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1. 发明授权

US08377967B2 Piperidine derivative 有权
标题翻译：哌啶衍生物
公开(公告)号：US08377967B2
公开(公告)日：2013-02-19
申请号：US12864878
申请日：2008-11-20
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
IPC分类号： A61K31/4535 , C07D409/02 , A61P37/08
CPC分类号： C07D495/04 , C07D409/04 , C07D497/04
摘要： The present invention provides a compound a piperidine derivative having excellent histamine receptor antagonistic action, which is useful as active ingredients of a pharmaceutical composition, especially an antihistamine. The piperidine derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low brain transfer even in a cerebral receptor binding test where a mouse is orally administered with the compound, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The piperidine derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
摘要翻译：本发明提供了具有优异的组胺受体拮抗作用的化合物哌啶衍生物，其可用作药物组合物，特别是抗组胺药的活性成分。本发明的哌啶衍生物具有有效的组胺受体拮抗作用。此外，本发明的化合物即使在小鼠口服给药化合物的脑受体结合试验中也显示低脑转移，因此该化合物具有减轻中枢神经系统中的副作用的优选性质，例如嗜睡。本发明的哌啶衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药例如嗜睡是非常有用的。

2. 发明申请

US20100331365A1 PIPERIDINE DERIVATIVE 有权
标题翻译：哌啶衍生物
公开(公告)号：US20100331365A1
公开(公告)日：2010-12-30
申请号：US12864878
申请日：2008-11-20
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Hiroyuki Iwatsuki
IPC分类号： A61K31/4535 , C07D409/02 , A61P37/08
CPC分类号： C07D495/04 , C07D409/04 , C07D497/04
摘要： The present invention provides a compound a piperidine derivative having excellent histamine receptor antagonistic action, which is useful as active ingredients of a pharmaceutical composition, especially an antihistamine. The piperidine derivative of the present invention has a potent histamine receptor antagonistic action. Further, the compound of the present invention shows low brain transfer even in a cerebral receptor binding test where a mouse is orally administered with the compound, so that the compound has preferred properties of alleviating side effects in the central nervous system, such as drowsiness. The piperidine derivative of the present invention is very useful as a novel antihistamine having smaller side effects in the central nervous system, such as drowsiness.
摘要翻译：本发明提供了具有优异的组胺受体拮抗作用的化合物哌啶衍生物，其可用作药物组合物，特别是抗组胺药的活性成分。本发明的哌啶衍生物具有有效的组胺受体拮抗作用。此外，本发明的化合物即使在小鼠口服给药化合物的脑受体结合试验中也显示低脑转移，因此该化合物具有减轻中枢神经系统中的副作用的优选性质，例如嗜睡。本发明的哌啶衍生物作为在中枢神经系统中具有较小副作用的新型抗组胺药例如嗜睡是非常有用的。

3. 发明授权

US08653285B2 Aminopropylidene derivative 有权
标题翻译：氨基亚丙基衍生物
公开(公告)号：US08653285B2
公开(公告)日：2014-02-18
申请号：US13055780
申请日：2009-07-31
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
IPC分类号： C07D313/08 , C07D333/50 , A61K31/38 , A61K31/335
CPC分类号： C07D495/04 , C07D333/78
摘要： An aminopropylidene derivative having excellent histamine receptor antagonistic action, a compound which is useful as a pharmaceutical composition, especially as an active ingredient, having alleviated side effects in the central nervous system is described. In the aminopropylidene derivative, R1 and R2, which may be identical or different, stand for a hydrogen, a substituted carbonyl, a substituted carbonylalkyl, and acrylic acid, excluding a case where both are hydrogen; R3 and R4, which may be identical or different, stand for hydrogen, an alkyl which may be substituted with phenyl, or the like; A stands for unsubstituted or an oxo; B stands for a carbon or an oxygen; one of X and Y stands for a carbon and the other stands for a sulfur, a broken line part stands for a single bond or a double bond, and a wavy line stands for cis-form and/or trans-form.
摘要翻译：描述了具有优异的组胺受体拮抗作用的氨基亚丙基衍生物，可用作药物组合物的化合物，特别是作为活性成分，在中枢神经系统中具有缓解的副作用。在氨基亚丙基衍生物中，R 1和R 2可以相同或不同，代表氢，取代的羰基，取代的羰基烷基和丙烯酸，不包括两者均为氢的情况; R3和R4可以相同或不同，代表氢，可被苯基取代的烷基等; A代表未取代或氧代; B代表碳或氧; X和Y中的一个代表碳，另一个代表硫，虚线部分代表单键或双键，波浪线代表顺式和/或反式。

4. 发明申请

US20110124856A1 AMINOPROPYLIDENE DERIVATIVE 有权
标题翻译：氨基酚衍生物
公开(公告)号：US20110124856A1
公开(公告)日：2011-05-26
申请号：US13055780
申请日：2009-07-31
申请人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
发明人： Kunihiko Higashiura , Takashi Ogino , Taizo Ito , Koji Kunimasu , Kazuhito Furukawa
IPC分类号： C07D279/12 , C07C211/32 , C07D209/56 , C07C57/50 , C07D265/30 , C07D211/08
CPC分类号： C07D495/04 , C07D333/78
摘要： An aminopropylidene derivative having excellent histamine receptor antagonistic action, a compound which is useful as a pharmaceutical composition, especially as an active ingredient, having alleviated side effects in the central nervous system is described. In the aminopropylidene derivative, R1 and R2, which may be identical or different, stand for a hydrogen, a substituted carbonyl, a substituted carbonylalkyl, and acrylic acid, excluding a case where both are hydrogen; R3 and R4, which may be identical or different, stand for hydrogen, an alkyl which may be substituted with phenyl, or the like; A stands for unsubstituted or an oxo; B stands for a carbon or an oxygen; one of X and Y stands for a carbon and the other stands for a sulfur, a broken line part stands for a single bond or a double bond, and a wavy line stands for cis-form and/or trans-form.
摘要翻译：描述了具有优异的组胺受体拮抗作用的氨基亚丙基衍生物，可用作药物组合物的化合物，特别是作为活性成分，在中枢神经系统中具有缓解的副作用。在氨基亚丙基衍生物中，R 1和R 2可以相同或不同，代表氢，取代的羰基，取代的羰基烷基和丙烯酸，不包括两者均为氢的情况; R3和R4可以相同或不同，代表氢，可被苯基取代的烷基等; A代表未取代或氧代; B代表碳或氧; X和Y中的一个代表碳，另一个代表硫，虚线部分代表单键或双键，波浪线代表顺式和/或反式。

5. 发明授权

US08536342B2 Process for producing thiabenzoazulene-propionic acid derivative 失效
标题翻译：硫代薁 - 丙酸衍生物的制备方法
公开(公告)号：US08536342B2
公开(公告)日：2013-09-17
申请号：US13383441
申请日：2010-07-26
申请人： Kunihiko Higashiura , Taizo Ito , Takashi Ogino , Taisuke Hasegawa
发明人： Kunihiko Higashiura , Taizo Ito , Takashi Ogino , Taisuke Hasegawa
IPC分类号： C07C409/00 , A61K31/445
CPC分类号： C07D409/04
摘要： Disclosed is a process for producing a thiabenzoazulene-propionic acid derivative which is useful as an active ingredient of an antihistaminic agent or the like. According to the producing process of the present invention, it is possible to produce a thiabenzoazulene-propionic acid derivative where the 2-position of the thiabenzoazulene skeleton is substituted with propionic acid. The thiabenzoazulene propionic-acid derivative thus synthesized has excellent antagonistic action to histamine H1 receptor and low intracerebral transmigration and, therefore, is useful as an active ingredient of the pharmaceutical composition such as an antihistaminic agent.
摘要翻译：公开了可用作抗组胺剂等的有效成分的噻哆烷 - 丙酸衍生物的制造方法。根据本发明的制造方法，可以制备噻吩并薁类骨架的2位用丙酸取代的噻吩并薁 - 丙酸衍生物。由此合成的硫代苯并薁丙酸衍生物对组胺H1受体和低脑内转移具有优异的拮抗作用，因此可用作药物组合物如抗组胺剂的活性成分。

6. 发明申请

US20120123127A1 PROCESS FOR PRODUCING THIABENZOAZULENE-PROPIONIC ACID DERIVATIVE 失效
标题翻译：生产噻唑烷 - 丙酸衍生物的方法
公开(公告)号：US20120123127A1
公开(公告)日：2012-05-17
申请号：US13383441
申请日：2010-07-26
申请人： Kunihiko Higashiura , Taizo Ito , Takashi Ogino , Taisuke Hasegawa
发明人： Kunihiko Higashiura , Taizo Ito , Takashi Ogino , Taisuke Hasegawa
IPC分类号： C07D409/08
CPC分类号： C07D409/04
摘要： Disclosed is a process for producing a thiabenzoazulene-propionic acid derivative which is useful as an active ingredient of an antihistaminic agent or the like. According to the producing process of the present invention, it is possible to produce a thiabenzoazulene-propionic acid derivative where the 2-position of the thiabenzoazulene skeleton is substituted with propionic acid. The thiabenzoazulene propionic-acid derivative thus synthesized has excellent antagonistic action to histamine H1 receptor and low intracerebral transmigration and, therefore, is useful as an active ingredient of the pharmaceutical composition such as an antihistaminic agent.
摘要翻译：公开了可用作抗组胺剂等的有效成分的噻哆烷 - 丙酸衍生物的制造方法。根据本发明的制造方法，可以制备噻吩并薁类骨架的2位用丙酸取代的噻吩并薁 - 丙酸衍生物。由此合成的硫代苯并薁丙酸衍生物对组胺H1受体和低脑内转移具有优异的拮抗作用，因此可用作药物组合物如抗组胺剂的活性成分。

7. 发明申请

US20100171553A1 POWER CIRCUIT 有权
标题翻译：电源电路
公开(公告)号：US20100171553A1
公开(公告)日：2010-07-08
申请号：US12644833
申请日：2009-12-22
申请人： Yoichi Okubo , Manabu Nakamura , Junya Dosaka , Yasuhiro Takeda , Taizo Ito , Naoki Hongo , Taizo Yamawaki , Takashi Kawamoto , Akira Maeki
发明人： Yoichi Okubo , Manabu Nakamura , Junya Dosaka , Yasuhiro Takeda , Taizo Ito , Naoki Hongo , Taizo Yamawaki , Takashi Kawamoto , Akira Maeki
IPC分类号： H03G1/00
CPC分类号： H03F1/0227 , H03F3/19 , H03F2200/451 , H03F2200/462
摘要： A power circuit used for an amplifier, which includes an amplifier provided with a linear amplifier serving as a voltage source, a DC/DC converter serving as a current source, a hysteresis comparator controlling the DC/DC converter, and a current detector detecting output current from the linear amplifier to output the detected output current to the hysteresis comparator; and a switching restricting means for restricting a switching interval in the DC/DC converter such that the switching interval is not equal to or less than a constant time or is not shorter than the constant time.
摘要翻译：用于放大器的电源电路，其包括放大器，该放大器设置有用作电压源的线性放大器，用作电流源的DC / DC转换器，控制DC / DC转换器的滞环比较器以及电流检测器检测输出电流从线性放大器输出检测输出电流到滞后比较器; 以及切换限制装置，用于限制DC / DC转换器中的切换间隔，使得切换间隔不等于或小于恒定时间或不短于恒定时间。

8. 发明授权

US06292993B1 Vulcanizing machine with segmented mold 有权
标题翻译：具有分段模具的硫化机
公开(公告)号：US06292993B1
公开(公告)日：2001-09-25
申请号：US09294049
申请日：1999-04-19
申请人： Taizo Ito , Tomotaka Goto , Masami Nagata
发明人： Taizo Ito , Tomotaka Goto , Masami Nagata
IPC分类号： B29C3502
CPC分类号： B29D30/0662 , B29D30/0629 , B29D2030/0653 , Y10T29/49815 , Y10T29/49826
摘要： A vulcanizing machine for producing pneumatic tires includes an exchangeable segmented mold comprised of tread mold pieces for defining the outer contour of a tire tread portion, and upper and lower side mold members engaged with the tread mold pieces, for defining the outer contours of the sidewall portions. The tread mold pieces are detachably connected to connector segments which are slidably engaged with a container ring so that vertical movement of the container ring causes radial movement of the connector segments relative to the tread mold pieces. After production of tires of a predetermined size has been completed, the mold is removed from the machine by moving the container ring upwards to disconnect the connector segments from the tread mold pieces, and disconnecting the upper side mold member from a top plate of the machine. Another segmented mold for tires of a different size is incorporated into the machine, by placing and centering the mold relative to the machine, moving the container ring downwards to connect the connector segments to the tread mold pieces, and connecting the top plate to the upper side mold member. The mold can be efficiently exchanged with respect to the machine under a high temperature condition, thereby improving the manufacturing productivity of tires.
摘要翻译：一种用于生产充气轮胎的硫化机包括一个可更换的分段模具，其包括用于限定轮胎胎面部分的外轮廓的胎面模具件，以及与胎面模具件接合的上下侧模具构件，用于限定侧壁的外轮廓部分。胎面模具可拆卸地连接到与容器环可滑动地接合的连接器部分，使得容器环的垂直运动导致连接器部分相对于胎面模具件的径向移动。在已经完成了预定尺寸的轮胎的生产之后，通过向上移动容器环从模具中取出模具以将连接器段与胎面模具件断开，并将上侧模具构件与机器的顶板断开。通过将模具相对于机器放置和对中而将不同尺寸的轮胎的另一个分段模具并入机器中，向下移动容器环以将连接器部分连接到胎面模具件，并将顶板连接到上部侧模构件。可以在高温条件下相对于机器有效地更换模具，从而提高轮胎的制造生产率。

9. 发明授权

US07626455B2 Distortion compensation apparatus 有权
标题翻译：失真补偿装置
公开(公告)号：US07626455B2
公开(公告)日：2009-12-01
申请号：US12060502
申请日：2008-04-01
申请人： Taizo Ito , Yoichi Okubo , Junya Dosaka , Toshio Nojima
发明人： Taizo Ito , Yoichi Okubo , Junya Dosaka , Toshio Nojima
IPC分类号： H03F1/26
CPC分类号： H03F1/3252
摘要： A distortion compensation apparatus includes distortion generating means for generating distortions to compensate for a distortion generated in an amplifier 2. The distortion generating means includes a nonlinear circuit 13 having an input/output expansion characteristic as a circuit which generates a distortion of the lowest odd order as a compensation target and also includes a nonlinear circuit 18 having an input/output saturation characteristic as a circuit which generates a distortion of another odd order as a compensation target.
摘要翻译：失真补偿装置包括：失真产生装置，用于产生失真以补偿放大器2中产生的失真。失真发生装置包括具有输入/输出扩展特性的非线性电路13作为产生最低奇数阶失真的电路作为补偿对象，并且还包括具有输入/输出饱和特性的非线性电路18作为产生作为补偿目标的另一奇数阶失真的电路。

10. 发明授权

US4804426A Cylindrical tire forming member manufacturing method and apparatus 失效
标题翻译：圆筒形轮胎成形构件的制造方法和装置
公开(公告)号：US4804426A
公开(公告)日：1989-02-14
申请号：US168048
申请日：1988-03-14
申请人： Kouji Okuyama , Makoto Yamamoto , Hidetoshi Kimura , Taizo Ito
发明人： Kouji Okuyama , Makoto Yamamoto , Hidetoshi Kimura , Taizo Ito
IPC分类号： B29D30/30 , B29D9/00 , B29D30/16 , B29D30/20
CPC分类号： B29D30/3007 , B29D2030/4406 , B29D2030/4418 , B29D2030/4437 , B29D2030/4462 , B29L2030/002
摘要： In a cylindrical tire forming member building method or apparatus, after the front end portion of a belt-shaped material is pressed against the drum, the belt-shaped material is wound on the drum while being centered, and with the central portion of the rear end portion of the belt-shaped material pressed against the drum with a robot hand, both edge portions of the rear end portion of the belt-shaped material are elongated longitudinally and pressed against the drum with the robot hand, so that the front and rear ends of the belt-shaped material are butt-joined without forming a gap therebetween or without being overlapped.
摘要翻译：在圆筒形轮胎成型构件的制造方法或装置中，在带状材料的前端部被压靠在滚筒上之后，带状材料被卷绕在滚筒上同时居中，并且与后部的中心部分带状材料的端部用机器人手压靠在滚筒上，带状材料的后端部分的两个边缘部分纵向伸长并用机器人手压靠在滚筒上，使得前后带状材料的端部在不形成间隙的情况下对接而不重叠。

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