A是低级亚烷基。

3. 发明授权

US4500709A Thiinyl and oxothiolyl derivatives 失效
标题翻译：噻吩基和氧代噻吩衍生物
公开(公告)号：US4500709A
公开(公告)日：1985-02-19
申请号：US428658
申请日：1982-09-30
申请人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
发明人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
IPC分类号： C07D501/34 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07C20060101 , C07D279/10 , C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08 , C07D501/20 , C07D501/36
CPC分类号： C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08
摘要： This invention relates to novel compounds useful as intermediates in the preparation of cephalosporin compounds of antibacterial activity, having the formula ##STR1## wherein R.sup.1 is a group of the formula ##STR2## in which X is sulfur, oxygen or substituted or unsubstituted imino, andR.sup.2 is hydrogen or a saturated or unsaturated aliphatic hydrocarbon residue,a derivative at the carboxy group thereof and salt thereof.
摘要翻译：本发明涉及可用作制备抗菌活性头孢菌素化合物的中间体的新化合物，其具有下式：其中R1是式为“IMAGE”的基团，其中X为硫，氧或取代或未取代的亚氨基，以及 R2是氢或饱和或不饱和的脂族烃残基，其羧基上的衍生物及其盐。

4. 发明授权

US4242510A Cephalosporin compounds and processes for the preparation thereof 失效
标题翻译：头孢菌素化合物及其制备方法
公开(公告)号：US4242510A
公开(公告)日：1980-12-30
申请号：US916858
申请日：1978-06-19
申请人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
发明人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
IPC分类号： C07D501/34 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07C20060101 , C07D279/10 , C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08 , C07D501/20 , C07D501/36 , C07D501/56
CPC分类号： C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08
摘要： Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 is a group of the formula: ##STR2## in which X is sulfur, oxygen or substituted or unsubstituted imino,M is sulfur or oxygen,R.sup.2 is hydrogen, or a saturated or unsaturated aliphatic hydrocarbon residue,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, halogen, lower alkyl, acyloxymethyl or heterocyclic-thiomethyl which may be substituted with lower alkyl, andR.sup.5 is carboxy or its derivative, and nontoxic, pharmaceutically salt thereof.
摘要翻译：式（I）的头孢菌素化合物：其中R1是下式的基团：其中X是硫，氧或取代或未取代的亚氨基，M是硫或氧，R 2是氢，或饱和或不饱和的脂族烃残基，R 3为氢或低级烷基，R 4为氢，卤素，低级烷基，酰氧基甲基或可被低级烷基取代的杂环硫甲基，R5为羧基或其衍生物，且为无毒的的盐。

5. 发明授权

US4371531A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4371531A
公开(公告)日：1983-02-01
申请号：US178898
申请日：1980-08-18
申请人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
发明人： Takao Takaya , Takashi Masugi , Takashi Ogino , Kiyoshi Tsuji
IPC分类号： C07D501/34 , A61K20060101 , A61K31/545 , A61K31/546 , A61P31/04 , C07C20060101 , C07D279/10 , C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08 , C07D501/20 , C07D501/36
CPC分类号： C07D279/12 , C07D327/06 , C07D339/06 , C07D339/08
摘要： The invention relates to new cephalosporin compounds of high antimicrobial activity, the compounds being of the formula: ##STR1## wherein R.sup.1 is a group of the formula ##STR2## in which X is sulfur, oxygen, imino or lower-alkanoyl-substituted imino, R.sup.2 is hydrogen, lower alkyl or lower alkenyl,R.sup.3 is hydrogen or lower alkyl,R.sup.4 is hydrogen, halogen, lower alkyl, carbamoyloxymethyl or lower alkanoyloxymethyl, andR.sup.5 is carboxy or its ester, and a non-toxic, pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及高抗微生物活性的新型头孢菌素化合物，该化合物具有下式：其中R 1是下式的基团：其中X是硫，氧，亚氨基或低级烷酰基取代的亚氨基， R2是氢，低级烷基或低级烯基，R3是氢或低级烷基，R4是氢，卤素，低级烷基，氨基甲酰氧基甲基或低级烷酰氧基甲基，R5是羧基或其酯，以及它们无毒的药学上可接受的盐。

6. 发明授权

US08494384B2 Image forming apparatus 有权
标题翻译：图像形成装置
公开(公告)号：US08494384B2
公开(公告)日：2013-07-23
申请号：US13205084
申请日：2011-08-08
申请人： Takao Furuya , Yoshinari Iwaki , Seigo Makida , Takashi Ogino , Kiyoshi Hosoi , Katsumi Sakamaki
发明人： Takao Furuya , Yoshinari Iwaki , Seigo Makida , Takashi Ogino , Kiyoshi Hosoi , Katsumi Sakamaki
IPC分类号： G03G15/00
CPC分类号： G03G15/5029 , G03G15/235 , G03G2215/00776
摘要： An image forming apparatus includes a forming section that forms an image on a side of paper; a fixing section that applies heat to fix the image onto the side of the paper; a paper reversing section that reverses a front and back of the paper having the image fixed onto a first side in the fixing section; a first measuring section that is provided between a registration roller and the forming section to measure a first moisture content of the paper before an image is formed on the first side, and a second moisture content of the paper before an image is formed on a second side, after the image is fixed on the first side; and a calculating section that calculates amount of change of the size of the paper on the basis of the difference between the first moisture content and the second moisture content.
摘要翻译：图像形成装置包括在纸侧形成图像的成形部; 固定部分，其施加热量以将图像固定到纸张的侧面; 纸张反转部分，其将具有固定在固定部分的第一侧上的图像的纸张的正面和背面反转; 第一测量部分，设置在定位辊和成形部分之间，以在第一侧形成图像之前测量纸张的第一含水量，并且在第二侧形成图像之前的纸张的第二含水量在图像固定在第一面之后; 以及计算部，其基于第一含水量和第二湿度含量之间的差来计算纸的尺寸的变化量。

7. 发明授权

US08377967B2 Piperidine derivative 有权
标题翻译：哌啶衍生物
公开(公告)号：US08377967B2
公开(公告)日：2013-02-19
申请号：US12864878
申请日：2008-11-20
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
IPC分类号： A61K31/4535 , C07D409/02 , A61P37/08
CPC分类号： C07D495/04 , C07D409/04 , C07D497/04
摘要： The present invention provides a compound a piperidine derivative having excellent histamine receptor antagonistic action, which is useful as active ingredients of a pharmaceutical composition, especially an antihistamine. The piperidine derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low brain transfer even in a cerebral receptor binding test where a mouse is orally administered with the compound, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The piperidine derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
摘要翻译：本发明提供了具有优异的组胺受体拮抗作用的化合物哌啶衍生物，其可用作药物组合物，特别是抗组胺药的活性成分。本发明的哌啶衍生物具有有效的组胺受体拮抗作用。此外，本发明的化合物即使在小鼠口服给药化合物的脑受体结合试验中也显示低脑转移，因此该化合物具有减轻中枢神经系统中的副作用的优选性质，例如嗜睡。本发明的哌啶衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药例如嗜睡是非常有用的。

8. 发明授权

US07845051B2 Hinge device and opening/closing mechanism using the hinge device 有权
标题翻译：铰链装置和使用铰链装置的打开/关闭机构
公开(公告)号：US07845051B2
公开(公告)日：2010-12-07
申请号：US11576083
申请日：2005-09-27
申请人： Makoto Saito , Takashi Ogino , Yoshihiro Hemmi
发明人： Makoto Saito , Takashi Ogino , Yoshihiro Hemmi
IPC分类号： E05D11/10
CPC分类号： G06F1/1681 , E05D11/087 , E05F1/1215 , E05Y2900/606 , F16M11/10 , F16M13/027 , F16M2200/024 , F16M2200/041 , G06F1/1616 , Y10T16/5402 , Y10T16/5403 , Y10T16/540345
摘要： Provided is a hinge device which allows the display device to be watched at an arbitrary angle, thus enabling all the passengers to watch the display at an optimum angle, which helps to achieve an improvement in terms of quality and reliable dropping/opening by causing the dropping/opening movement of the display device due to its own weight to be reliable and gentle in the range from the start to an angle of approximately 30° , and which helps to achieve an improvement in terms of operational feel in the free stop range, thus allowing light operation.
摘要翻译：提供一种能够以任意角度观看显示装置的铰链装置，从而能够使所有的乘客以最佳的角度观看显示，这有助于通过使所述显示装置的质量和可靠的下降/打开来实现改进显示装置由于自身的重量的下降/打开运动在从开始到大约30°的范围内可靠和温和，并且有助于在自由停止范围内实现操作感觉的改善，从而允许轻操作。

9. 发明授权

US07743472B2 Boot band 有权
标题翻译：启动乐队
公开(公告)号：US07743472B2
公开(公告)日：2010-06-29
申请号：US10513917
申请日：2003-06-05
申请人： Takashi Ogino
发明人： Takashi Ogino
IPC分类号： F16L33/02
CPC分类号： F16L33/035 , F16L33/025 , Y10T24/1457 , Y10T24/1478 , Y10T24/1482
摘要： A boot-band that (a) does not excessively clamp a boot, (b) can prevent leakage of grease from the boot and the boot-band, and (c) uniformly produces a tight contact force on the boot without deteriorating the contact force on the boot. This boot-band includes a metallic belt-shaped member (2), and its clamping force, which is generated in the direction that shortens the circumference of the metallic belt-shaped member (2), is exercised under a ring-shaped condition in such a way that one end of the metallic belt-shaped member overlaps the other end thereof, and in such a way that both ends are wound around the outer periphery of the boot. A smaller-cross-sectional area (5a) is formed in a part of the belt-shaped member (2); the smaller-cross-sectional area (5a) and the general part (8), whose cross-sectional area is not reduced, are elongated due to plastic deformation caused by the clamping force.
摘要翻译：（a）不过分夹紧靴子的靴带，（b）可以防止靴子和靴带的润滑脂泄漏，（c）在靴子上均匀地产生紧密的接触力而不会使接触力恶化在开机这种靴带包括金属带状构件（2），并且其在缩短金属带状构件（2）的圆周的方向上产生的夹紧力在环形状态下被执行使得金属带状构件的一端与其另一端重叠的方式，并且以这样的方式将两端缠绕在护罩的外周。在带状构件（2）的一部分中形成有较小的横截面积（5a）; 截面积不减小的较小横截面积（5a）和一般部分（8）由于夹紧力引起的塑性变形而伸长。

10. 发明申请

US20100004456A1 Oxepin derivative 有权
标题翻译：奥克辛衍生物
公开(公告)号：US20100004456A1
公开(公告)日：2010-01-07
申请号：US12311215
申请日：2007-09-27
申请人： Kunihiko Higashiura , Takashi Ogino , Kazuhito Furukawa , Yuriko Yamazaki
发明人： Kunihiko Higashiura , Takashi Ogino , Kazuhito Furukawa , Yuriko Yamazaki
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： The present invention provides a compound, an oxepin derivative having excellent histamine receptor antagonistic action, which is useful as an antihistamine. The oxepin derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low intracerebral migration even when a mouse that is orally administered with the compound is subjected to an intracerebral receptor binding test, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The oxepin derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
摘要翻译：本发明提供一种化合物，具有优异的组胺受体拮抗作用的氧杂环丁衍生物，其可用作抗组胺药。本发明的oxepin衍生物具有有效的组胺受体拮抗作用。此外，本发明的化合物即使经口给予该化合物的小鼠进行脑内受体结合试验，也显示低脑内迁移，使得该化合物具有优选的减轻中枢神经系统副作用的性质，例如作为嗜睡本发明的oxepin衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药如睡意觉是非常有用的。

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