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1. 发明授权

US06315907B1 Method for removing toxic shock syndrome toxin-1 in body fluids by adsorption 有权
标题翻译：通过吸附去除体液中毒性休克综合征毒素-1的方法
公开(公告)号：US06315907B1
公开(公告)日：2001-11-13
申请号：US09403281
申请日：1999-10-19
申请人： Fumiyasu Hirai , Eiji Ogino , Hiroyuki Maruyama , Takayuki Sakogawa , Takashi Asahi , Nobutaka Tani
发明人： Fumiyasu Hirai , Eiji Ogino , Hiroyuki Maruyama , Takayuki Sakogawa , Takashi Asahi , Nobutaka Tani
IPC分类号： B01D1500
CPC分类号： B01J20/3242 , A61M1/3679 , B01D15/00 , B01J20/22 , B01J20/28078 , B01J20/3092 , B01J20/3212 , B01J20/3217 , B01J20/3219 , B01J20/3248 , B01J20/3255 , B01J2220/58
摘要： An adsorbent for toxic shock syndrome toxin-1 (TSST-1) comprising a compound which has a log P value of at least 2.50 wherein P is a partition coefficient in an octanol-water system and which is immobilized on a water-insoluble carrier; a method for removing TSST-1 body fluids by adsorption which comprises bringing a body fluid containing TSST-1 into contact with the adsorbent; an adsorber for TSST-1 comprising an adsorbent packed in a container having an inlet and an outlet for a body fluid and a means for preventing the adsorbent from flowing out of the container; and use of the adsorbent. TSST-1 in body fluids can be efficiently removed by the adsorbent.
摘要翻译：用于毒性休克综合征毒素-1（TSST-1）的吸附剂，其包含log P值至少为2.50的化合物，其中P是辛醇 - 水体系中的分配系数并固定在水不溶性载体上; 一种通过吸附除去TSST-1体液的方法，其包括使含有TSST-1的体液与吸附剂接触; 用于TSST-1的吸附器，其包括填充在具有用于体液的入口和出口的容器中的吸附剂和用于防止吸附剂从容器流出的装置; 并使用吸附剂。体液中的TSST-1可以被吸附剂有效地去除。

2. 发明授权

US6132610A Endotoxin adsorption system 失效
标题翻译：内毒素吸附系统
公开(公告)号：US6132610A
公开(公告)日：2000-10-17
申请号：US905710
申请日：1997-08-05
申请人： Fumiyasu Hirai , Eiji Ogino , Takashi Asahi , Nobutaka Tani
发明人： Fumiyasu Hirai , Eiji Ogino , Takashi Asahi , Nobutaka Tani
IPC分类号： A61M1/36 , B01J39/04 , B01J47/00 , B01J47/02 , B01J47/04
CPC分类号： B01J39/04 , B01J47/003
摘要： An endotoxin adsorption system of the present invention comprises a combination of a cation exchange resin having sodium as a counter ion and a cation exchange resin having sodium and one or more metal ions other than sodium as a counter ion, and adsorbs an endotoxin without decreasing of the concentration of cations.
摘要翻译：本发明的内毒素吸附系统包括具有钠作为抗衡离子的阳离子交换树脂和具有钠和一种或多种除了钠之外的金属离子作为抗衡离子的阳离子交换树脂的组合，并且不降低内毒素吸附内毒素阳离子的浓度。

3. 发明授权

US5902877A Adsorbent of interleukins, process for removing the same, and adsorber for the same 失效
标题翻译：白细胞介素的吸附剂，其除去方法和吸附剂
公开(公告)号：US5902877A
公开(公告)日：1999-05-11
申请号：US646266
申请日：1996-05-20
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi , Yuji Okubo , Osamu Odawara , Michio Nomura
IPC分类号： B01J20/26 , B01J20/32 , C07K14/54 , A23J1/00
CPC分类号： B01J20/3212 , B01J20/26 , B01J20/3204 , B01J20/321 , B01J20/3251 , C07K14/54
摘要： The present invention relates to an adsorbent being capable of efficiently adsorbing and removing interleukins in a body fluid and to a method for adsorbing and removing, if necessary, and recovering interleukins in a body fluid with the above-mentioned adsorbent. According to the present invention, there are provided an adsorbent of interleukins which comprises a water-insoluble carrier having an anionic functional group, a method for adsorbing, removing and recovering interleukins using the same and an adsorber using the same.
摘要翻译： PCT No.PCT / JP95 / 01859 Sec。 371日期：1996年5月20日 102（e）日期1996年5月20日PCT提交1995年9月18日PCT公布。出版物WO96 / 09115 日期：1996年3月28日本发明涉及能够有效吸附和去除体液中的白细胞介素的吸附剂，如果需要，涉及吸附和除去体液中的白细胞介素的方法。根据本发明，提供一种白细胞介素的吸附剂，其包含具有阴离子官能团的水不溶性载体，使用其的吸附，除去和回收白细胞介素的方法和使用该吸附剂的吸附剂。

4. 发明授权

US06387362B1 Adsorbent for bradykinin, method for eliminating the same by adsorption, and adsorber 失效
标题翻译：用于缓激肽的吸附剂，通过吸附除去其的方法和吸附剂
公开(公告)号：US06387362B1
公开(公告)日：2002-05-14
申请号：US09043537
申请日：1998-08-14
申请人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
发明人： Fumiyasu Hirai , Nobutaka Tani , Takamune Yasuda , Takashi Asahi
IPC分类号： A61K31795
CPC分类号： B01J20/26 , A61M1/3679
摘要： An adsorbent or bradykinin comprising styrene-divinylbenzene copolymer having sulfonic acid groups and a method for adsorbing and removing bradykinin comprising contacting the adsorbent with a fluid containing bradykinin are provided. An adsorber for adsorbing bradykinin in which the adsorbent is charged in a vessel having an inlet and an outlet for a fluid is also provided.
摘要翻译：提供了包含具有磺酸基的苯乙烯 - 二乙烯基苯共聚物的吸附剂或缓激肽以及吸收和去除缓激肽的方法，包括使吸附剂与含有缓激肽的流体接触。还提供了用于吸附缓冲激肽的吸附剂，其中将吸附剂装入具有流体入口和出口的容器中。

5. 发明授权

US06127528A Process for adsorbing and removing tumor necrosis factor-.alpha. 有权
标题翻译：吸附和去除肿瘤坏死因子-α的方法
公开(公告)号：US06127528A
公开(公告)日：2000-10-03
申请号：US283964
申请日：1999-04-02
申请人： Fumiyasu Hirai , Nobutaka Tani , Takashi Asahi
发明人： Fumiyasu Hirai , Nobutaka Tani , Takashi Asahi
IPC分类号： C07K14/525 , C07K1/22 , A61K38/19 , C07K1/14 , C07K14/00
CPC分类号： C07K14/525 , Y10S930/144
摘要： The present invention relates to an adsorbent being capable of efficiently removing tumor necrosis factor-.alpha. (TNF-.alpha.) in a body fluid, an adsorber using the adsorbent and a process for adsorbing and removing TNF-.alpha., namely an adsorbent of TNF-.alpha., wherein onto a water-insoluble carrier a compound having a functional group represented by the formula (I): ##STR1## wherein X.sup.- is an anionic functional group, A is a substituent group except for the anionic functional group, n is an integer of 0 to 4 and in case n is at least 2, groups A, the number of which is n, may be the same or different from each other; a process for adsorbing and removing TNF-.alpha., which comprises coming the adsorbent into contact with a body fluid; and an adsorber for adsorbing TNF-.alpha. wherein a vessel having an inlet and an outlet for a body fluid and being equipped with a means for preventing the adsorbent from flowing to the outside of the vessel, is charged with the adsorbent.
摘要翻译：本发明涉及能够有效地去除体液中的肿瘤坏死因子-α（TNF-α）的吸附剂，使用吸附剂的吸附剂和吸附和去除TNF-α的方法，即TNF-α的吸附剂其特征在于，在水不溶性载体上具有由式（I）表示的官能团的化合物：其中，X为阴离子官能团，A为阴离子官能团以外的取代基，n为0〜 4，在n至少为2的情况下，其数目为n的基团A可以相同或不同; 一种吸附和去除TNF-α的方法，其包括使吸附剂与体液接触; 和用于吸附TNF-α的吸附器，其中具有用于体液的入口和出口的容器并且装备有用于防止吸附剂流向容器外部的装置的吸附器装入吸附剂。

6. 发明授权

US6037458A Adsorbent for serum amyloid protein 失效
标题翻译：血清淀粉样蛋白用吸附剂
公开(公告)号：US6037458A
公开(公告)日：2000-03-14
申请号：US948470
申请日：1992-09-22
申请人： Fumiyasu Hirai , Nobutaka Tani
发明人： Fumiyasu Hirai , Nobutaka Tani
IPC分类号： A61M1/34 , A61M1/36 , B01D15/00 , B01J20/32 , A23J1/00 , A61K35/14 , A61M37/00
CPC分类号： A61M1/3486 , B01D15/00 , B01J20/3204 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3253 , B01J20/3274 , B01J20/328 , A61M1/3679
摘要： An adsorbent for a serum amyloid protein, which comprises a water-insoluble carrier and either a compound selected from the group consisting of a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, said compound being immobilized onto said carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, said group being bonded to said carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.
摘要翻译：一种血清淀粉样蛋白的吸附剂，其包含水不溶性载体和选自具有阴离子官能团的化合物，具有多于一个阴离子官能团的聚阴离子化合物，苯胺和苯胺衍生物，所述化合物被固定在所述载体上，或下式-NR 1 R 2基团，其中R 1是氢原子，甲基或乙基，R 2是满足log P值的原子团，其中P是分布在水 - 辛醇体系中，式R2H的化合物的系数为0至3.2，所述基团键合到所述载体上，以及通过使用上述吸附剂的去除装置从体液中除去血清淀粉样蛋白的方法。根据本发明，SA蛋白质，特别是SAA蛋白质和SAP蛋白质可以选择性地从体液中除去而不会大大降低HDL。此外，可以以低成本提供吸附剂。

7. 发明授权

US5216127A Adsorbent for serum amyloid protein 失效
标题翻译：血清淀粉样蛋白用吸附剂
公开(公告)号：US5216127A
公开(公告)日：1993-06-01
申请号：US729234
申请日：1991-07-12
申请人： Fumiyasu Hirai , Nobutaka Tani
发明人： Fumiyasu Hirai , Nobutaka Tani
IPC分类号： A61M1/34 , A61M1/36 , B01D15/00 , B01J20/32
CPC分类号： B01D15/00 , A61M1/3486 , B01J20/3204 , B01J20/3212 , B01J20/3248 , B01J20/3253 , A61M1/3679
摘要： An adsorbent for a serum amyloid protein, which includes a water-insoluble carrier and either a compound selected from a compound having an anionic functional group, a polyanionic compound having more than one anionic functional groups, aniline and an aniline derivative, the compound being immobilized onto the carrier, or a group of the formula: --NR.sup.1 R.sup.2, wherein R.sup.1 is hydrogen atom, methyl group or ethyl group, and R.sup.2 is an atomic group satisfying that the value of log P, in which P is a distribution coefficient in a water-octanol system, of a compound of the formula: R.sup.2 H is from 0 to 3.2, the group being bonded to the carrier, and a method for removing a serum amyloid protein from body fluid through a removing apparatus using the above adsorbent. According to the present invention, SA proteins, particularly SAA proteins and SAP proteins can be selectively removed from body fluid without decreasing HDL largely. Besides, the adsorbent can be provided at a low cost.
摘要翻译：用于血清淀粉样蛋白的吸附剂，其包括水不溶性载体和选自具有阴离子官能团的化合物，具有多于一个阴离子官能团的聚阴离子化合物，苯胺和苯胺衍生物，所述化合物被固定或载体，或下式的基团：-NR1R2，其中R1是氢原子，甲基或乙基，R2是满足logP值的原子团，其中P是水中的分布系数正辛醇体系，R2H的化合物为0至3.2，该基团与载体结合，以及通过使用上述吸附剂的去除装置从体液中除去血清淀粉样蛋白的方法。根据本发明，SA蛋白质，特别是SAA蛋白质和SAP蛋白质可以选择性地从体液中除去而不会大大降低HDL。此外，可以以低成本提供吸附剂。

8. 发明授权

US07309488B2 Adsorbents for dilated cardiomyopathy 有权
标题翻译：扩张型心肌病的吸附剂
公开(公告)号：US07309488B2
公开(公告)日：2007-12-18
申请号：US10221042
申请日：2001-04-09
申请人： Eiji Ogino , Shigeo Furuyoshi , Fumiyasu Hirai , Takehiro Nishimoto
发明人： Eiji Ogino , Shigeo Furuyoshi , Fumiyasu Hirai , Takehiro Nishimoto
IPC分类号： A61K39/00 , C07K1/22
CPC分类号： C07K14/705 , A61K38/00 , A61M1/3679
摘要： An adsorbent which comprises a water-insoluble carrier and a compound, which is immobilized on said carrier, having a binding affinity for an antibody against β1-adrenoceptor and/or an antibody against M2 muscarinic receptor exhibits a remarkably large adsorptive capacity.
摘要翻译：包含水不溶性载体和固定在所述载体上的具有对抗β1肾上腺素能受体的抗体和/或针对M2毒蕈碱受体的抗体的结合亲和力的吸附剂显示出非常大的吸附能力。

9. 发明授权

US08785141B2 Bacterial toxin adsorbing material, method of removing the toxin by adsorbing, and an adsorber formed by filling the adsorbing material therein 失效
标题翻译：细菌毒素吸附材料，通过吸附除去毒素的方法和通过在其中填充吸附材料而形成的吸附剂
公开(公告)号：US08785141B2
公开(公告)日：2014-07-22
申请号：US10362534
申请日：2001-08-24
申请人： Tamiji Fujimoto , Fumiyasu Hirai , Shigeo Furuyoshi
发明人： Tamiji Fujimoto , Fumiyasu Hirai , Shigeo Furuyoshi
IPC分类号： G01N1/30 , G01N33/53 , C12Q1/00 , C12N11/00 , G01N33/569 , B01J20/20 , A61M1/36 , B01J20/28 , B01J20/26
CPC分类号： B01J20/26 , A61M1/3627 , A61M1/3679 , B01J20/20 , B01J20/261 , B01J20/264 , B01J20/28078 , Y10T428/13 , Y10T428/1376 , Y10T428/268
摘要： The invention aims at providing an adsorbent for bacterial toxins, a method for removal of such toxins by adsorption, and an adsorber packed with said adsorbent.Provided are an adsorbent for bacterial toxins, which comprises a water-insoluble porous material having a mode of pore radius of 20 angstroms to 1,000 angstroms, a method for removal of bacterial toxins using said adsorbent, and an adsorber packed with said adsorbent.
摘要翻译：本发明的目的在于提供细菌毒素的吸附剂，通过吸附除去这些毒素的方法以及填充有所述吸附剂的吸附剂。提供了一种用于细菌毒素的吸附剂，其包括孔半径为20埃至1000埃的水不溶性多孔材料，使用所述吸附剂除去细菌毒素的方法和填充有所述吸附剂的吸附剂。

10. 发明授权

US08720630B2 Motorcycle 有权
标题翻译：摩托车
公开(公告)号：US08720630B2
公开(公告)日：2014-05-13
申请号：US12327689
申请日：2008-12-03
申请人： Fumiyasu Hirai
发明人： Fumiyasu Hirai
IPC分类号： B62J17/02
CPC分类号： B62J17/02 , B62J99/00
摘要： A motorcycle in which a plate member can be mounted to a front cover disposed above a headlight. The front cover includes a front cover main body portion and a hole formed in the front cover main body portion. The front cover main body portion is provided at a back side thereof with a mount portion for a bracket having a portion passing through the hole. The portion passing through the hole includes a retaining portion for retaining the plate member in front of the front cover main body portion.
摘要翻译：一种摩托车，其中板构件可以安装在设置在头灯上方的前盖上。前盖包括前盖主体部分和形成在前盖主体部分中的孔。前盖主体部分在其后侧设置有具有穿过该孔的部分的托架的安装部分。穿过孔的部分包括用于将板构件保持在前盖主体部分前面的保持部分。

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